• I am an associate professor in the department of Epidemiology at the University of Alabama at Birmingham (UAB). After working as a statistician/epidemiologist, I have accumulated more than 10 years of experience in the study design, analysis, and methodological development using a variety of data system, including electronic medical records, Medicare, Medicaid, SEER, commercial administrative data, and patient surveys. At the same time, I have established strong collaboration with experts on a variety of projects. With a focus on chronic disease, such as osteoporosis, cancer and auto-immune diseases, my current work is mainly related to comparative effectiveness research, pharmacoepidemiology, drug safety and patient reported outcomes.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2022 ISPE-Endorsed Guidance in Using Electronic Health Records for Comparative Effectiveness Research in COVID-19: Opportunities and Trade-OffsClinical Pharmacology and Therapeutics.  112:990-999. 2022
    2022 Inpatient Diagnosis of Delirium and Encephalopathy: Coding Trends in 2011–2018 2022
    2022 Rheumatoid arthritis disease activity and hospitalized infection in a large U.S. registry.Arthritis Care and Research2022
    2022 Patient-Reported Nausea and Fatigue Related to Methotrexate: A Prospective, Self-Controlled Study in the ArthritisPower® RegistryRheumatology and Therapy.  9:207-221. 2022
    2021 The Annual Diagnostic Prevalence of Ankylosing Spondylitis and Axial Spondyloarthritis in the United States Using Medicare and MarketScan DatabasesAcr Open Rheumatology.  3:743-752. 2021
    2021 Variability in Glucocorticoid Prescribing for Rheumatoid Arthritis and the Influence of Provider Preference on Long-Term Use of GlucocorticoidsArthritis Care and Research.  73:1597-1605. 2021
    2021 Effects of the SARS-CoV-2 global pandemic on U.S. rheumatology outpatient care delivery and use of telemedicine: an analysis of data from the RISE registryRheumatology International: clinical and experimental investigations.  41:1755-1761. 2021
    2021 Tofacitinib Treatment Safety in Moderate to Severe Ulcerative Colitis: Comparison of Observational Population Cohort Data from the IBM MarketScan® Administrative Claims Database with Tofacitinib Trial DataInflammatory Bowel Diseases.  27:1394-1408. 2021
    2021 Meaningful change thresholds for patient-reported outcomes measurement information system (PROMIS) fatigue and pain interference scores in patients with rheumatoid arthritisJournal of Rheumatology.  48:1239-1242. 2021
    2021 Anca-Associated vasculitis management in the united states: Data from the rheumatology informatics system for effectiveness (rise) registryJournal of Rheumatology.  48:1060-1064. 2021
    2021 Evaluation of the Effect of Diabetes on Rheumatoid Arthritis-related Outcomes in an Electronic Health Record-based Rheumatology RegistryJournal of Rheumatology.  48:992-1001. 2021
    2021 Benefits of methotrexate use on cardiovascular disease risk among rheumatoid arthritis patients initiating biologic disease-modifying antirheumatic drugsJournal of Rheumatology.  48:804-812. 2021
    2021 Association of anti-tumor necrosis factor therapy with mortality among veterans with inflammatory bowel diseaseJAMA Network Open.  4. 2021
    2021 Influence of Multimorbidity on New Treatment Initiation and Achieving Target Disease Activity Thresholds in Active Rheumatoid Arthritis: A Cohort Study Using the Rheumatology Informatics System for Effectiveness RegistryArthritis Care and Research2021
    2020 Risk for Serious Infection With Low-Dose Glucocorticoids in Patients With Rheumatoid Arthritis : A Cohort StudyAnnals of Internal Medicine.  173:870-878. 2020
    2020 Use of ICD-10 diagnosis codes to identify seropositive and seronegative rheumatoid arthritis when lab results are not availableArthritis Research and Therapy.  22. 2020
    2020 Incidence of venous and arterial thromboembolic events reported in the tofacitinib rheumatoid arthritis, psoriasis and psoriatic arthritis development programmes and from real-world dataAnnals of the Rheumatic Diseases.  79:1400-1413. 2020
    2020 Capture of biologic and biosimilar dispensings in a consortium of U.S.-based claims databases: Utilization of national drug codes and Healthcare Common Procedure Coding System modifiers in medical claimsPharmacoepidemiology and Drug Safety.  29:778-785. 2020
    2020 Duration of Bisphosphonate Drug Holidays and Associated Fracture RiskMedical Care.  58:419-426. 2020
    2020 An Integrated Analysis of the Safety of Tofacitinib in Psoriatic Arthritis across Phase III and Long-Term Extension Studies with Comparison to Real-World Observational DataDrug Safety.  43:379-392. 2020
    2020 Assessing Rheumatoid Arthritis Disease Activity With Patient-Reported Outcomes Measurement Information System Measures Using Digital TechnologyArthritis Care and Research.  72:553-560. 2020
    2020 Temporal Trends and Factors Associated with Bisphosphonate Discontinuation and RestartJournal of Bone and Mineral Research.  35:478-487. 2020
    2020 Do Patients With Moderate or High Disease Activity Escalate Rheumatoid Arthritis Therapy According to Treat-to-Target Principles? Results From the Rheumatology Informatics System for Effectiveness Registry of the American College of RheumatologyArthritis Care and Research.  72:166-175. 2020
    2020 Factors associated with breast cancer screening behaviors in a sample of Jamaican women in 2013Women and Health: the multidisciplinary journal of women's health issues.  1032-1039. 2020
    2020 Human papillomavirus vaccination schedule: Adherence among commercially insured adolescents and young adults in the United States, 2011-2017American Journal of Public Health.  110:385-390. 2020
    2019 Screening of Hyperlipidemia Among Patients With Rheumatoid Arthritis in the United StatesArthritis Care and Research.  71:1593-1599. 2019
    2019 Risk for Herpes Zoster in Tofacitinib-Treated Rheumatoid Arthritis Patients With and Without Concomitant Methotrexate and GlucocorticoidsArthritis Care and Research.  71:1249-1254. 2019
    2019 Tocilizumab and the Risk of Cardiovascular Disease: Direct Comparison Among Biologic Disease-Modifying Antirheumatic Drugs for Rheumatoid Arthritis PatientsArthritis Care and Research.  71:1004-1018. 2019
    2019 Tools and Methods for Real-World Evidence Generation: Pragmatic Trials, Electronic Consent, and Data LinkagesRheumatic Disease Clinics of North America.  45:275-289. 2019
    2019 Improved Quality of Life with Anti-TNF Therapy Compared with Continued Corticosteroid Utilization in Crohn's DiseaseInflammatory Bowel Diseases.  25:925-936. 2019
    2019 Perspectives of Rheumatoid Arthritis Patients on Electronic Communication and Patient-Reported Outcome Data Collection: A Qualitative StudyArthritis Care and Research.  71:80-87. 2019
    2019 Which patient reported outcome domains are important to the rheumatologists while assessing patients with rheumatoid arthritis?BMC Rheumatology.  3. 2019
    2018 Socioeconomic Status and Race are both Independently associated with Increased Hospitalization Rate among Crohn's Disease PatientsScientific Reports.  8. 2018
    2018 Use of Medicare Claims Data for the Identification of Myocardial Infarction: The Reasons for Geographic and Racial Differences in Stroke StudyMedical Care.  56:1051-1059. 2018
    2018 Is Rheumatoid Arthritis a Cardiovascular Risk-Equivalent to Diabetes Mellitus?Arthritis Care and Research.  70:1694-1699. 2018
    2018 An Observational Study of Cardiovascular Risks Associated with Rheumatoid Arthritis Therapies: A Comparison of Two Analytical ApproachesThe Permanente Journal.  22. 2018
    2018 Gastrointestinal Perforations with Biologics in Patients with Rheumatoid Arthritis: Implications for CliniciansDrug Safety.  41:545-553. 2018
    2018 Satisfaction with Subcutaneous Golimumab and its Auto-Injector among Rheumatoid Arthritis Patients with Inadequate Response to Adalimumab or EtanerceptThe Patient: Patient Centered Outcomes Research.  11:361-369. 2018
    2018 ReplyArthritis and Rheumatology.  70:795-796. 2018
    2018 Biomarker-related risk for myocardial infarction and serious infections in patients with rheumatoid arthritis: A population-based studyAnnals of the Rheumatic Diseases.  77:386-392. 2018
    2018 Increased mortality rates with prolonged corticosteroid therapy when compared with antitumor necrosis factor-α-directed therapy for inflammatory bowel diseaseAmerican Journal of Gastroenterology.  113:405-417. 2018
    2018 Comparative Effectiveness of Vedolizumab vs. Infliximab Induction Therapy in Ulcerative Colitis: Experience of a Real-World Cohort at a Tertiary Inflammatory Bowel Disease Center.Gastroenterology Research.  11:41-45. 2018
    2017 Accuracy of Medicare Claim-based Algorithm to Detect Breast, Prostate, or Lung Cancer Bone Metastases.Medical Care.  55:e144-e149. 2017
    2017 Perioperative Timing of Infliximab and the Risk of Serious Infection After Elective Hip and Knee ArthroplastyArthritis Care and Research.  69:1845-1854. 2017
    2017 Is gout a risk equivalent to diabetes for stroke and myocardial infarction? A retrospective claims database studyArthritis Research and Therapy.  19. 2017
    2017 Risk of Hypersensitivity to Biologic Agents Among Medicare Patients With Rheumatoid ArthritisArthritis Care and Research.  69:1526-1534. 2017
    2017 Changing Trends in Opioid Use Among Patients With Rheumatoid Arthritis in the United StatesArthritis and Rheumatology.  69:1733-1740. 2017
    2017 Availability of healthcare resources and epithelial ovarian cancer stage of diagnosis and mortality among Blacks and WhitesJournal of Ovarian Research.  10. 2017
    2017 Longterm effectiveness of herpes zoster vaccine among patients with autoimmune and inflammatory diseasesJournal of Rheumatology.  44:1083-1087. 2017
    2017 The clinical status and economic savings associated with remission among patients with rheumatoid arthritis: leveraging linked registry and claims data for synergistic insightsPharmacoepidemiology and Drug Safety.  26:310-319. 2017
    2017 Herpes Zoster and the Risk of Stroke in Patients With Autoimmune DiseasesArthritis and Rheumatology.  69:439-446. 2017
    2017 Accuracy of Medicare Claim-based Algorithm to Detect Breast, Prostate, or Lung Cancer Bone MetastasesMedical Care.  55:e144-e149. 2017
    2016 Brief Report: Risk of Gastrointestinal Perforation Among Rheumatoid Arthritis Patients Receiving Tofacitinib, Tocilizumab, or Other Biologic TreatmentsArthritis and Rheumatology.  68:2612-2617. 2016
    2016 Association Between Breast Cancer Recurrence and Immunosuppression in Rheumatoid Arthritis and Inflammatory Bowel Disease: A Cohort StudyArthritis and Rheumatology.  68:2403-2411. 2016
    2016 Comparative effects of biologics on cardiovascular risk among older patients with rheumatoid arthritisAnnals of the Rheumatic Diseases.  75:1813-1818. 2016
    2016 Real-world comparative risks of herpes virus infections in tofacitinib and biologic-treated patients with rheumatoid arthritisAnnals of the Rheumatic Diseases.  75:1843-1847. 2016
    2016 Risk of Herpes Zoster in Autoimmune and Inflammatory Diseases: Implications for VaccinationArthritis and Rheumatology.  68:2328-2337. 2016
    2016 LDL cholesterol response and statin adherence among high-risk patients initiating treatmentAmerican Journal of Managed Care.  22. 2016
    2016 Risk of nonmelanoma skin cancer associated with the use of immunosuppressant and biologic agents in patients with a history of autoimmune disease and nonmelanoma skin cancerJAMA Dermatology.  152:164-172. 2016
    2016 Comparative Risk of Hospitalized Infection Associated with Biologic Agents in Rheumatoid Arthritis Patients Enrolled in MedicareArthritis and Rheumatology.  68:56-66. 2016
    2016 LDL cholesterol response and statin adherence among high-risk patients initiating treatmentJournal of managed care & specialty pharmacy.  22:e106-e115. 2016
    2016 Risk of Cardiovascular Outcomes among Psoriasis Patients Treated with Biologics and Other Systemic Agents. 2016
    2015 The comparative effectiveness of biologics among older adults and disabled rheumatoid arthritis patients in the Medicare populationBritish Journal of Clinical Pharmacology.  80:1447-1457. 2015
    2015 ReplyArthritis Care and Research.  67:1041-1042. 2015
    2015 Risk of hospitalised infection in rheumatoid arthritis patients receiving biologics following a previous infection while on treatment with anti-TNF therapyAnnals of the Rheumatic Diseases.  74:1065-1071. 2015
    2015 Risk of hospitalized infection among rheumatoid arthritis patients concurrently treated with a biologic agent and denosumabArthritis and Rheumatology.  67:1456-1464. 2015
    2015 Impact of biologic agents with and without concomitant methotrexate and at reduced doses in older rheumatoid arthritis patientsArthritis Care and Research.  67:624-632. 2015
    2015 Risks of herpes zoster in patients with rheumatoid arthritis according to biologic disease-modifying therapyArthritis Care and Research.  67:731-736. 2015
    2015 Statin use following hospitalization among Medicare beneficiaries with a secondary discharge diagnosis of acute myocardial infarctionJournal of the American Heart Association.  4. 2015
    2015 Cost and effectiveness of biologics for rheumatoid arthritis in a commercially insured populationJournal of Managed Care Pharmacy.  21:318-328. 2015
    2015 Fractures and mortality in relation to different osteoporosis treatmentsClinical and Experimental Rheumatology.  33:302-309. 2015
    2015 Underutilization of high-intensity statin therapy after hospitalization for coronary heart diseaseJournal of the American College of Cardiology.  65:270-277. 2015
    2014 Linkage of a de-identified united states rheumatoid arthritis registry with administrative data to facilitate comparative effectiveness researchArthritis Care and Research.  66:1790-1798. 2014
    2014 Use of Oral and Subcutaneous Methotrexate in Rheumatoid Arthritis Patients in the United StatesArthritis Care and Research.  66:1604-1611. 2014
    2014 Ability of low antihypertensive medication adherence to predict statin discontinuation and low statin adherence in patients initiating treatment after a coronary eventAmerican Journal of Cardiology.  114:826-831. 2014
    2014 Estimating effectiveness and cost of biologics for rheumatoid arthritis: Application of a validated algorithm to commercial insurance claimsClinical Therapeutics: the international peer-reviewed journal of drug therapy.  36:996-1004. 2014
    2014 Patterns and predictors of osteoporosis medication discontinuation and switching among Medicare beneficiariesBMC Musculoskeletal Disorders.  15. 2014
    2014 Death, debility, and destitution following hip fractureJournal of Gerontology Series A: Biological Sciences and Medical Sciences.  69 A:346-353. 2014
    2014 Ability of low antihypertensive medication adherence to predict statin discontinuation and low statin adherence in patients initiating treatment after a coronary event.American Journal of Cardiology.  114:826-831. 2014
    2014 Declines in coronary heart disease incidence and mortality among middle-aged adults with and without diabetesAnnals of Epidemiology.  24:581-587. 2014
    2014 Statin underuse and low prevalence of LDL-C control among U.S. Adults at high risk of coronary heart diseaseAmerican Journal of the Medical Sciences.  348:108-114. 2014
    2014 Trends in the utilization and outcomes of medicare patients hospitalized for hip fracture, 2000-2008Journal of Aging and Health.  26:360-379. 2014
    2014 Use of a validated algorithm to estimate the annual cost of effective biologic treatment for rheumatoid arthritisJournal of Medical Economics.  17:555-566. 2014
    2013 Identifying newly approved medications in Medicare claims data: A case study using tocilizumabPharmacoepidemiology and Drug Safety.  22:1214-1221. 2013
    2013 Awareness, treatment, and control of LDL cholesterol are lower among U.S. adults with undiagnosed diabetes versus diagnosed diabetesDiabetes Care.  36:2734-2740. 2013
    2013 Trends in the prevalence, awareness, treatment and control of high low density lipoprotein-cholesterol among United States adults from 1999-2000 Through 2009-2010American Journal of Cardiology.  112:664-670. 2013
    2013 New methods for determining comparative effectiveness in rheumatoid arthritisCurrent Opinion in Rheumatology.  25:325-333. 2013
    2013 Further evaluation of a claims-based algorithm to determine the effectiveness of biologics for rheumatoid arthritis using commercial claims dataArthritis Research and Therapy.  15. 2013
    2013 Physicians' explanations for apparent gaps in the quality of rheumatology care: Results from the US Medicare Physician Quality Reporting SystemArthritis Care and Research.  65:235-243. 2013
    2013 Generic alendronate use among medicare beneficiaries: Are part d data complete?Pharmacoepidemiology and Drug Safety.  22:55-63. 2013
    2013 Trends in the use of biologic agents among rheumatoid arthritis patients enrolled in the US medicare programArthritis Care and Research.  65:1743-1751. 2013
    2012 Does medication adherence itself confer fracture protection? An investigation of the healthy adherer effect in observational dataArthritis Care and Research.  64:1855-1863. 2012
    2012 Recent trends in hip fracture rates by race/ethnicity among older US adultsJournal of Bone and Mineral Research.  27:2325-2332. 2012
    2012 Adherence with intravenous zoledronate and intravenous ibandronate in the United States medicare populationArthritis Care and Research.  64:1054-1060. 2012
    2012 Central DXA utilization shifts from office-based to hospital-based settings among medicare beneficiaries in the wake of reimbursement changesJournal of Bone and Mineral Research.  27:858-864. 2012
    2011 Minor, Major, Low-Trauma, and high-trauma fractures: What are the subsequent fracture risks and how do they vary?Current Osteoporosis Reports.  9:122-128. 2011
    2011 Potential and pitfalls of using large administrative claims data to study the safety of osteoporosis therapiesCurrent Rheumatology Reports.  13:273-282. 2011
    2011 Erratum: Clinical and demographic factors associated with fractures among older Americans (Osteoporosis International DOI: 10.1007/s00198-010-1300-8)Osteoporosis International.  22:1275-1276. 2011
    2011 Clinical and demographic factors associated with fractures among older AmericansOsteoporosis International.  22:1263-1274. 2011
    2010 Predicting hip and major osteoporotic fractures using administrative dataArchives of Internal Medicine.  170:1940-1942. 2010
    2010 Health services utilization after fractures: Evidence from MedicareJournal of Gerontology Series A: Biological Sciences and Medical Sciences.  65 A:1012-1020. 2010
    2010 Identifying types of nursing facility stays using medicare claims data: An algorithm and validationHealth Services and Outcomes Research Methodology: an international journal devoted to quantitative methods for the study of the utilization, quality, cost and outcomes of health care.  10:100-110. 2010
    2009 Health care expenditures associated with skeletal fractures among medicare beneficiaries, 1999-2005Journal of Bone and Mineral Research.  24:2050-2055. 2009
    2009 Estimated prevalence and patterns of presumed osteoporosis among older Americans based on Medicare dataOsteoporosis International.  20:1507-1515. 2009
    2009 The effects of the Balanced Budget Act of 1997 on home health and hospice in older adult cancer patientsMedical Care.  47:279-285. 2009
    2008 Adaptation of bayesian data mining algorithms to longitudinal claims data: Coxib safety as an exampleMedical Care.  46:969-975. 2008
    2008 Does cholecystectomy prior to the diagnosis of pancreatic cancer affect outcome?American Surgeon.  74:602-605. 2008
    2008 Secondary Analysis of Merged American Hospital Association Data and U.S. Census Data: Beginning to Understand the Supply-Demand Chain in Pediatric Inpatient CareJournal of Pediatric Nursing.  23:161-168. 2008
    2006 Trends in hospital and surgeon volume and operative mortality for cancer surgeryAnnals of Surgical Oncology.  13:851-858. 2006
    2005 Physician supply, treatment, and amputation rates for peripheral arterial diseaseJournal of Vascular Surgery.  42:81-87. 2005

    Teaching Activities

  • EPI609 - Intro Pharmacoepi /Drug Safety (Fall Term 2018)
  • EPI609 - Intro Pharmacoepi /Drug Safety (Fall Term 2019)
  • EPI609 - Intro Pharmacoepi /Drug Safety (Fall Term 2020)
  • EPI609 - Intro Pharmacoepi /Drug Safety (Fall Term 2021)
  • EPI609 - Intro Pharmacoepi /Drug Safety (Fall Term 2022)
  • EPI614 - EPI Methods Applied CER (Spring Term 2015)
  • EPI614 - EPI Methods Applied CER (Spring Term 2016)
  • EPI614 - EPI Methods Applied CER (Spring Term 2017)
  • EPI614 - EPI Methods Applied CER (Spring Term 2018)
  • EPI614 - EPI Methods Applied CER (Spring Term 2019)
  • EPI614 - EPI Methods Applied CER (Spring Term 2020)
  • EPI614 - EPI Methods Applied CER (Spring Term 2021)
  • EPI614 - EPI Methods Applied CER (Spring Term 2022)
  • EPI697 - Internship (Fall Term 2018)
  • EPI697 - Internship (Fall Term 2020)
  • EPI697 - Internship (Fall Term 2020)
  • EPI697 - Internship (Spring Term 2017)
  • EPI697 - Internship (Spring Term 2020)
  • EPI697 - Internship (Spring Term 2021)
  • EPI697 - Internship (Summer Term 2016)
  • EPI697 - Internship (Summer Term 2018)
  • EPI697 - Internship (Summer Term 2019)
  • EPI697 - Internship (Summer Term 2021)
  • EPI697Q - Internship Online (Spring Term 2018)
  • EPI698 - Directed Research (Fall Term 2019)
  • EPI698 - Directed Research (Fall Term 2020)
  • EPI698 - Directed Research (Fall Term 2021)
  • EPI698 - Directed Research (Spring Term 2016)
  • EPI698 - Directed Research (Spring Term 2017)
  • EPI698 - Directed Research (Spring Term 2020)
  • EPI698 - Directed Research (Spring Term 2021)
  • EPI698 - Directed Research (Summer Term 2015)
  • EPI698 - Directed Research (Summer Term 2019)
  • EPI698 - Directed Research (Summer Term 2021)
  • EPI699 - Project Research (Fall Term 2017)
  • EPI699 - Project Research (Fall Term 2020)
  • EPI699 - Project Research (Fall Term 2021)
  • EPI699 - Project Research (Spring Term 2019)
  • EPI699 - Project Research (Spring Term 2021)
  • EPI699 - Project Research (Summer Term 2017)
  • EPI699 - Project Research (Summer Term 2020)
  • Full Name

  • Huifeng Yun