Selected Publications

Academic Article

Year Title Altmetric
2021 Early life and adult stress promote sex dependent changes in hypothalamic miRNAs and environmental enrichment prevents stress-induced miRNA and gene expression changes in ratsBMC Genomics.  22. 2021
2021 Advances in novel molecular targets for antidepressantsProgress in Neuro-Psychopharmacology and Biological Psychiatry.  104. 2021
2020 Elevated expression of unfolded protein response genes in the prefrontal cortex of depressed subjects: Effect of suicideJournal of Affective Disorders.  262:229-236. 2020
2020 MicroRNA mediators of early life stress vulnerability to depression and suicidal behaviorMolecular Psychiatry.  25:308-320. 2020
2019 A Novel Animal Model for Studying Depression Featuring the Induction of the Unfolded Protein Response in HippocampusMolecular Neurobiology.  56:8524-8536. 2019
2019 Co-expression network modeling identifies key long non-coding RNA and mRNA modules in altering molecular phenotype to develop stress-induced depression in ratsTranslational Psychiatry.  9. 2019
2019 Linking unfolded protein response to inflammation and depression: potential pathologic and therapeutic implicationsMolecular Psychiatry.  24:987-994. 2019
2019 Chronic Testosterone Increases Impulsivity and Influences the Transcriptional Activity of the Alpha-2A Adrenergic Receptor Signaling Pathway in Rat BrainMolecular Neurobiology.  56:4061-4071. 2019
2019 Role of HPA and the HPG Axis Interaction in Testosterone-Mediated Learned Helpless BehaviorMolecular Neurobiology.  56:394-405. 2019
2018 MicroRNAs in depression and suicide: Recent insights and future perspectivesJournal of Affective Disorders.  240:146-154. 2018
2018 Long Noncoding RNA-Associated Transcriptomic Changes in Resiliency or Susceptibility to Depression and Response to Antidepressant TreatmentInternational Journal of Neuropsychopharmacology.  21:461-472. 2018
2018 Role of complex epigenetic switching in tumor necrosis factor-α upregulation in the prefrontal cortex of suicide subjectsAmerican Journal of Psychiatry.  175:262-274. 2018
2018 Unfolded protein response and associated alterations in toll-like receptor expression and interaction in the hippocampus of restraint ratsPsychoneuroendocrinology.  89:185-193. 2018
2018 The concept of violent suicide, its underlying trait and neurobiology: A critical perspectiveEuropean Neuropsychopharmacology.  28:243-251. 2018
2018 Interaction between early-life stress and FKBP5 gene variants in major depressive disorder and post-traumatic stress disorder: A systematic review and meta-analysisJournal of Affective Disorders.  225:422-428. 2018
2018 Understanding the Neuroepigenetic Constituents of Suicide BrainProgress in Molecular Biology and Translational Science.  157:233-262. 2018
2017 Altered miRNA expression network in locus coeruleus of depressed suicide subjectsScientific Reports.  7. 2017
2017 Transcriptional profiling of mitochondria associated genes in prefrontal cortex of subjects with major depressive disorderWorld Journal of Biological Psychiatry.  18:592-603. 2017
2017 Albumin Protein Cleavage Affects the Wear and Friction of Ultra-High Molecular Weight Polyethylene.Lubricants.  5. 2017
2017 The recent progress in animal models of depressionProgress in Neuro-Psychopharmacology and Biological Psychiatry.  77:99-109. 2017
2017 microRNA-124: a putative therapeutic target and biomarker for major depressionExpert Opinion on Therapeutic Targets.  21:653-656. 2017
2017 DNA methylation and expression of stress related genes in PBMC of MDD patients with and without serious suicidal ideationJournal of Psychiatric Research.  89:115-124. 2017
2017 Cognitive flexibility impairment and reduced frontal cortex BDNF expression in the ouabain model of maniaNeuroscience.  345:229-242. 2017
2017 Identification of MicroRNA-124-3p as a Putative Epigenetic Signature of Major Depressive DisorderNeuropsychopharmacology.  42:864-875. 2017
2017 The life span model of suicide and its neurobiological foundationFrontiers in Neuroscience.  11. 2017
2017 Animal models to improve our understanding and treatment of suicidal behaviorTranslational Psychiatry.  7. 2017
2017 Understanding epigenetic architecture of suicide neurobiology: A critical perspectiveNeuroscience and Biobehavioral Reviews.  72:10-27. 2017
2016 Dissecting bipolar disorder complexity through epigenomic approachMolecular Psychiatry.  21:1490-1498. 2016
2016 Altered expression of endoplasmic reticulum stress associated genes in hippocampus of learned helpless rats: Relevance to depression pathophysiologyFrontiers in Pharmacology.  6. 2016
2016 Pathogenetic and therapeutic applications of microRNAs in major depressive disorderProgress in Neuro-Psychopharmacology and Biological Psychiatry.  64:341-348. 2016
2016 Altered ERK1/2 signaling in the brain of learned helpless rats: Relevance in vulnerability to developing stress-induced depressionNeural Plasticity.  2016. 2016
2015 Chronic corticosterone-mediated dysregulation of microRNA network in prefrontal cortex of rats: Relevance to depression pathophysiologyTranslational Psychiatry.  5. 2015
2015 Noncoding RNAs and neurobehavioral mechanisms in psychiatric diseaseMolecular Psychiatry.  20:677-684. 2015
2015 Serotonergic and Noradrenergic Neurotransmitter Systems in SuicideAdvances in Biological Psychiatry -Basel-.  30:21-36. 2015
2014 Expression of micrornas and other small RNAs in prefrontal cortex in schizophrenia, bipolar disorder and depressed subjectsPLoS ONE.  9. 2014
2014 Alteration of cyclic-AMP response element binding protein in the postmortem brain of subjects with bipolar disorder and schizophreniaJournal of Affective Disorders.  152-154:326-333. 2014
2014 Emerging role of microRNAs in major depressive disorder: Diagnosis and therapeutic implicationsDialogues in Clinical Neuroscience.  16:43-61. 2014
2014 Enoxacin elevates microRNA levels in rat frontal cortex and prevents learned helplessnessFrontiers in Psychiatry.  5. 2014
2014 Hippocampal neurogenesis, neurotrophic factors and depression: Possible therapeutic targets? 2014
2014 The involvement of micrornas in major depression, suicidal behavior, and related disorders: A focus on miR-185 and miR-491-3pCellular and Molecular Neurobiology.  34:17-30. 2014
2014 Toll-like receptors in the depressed and suicide brainJournal of Psychiatric Research.  53:62-68. 2014
2013 MicroRNAs: Fundamental regulators of gene expression in major affective disorders and suicidal behavior?Frontiers in Cellular Neuroscience.  6. 2013
2013 Region-specific alterations in glucocorticoid receptor expression in the postmortem brain of teenage suicide victimsPsychoneuroendocrinology.  38:2628-2639. 2013
2013 The role of neuropeptides in suicidal behavior: A systematic reviewBioMed Research International.  2013. 2013
2013 Altered Wnt signalling in the teenage suicide brain: Focus on glycogen synthase kinase-3β and β-cateninInternational Journal of Neuropsychopharmacology.  16:945-955. 2013
2013 Pharmacological properties of glutamatergic drugs targeting NMDA receptors and their application in major depressionCurrent Pharmaceutical Design.  19:1898-1922. 2013
2013 Adult medication-free schizophrenic patients exhibit long-chain omega-3 fatty acid deficiency: Implications for cardiovascular disease riskCardiovascular Psychiatry and Neurology.  2013. 2013
2013 Involvement of brain-derived neurotrophic factor in late-life depressionAmerican Journal of Geriatric Psychiatry.  21:433-449. 2013
2013 Lower docosahexaenoic acid concentrations in the postmortem prefrontal cortex of adult depressed suicide victims compared with controls without cardiovascular diseaseJournal of Psychiatric Research.  47:1187-1191. 2013
2013 microRNAs as Biomarker in Depression Pathogenesis.Annals of Psychiatry and Mental Health.  1:1003. 2013
2012 The role of microRNAs in synaptic plasticity, major affective disorders and suicidal behaviorNeuroscience Research.  73:179-190. 2012
2012 MicroRNA expression is down-regulated and reorganized in prefrontal cortex of depressed suicide subjectsPLoS ONE.  7. 2012
2012 Proinflammatory cytokines in the prefrontal cortex of teenage suicide victimsJournal of Psychiatric Research.  46:57-63. 2012
2011 MicroRNA expression in rat brain exposed to repeated inescapable shock: Differential alterations in learned helplessness vs. non-learned helplessnessInternational Journal of Neuropsychopharmacology.  14:1315-1325. 2011
2011 Evidence demonstrating role of microRNAs in the etiopathology of major depressionJournal of Chemical Neuroanatomy.  42:142-156. 2011
2011 Elucidating biological risk factors in suicide: Role of protein kinase AProgress in Neuro-Psychopharmacology and Biological Psychiatry.  35:831-841. 2011
2011 Glycosides, depression and suicidal behaviour: The role of glycoside-linked proteinsMolecules.  16:2688-2713. 2011
2011 Cyclic-AMP response element binding protein (CREB) in the neutrophils of depressed patientsPsychiatry Research.  185:108-112. 2011
2010 Selective deficits in erythrocyte docosahexaenoic acid composition in adult patients with bipolar disorder and major depressive disorderJournal of Affective Disorders.  126:303-311. 2010
2010 What can post-mortem studies tell us about the pathoetiology of suicide?Future Neurology.  5:701-720. 2010
2010 Modulation in Activation and Expression of Phosphatase and Tensin Homolog on Chromosome Ten, Akt1, and 3-Phosphoinositide-Dependent Kinase 1: Further Evidence Demonstrating Altered Phosphoinositide 3-Kinase Signaling in Postmortem Brain of Suicide SubjectsBiological Psychiatry.  67:1017-1025. 2010
2010 Brain-derived neurotrophic factor gene and protein expression in pediatric and adult depressed subjectsProgress in Neuro-Psychopharmacology and Biological Psychiatry.  34:645-651. 2010
2010 Glycogen synthase kinase-3β in the platelets of patients with mood disorders: Effect of treatmentJournal of Psychiatric Research.  44:143-148. 2010
2010 Brain-derived neurotrophic factor and suicide pathogenesis.Annals of Medicine.  42:87-96. 2010
2009 Aberrant extracellular signal-regulated kinase (ERK)1/2 signalling in suicide brain: Role of ERK kinase 1 (MEK1)International Journal of Neuropsychopharmacology.  12:1337-1354. 2009
2009 Neurotrophin Receptor Activation and Expression in Human Postmortem Brain: Effect of SuicideBiological Psychiatry.  65:319-328. 2009
2009 GSK-3β gene expression in human postmortem brain: Regional distribution, effects of age and suicideNeurochemical Research.  34:274-285. 2009
2009 Brain-derived neurotrophic factor: Role in depression and suicideNeuropsychiatric Disease and Treatment.  5:433-449. 2009
2009 Fatty acid composition of the postmortem prefrontal cortex of adolescent male and female suicide victims 2009
2009 Pharmacological Characterization of Inositol 1,4,5-tris Phosphate Receptors in Human Platelet Membranes.Cardiovascular Psychiatry and Neurology.  2009:618586. 2009
2008 Brain-derived neurotrophic factor and tyrosine kinase B receptor signalling in post-mortem brain of teenage suicide victimsInternational Journal of Neuropsychopharmacology.  11:1047-1061. 2008
2008 Lower phosphoinositide 3-kinase (PI 3-kinase) activity and differential expression levels of selective catalytic and regulatory PI 3-kinase subunit isoforms in prefrontal cortex and hippocampus of suicide subjectsNeuropsychopharmacology.  33:2324-2340. 2008
2008 Postmortem brain tissue of depressed suicides reveals increased Gsα localization in lipid raft domains where it is less likely to activate adenylyl cyclase 2008
2008 Adenylyl cyclase-cyclicAMP signaling in mood disorders: role of the crucial phosphorylating enzyme protein kinase A.Neuropsychiatric Disease and Treatment.  4:161-176. 2008
2008 5-Lipoxygenase in the Prefrontal Cortex of Suicide Victims.The open neuropsychopharmacology journal.  1:1-5. 2008
2008 Adenylyl cyclase-cyclicAMP signaling in mood disorders: Role of the crucial phosphorylating enzyme protein kinase ANeuropsychiatric Disease and Treatment.  4:161-176. 2008
2008 Brain-derived neurotrophic factor gene expression in pediatric bipolar disorder: Effects of treatment and clinical responseJournal of the American Academy of Child and Adolescent Psychiatry.  47:1077-1085. 2008
2008 Decreased protein kinase C (PKC) in platelets of pediatric bipolar patients: Effect of treatment with mood stabilizing drugsJournal of Psychiatric Research.  42:106-116. 2008
2007 Aberrant extracellular signal-regulated kinase (ERK) 5 signaling in hippocampus of suicide subjectsNeuropsychopharmacology.  32:2338-2350. 2007
2007 Role of protein kinase A in the etiology of suicide: Evidence from human postmortem brain and preclinical studies 2007
2007 Cyclic AMP response element-binding protein in post-mortem brain of teenage suicide victims: Specific decrease in the prefrontal cortex but not the hippocampusInternational Journal of Neuropsychopharmacology.  10:621-629. 2007
2007 Noradrenergic function in suicideArchives of Suicide Research.  11:235-246. 2007
2006 Differential and brain region-specific regulation of Rap-1 and Epac in depressed suicide victimsArchives of General Psychiatry.  63:639-648. 2006
2006 Hippocampal cell proliferation regulation by repeated stress and antidepressantsNeuroReport.  17:863-867. 2006
2006 Antidepressants reverse corticosterone-mediated decrease in brain-derived neurotrophic factor expression: Differential regulation of specific exons by antidepressants and corticosteroneNeuroscience.  139:1017-1029. 2006
2006 Monoamine receptors and signal transduction mechanisms in suicideCurrent Psychiatry Reviews.  2:51-75. 2006
2006 Regional distribution and relative abundance of serotonin2c receptors in human brain: Effect of suicideNeurochemical Research.  31:167-176. 2006
2006 ERK MAP kinase signaling in post-mortem brain of suicide subjects: Differential regulation of upstream Raf kinases Raf-1 and B-RafMolecular Psychiatry.  11:86-98. 2006
2005 Suicide brain is associated with decreased expression of neurotrophinsBiological Psychiatry.  58:315-324. 2005
2005 Brain region specific alterations in the protein and mRNA levels of protein kinase A subunits in the post-mortem brain of teenage suicide victimsNeuropsychopharmacology.  30:1548-1556. 2005
2005 The regional and cellular expression profile of the melatonin receptor MT1 in the central dopaminergic systemBrain Research.  136:45-53. 2005
2005 Focus on protein kinase A and protein kinase C, critical components of signal transduction system, in mood disorders and suicideInternational Journal of Neuropsychopharmacology.  8:1-4. 2005
2005 Single and repeated stress-induced modulation of phospholipase C catalytic activity and expression: Role in LH behaviorNeuropsychopharmacology.  30:473-483. 2005
2005 Chapter 5.1 The intracellular signaling cascade and stressTechniques in the Behavioral and Neural Sciences.  15:643-663. 2005
2005 Differential regulation of serotonin (5HT)2A receptor mRNA and protein levels after single and repeated stress in rat brain: Role in learned helplessness behaviorNeuropharmacology.  48:204-214. 2005
2004 Altered protein kinase A in brain of learned helpless rats: Effects of acute and repeated stressBiological Psychiatry.  56:30-40. 2004
2004 Decreased catalytic activity and expression of protein kinase C isozymes in teenage suicide victims: A postmortem brain studyArchives of General Psychiatry.  61:685-693. 2004
2004 Protein kinase a in postmortem brain of depressed suicide victims: Altered expression of specific regulatory and catalytic subunitsBiological Psychiatry.  55:234-243. 2004
2003 Serotonin receptors in platelets of bipolar and schizoaffective patients: Effect of lithium treatmentPsychopharmacology.  170:115-123. 2003
2003 Altered gene expression of brain-derived neurotrophic factor and receptor tyrosine kinase B in postmortem brain of suicide subjectsArchives of General Psychiatry.  60:804-815. 2003
2003 Abnormal expression and functional characteristics of cyclic adenosine monophosphate response element binding protein in postmortem brain of suicide subjectsArchives of General Psychiatry.  60:273-282. 2003
2003 Altered expression and phosphorylation of myristoylated alanine-rich C kinase substrate (MARCKS) in postmortem brain of suicide victims with or without depressionJournal of Psychiatric Research.  37:421-432. 2003
2002 Erratum: mRNA and protein expression of selective alpha subunits of G proteins are abnormal in prefrontal cortex of suicide victims (Neuropsychopharmacology (October 2002) 27:4 (499-517) PII:S0893133X02003354)Neuropsychopharmacology.  27:1092. 2002
2002 mRNA and protein expression of selective alpha subunits of G proteins are abnormal in prefrontal cortex of suicide victimsNeuropsychopharmacology.  27:499-517. 2002
2002 Differential effects of haloperidol and clozapine on [3H]cAMP binding, protein kinase A (PKA) activity, and mRNA and protein expression of selective regulatory and catalytic subunit isoforms of PKA in rat brainJournal of Pharmacology and Experimental Therapeutics.  301:197-209. 2002
2002 Higher expression of serotonin 5-HT2A receptors in the postmortem brains of teenage suicide victimsAmerican Journal of Psychiatry.  159:419-429. 2002
2002 Protein kinase C and phospholipase C activity and expression of their specific isozymes is decreased and expression of MARCKS is increased in platelets of bipolar but not in unipolar patientsNeuropsychopharmacology.  26:216-228. 2002
2002 Antidepressants reduce phosphoinositide-specific phospholipase C (PI-PLC) activity and the mRNA and protein expression of selective PLC β1 isozyme in rat brainNeuropharmacology.  43:1269-1279. 2002
2002 [3H]cAMP binding sites and protein kinase A activity in the prefrontal cortex of suicide victimsAmerican Journal of Psychiatry.  159:66-73. 2002
2001 Hyperactive phosphoinositide signaling pathway in platelets of depressed patients: Effect of desipramine treatmentPsychiatry Research.  105:23-32. 2001
2001 Reduced activation and expression of ERK1/2 MAP kinase in the post-mortem brain of depressed suicide subjectsJournal of Neurochemistry.  77:916-928. 2001
2001 Glucocorticoid receptors are required for up-regulation of neuronal 5-lipoxygenase (5LOX) expression by dexamethasone.The FASEB Journal.  15:1792-1794. 2001
2000 Modifications in the phosphoinositide signaling pathway by adrenal glucocorticoids in rat brain: Focus on phosphoinositide-specific phospholipase C and inositol 1,4,5-trisphosphateJournal of Pharmacology and Experimental Therapeutics.  295:244-254. 2000
2000 Adrenal glucocorticoids modulate [3H]cyclic AMP binding to protein kinase A (PKA), cyclic AMP-dependent PKA activity, and protein levels of selective regulatory and catalytic subunit isoforms of PKA in rat brainJournal of Pharmacology and Experimental Therapeutics.  294:103-116. 2000
2000 Decrease in reelin and glutamic acid decarboxylase67 (GAD67) expression in schizophrenia and bipolar disorder: A postmortem brain studyArchives of General Psychiatry.  57:1061-1069. 2000
1999 Low phosphoinositide-specific phospholipase C activity and expression of phospholipase C β1 protein in the prefrontal cortex of teenage suicide subjectsAmerican Journal of Psychiatry.  156:1895-1901. 1999
1999 Effects of treatment with haloperidol, chlorpromazine, and clozapine on protein kinase C (PKC) and phosphoinositide-specific phospholipase C (PI-PLC) activity and on mRNA and protein expression of PKC and PLC isozymes in rat brainJournal of Pharmacology and Experimental Therapeutics.  291:688-704. 1999
1999 Glucocorticoids stimulate inflammatory 5-lipoxygenase gene expression and protein translocation in the brainJournal of Neurochemistry.  73:693-699. 1999
1999 Repeated administration of dexamethasone increases phosphoinositide- specific phospholipase C activity and mRNA and protein expression of the phospholipase C β1 isozyme in rat brainJournal of Neurochemistry.  73:780-790. 1999
1999 The phenotypic characteristics of heterozygous reeler mouseNeuroReport.  10:1329-1334. 1999
1999 Administration of dexamethasone up-regulates protein kinase C activity and the expression of γ and ε protein kinase C isozymes in the rat brainJournal of Neurochemistry.  72:380-387. 1999
1998 A decrease of reelin expression as a putative vulnerability factor in schizophrenia 1998
1998 Quantitation of 5HT(2A) receptor mRNA in human postmortem brain using competitive RT-PCRNeuroReport.  9:3761-3765. 1998
1998 Protein kinase C in platelets of depressed patientsBiological Psychiatry.  44:909-911. 1998
1998 Elevated [3H]inositol 1,4,5-trisphosphate binding sites and expressed inositol 1,4,5-trisphosphate receptor protein level in platelets of depressed patientsPsychopharmacology.  138:47-54. 1998
1997 Effects of subchronic administration of antidepressants and anxiolytics on levels of the α subunits of G proteins in the rat brainJournal of Neural Transmission.  104:747-760. 1997
1997 Protein kinase C in the postmortem brain of teenage suicide victimsNeuroscience Letters.  228:111-114. 1997
1996 Pharmacological characterization of inositol 1,4,5trisphosphate receptors in human platelet membranes: Effects of calcium and cyclic ampThe FASEB Journal.  10. 1996
1995 Platelet serotonin-2A receptors: A potential biological marker for suicidal behaviorAmerican Journal of Psychiatry.  152:850-855. 1995
1993 Chronic ethanol consumption decreases the phorbol ester binding to membranal but not cytosolic protein kinase C in rat brainAlcohol.  10:259-262. 1993


Year Title Altmetric
2017 Genetics of suicidal behaviour.  73-90. 2017
2015 Neuropeptides: Active neuromodulators involved in the pathophysiology of suicidal behavior and major affective disorders.  409-442. 2015
2015 microRNAs as novel players in depression pathogenesis and in the mechanisms of action of fluoxetine and other antidepressants.  147-166. 2015
2014 MicroRNA function and dysregulation in depression and suicide.  273-294. 2014
2013 MicroRNAs, major affective disorders and suicidal behaviour.  39-64. 2013

Education And Training

  • Doctor of Science in Biochemistry, 1992
  • Full Name

  • Yogesh Dwivedi