Selected Publications

Academic Article

Year Title Altmetric
2022 Novel Allosteric Inhibitor-Derived AKT Proteolysis Targeting Chimeras (PROTACs) Enable Potent and Selective AKT Degradation in KRAS/BRAF Mutant Cells.Journal of Medicinal Chemistry.  65:14237-14260. 2022
2022 A local tumor microenvironment acquired super-enhancer induces an oncogenic driver in colorectal carcinoma.Nature Communications.  13:6041. 2022
2022 Discovery of Potent, Selective, and In Vivo Efficacious AKT Kinase Protein Degraders via Structure-Activity Relationship Studies.Journal of Medicinal Chemistry.  65:3644-3666. 2022
2021 Design, Synthesis, and Evaluation of Potent, Selective, and Bioavailable AKT Kinase Degraders.Journal of Medicinal Chemistry.  64:18054-18081. 2021
2021 AKT Degradation Selectively Inhibits the Growth of PI3K/PTEN Pathway-Mutant Cancers with Wild-Type KRAS and BRAF by Destabilizing Aurora Kinase B.Cancer Discovery.  11:3064-3089. 2021
2017 p53 Maintains Baseline Expression of Multiple Tumor Suppressor Genes.Molecular Cancer Research.  15:1051-1062. 2017
2016 Upregulation of lactate dehydrogenase a by 14-3-3ζ leads to increased glycolysis critical for breast cancer initiation and progression.Oncotarget.  7:35270-35283. 2016
2016 Downregulation of GLUT4 contributes to effective intervention of estrogen receptor-negative/HER2-overexpressing early stage breast disease progression by lapatinib.American Journal of Cancer Research.  6:981-995. 2016
2015 14-3-3ζ turns TGF-β's function from tumor suppressor to metastasis promoter in breast cancer by contextual changes of Smad partners from p53 to Gli2.Cancer Cell.  27:177-192. 2015
2012 Methylation of HIN-1, RASSF1A, RIL and CDH13 in breast cancer is associated with clinical characteristics, but only RASSF1A methylation is associated with outcome.BMC Cancer.  12:243. 2012
2012 Overexpression of 14-3-3ζ in cancer cells activates PI3K via binding the p85 regulatory subunit.Oncogene.  31:897-906. 2012
2012 Evidence that GTP-binding domain but not catalytic domain of transglutaminase 2 is essential for epithelial-to-mesenchymal transition in mammary epithelial cells.Breast Cancer Research.  14:R4. 2012
2011 Evidence that aberrant expression of tissue transglutaminase promotes stem cell characteristics in mammary epithelial cells.PLoS One.  6:e20701. 2011
2010 Tissue transglutaminase promotes drug resistance and invasion by inducing mesenchymal transition in mammary epithelial cells.PLoS One.  5:e13390. 2010
2010 Tumor suppressor genes are frequently methylated in lymph node metastases of breast cancers.BMC Cancer.  10:378. 2010
2009 Upregulation of neutrophil gelatinase-associated lipocalin by ErbB2 through nuclear factor-kappaB activation.Cancer Research.  69:9163-9168. 2009
2006 Isolation and RNA1 nucleotide sequence determination of a new insect nodavirus from Pieris rapae larvae in Wuhan city, China.Virus Research.  120:28-35. 2006

Education And Training

  • Doctor of Philosophy in Oncology and Cancer Biology, The University of Texas Health Science Center at Houston 2012
  • Master of Science in Microbiology, 2006
  • Bachelor of Science or Mathematics in Biomedical Sciences, 2004
  • Full Name

  • Jia Xu