Positions

Overview

  • Dr. Xin Xu received his MD from the Taishan Medical College of China, his PhD in Immunology at the Ehime University of Japan, and an MLS in Clinical Laboratory Science at the University of Alabama at Birmingham (UAB). Following a post-doctoral research fellowship under the mentorship of Dr. John Mountz at the UAB Division of Clinical Immunology and Rheumatology, he joined the Division of Pulmonary, Allergy & Critical Care Medicine. Dr. Xu is currently an Assistant Professor in Medicine.

    • Selected Publications

    Academic Article

    Year Title Altmetric
    2023 Different-sized extracellular vesicles derived from stored red blood cells package diverse cargoes and cause distinct cellular effects.  Transfusion.  2023
    2022 Efficacy of a Probiotic and Herbal Supplement in Models of Lung Inflammation.  Microorganisms.  10. 2022
    2022 Modulation of epileptiform activity by three subgroups of GABAergic interneurons in mouse somatosensory cortex.  Journal of epilepsy.  183. 2022
    2021 A mechanism for matrikine regulation in acute inflammatory lung injury.  JCI Insight.  6. 2021
    2021 Prolyl endopeptidase contributes to early neutrophilic inflammation in acute myocardial transplant rejection.  JCI Insight.  6. 2021
    2020 Differences in airway microbiome and metabolome of single lung transplant recipients.  Respiratory Research.  21. 2020
    2019 Neutrophil-Targeted, protease-Activated pulmonary drug delivery blocks airway and systemic inflammation.  JCI Insight.  4. 2019
    2019 An Ancient CFTR Ortholog Informs Molecular Evolution in ABC Transporters.  Developmental Cell.  51:421-430.e3. 2019
    2019 Benzyloxycarbonyl-proline-prolinal (ZPP): Dual complementary roles for neutrophil inhibition.  Biochemical and Biophysical Research Communications.  517:691-696. 2019
    2019 Activated PMN Exosomes: Pathogenic Entities Causing Matrix Destruction and Disease in the Lung.  Cell.  176:113-126.e15. 2019
    2019 Proline-glycine-proline peptides are critical in the development of smoke-induced emphysema.  American Journal of Respiratory Cell and Molecular Biology.  61:560-566. 2019
    2018 The neutrophil chemoattractant peptide proline-glycine-proline is associated with acute respiratory distress syndrome 2018
    2018 An extracellular matrix fragment drives epithelial remodeling and airway hyperresponsiveness.  Science Translational Medicine.  10. 2018
    2018 Fibroblast growth factor 23 and Klotho contribute to airway inflammation.  European Respiratory Journal.  52. 2018
    2017 The Matrikine Acetylated Proline-Glycine-Proline Couples Vascular Inflammation and Acute Cardiac Rejection.  Scientific Reports.  7. 2017
    2017 Abstract 21106: The Matrikine Proline-Glycine-Proline is Locally Generated Following Acute Arterial Vascular Injury.  Circulation.  136. 2017
    2017 Doxycycline improves clinical outcomes during cystic fibrosis exacerbations.  European Respiratory Journal.  49. 2017
    2017 Ureaplasma infection-mediated release of matrix metalloproteinase-9 and PGP: A novel mechanism of preterm rupture of membranes and chorioamnionitis.  Pediatric Research.  81:75-79. 2017
    2016 464 Characterization of Microparticles and Exosomes from Red Blood Cells During Storage: Implications for Transfusion Toxicity.  Free Radical Biology and Medicine.  100:s193. 2016
    2016 Absorbance and redox based approaches for measuring free heme and free hemoglobin in biological matrices.  Redox Biology.  9:167-177. 2016
    2016 Toll-like receptor 4 engagement mediates prolyl endopeptidase release from airway epithelia via exosomes.  American Journal of Respiratory Cell and Molecular Biology.  54:359-369. 2016
    2016 Protective effect of suppressing STAT3 activity in LPS-induced acute lung injury 2016
    2015 A randomized, placebo-controlled trial of roflumilast effect on proline-glycine-proline and neutrophilic inflammation in chronic obstructive pulmonary disease.  American Journal of Respiratory and Critical Care Medicine.  192:934-942. 2015
    2015 Neutrophil Chemoattractant Peptide Proline-Glycine-Proline Is Increased in Acute Respiratory Distress Syndrome.  Chest.  148:180a. 2015
    2015 Matrikines are key regulators in modulating the amplitude of lung inflammation in acute pulmonary infection.  Nature Communications.  6. 2015
    2015 A Potential Role for Acrolein in Neutrophil-Mediated Chronic Inflammation.  Inflammation.  38:2279-2287. 2015
    2015 A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging.  Science.  348:1160-1163. 2015
    2015 A widely adaptable approach to generate integration-free iPSCs from non-invasively acquired human somatic cells 2015
    2015 The matrikine N-α-PGP couples extracellular matrix fragmentation to endothelial permeability.  Science Advances.  1. 2015
    2014 L-4F Inhibits Lipopolysaccharide-Mediated Activation of Primary Human Neutrophils.  Inflammation.  37:1401-1412. 2014
    2014 Targeted gene correction minimally impacts whole-genome mutational load in human-disease-specific induced pluripotent stem cell clones.  Cell Stem Cell.  15:31-36. 2014
    2014 Pulmonary matrix metalloproteinase-9 activity in mechanically ventilated children with respiratory syncytial virus.  European Respiratory Journal.  43:1086-1096. 2014
    2014 Direct reprogramming of porcine fibroblasts to neural progenitor cells 2014
    2013 Anti-Inflammatory Mechanisms of Apolipoprotein A-I Mimetic Peptide in Acute Respiratory Distress Syndrome Secondary to Sepsis.  PLoS One.  8. 2013
    2011 Free radical-producing myeloid-derived regulatory cells: Potent activators and suppressors of lung inflammation and airway hyperresponsiveness.  Mucosal Immunology.  4:503-518. 2011
    2011 A self-propagating matrix metalloprotease-9 (MMP-9) dependent cycle of chronic neutrophilic inflammation.  PLoS One.  6. 2011
    2010 Human neutrophil elastase-mediated cleavage sites of MMP-9 and TIMP-1: Implications to cystic fibrosis proteolytic dysfunction.  Molecular Medicine.  16:159-166. 2010
    2009 Neutrophils contain prolyl endopeptidase and generate the chemotactic peptide, PGP, from collagen.  Journal of Neuroimmunology.  217:51-54. 2009
    2009 Increased expression of activation-induced cytidine deaminase is associated with anti-CCP and rheumatoid factor in rheumatoid arthritis.  Scandinavian Journal of Immunology.  70:309-316. 2009
    2007 Age-related increase of tumor susceptibility is associated with myeloid-derived suppressor cell mediated suppression of T cell cytotoxicity in recombinant inbred BXD12 mice.  Mechanisms of Ageing and Development.  128:672-680. 2007
    2006 In vivo analysis of adenovirus-specific cytotoxic T lymphocyte response in mice deficient in CD28, Fas ligand, and perforin.  Human gene therapy. Clinical development.  17:669-682. 2006
    2006 In Vivo Analysis of Adenovirus-Specific Cytotoxic T Lymphocyte Response in Mice Deficient in CD28, Fas Ligand, and Perforin.  Human gene therapy. Clinical development.  0:060801084750020. 2006
    2006 130 IN VIVO ANALYSIS OF THE ADENOVIRUS-SPECIFIC CYTOTOXIC T-LYMPHOCYTE RESPONSE IN CD28-, FASL-, AND PERFORIN-DEFICIENT MICE..  Journal of Investigative Medicine.  54:s279. 2006
    2006 152 IN VIVO ANALYSIS OF THE ADENOVIRUS-SPECIFIC CYTOTOXIC T-LYMPHOCYTE RESPONSE IN CD28-, FASL-, AND PERFORIN-DEFICIENT MICE..  Journal of Investigative Medicine.  54:s283. 2006
    2006 OR.36. A Novel Model of Human Rheumatoid Arthritis Synovial Fibroblast (Rasf)-Mediated Bone Erosion in Nude Mice Administrated By LPS.  Clinical Immunology.  119:s17. 2006
    2005 Synovial fibroblasts promote osteoclast formation by RANKL in a novel model of spontaneous erosive arthritis.  Arthritis and Rheumatism.  52:3257-3268. 2005
    2005 Primary adenovirus-specific cytotoxic T lymphocyte response occurs after viral clearance and liver enzyme elevation 2005
    2004 Defective clearance of adenovirus in IRF-1-/- mice associated with defects in NK and T cells but not macrophages.  Scandinavian Journal of Immunology.  60:89-99. 2004
    2003 CII-DC-AdTRAIL cell gene therapy inhibits infiltration of CII-reactive T cells and CII-induced arthritis.  Journal of Clinical Investigation.  112:1332-1341. 2003
    2003 Age-related thymic involution in C57BL/6J x DBA/2J recombinant-inbred mice maps to mouse chromosomes 9 and 10.  Genes and Immunity.  4:402-410. 2003
    2003 Identification of IFN regulatory factor-1 binding site in IL-12 p40 gene promoter..  Journal of Immunology.  170:997-1001. 2003
    2002 BXD recombinant inbred mice represent a novel T cell-mediated immune response tumor model.  International Journal of Cancer.  101:270-279. 2002
    2002 Hepatic DR5 induces apoptosis and limits adenovirus gene therapy product expression in the liver.  Journal of Virology.  76:5692-5700. 2002
    2002 Age-related change in thymic T-cell development is associated with genetic loci on mouse chromosomes 1, 3, and 11.  Mechanisms of Ageing and Development.  123:1145-1158. 2002
    2001 Activated CD8+ T cells from aged mice exhibit decreased activation-induced cell death.  Mechanisms of Ageing and Development.  122:1663-1684. 2001
    2001 Down-regulation of IL-12 p40 gene in Plasmodium berghei-infected mice..  Journal of Immunology.  167:235-241. 2001

    Chapter

    Year Title Altmetric
    2013 Liver function.  519-544. 2013
    2010 Neutrophil elastase-mediated modulation of pathophysiology in cystic fibrosis lung disease.  87-111. 2010

    Research Overview

  • Dr. Xu has focused on basic and translational research in inflammatory diseases. He is currently investigating the role of proteases and matrikine regulation in the airway inflammatory response and autoimmune disorder. Dr. Xu’s current research interests are to explore the potential role and molecular mechanism by which Ac-PGP mediates vascular endothelial dysfunction and pulmonary hypertension, to investigate PE- mediated regulation of the balance of T regulatory cells and Th17 cells which control the tolerance vs inflammation, and to study the molecular mechanisms of smoking related disease through the dysregulation of cytokine/chemokine/matrikine.

    • Principal Investigator On

    Investigator On

    Education And Training

  • Doctor of Science in Immunology, 2002
  • Doctor of Medicine, Taishan Medical University 1985

    • Full Name

  • Xin Xu