Selected Publications

Academic Article

Year Title Altmetric
2022 Joint specificity of stretch shortening cycle potentiation at propulsion onset during jump test performance.The Journal of Sports Medicine and Physical Fitness2022
2022 Effects of sensory manipulations on locomotor adaptation to split-belt treadmill walking in healthy younger and older adults 2022
2022 Sex‐Related Pain Behavioral Differences following Unilateral NGF Injections in a Rat Model of Low Back PainBiology.  11. 2022
2022 Asymmetric walking on an incline affects aspects of positive mechanical work asymmetricallyJournal of Biomechanics.  136. 2022
2022 The Impact of Complementary and Integrative Medicine Following Traumatic Brain Injury: A Scoping Review.Journal of Head Trauma Rehabilitation2022
2022 Preventive Supplementation of Omega-3 Reduces Pain and Pro-inflammatory Cytokines in a Mouse Model of Complex Regional Pain Syndrome Type IFrontiers in Integrative Neuroscience.  16. 2022
2022 Effects of Advanced Age and Parkinson’s Disease on Joint-Level Kinetic Adaptations to Faster Walking Speeds 2022
2022 Somatosensory behavioral alterations in a NGF-induced persistent low back pain modelBehavioural Brain Research.  418. 2022
2021 The role of the vagus nerve in fibromyalgia syndromeNeuroscience and Biobehavioral Reviews.  131:1136-1149. 2021
2021 Potential nociceptive role of the thoracolumbar fascia: A scope review involving in vivo and ex vivo studiesJournal of Clinical Medicine.  10. 2021
2021 Influence of intervertebral fixation and segmental thrust level on immediate post-spinal manipulation trunk muscle spindle response in an animal modelBrain Sciences.  11. 2021
2021 Effects of Thrust Magnitude and Duration on Immediate Postspinal Manipulation Trunk Muscle Spindle ResponsesJournal of Manipulative and Physiological Therapeutics.  44:363-371. 2021
2021 Electroacupuncture decreases inflammatory pain through a pro-resolving mechanism involving the peripheral annexin A1-formyl peptide receptor 2/ALX-opioid receptor pathwayPfluegers Archiv: European journal of physiology.  473:683-695. 2021
2021 The Neurophysiological Impact of Experimentally-Induced Pain on Direct Muscle Spindle Afferent Response: A Scoping ReviewFrontiers in Cellular Neuroscience.  15. 2021
2020 Impact of COVID-19 outbreak on mental health and perceived strain among caregivers tending children with special needsResearch in Developmental Disabilities.  107. 2020
2020 High-intensity swimming exercise reduces inflammatory pain in mice by activation of the endocannabinoid systemScandinavian Journal of Medicine and Science in Sports.  30:1369-1378. 2020
2020 Medium- and long-term functional behavior evaluations in an experimental focal ischemic stroke mouse modelCognitive Neurodynamics.  14:473-481. 2020
2020 Using a Survey to Characterize Rehabilitation Professionals' Perceptions and Use of Complementary, Integrative, and Alternative MedicineJournal of Alternative and Complementary Medicine.  26:663-665. 2020
2020 Spinal Mobilization Prevents NGF-Induced Trunk Mechanical Hyperalgesia and Attenuates Expression of CGRPFrontiers in Neuroscience.  14. 2020
2020 Physiological responses induced by manual therapy in animal models: A scoping reviewFrontiers in Neuroscience.  14. 2020
2019 Manual therapy reduces pain behavior and oxidative stress in a murine model of complex regional pain syndrome type iBrain Sciences.  9. 2019
2019 Orofacial operant behaviors and electrophysiological properties of trigeminal ganglion neurons following masseter muscle inflammation in ratsNeuroscience Letters.  694:208-214. 2019
2018 Integrative CNS Plasticity With Exercise in MS: The PRIMERS (PRocessing, Integration of Multisensory Exercise-Related Stimuli) Conceptual FrameworkNeurorehabilitation and Neural Repair.  32:847-862. 2018
2018 Interaction of factors affecting vibration transmission to skeleton during standing: A narrative reviewInternational Journal of Applied Sports Sciences.  30. 2018
2018 Interaction of factors affecting vibration transmission to skeleton during standing: A narrative reviewInternational Journal of Applied Sports Sciences.  30:1-10. 2018
2018 Neural responses to physical characteristics of a high-velocity, low-amplitude spinal manipulationSpine.  43:1-9. 2018
2017 Decreased spontaneous activity and altered evoked nociceptive response of rat thalamic submedius neurons to lumbar vertebra thrustExperimental Brain Research.  235:2883-2892. 2017
2017 Characteristics of Paraspinal Muscle Spindle Response to Mechanically Assisted Spinal Manipulation: A Preliminary ReportJournal of Manipulative and Physiological Therapeutics.  40:371-380. 2017
2016 Similar effects of thrust and nonthrust spinal manipulation found in adults with subacute and chronic low back painSpine.  41:E702-E709. 2016
2015 Neural responses to the mechanical characteristics of high velocity, low amplitude spinal manipulation: Effect of specific contact siteManual Therapy.  20:797-804. 2015
2015 Neural Response During a Mechanically Assisted Spinal Manipulation in an Animal Model: A Pilot Study. 2015
2015 Paraspinal muscle spindle response to intervertebral fixation and segmental thrust level during spinal manipulation in an animal modelSpine.  40:E752-E759. 2015
2015 Antinociceptive Effects of Spinal Manipulative Therapy on Nociceptive Behavior of Adult Rats during the Formalin TestEvidence-Based Complementary and Alternative Medicine.  2015. 2015
2014 Effect of spinal manipulation thrust duration on trunk mechanical activation thresholds of nociceptive-specific lateral thalamic neuronsJournal of Manipulative and Physiological Therapeutics.  37:552-560. 2014
2014 Bladder and bowel symptoms among adults presenting with low back pain to an academic chiropractic clinic: Results of a preliminary studyJournal of Chiropractic Medicine.  13:178-187. 2014
2014 Neural responses to the mechanical parameters of a high-velocity, low-amplitude spinal manipulation: Effect of preload parametersJournal of Manipulative and Physiological Therapeutics.  37:68-78. 2014
2014 Effect of changing lumbar stiffness by single facet joint dysfunction on the responsiveness of lumbar muscle spindles to vertebral movementJournal of the Canadian Chiropractic Association.  58:160-169. 2014
2014 Effect of spinal manipulation thrust magnitude on trunk mechanical activation thresholds of lateral thalamic neuronsJournal of Manipulative and Physiological Therapeutics.  37:277-286. 2014
2013 Effects of unilateral facet fixation and facetectomy on muscle spindle responsiveness during simulated spinal manipulation in an animal modelJournal of Manipulative and Physiological Therapeutics.  36:585-594. 2013
2013 Relationship between biomechanical characteristics of spinal manipulation and neural responses in an animal model: Effect of linear control of thrust displacement versus force, thrust amplitude, thrust duration, and thrust rateEvidence-Based Complementary and Alternative Medicine.  2013. 2013
2013 Using vertebral movement and intact paraspinal muscles to determine the distribution of intrafusal fiber innervation of muscle spindle afferents in the anesthetized catExperimental Brain Research.  225:205-215. 2013
2013 Effects of thrust amplitude and duration of high-velocity, low-amplitude spinal manipulation on lumbar muscle spindle responses to vertebral position and movementJournal of Manipulative and Physiological Therapeutics.  36:68-77. 2013
2013 Cervical response among ascending ventrolateral funiculus pathways of the neonatal ratBrain Research.  1491:136-146. 2013
2010 The major histocompatibility complex genes are associated with basal pain sensitivity differences between Dark-Agouti and novel congenic DA.1U ratsLife Sciences.  86:972-978. 2010
2010 Select spinal lesions reveal multiple ascending pathways in the rat conveying input from the male genitaliaThe Journal of Physiology.  588:1073-1083. 2010
2009 Anterograde labeling of ventrolateral funiculus pathways with spinal enlargement connections in the adult rat spinal cordBrain Research.  1302:76-84. 2009
2009 Effects of 17β-estradiol on responses of viscerosomatic convergent thalamic neurons in the ovariectomized female ratJournal of Neurophysiology.  102:1062-1074. 2009
2008 Reticulospinal pathways in the ventrolateral funiculus with terminations in the cervical and lumbar enlargements of the adult rat spinal cordNeuroscience.  151:505-517. 2008
2006 Inter-enlargement pathways in the ventrolateral funiculus of the adult rat spinal cordNeuroscience.  142:1195-1207. 2006
2006 Magnetically evoked inter-enlargement response: An assessment of ascending propriospinal fibers following spinal cord injuryExperimental Neurology.  201:428-440. 2006
1994 Chiropractic management of primary nocturnal enuresisJournal of Manipulative and Physiological Therapeutics.  17:596-600. 1994

Research Overview

  • Globally, there is growing popularity and increased use of non-pharmacological approaches for acute and chronic musculoskeletal pain. Maximizing clinical efficacy of spinal manual therapy interventions will require a greater understanding of their underlying neurophysiological mechanisms. The primary focus of the MSMT lab is directed towards determining the peripheral and central mechanisms of spinal manual therapy (i.e. spinal manipulation/spinal mobilization) for the treatment of musculoskeletal pain and/or related disability. We use a variety of animal models, custom-made spinal manual therapy devices, behavioral and electrophysiological methods in our laboratory to investigate translationally relevant research questions with the ultimate goal of improving clinical care.
  • Full Name

  • William Reed