Positions

Selected Publications

Academic Article

Year Title Altmetric
2020 G551D mutation impairs PKA-dependent activation of CFTR channel that can be restored by novel GOF mutations 2020
2019 Slowing ribosome velocity restores folding and function of mutant CFTRJournal of Clinical Investigation.  129:5236-5253. 2019
2019 Evaluation of 1,2,3-Triazoles as Amide Bioisosteres In Cystic Fibrosis Transmembrane Conductance Regulator Modulators VX-770 and VX-809 2019
2017 The cystic fibrosis transmembrane conductance regulator potentiator ivacaftor augments mucociliary clearance abrogating cystic fibrosis transmembrane conductance regulator inhibition by cigarette smokeAmerican Journal of Respiratory Cell and Molecular Biology.  56:99-108. 2017
2016 Analysis of cystic fibrosis-associated P67L CFTR illustrates barriers to personalized therapeutics for orphan diseases.JCI insight.  1. 2016
2016 Robust stimulation of W1282X-CFTR channel activity by a combination of allosteric modulatorsPLoS ONE.  11. 2016
2016 Channel gating regulation by the cystic fibrosis transmembrane conductance regulator (CFTR) first cytosolic loopJournal of Biological Chemistry.  291:1854-1865. 2016
2014 An electrostatic interaction at the tetrahelix bundle promotes phosphorylation-dependent cystic fibrosis transmembrane conductance regulator (CFTR) channel openingJournal of Biological Chemistry.  289:30364-30378. 2014
2013 Converting nonhydrolyzable nucleotides to strong cystic fibrosis transmembrane conductance regulator (CFTR) agonists by gain of function (GOF) mutationsJournal of Biological Chemistry.  288:17122-17133. 2013
2011 Thermally unstable gating of the most common cystic fibrosis mutant channel (ΔF508): "Rescue" by suppressor mutations in nucleotide binding domain 1 and by constitutive mutations in the cytosolic loopsJournal of Biological Chemistry.  286:41937-41948. 2011
2011 A unified view of cystic fibrosis transmembrane conductance regulator (CFTR) gating: Combining the allosterism of a ligand-gated channel with the enzymatic activity of an ATP-binding cassette (ABC) transporterJournal of Biological Chemistry.  286:12813-12819. 2011
2010 The cystic fibrosis-causing mutation ΔF508 affects multiple steps in cystic fibrosis transmembrane conductance regulator biogenesisJournal of Biological Chemistry.  285:35825-35835. 2010
2010 ATP-independent CFTR channel gating and allosteric modulation by phosphorylation 2010
2009 Curcumin cross-links cystic fibrosis transmembrane conductance regulator (CFTR) polypeptides and potentiates CFTR channel activity by distinct mechanismsJournal of Biological Chemistry.  284:30754-30765. 2009
2007 Curcumin opens cystic fibrosis transmembrane conductance regulator channels by a novel mechanism that requires neither ATP binding nor dimerization of the nucleotide-binding domainsJournal of Biological Chemistry.  282:4533-4544. 2007
2006 Adenosine regulation of cystic fibrosis transmembrane conductance regulator through prostenoids in airway epitheliaAmerican Journal of Respiratory Cell and Molecular Biology.  34:600-608. 2006
2005 Activating cystic fibrosis transmembrane conductance regulator channels with pore blocker analogsJournal of Biological Chemistry.  280:23622-23630. 2005
2005 Reversible silencing of CFTR chloride channels by glutathionylationJournal of General Physiology.  125:127-141. 2005

Full Name

  • Wei Wang