Positions

Selected Publications

Academic Article

Year Title Altmetric
2018 Spheroids of cardiomyocytes derived from human-induced pluripotent stem cells improve recovery from myocardial injury in mice 2018
2018 Large cardiac muscle patches engineered from human induced-pluripotent stem cell-derived cardiac cells improve recovery from myocardial infarction in swine.  Circulation.  137:1712-1730. 2018
2018 The stress kinase JNK regulates gap junction Cx43 gene expression and promotes atrial fibrillation in the aged heart.  Journal of Molecular and Cellular Cardiology.  114:105-115. 2018
2017 Electrophysiological Properties and Viability of Neonatal Rat Ventricular Myocyte Cultures with Inducible ChR2 Expression.  Scientific Reports.  7. 2017
2017 Myocardial Tissue Engineering with Cells Derived from Human-Induced Pluripotent Stem Cells and a Native-Like, High-Resolution, 3-Dimensionally Printed Scaffold.  Circulation Research.  120:1318-1325. 2017
2016 Biomimetic Cardiac Tissue Model Enables the Adaption of Human Induced Pluripotent Stem Cell Cardiomyocytes to Physiological Hemodynamic Loads.  Analytical Chemistry.  88:9862-9868. 2016
2015 Voltage and calcium dual channel optical mapping of cultured HL-1 atrial myocyte monolayer.  Journal of Visualized Experiments.  2015. 2015
2014 The role of dye affinity in optical measurements of Cai2+ transients in cardiac muscle 2014
2013 C-Jun N-terminal kinase activation contributes to reduced connexin43 and development of atrial arrhythmias.  Cardioscience.  97:589-597. 2013
2012 Intramural optical mapping of Vm and cai2+ during long-duration ventricular fibrillation in canine hearts 2012
2012 Ionic mechanism of shock-induced arrhythmias: Role of intracellular calcium.  Heart Rhythm.  9:96-104. 2012
2011 A new optrode design for intramural optical recordings.  IEEE Transactions on Biomedical Engineering.  58:3130-3134. 2011
2011 Transmural heterogeneity and remodeling of ventricular excitation- contraction coupling in human heart failure.  Circulation.  123:1881-1890. 2011
2011 Transmural heterogeneity and remodeling of ventricular excitation- contraction coupling in human heart failure.  Circulation.  123:1881-1890. 2011
2010 Mechanisms of defibrillation.  Annual Review of Biomedical Engineering.  12:233-258. 2010
2009 Simultaneous Transmural Mapping of Voltage and Calcium in the Human Heart.  Circulation.  120:S667-S667. 2009
2009 Simultaneous Transmural Measurements of V-m and Ca-j(2+) During Rapid Pacing and Long-Duration Ventricular Fibrillation in Canine Hearts.  Circulation.  120:S689-S689. 2009
2009 Can mapping differentiate microreentry from a focus in the ventricle?.  Heart Rhythm.  6:1666-1669. 2009
2009 Transmural optical measurements of Vm dynamics during long-duration ventricular fibrillation in canine hearts.  Heart Rhythm.  6:796-802. 2009
2009 Optical mapping of impulse propagation in engineered cardiac tissue 2009
2009 Change in conduction velocity due to fiber curvature in cultured neonatal rat ventricular myocytes.  IEEE Transactions on Biomedical Engineering.  56:855-861. 2009
2007 Optical measurements of intramural action potentials in isolated porcine hearts using optrodes.  Heart Rhythm.  4:1430-1436. 2007
2007 Optical mapping of V m and Cai2+ in a model of arrhythmias induced by local catecholamine application in patterned cell cultures 2007
2007 Shock-induced changes of Cai2+ and Vm in myocyte cultures and computer model: Dependence on the timing of shock application.  Cardioscience.  73:101-110. 2007
2006 Role of intramural virtual electrodes in shock-induced activation of left ventricle: Optical measurements from the intact epicardial surface.  Heart Rhythm.  3:1063-1073. 2006
2005 Simultaneous optical imaging of membrane potential and intracellular calcium.  Journal of Electrocardiology.  38:107-112. 2005
2005 Simultaneous optical imaging of membrane potential and intracellular calcium.  Journal of Electrocardiology.  38. 2005
2005 Role of Microscopic Tissue Structure in Shock‐Induced Activation Assessed by Optical Mapping in Myocyte Cultures.  Journal of Cardiovascular Electrophysiology.  16:991-1000. 2005
2005 Role of microscopic tissue structure in shock-induced activation assessed by optical mapping in myocyte cultures.  Journal of Cardiovascular Electrophysiology.  16:991-1000. 2005
2004 High-resolution optical mapping of intramural virtual electrodes in porcine left ventricular wall.  Cardioscience.  64:448-456. 2004
2004 Role of microscopic tissue structure in shock-induced activation assessed by optical mapping in myocyte cultures.  Circulation.  110:98-98. 2004
2004 Effects of electrical shocks on Cai2+ and V m in myocyte cultures.  Circulation Research.  94:1589-1597. 2004
2004 Intramural virtual electrodes in ventricular wall: Effects on epicardial polarizations.  Circulation.  109:2349-2356. 2004
2004 Nonlinear Changes of Transmembrane Potential, during Electrical Shocks: Role of Membrane Electroporation.  Circulation Research.  94:208-214. 2004
2003 Development of an Optrode for Intramural Multisite Optical Recordings of Vm in the Heart.  Journal of Cardiovascular Electrophysiology.  14:1196-1202. 2003
2003 Optical Mapping of Transmural Activation Induced by Electrical Shocks in Isolated Left Ventricular Wall Wedge Preparations.  Journal of Cardiovascular Electrophysiology.  14:1215-1222. 2003
2003 The relationship of defibrillation and stimulation: Design implications for the optimum defibrillation waveform 2003
2002 Modulation of triggered activity by uncoupling in the ischemic border: A model study with phase 1b-like conditions.  Cardioscience.  56:381-392. 2002
2002 Optical mapping of V-m and Ca-i(2+) during arrhythmias induced by local perfusion of norepinephrine in cultured cell monolayers.  Circulation.  106:192-192. 2002
2002 Intramural virtual electrodes during defibrillation shocks in left ventricular wall assessed by optical mapping of membrane potential.  Circulation.  106:1007-1014. 2002
2002 Optical mapping of arrhythmias induced by strong electrical shocks in myocyte cultures.  Circulation Research.  90:664-670. 2002
2001 Recent fibrillation studies: Attempts to wrest order from disorder.  Circulation Research.  89:1089-1091. 2001
2000 Shock-induced arrhythmias assessed using mapping of transmembrane potential and intracellular calcium in myocyte cultures.  Circulation.  102:341-341. 2000
2000 The role of calcium current in the nonlinear changes of transmembrane potential during defibrillation shocks.  Circulation.  102:340-340. 2000
2000 Nonlinear changes of transmembrane potential during defibrillation shocks: Role of Ca2+ current.  Circulation Research.  87:453-459. 2000
2000 Mechanism of ventricular defibrillation: The role of tissue geometry in the changes in transmembrane potential in patterned myocyte cultures.  Circulation.  101:2438-2445. 2000
2000 Nonlinear changes of transmembrane potential caused by defibrillation shocks in strands of cultured myocytes. 2000
2000 Effects of electrode-myocardial separation on cardiac stimulation in conductive solution.  Journal of Cardiovascular Electrophysiology.  11:1132-1143. 2000
2000 Nonlinear changes of transmembrane potential caused by defibrillation shocks in strands of cultured myocytes 2000
2000 Simultaneous imaging of transmembrane potential and intracellular calcium in myocyte cultures.  European Heart Journal.  21:549-549. 2000
2000 Simultaneous optical mapping of transmembrane potential and intracellular calcium in myocyte cultures.  Journal of Cardiovascular Electrophysiology.  11:547-556. 2000
1999 Anisotropy of membrane polarization decreases when an electrode is separated from the myocardial surface.  Circulation.  100:786-786. 1999
1998 Effect of defibrillation shocks on transmembrane potential in strands of cultured myocytes.  Circulation.  98:52-52. 1998
1998 Activation of cardiac tissue by extracellular electrical shocks: Formation of 'secondary sources' at intercellular clefts in monolayers of cultured myocytes.  Circulation Research.  82:375-385. 1998
1997 Effects of biphasic shocks on the spatial distribution of the transmembrane potential.  Circulation.  96:688-688. 1997
1997 Excitation of cardiac tissue by defibrillation shocks: Role of microscopic tissue geometry.  Circulation.  96:683-683. 1997
1997 Gap junctional uncoupling facilitates conduction in discontinuous cardiac tissue structures 1997
1997 Paradoxical improvement of impulse conduction in cardiac tissue by partial cellular uncoupling.  Science.  275:841-844. 1997
1997 Partial cellular uncoupling reverses unidirectional conduction block across abrupt expansions of cardiac tissue..  Biophysical Journal.  72:WAMD6-WAMD6. 1997
1997 Role of wavefront curvature in propagation of cardiac impulse.  Cardioscience.  33:258-271. 1997
1997 Molecular and cellular aspects of re-entrant arrhythmias.  Basic Research in Cardiology.  92:111-119. 1997
1996 Physiology and pathophysiology of cardiac impulse conduction.  Clinical Research in Cardiology.  85:25-33. 1996
1996 Anisotropic Activation Spread in Heart Cell Monolayers Assessed by High-Resolution Optical Mapping: Role of Tissue Discontinuities.  Circulation Research.  79:115-127. 1996
1996 Functional and structural assessment of intercellular communication: Increased conduction velocity and enhanced connexin expression in dibutyryl cAMP-treated cultured cardiac myocytes.  Circulation Research.  79:174-183. 1996
1996 Spatial changes in transmembrane potential during extracellular electrical shocks in cultured monolayers of neonatal rat ventricular myocytes.  Circulation Research.  79:676-690. 1996
1995 DIRECT LINK BETWEEN GAP JUNCTION REMODELING AND CHANGES IN CONDUCTION IN CULTURED MYOCYTES.  Circulation.  92:189-189. 1995
1995 RELATION BETWEEN GAP JUNCTION DISTRIBUTION AND ANISOTROPIC ACTIVATION SPREAD IN CULTURED MONOLAYERS OF NEONATAL RAT MYOCYTES.  Circulation.  92:188-188. 1995
1995 Block of impulse propagation at an abrupt tissue expansion: evaluation of the critical strand diameter in 2- and 3-dimensional computer models.  Cardioscience.  30:449-459. 1995
1995 Block of impulse propagation at an abrupt tissue expansion: Evaluation of the critical strand diameter in 2- and 3-dimensional computer models.  Cardioscience.  30:449-459. 1995
1995 Cardiac tissue geometry as a determinant of unidirectional conduction block: Assessment of microscopic excitation spread by optical mapping in patterned cell cultures and in a computer model.  Cardioscience.  29:697-707. 1995
1994 2-DIMENSIONAL HIGH-RESOLUTION OPTICAL MAPPING OF ANISOTROPIC IMPULSE CONDUCTION IN NEONATAL RAT-HEART CEL MONOLAYERS.  Circulation.  90:40-40. 1994
1994 CONDUCTION-VELOCITY AND SHAPE OF ACTION-POTENTIAL UPSTROKE IN A COMPUTER-MODEL OF AN ANISOTROPIC HEART CELL MONOLAYER.  Circulation.  90:411-411. 1994
1994 Cardiac tissue geometry as a determinant of unidirectional conduction block: Assessment of microscopic excitation spread by optical mapping in patterned cell cultures and in a computer model.  Cardiovascular Research.  28:697-707. 1994
1994 Anisotropic conduction in monolayers of neonatal rat heart cells cultured on collagen substrate.  Circulation Research.  75:591-595. 1994
1993 TISSUE GEOMETRY AS A DETERMINANT OF UNIDIRECTIONAL CONDUCTION BLOCK - ASSESSMENT OF MICROSCOPIC EXCITATION SPREAD BY OPTICAL MAPPING IN PATTERNED MYOCYTE CULTURES.  Circulation.  88:623-623. 1993
1993 Microscopic conduction in cultured strands of neonatal rat heart cells measured with voltage-sensitive dyes.  Circulation Research.  73:914-925. 1993
1992 DISCONTINUOUS IMPULSE PROPAGATION AT A CELLULAR-LEVEL IN CULTURED STRANDS OF NEONATAL RAT-HEART CELLS.  Circulation.  86:752-752. 1992
1992 OPTICAL VERSUS ELECTRICAL DETECTION OF RAPID MEMBRANE-POTENTIAL CHANGES IN CULTURED NEONATAL RAT-HEART CELLS.  Circulation.  86:820-820. 1992
1992 Shift and Termination of Functional Reentry in Isolated Ventricular Preparations with Quinidine‐Induced Inhomogeneity in Refractory Period.  Journal of Cardiovascular Electrophysiology.  3:255-265. 1992
1991 [Isolated right ventricle after coronary perfusion as a model for the study of ischemic and reperfusion-induced arrhythmia in rats]..  Kardiologiia.  31:58-61. 1991
1991 Stability of vortex rotation in an excitable cellular medium.  Physica D: Nonlinear Phenomena.  49:75-81. 1991
1991 Isolated coronary perfused rat right ventricle as a model for examination of ischemic and perfusion arrhythmias.  Kardiologiia.  31:58-61. 1991
1991 Vagally induced depression of impulse propagation as a cause of atrial tachycardia.  Journal of Molecular and Cellular Cardiology.  23:3-9. 1991
1990 Transition from circular to linear rotation of a vortex in an excitable cellular medium 1990
1990 Drift of a vortex in the myocardium.  Biofizika / Biophysics.  35:489-494. 1990
1990 [Effects of lidocaine on intramural circulation in isolated rabbit heart ventricle preparations]..  Kardiologiia.  30:93-96. 1990
1990 Drift of vortex in myocardium.  Biofizika / Biophysics.  35:478-482. 1990
1990 Effects of lidocaine on intramural reentry in isolated rabbit ventricular specimens.  Kardiologiia.  30:93-96. 1990
1989 Study of spontaneous acetylcholine-dependent tachyarrhythmias using isolated specimens of the right canine atrium by bilateral mapping of the spread of excitation.  Kardiologiia.  29:80-85. 1989
1989 Vagally induced block and delayed conduction as a mechanism for circus movement tachycardia in frog atria.  Circulation Research.  64:213-226. 1989
1988 The mechanism of the development of atrial tachyarrhythmia after stimulation of the vagus nerve.  Kardiologiia.  28:79-84. 1988
1987 3-dimensional reentry in paroxysmal ventricular tachycardias: the results of electrophysiological mapping.  Kardiologiia.  27:75-79. 1987
1986 Effect of lidocaine on the leading cycle and focal source of arrhythmia in isolated specimens of rabbit cardiac tissue during hypothermia.  Kardiologiia.  26:83-86. 1986
1986 Characteristics of the restoration of the electromechanical properties of the isolated myocardium following fluorocarbon cardioplegia.  Annals of the Russian academy of medical sciences.  43-49. 1986
1985 [Cold-induced arrhythmias in the isolated rabbit atrium studied by mapping]..  Kardiologiia.  25:93-97. 1985
1985 A mapping study of hyperthermic arrhythmias in the isolated rabbit atrium.  Kardiologiia.  25:93-97. 1985

Chapter

Year Title Altmetric
2013 Mechanisms of defibrillation.  199-215. 2013
2009 The role of microscopic tissue structure in defibrillation.  255-281. 2009
2005 Recording action potentials using voltage-sensitive dyes.  233-255. 2005
2004 Cellular mechanisms of defibrillation.  407-416. 2004

Teaching Activities

  • BME210 - Engineering Biology (Spring Term 2008)
  • BME210 - Engineering Biology (Spring Term 2009)
  • BME210 - Engineering Biology (Spring Term 2010)
  • BME210 - Engineering Biology (Spring Term 2011)
  • BME210 - Engineering Biology (Spring Term 2012)
  • BME210 - Engineering Biology (Spring Term 2013)
  • BME210 - Engineering in Biology (Fall Term 2014)
  • BME210 - Engineering in Biology (Spring Term 2014)
  • BME210 - Engineering in Biology (Spring Term 2015)
  • BME210 - Engineering in Biology (Spring Term 2016)
  • BME210 - Engineering in Biology (Spring Term 2017)
  • BME210 - Engineering in Biology (Spring Term 2018)
  • BME210 - Engineering in Biology (Spring Term 2019)
  • BME210 - Engineering in Biology (Spring Term 2020)
  • BME210 - Engineering in Biology (Spring Term 2021)
  • BME210 - Engineering in Biology (Spring Term 2022)
  • BME210 - Engineering in Biology (Spring Term 2023)
  • BME462 - Cardiac Electrophysiology (Spring Term 2022)
  • BME491 - Individual Study in (Area) (Spring Term 2014)
  • BME494 - Honors Research I (Fall Term 2010)
  • BME494 - Honors Research I (Spring Term 2014)
  • BME495 - Honors Research II (Fall Term 2014)
  • BME698 - Non-Thesis Research (Fall Term 2009)
  • BME698 - Non-Thesis Research (Fall Term 2010)
  • BME698 - Non-Thesis Research (Fall Term 2013)
  • BME698 - Non-Thesis Research (Spring Term 2010)
  • BME698 - Non-Thesis Research (Spring Term 2011)
  • BME698 - Non-Thesis Research (Spring Term 2014)
  • BME698 - Non-Thesis Research (Summer Term 2010)
  • BME699 - Masters Thesis Research (Summer Term 2011)
  • BME798 - Non-Dissertation Research (Fall Term 2013)
  • BME798 - Non-Dissertation Research (Fall Term 2015)
  • BME798 - Non-Dissertation Research (Spring Term 2014)
  • BME798 - Non-Dissertation Research (Spring Term 2016)
  • EGR150 - Computer Meth in Engineering (Fall Term 2009)
  • EGR150 - Computer Meth in Engineering (Fall Term 2020)
  • EGR150 - Computer Meth in Engineering (Fall Term 2021)
  • EGR150 - Computer Meth in Engineering (Fall Term 2022)
  • EGR150 - Computer Meth in Engineering (Spring Term 2023)

    • Education And Training

    Full Name

  • Vladimir Fast