Talene Yacoubian

Talene Yacoubian
Professor

Professor (P), Neurology , School of Medicine
Director/ Medical Scientist Training Program (MSTP), Neurology , School of Medicine
Scientist (C), Comprehensive Neuroscience Center , General Clinical Research Center
Scientist (C), Neurodegeneration and Experimental Therapeutics (CNET) , Neurology
Associate Scientist (C), Alzheimer's Disease Center , Neurology
Scientist (C), Multiple Sclerosis Center , Neurology
Scientist (C), Civitan International Research Center , Academic Joint Departments
Assistant Professor (S), Neurobiology , Academic Joint Departments

Selected Publications

Academic Article

Year	Title	Altmetric
2023	Brain and Systemic Inflammation in De Novo Parkinson's Disease.. Movement Disorders. 2023
2023	Connectomic Basis for Tremor Control in Stereotactic Radiosurgical Thalamotomy. American Journal of Neuroradiology. 44:157-164. 2023
2022	Deletion in chromosome 6 spanning alpha-synuclein and multimerin1 loci in the Rab27a/b double knockout mouse. Scientific Reports. 12. 2022
2022	Pathological α-synuclein recruits LRRK2 expressing pro-inflammatory monocytes to the brain. Molecular Neurodegeneration. 17. 2022
2022	Fostering a diverse regional community of physician-scientist trainees. Journal of the National Medical Association. 114:251-257. 2022
2022	14-3-3θ Does Not Protect against Behavioral or Pathological Deficits in Alzheimer’s Disease Mouse Models. eNeuro. 9. 2022
2022	Image Quantification for TSPO PET with a Novel Image-Derived Input Function Method. Diagnostics. 12. 2022
2022	A novel curricular framework to develop grant writing skills among MD-PhD students. Journal of Clinical and Translational Science. 6. 2022
2022	Mutant glucocerebrosidase impairs α-synuclein degradation by blockade of chaperone-mediated autophagy. Science Advances. 8. 2022
2022	The S-Factor, a New Measure of Disease Severity in Spinocerebellar Ataxia: Findings and Implications 2022
2021	14-3-3 mitigates alpha-synuclein aggregation and toxicity in the in vivo preformed fibril model. Acta Neuropathologica Communications. 9. 2021
2021	Pathways to Parkinson’s disease: a spotlight on 14-3-3 proteins. npj Parkinson's Disease. 7. 2021
2021	Sex-based differences in the activation of peripheral blood monocytes in early Parkinson disease. npj Parkinson's Disease. 7. 2021
2021	14-3-3 Proteins: Novel Pharmacological Targets in Neurodegenerative Diseases. Trends in Pharmacological Sciences. 42:226-238. 2021
2020	14-3-3 mitigates alpha-synuclein aggregation and toxicity in the in vivo preformed fibril model 2020
2020	007 (x2)-3-3: 14-3-3 Targeted Compounds as Double Agents. Trends in Pharmacological Sciences. 41:431-433. 2020
2020	The GTPase Rab27b regulates the release, autophagic clearance, and toxicity of alpha-synuclein. Journal of Biological Chemistry. 295:8005-8016. 2020
2018	Primary Bone Marrow Diffuse Large B-cell Lymphoma Presenting as Transverse Myelitis. American Journal of the Medical Sciences. 356:561-566. 2018
2018	14-3-3 proteins reduce cell-to-cell transfer and propagation of pathogenic α-synuclein 2018
2017	Dysregulation of 14-3-3 proteins in neurodegenerative diseases with Lewy body or Alzheimer pathology. Annals of Clinical and Translational Neurology. 4:466-477. 2017
2017	Disparate genes come together: Spatial and genetic screens point to disruptions in vesicle trafficking and mRNA metabolism in synucleinopathies. Movement Disorders. 32:840. 2017
2016	14-3-3 Proteins regulate mutant LRRK2 kinase activity and neurite shortening. Human Molecular Genetics. 25:109-122. 2016
2016	CoQ10 in progressive supranuclear palsy: A randomized, placebo-controlled, double-blind trial 2016
2015	14-3-3 inhibition promotes dopaminergic neuron loss and 14-3-3θ overexpression promotes recovery in the MPTP mouse model of Parkinson's disease. Neuroscience. 307:73-82. 2015
2015	Increased 14-3-3 phosphorylation observed in Parkinson's disease reduces neuroprotective potential of 14-3-3 proteins. Neurobiology of Disease. 79:1-13. 2015
2014	Reaping what you sow: Cross-seeding between aggregation-prone proteins in neurodegeneration. Movement Disorders. 29:306-306. 2014
2013	LRRK2 secretion in exosomes is regulated by 14-3-3. Human Molecular Genetics. 22:4988-5000. 2013
2013	α-synuclein overexpression represses 14-3-3θ transcription. Journal of Molecular Neuroscience. 51:1000-1009. 2013
2013	IPX066: a new intermediate-and extended-release carbidopa-levodopa formulation.. Neurodegenerative Disease Management. 3:123-131. 2013
2013	Angiogenin in Parkinson Disease Models: Role of Akt Phosphorylation and Evaluation of AAV-Mediated Angiogenin Expression in MPTP Treated Mice. PLoS One. 8. 2013
2012	Functional analysis of VPS41-mediated neuroprotection in Caenorhabditis elegans and mammalian models of Parkinson's disease 2012
2011	14-3-3theta protects against neurotoxicity in a cellular parkinson's disease model through inhibition of the apoptotic factor Bax. PLoS One. 6. 2011
2011	A neuroprotective role for angiogenin in models of Parkinson's disease. Journal of Neurochemistry. 116:334-341. 2011
2011	Defects in very long chain fatty acid synthesis enhance alpha-synuclein toxicity in a yeast model of Parkinson's disease. PLoS One. 6. 2011
2010	Target validation: The Parkinson disease perspective. Disease Models and Mechanisms. 3:259-262. 2010
2010	Differential neuroprotective effects of 14-3-3 proteins in models of Parkinson's disease. Cell Death and Disease. 1. 2010
2009	Targets for neuroprotection in Parkinson's disease 2009
2009	Racial differences in parkinson's disease medication use in the reasons for geographic and racial differences in stroke cohort: A cross-sectional study. Neuroepidemiology. 33:329-334. 2009
2008	Transcriptional dysregulation in a transgenic model of Parkinson disease. Neurobiology of Disease. 29:515-528. 2008
2008	Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity.. Molecular Brain. 1:17. 2008
2000	Truncated and full-length TrkB receptors regulate distinct modes of dendritic growth. Nature Neuroscience. 3:342-349. 2000
1999	Subcellular localization of full-length and truncated Trk receptor isoforms in polarized neurons and epithelial cells 1999