Positions

Overview

  • Dr. Tollefsbol is a professor of Biology and a senior scientist in the UAB Comprehensive Cancer Center, Comprehensive Center for Healthy Aging, Nutrition Obesity Research Center, and the Comprehensive Diabetes Center. He is director of the UAB Cell Senescence Culture Facility, which he established in 1999.

    Dr. Tollefsbol holds doctorate degrees in molecular biology and osteopathic medicine and has published over 120 articles related to the fields of epigenetics, telomerase, aging, and cancer. He has received generous funding from the National Institutes of Health as well as the Glenn Foundation for Medical Research, Susan G. Komen for the Cure, the American Federation for Aging Research (AFAR), and the American Institute for Cancer Research (AICR), among other sources. Work from his laboratory has been featured in Women’s Health, Shape, AICR Newsletter, Nutrition Action HealthLetter, More Magazine, and AARP The Magazine, among others, with a total readership of over 30 million. He has been a Scientist in the Spotlight in ScienceNow.

    Dr. Tollefsbol is series editor for Translational Epigenetics published by Elsevier. In addition, he serves as an associate editor for Frontiers in Epigenomics and for Clinical Epigenetics. He is a contributing editor of Lewin’s GENES, the classic textbook on molecular biology, and is on the editorial board of Molecular Biotechnology. Dr. Tollefsbol has been invited to give presentations on his research in many countries including Germany, China, Italy, Switzerland, the Netherlands, and Sweden, as well as at various leading institutions in the US. His research has received considerable media attention both nationally and internationally and has been highlighted in eScience News and ScienceDaily. He has published over 14 co-authored and edited books on varied topics such as epigenetics, telomerase, aging, cancer, and molecular biology.
  • Selected Publications

    Book

    Year Title Altmetric
    2021 Epigenetics and Metabolomics: Volume 28 in Translational Epigenetics 2021
    2021 Epigenetics in Cardiovascular Disease: Volume 24 in Translational Epigenetics 2021
    2021 Medical Epigenetics 2021
    2021 Preface 2021
    2020 Developmental Human Behavioral Epigenetics: Principles, Methods, Evidence, and Future Directions 2020
    2020 Epigenetics Methods 2020
    2020 Epigenetics and Reproductive Health: Volume 21 in Translational Epigenetics 2020
    2020 Preface 2020
    2019 Translational Epigenetics Series 2019
    2019 Translational Epigenetics Series 2019
    2018 Epigenetics in Human Disease: Volume 6 in Translational Epigenetics 2018
    2018 Foreword 2018
    2018 Preface 2018
    2017 Handbook of epigenetics: The new molecular and medical genetics 2017
    2017 Preface 2017
    2017 Translational Epigenetics Series 2017
    2016 Medical Epigenetics 2016
    2016 Preface 2016
    2015 Personalized Epigenetics 2015
    2015 Preface 2015
    2014 Transgenerational Epigenetics 2014
    2013 Preface.  Ed. 1048.  2013
    2013 Preface.  Ed. 1048.  2013
    2012 Epigenetics in Human Disease 2012
    2012 Preface 2012
    2012 Epigenetics in Human Disease 2012
    2011 Handbook of Epigenetics 2011
    2011 Handbook of Epigenetics 2011
    2010 Handbook of Epigenetics: The New Molecular and Medical Genetics 2010
    2010 Epigenetics of aging 2010
    2010 Preface 2010
    2008 Cancer epigenetics 2008
    2008 Preface 2008
    2007 Telomerase Inhibition Strategies and Protocols 2007
    2007 Methods in Molecular Biology: Preface.  Ed. 371.  2007
    2004 Epigenetics Protocols 2004

    Chapter

    Year Title Altmetric
    2021 Advances in medical epigenetics.  3-8. 2021
    2021 Chapter 1 Advances in medical epigenetics.  3-8. 2021
    2021 Chapter 2 Outline of epigenetics.  25-45. 2021
    2021 Outline of epigenetics.  25-45. 2021
    2021 Perspectives and future directions of translational epigenetics in personalized and precision medicine.  1-18. 2021
    2021 Preface.  xxi. 2021
    2020 Chapter One Epigenetics methods in biological research.  3-14. 2020
    2020 Epigenetics methods in biological research.  3-14. 2020
    2020 Preface.  xxiii-xxiv. 2020
    2019 Foreword.  xiii-xiv. 2019
    2018 Chapter 7 Epigenetic Approaches to Cancer Therapy.  219-247. 2018
    2018 Epigenetic Approaches to Cancer Therapy.  219-247. 2018
    2018 Epigenetics of Human Disease.  3-10. 2018
    2018 Preface.  xxxv-xxxvi. 2018
    2017 An overview of epigenetics.  1-6. 2017
    2017 DNA and Histone Methylation in Epigenetics.  1-15. 2017
    2016 An Overview of Medical Epigenetics.  3-7. 2016
    2016 Epigenetic modifications by dietary phytochemicals in cancer prevention.  577-588. 2016
    2016 Epigenetic Biomarkers: New Findings, Perspectives, and Future Directions in Diagnostics.  1-18. 2016
    2015 Epigenetics of Personalized Medicine.  3-13. 2015
    2014 Outline of Epigenetics.  27-44. 2014
    2014 Chapter 1 Transgenerational Epigenetics.  1-8. 2014
    2014 Chapter 2 Outline of Epigenetics.  27-44. 2014
    2014 Preface.  xiii. 2014
    2014 Transgenerational Epigenetics.  1-8. 2014
    2013 Analysis of Biomarkers of Caloric Restriction in Aging Cells.  19-29. 2013
    2013 Cell Senescence Culturing Methods.  1-10. 2013
    2012 Epigenetic Approaches to Cancer Therapy.  111-125. 2012
    2012 Epigenetics of Human Disease.  1-6. 2012
    2012 Chapter 1 Epigenetics of Human Disease.  1-6. 2012
    2012 Chapter 6 Epigenetic Approaches to Cancer Therapy.  111-125. 2012
    2012 Preface.  vii. 2012
    2011 Epigenetics: The new science of genetics.  1-6. 2011
    2011 Chapter 1 Epigenetics The New Science of Genetics.  1-6. 2011
    2010 Epigenetics: The New Science of Genetics.  1-6. 2010
    2010 Dietary effect on epigenetics during the aging process.  407-416. 2010
    2010 Environmental effects on age-associated epigenetics.  417-429. 2010
    2010 Epigenetics and the aging process.  1-8. 2010
    2010 Role of epigenetics in age-related long-term memory loss.  275-281. 2010
    2010 Telomerase control by epigenetic processes in cellular senescence.  191-204. 2010
    2009 Telomerase regulation in response to green tea.  365-382. 2009
    2009 978-1-4200-4579-6.  197-214. 2009
    2008 Alterations in histone acetylation in tumorigenesis.  97-108. 2008
    2008 DNA hypermethylation and oncogenesis.  39-49. 2008
    2008 Dietary and environmental influences on histone modifications in cancer.  197-214. 2008
    2008 Proteins that modulate DNA methylation aberrations in cancer.  65-78. 2008
    2008 Role of epigenetics in cancer.  1-4. 2008
    2007 A Method to Detect DNA Methyltransferase I Gene Transcription In Vitro in Aging Systems.  73-80. 2007
    2007 A Method to Study the Expression of DNA Methyltransferases in Aging Systems In Vitro.  81-87. 2007
    2007 Aging Cell Culture.  9-19. 2007
    2007 Techniques for Analysis of Biological Aging.  1-7. 2007
    2004 Methods of Epigenetic Analysis.  1-8. 2004
    2004 Profiling DNA Methylation by Bisulfite Genomic Sequencing.  169-179. 2004
    1985 Molecular Basis of the Accumulation of Abnormal Proteins in Progeria and Aging Fibroblasts.  427-442. 1985

    Research Overview

  • Dr. Tollefsbol's research is primarily involved with cancer and aging epigenetics, the underlying mechanisms of cancer and aging and novel therapeutic approaches to cancer. This work has also involved translational research on breast and ovarian cancer as well as other cancers. The single most important risk factor for developing cancer is age; therefore, both cancer and aging have been a focus of his research.

    Epigenetic processes are heritable changes that do not involve mutations, but rather, modifications of DNA or its associated proteins and Dr. Tollefsbol's laboratory is interested in these processes as controllers of gene expression in cancer and aging in general. We are interested in discovering novel approaches of modifying epigenetic gene expression in cancers and aging and the translational potential of epigenetic-modulating nutritional compounds in inhibiting cancer and impacting aging. The laboratory is using or has plans to use many cutting-edge technological developments in cancer and aging genetics and translational research such as chromatin immunoprecipitation-genomic bisulfite sequencing, ChIP-seq, and MeDIP-seq.

    Studies on the role of telomerase in cancer and aging have made many lists of the most important future research areas in biological sciences. Dr. Tollefsbol's laboratory is also interested in the epigenetic regulation of the gene that produces telomerase (hTERT) and in unraveling the mysteries of how this gene relates to cancer and aging. Located at the ends of eukaryotic chromosomes and synthesized by the enzyme telomerase, telomeres maintain the length of chromosomes. The majority of human cancer cells express high levels of telomerase and inhibition of telomerase activity kills the cancer cells without effect on most normal somatic cells.

    Dr. Tollefsbol’s laboratory directs a Cell Senescence Culture Facility that provides various types of aging cells to investigators nationwide. This facility is one of only a few of this type in the United States and is designed to not only facilitate studies of aging, but to also participate in new investigations in the mechanisms of cellular aging and age-related diseases such as cancer.

    Epigenetics, Telomerase, Cancer Prevention, Aging, Molecular Biology, Gene Regulation
  • Teaching Activities

  • BY314 - Embryology (Spring Term 2008)
  • BY314 - Embryology (Spring Term 2009)
  • BY314 - Embryology (Spring Term 2010)
  • BY314 - Embryology (Spring Term 2011)
  • BY314 - Embryology (Spring Term 2012)
  • BY314 - Embryology (Spring Term 2013)
  • BY314 - Embryology (Spring Term 2014)
  • BY397 - Advanced Directed Readings (Fall Term 2014)
  • BY398 - Undergrad Research - RES (Fall Term 2014)
  • BY398 - Undergrad Research - RES (Fall Term 2015)
  • BY398 - Undergrad Research - RES (Fall Term 2016)
  • BY398 - Undergrad Research - RES (Fall Term 2017)
  • BY398 - Undergrad Research - RES (Spring Term 2015)
  • BY398 - Undergrad Research - RES (Spring Term 2018)
  • BY398 - Undergrad Research - RES (Spring Term 2020)
  • BY398 - Undergrad Research - RES (Spring Term 2023)
  • BY398 - Undergrad Research - RES (Summer Term 2021)
  • BY433 - Advanced Molecular Genetics (Fall Term 2007)
  • BY433 - Advanced Molecular Genetics (Fall Term 2008)
  • BY433 - Advanced Molecular Genetics (Fall Term 2010)
  • BY433 - Advanced Molecular Genetics (Fall Term 2013)
  • BY433 - Advanced Molecular Genetics (Fall Term 2014)
  • BY433 - Advanced Molecular Genetics (Fall Term 2015)
  • BY433 - Advanced Molecular Genetics (Fall Term 2016)
  • BY433 - Advanced Molecular Genetics (Fall Term 2017)
  • BY433 - Advanced Molecular Genetics (Fall Term 2018)
  • BY433 - Advanced Molecular Genetics (Fall Term 2019)
  • BY433 - Advanced Molecular Genetics (Fall Term 2020)
  • BY433 - Advanced Molecular Genetics (Fall Term 2021)
  • BY433 - Advanced Molecular Genetics (Fall Term 2022)
  • BY499 - Biology Seminar (Fall Term 2010)
  • BY499 - Biology Seminar (Summer Term 2014)
  • BY633 - Advanced Molecular Genetics (Fall Term 2007)
  • BY633 - Advanced Molecular Genetics (Fall Term 2008)
  • BY633 - Advanced Molecular Genetics (Fall Term 2010)
  • BY633 - Advanced Molecular Genetics (Fall Term 2013)
  • BY633 - Advanced Molecular Genetics (Fall Term 2014)
  • BY633 - Advanced Molecular Genetics (Fall Term 2015)
  • BY633 - Advanced Molecular Genetics (Fall Term 2016)
  • BY633 - Advanced Molecular Genetics (Fall Term 2017)
  • BY633 - Advanced Molecular Genetics (Fall Term 2018)
  • BY633 - Advanced Molecular Genetics (Fall Term 2019)
  • BY633 - Advanced Molecular Genetics (Fall Term 2020)
  • BY633 - Advanced Molecular Genetics (Fall Term 2021)
  • BY693 - Seminar in Embryology (Fall Term 2010)
  • BY693 - Seminar in Embryology (Summer Term 2014)
  • BY698 - Nonthesis Research (Fall Term 2013)
  • BY698 - Nonthesis Research (Fall Term 2014)
  • BY698 - Nonthesis Research (Fall Term 2015)
  • BY698 - Nonthesis Research (Fall Term 2018)
  • BY698 - Nonthesis Research (Spring Term 2014)
  • BY698 - Nonthesis Research (Spring Term 2015)
  • BY698 - Nonthesis Research (Spring Term 2016)
  • BY698 - Nonthesis Research (Spring Term 2020)
  • BY698 - Nonthesis Research (Summer Term 2015)
  • BY698 - Nonthesis Research (Summer Term 2018)
  • BY793 - Seminar in Embryology (Fall Term 2010)
  • BY793 - Seminar in Embryology (Summer Term 2014)
  • BY798 - Nondissertation Research (Fall Term 2013)
  • BY798 - Nondissertation Research (Fall Term 2014)
  • BY798 - Nondissertation Research (Fall Term 2015)
  • BY798 - Nondissertation Research (Fall Term 2016)
  • BY798 - Nondissertation Research (Fall Term 2017)
  • BY798 - Nondissertation Research (Fall Term 2018)
  • BY798 - Nondissertation Research (Fall Term 2019)
  • BY798 - Nondissertation Research (Fall Term 2020)
  • BY798 - Nondissertation Research (Fall Term 2021)
  • BY798 - Nondissertation Research (Fall Term 2022)
  • BY798 - Nondissertation Research (Spring Term 2014)
  • BY798 - Nondissertation Research (Spring Term 2015)
  • BY798 - Nondissertation Research (Spring Term 2016)
  • BY798 - Nondissertation Research (Spring Term 2017)
  • BY798 - Nondissertation Research (Spring Term 2019)
  • BY798 - Nondissertation Research (Spring Term 2020)
  • BY798 - Nondissertation Research (Spring Term 2021)
  • BY798 - Nondissertation Research (Spring Term 2022)
  • BY798 - Nondissertation Research (Spring Term 2023)
  • BY798 - Nondissertation Research (Summer Term 2014)
  • BY798 - Nondissertation Research (Summer Term 2015)
  • BY798 - Nondissertation Research (Summer Term 2016)
  • BY798 - Nondissertation Research (Summer Term 2019)
  • BY798 - Nondissertation Research (Summer Term 2020)
  • BY798 - Nondissertation Research (Summer Term 2021)
  • BY798 - Nondissertation Research (Summer Term 2022)
  • BY799 - Dissertation Research (Fall Term 2013)
  • BY799 - Dissertation Research (Fall Term 2014)
  • BY799 - Dissertation Research (Fall Term 2015)
  • BY799 - Dissertation Research (Fall Term 2016)
  • BY799 - Dissertation Research (Fall Term 2017)
  • BY799 - Dissertation Research (Fall Term 2018)
  • BY799 - Dissertation Research (Fall Term 2021)
  • BY799 - Dissertation Research (Fall Term 2022)
  • BY799 - Dissertation Research (Spring Term 2014)
  • BY799 - Dissertation Research (Spring Term 2015)
  • BY799 - Dissertation Research (Spring Term 2016)
  • BY799 - Dissertation Research (Spring Term 2017)
  • BY799 - Dissertation Research (Spring Term 2018)
  • BY799 - Dissertation Research (Spring Term 2019)
  • BY799 - Dissertation Research (Spring Term 2022)
  • BY799 - Dissertation Research (Spring Term 2023)
  • BY799 - Dissertation Research (Summer Term 2014)
  • BY799 - Dissertation Research (Summer Term 2015)
  • BY799 - Dissertation Research (Summer Term 2016)
  • BY799 - Dissertation Research (Summer Term 2017)
  • BY799 - Dissertation Research (Summer Term 2018)
  • BY799 - Dissertation Research (Summer Term 2021)
  • BY799 - Dissertation Research (Summer Term 2022)
  • NUR790 - Independent Study in Nursing (Fall Term 2017)
  • Education And Training

  • Doctor of Philosophy in Molecular Biology, University of North Texas 1982
  • Full Name

  • Trygve Tollefsbol