• Jessy Deshane received her PhD in Biochemistry and Molecular Genetics from University of Alabama at Birmingham under the mentorship of Dr. Anupam Agarwal. After completing her post-doctoral training in Immunology with Dr. David Chaplin, in Department of Microbiology, she joined the faculty of the Division of Pulmonary, Allergy, and Critical Care Medicine in the Department of Medicine in 2011 as an Assistant Professor.

    Dr. Deshane is committed to an academic career combining basic and translational research with an emphasis on inflammatory diseases of the airway. Research in Dr. Deshane’s laboratory is focused on myeloid-derived regulatory cells (MDRCs) and their immunoregulatory roles in chronic inflammatory lung diseases. Dr. Deshane is particularly interested in delineating mechanisms underlying the differentiation, activation, metabolism and function of MDRCs. Her group recently reported that a subset of reactive oxygen species (ROS)-producing MDRCs exacerbate T cell responses and airway hyper-reactivity in mice. They recently characterized human MDRC subsets in bronchoalveolar lavage of asthmatics.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2022 "Stick a Fork in Me; I'm Done": Epithelial Cell Expression of ORMDL Sphingolipid Biosynthesis Regulator 3 Mediates Autophagic Cell Death.American Journal of Respiratory Cell and Molecular Biology.  66:593-595. 2022
    2022 Ex Vivo Culture Models of Hidradenitis Suppurativa for Defining Molecular Pathogenesis and Treatment Efficacy of Novel DrugsInflammation.  45:1388-1401. 2022
    2021 Indoleamine 2, 3-Dioxygenase Promotes Aryl Hydrocarbon Receptor-Dependent Differentiation Of Regulatory B Cells in Lung CancerFrontiers in Immunology.  12. 2021
    2021 Sphingolipids in Lung Pathology in the Coronavirus Disease Era: A Review of Sphingolipid Involvement in the Pathogenesis of Lung DamageFrontiers in Physiology.  12. 2021
    2021 Mesenchymal stromal cell aging impairs the self-organizing capacity of lung alveolar epithelial stem cellseLife.  10. 2021
    2021 Divergent Regulation of Alveolar Type 2 Cell and Fibroblast Apoptosis by Plasminogen Activator Inhibitor 1 in Lung FibrosisAmerican Journal of Pathology.  191:1227-1239. 2021
    2021 Extracellular Vesicle Mediated Tumor-Stromal Crosstalk Within an Engineered Lung Cancer ModelFrontiers in Oncology.  11. 2021
    2021 Computational Simulation of Exosome Transport in Tumor MicroenvironmentFrontiers in Medicine.  8. 2021
    2020 Inhibition of Necroptosis to Prevent Long-term Cardiac Damage during Pneumococcal Pneumonia and Invasive DiseaseJournal of Infectious Diseases.  222:1882-1893. 2020
    2020 Mechanical strain induces phenotypic changes in breast cancer cells and promotes immunosuppression in the tumor microenvironmentLaboratory Investigation.  100:1503-1516. 2020
    2020 Extracellular vesicles: Bidirectional accelerators of cellular senescence in fibrosis?American Journal of Respiratory Cell and Molecular Biology.  63:547-548. 2020
    2020 The Innate Lymphoid System Is a Critical Player in the Manifestation of Mucoinflammatory Airway Disease in MiceJournal of Immunology.  205:1695-1708. 2020
    2020 Extracellular Vesicles as Mediators of Cellular Cross Talk in the Lung MicroenvironmentFrontiers in Medicine.  7. 2020
    2020 Lung Tumor Cell-Derived Exosomes Promote M2 Macrophage PolarizationCells.  9. 2020
    2020 Airway Remodeling in AsthmaFrontiers in Medicine.  7. 2020
    2019 Erratum: Microanatomic Distribution of Myeloid Heme Oxygenase-1 Protects against Free Radical-Mediated Immunopathology in Human Tuberculosis (Cell Reports (2018) 25(7) (1938–1952.e5), (S2211124718316772), (10.1016/j.celrep.2018.10.073))Cell Reports.  28:3286. 2019
    2019 Exosomes in Allergic Airway DiseasesCurrent Allergy and Asthma Reports.  19. 2019
    2019 Fibronectin on the surface of extracellular vesicles mediates fibroblast invasionAmerican Journal of Respiratory Cell and Molecular Biology.  60:279-288. 2019
    2019 Metabolic and functional reprogramming of myeloid-derived suppressor cells and their therapeutic control in glioblastomaCell Stress.  3:47-65. 2019
    2019 Deficiency of Socs3 leads to brain-targeted experimental autoimmune encephalomyelitis via enhanced neutrophil activation and ROS productionJCI insight.  4. 2019
    2018 Macrophage Rac2 is required to reduce the severity of cigarette smoke-induced pneumoniaAmerican Journal of Respiratory and Critical Care Medicine.  198:1288-1301. 2018
    2018 Microanatomic Distribution of Myeloid Heme Oxygenase-1 Protects against Free Radical-Mediated Immunopathology in Human TuberculosisCell Reports.  25:1938-1952.e5. 2018
    2018 Myeloid-derived suppressor cells impair B cell responses in lung cancer through IL-7 and STAT5Journal of Immunology.  201:278-295. 2018
    2018 Distal airway microbiome is associated with immunoregulatory myeloid cell responses in lung transplant recipients 2018
    2017 Exosomes in immunoregulation of chronic lung diseasesAllergy.  72:534-544. 2017
    2016 Macrophage Akt1 Kinase-Mediated Mitophagy Modulates Apoptosis Resistance and Pulmonary FibrosisImmunity.  44:582-596. 2016
    2016 PcpA promotes higher levels of infection and modulates recruitment of myeloid-derived suppressor cells during pneumococcal pneumoniaJournal of Immunology.  196:2239-2248. 2016
    2016 Therapeutic potential of an orally effective small molecule inhibitor of plasminogen activator inhibitor for asthma 2016
    2015 SOCS3 deficiency in myeloid cells promotes tumor development: Involvement of STAT3 activation and myeloid-derived suppressor cellsCancer Immunology Research.  3:727-740. 2015
    2015 Targeting the effector domain of the myristoylated alanine rich C-kinase substrate enhances lung cancer radiation sensitivityInternational Journal of Oncology.  46:1079-1088. 2015
    2015 Subsets of airway myeloid-derived regulatory cells distinguish mild asthma from chronic obstructive pulmonary diseaseJournal of Allergy and Clinical Immunology.  135:413-424.e15. 2015
    2014 Exposure to cigarette smoke impacts myeloid-derived regulatory cell function and exacerbates airway hyper-responsivenessLaboratory Investigation.  94:1312-1325. 2014
    2014 Human resistin promotes neutrophil proinflammatory activation and neutrophil extracellular trap formation and increases severity of acute lung injuryJournal of Immunology.  192:4795-4803. 2014
    2014 Refractory asthma: Mechanisms, targets, and therapyAllergy.  69:817-827. 2014
    2013 Enhancement of antitumor immunity in lung cancer by targeting myeloid-derived suppressor cell pathwaysCancer Research.  73:6609-6620. 2013
    2013 A myeloid cell-binding adenovirus efficiently targets gene transfer to the lung and escapes liver tropism 2013
    2013 Erratum: Elevated levels of NO are localized to distal airways in asthma (Free Radical Biology and Medicine (2011) 50 (1679-1688))Free Radical Biology and Medicine.  58:45. 2013
    2013 Myeloid-derived suppressor cells function as novel osteoclast progenitors enhancing bone loss in breast cancerCancer Research.  73:672-682. 2013
    2012 Vitronectin inhibits neutrophil apoptosis through activation of integrin-associated signaling pathwaysAmerican Journal of Respiratory Cell and Molecular Biology.  46:790-796. 2012
    2011 Neutrophils produce interleukin 17A (IL-17A) in a Dectin-1- and IL-23-dependent manner during invasive fungal infectionInfection and Immunity.  79:3966-3977. 2011
    2011 Inhibition of neutrophil apoptosis by PAI-1 2011
    2011 Elevated levels of NO are localized to distal airways in asthmaFree Radical Biology and Medicine.  50:1679-1688. 2011
    2010 Follicular dendritic cell makes environmental senseImmunity.  33:2-4. 2010
    2010 Sp1 regulates chromatin looping between an intronic enhancer and distal promoter of the human heme oxygenase-1 gene in renal cellsJournal of Biological Chemistry.  285:16476-16486. 2010
    2010 Repeated bouts of aerobic exercise enhance regulatory T cell responses in a murine asthma modelBrain, Behavior, and Immunity.  24:153-159. 2010
    2008 Heme oxygenase-1-derived carbon monoxide induces the Mycobacterium tuberculosis dormancy regulonJournal of Biological Chemistry.  283:18032-18039. 2008
    2008 Heme oxygenase-1 and carbon monoxide in vascular pathobiology: Focus on angiogenesisCirculation.  117:231-241. 2008
    2007 Heme oxygenase-1 expression in macrophages plays a beneficial role in atherosclerosisCirculation Research.  100:1703-1711. 2007
    2007 Stromal cell-derived factor 1 promotes angiogenesis via a heme oxygenase 1-dependent mechanismJournal of Experimental Medicine.  204:605-618. 2007
    2006 Proteomics analysis of the actions of grape seed extract in rat brain: Technological and biological implications for the study of the actions of psychoactive compoundsLife Sciences.  78:2060-2065. 2006
    2005 The case for well-conducted experiments to validate statistical protocols for 2D gels: Different pre-processing = different lists of significant proteinsBMC Biotechnology.  5. 2005
    2005 Heme oxygenase-1 expression in disease statesActa Biochimica Polonica.  52:273-284. 2005
    2004 Proteomics analysis of rat brain protein modulations by grape seed extractJournal of Agricultural and Food Chemistry.  52:7872-7883. 2004
    2003 Chlorotoxin inhibits glioma cell invasion via matrix metalloproteinase-2Journal of Biological Chemistry.  278:4135-4144. 2003
    1998 Regulation of casein kinase 2 by direct interaction with cell surface receptor CD5Journal of Biological Chemistry.  273:19183-19189. 1998
    1998 The level of erbB2 expression predicts sensitivity to the cytotoxic effects of an intracellular anti-erbB2 sFv 1998
    1997 A novel gene therapy strategy for elimination of prostate carcinoma cells from human bone marrowHuman Gene Therapy.  8:157-170. 1997
    1997 An intracellular anti-erbB-2 single-chain antibody is specifically cytotoxic to human breast carcinoma cells overexpressing erbB-2 1997
    1997 Transductional efficacy and safety of an intraperitoneally delivered adenovirus encoding an anti-erbB-2 intracellular single-chain antibody for ovarian cancer gene therapyGynecologic Oncology.  64:378-385. 1997
    1996 Intracellular antibody against erbB-2 mediates targeted tumor cell eradication by apoptosisCancer Gene Therapy.  3:89-98. 1996
    1996 Novel gene therapy strategy to accomplish growth factor modulation induces enhanced tumor cell chemosensitivityClinical Cancer Research.  2:1089-1095. 1996
    1996 erbB-2 Knockout Employing an Intracellular Single-chain Antibody (sFv) Accomplishes Specific Toxicity in erbB-2-expressing Lung Cancer CellsAmerican Journal of Respiratory Cell and Molecular Biology.  15:348-354. 1996
    1995 Neoplastic Reversion Accomplished by High Efficiency Adenoviral-mediated Delivery of an Anti-ras RibozymeCancer Research.  55:2024-2028. 1995
    1995 Targeted eradication of ovarian cancer mediated by intracellular expression of anti-erbb-2 single-chain antibodyGynecologic Oncology.  59:8-14. 1995
    1995 Targeted tumor killing via an intracellular antibody against erbB-2Journal of Clinical Investigation.  96:2980-2989. 1995
    1994 Intracellular single-chain antibody directed against erbB2 down-regulates cell surface erbB2 and exhibits a selective anti-proliferative effect in erbB2 overexpressing cancer cell lines 1994


    Year Title Altmetric
    2005 Nutriproteomics approach to understanding dementia-relevant brain protein changes in response to grape seed extract, a dietary antioxidant.  457-480. 2005
    2000 Eradication of c-erB-2 positive ovarian cancer cells mediated by intracellular expression of anti-erbB-2 sFv. 2000
    1998 In vivo efficacy of an anti-erbB-2 intracellular single chain antibody in combination with cisplatin in a murine model 1998

    Research Overview

  • Dr. Deshane’s current research interests are to study effects of MDRCs on post-translational oxidative and nitrative modifications of self-peptides. This study is based the hypothesis that these modified self-proteins are recognized as non-tolerized neo-antigens and stimulate Th responses that underlie the immunopathology of asthma. Furthermore, her lab investigates how environmental pollutants such as tobacco smoke would impact MDRC function and contribute to exacerbation of inflammation in asthmatic smokers. These studies will provide insight into the role of MDRC in tobacco related pathology of the lung.

    Dr. Deshane’s group also studies the function of these myeloid-lineage cells in anti-tumor immunity. They have developed novel therapeutic strategies to target these immunoregulatory cells to enhance anti-tumor immunity for lung cancer; in parallel, they seek to understand molecular signatures of the tumor microenvironment (TME). Their innovative therapeutic strategy targets Indoleamine 2, 3- dioxygenase (IDO), an enzyme that regulates tryptophan metabolism in the TME and suppresses the function of these regulatory myeloid cells. This novel strategy has distinct advantages over existing immunotherapy strategies targeting CTLA-4 and PD-1/PDL-1 in that it overrides the IDO resistance associated with current immunotherapy strategies. Dr. Deshane’s group investigates the mechanisms by which this therapeutic strategy induces metabolic reprogramming in the TME involving IDO and the nutrient sensing metabolic signaling pathways. They also seek to translate these findings in human studies to investigate efficacy of combination chemotherapy strategies in targeting these cells and amino acid metabolism pathways in lung cancer patients.
  • Investigator On

  • Asthma Cohort Support Contract  awarded by National Institute of Child Health and Human Development/NIH/DHHS
  • Impact of Airborne Heavy Metals on Lung Disease and the Environment  awarded by National Institute of Environmental Health Sciences/NIH/DHHS
  • Impact of Airborne Heavy Metals on Lung Diseases & the Environment - Predisposition to Asthma in Children Exposed to Heavy Metals Project 2  awarded by National Institute of Environmental Health Sciences/NIH/DHHS
  • Lung Macrophage Metabolic Reprogramming in Asbestos-Induced Toxicity  awarded by National Institute of Environmental Health Sciences/NIH/DHHS
  • Therapeutic Targeting of the Myofibroblast in Fibrotic Lung Disease  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Therapeutic Targeting of the Myofibroblast in Fibrotic Lung Disease  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Therapeutic Targeting of the Myofibroblast in Fibrotic Lung Disease - Project Three: Metabolic Regulation of Pro-Fibrotic Macrophages in Pulmonary Fibrosis  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Therapeutic Targeting of the Myofibroblast in Fibrotic Lung Disease: Project 1 - Activation of the Pleural Mesothelium in IPF  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Therapeutic Targeting of the Myofibroblast in Fibrotic Lung Disease: Project 3 - NOX4 as a Therapeutic Target in IPF  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Therapeutic Targeting of the Myofibroblasts in Fibrotic Lung Disease Project 3 - Carter  awarded by TULANE UNIVERSITY
  • UAB Center for AIDS Research (CFAR)  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS
  • UAB Center for AIDS Research - CFAR Administrative Supplement - Adipocyte-derived Exosomes and Mitochondrial Signaling in Immune Activation of Obese HIV+ Asthmatics  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS
  • UAB Predoctoral Training Program in Lung Diseases  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • UAB Skin Disease Research Center  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS
  • Education And Training

  • University of Alabama at Birmingham, Other
  • University of Alabama at Birmingham, Postdoctoral Research
  • Doctor of Philosophy in Biochemistry, Biophysics and Molecular Biology, University of Alabama at Birmingham 2007
  • Master of Life Sciences in Biology, University of Alabama in Huntsville 1990
  • Full Name

  • Jessy Deshane