Selected Publications

Academic Article

Year Title Altmetric
2015 Homocysteine, iron and cardiovascular disease: A hypothesisNutrients.  7:1108-1118. 2015
2015 13C-enrichment of urinary uric acid after L-[Ring-2-13C]histidine dose in adult humansNutrients.  7:697-705. 2015
2015 Folate-dependent purine nucleotide biosynthesis in humansAdvances in Nutrition.  6:564-571. 2015
2014 The second study of experimental human folate deficiencySpringerPlus.  3:1-2. 2014
2013 Relationship of cognitive function with B vitamin status, homocysteine, and tissue factor pathway inhibitor in cognitively impaired elderly: A cross-sectional surveyJournal of Alzheimer's Disease.  33:853-862. 2013
2012 Blood folate concentrations analyzed by microbiological assay and chemiluminescent immunoassay methodsJournal of Nutritional Science and Vitaminology.  58:59-62. 2012
2012 Meta-analysis of cancer risk in folic acid supplementation trials 2012
2012 Relationship between body-mass index and serum folate concentrations in pregnant womenEuropean Journal of Clinical Nutrition.  66:136-138. 2012
2011 Relation of body mass index to blood folate and total homocysteine concentrations in Japanese adults 2011
2011 Comparison of serum and red blood cell folate microbiologic assays for national population surveys 2011
2011 Serum iron parameters and plasma total homocysteine concentrations 2011
2011 Effect of paternal folate deficiency on placental folate content and folate receptor α expression in ratsNutrition research and practice.  5:112-116. 2011
2011 Oral clefts and maternal biomarkers of folate-dependent one-carbon metabolism in utahBirth Defects Research Part A: Clinical and Molecular Teratology.  91:153-161. 2011
2011 Zinc status and growth of korean infants fed human milk, casein-based, or soy-based formula:Three-year longitudinal studyNutrition research and practice.  5:46-51. 2011
2010 Evidence for the hypothesis that 10-formyldihydrofolate is the in vivo substrate for aminoimidazolecarboxamide ribotide transformylaseExperimental Biology and Medicine.  235:271-277. 2010
2009 Folate contents in human milk and casein-based and soya-based formulas, and folate status in Korean infants 2009
2009 Plasma zinc concentrations of mothers and the risk of oral clefts in their children in UtahBirth Defects Research Part A: Clinical and Molecular Teratology.  85:151-155. 2009
2008 In vitro formation of homocysteine in whole blood in the presence of anticoagulants 2008
2007 Iron-dependent formation of homocysteine from methionine and other thioethersEuropean Journal of Clinical Nutrition.  61:1359-1363. 2007
2007 13C-enrichment at carbons 8 and 2 of uric acid after 13C-labeled folate dose in manBiochemical and Biophysical Research Communications.  361:307-310. 2007
2007 13C enrichment of carbons 2 and 8 of purine by folate-dependent reactions after [13C]formate and [2-13C]glycine dosing in adult humans 2007
2007 Maternal plasma pyridoxal-5′-phosphate concentrations and risk of isolated oral clefts in the PhilippinesBirth Defects Research Part A: Clinical and Molecular Teratology.  79:276-280. 2007
2007 Vitamin K and the prevention of fractures [4]JAMA Internal Medicine.  167:94. 2007
2006 Increasing trend of spina bifida and decreasing birth weight in relation to declining body-mass index of young women in JapanMedical Hypotheses.  67:1023-1026. 2006
2006 Zinc status of women with low bone mineral density who receive calcium supplementsBiological Trace Element Research.  110:211-222. 2006
2006 Folate and human reproductionAmerican Journal of Clinical Nutrition.  83:993-1016. 2006
2006 Folate determination in human milkJournal of Nutritional Science and Vitaminology.  52:161. 2006
2005 Folate status of mothers during pregnancy and mental and psychomotor development of their children at five years of agePediatrics.  116:703-708. 2005
2005 Plasma zinc concentrations of mothers and the risk of nonsyndromic oral clefts in their children: A case-control study in the PhilippinesBirth Defects Research Part A: Clinical and Molecular Teratology.  73:612-616. 2005
2005 International inter-laboratory analyses of food folateJournal of Food Composition and Analysis.  18:387-397. 2005
2005 Blood homocysteine, folate and Vitamin B-12 concentrations in patients with epilepsy receiving lamotrigine or sodium valproate for initial monotherapyJournal of epilepsy.  64:161-166. 2005
2005 Trienzyme extraction in combination with microbiologic assay in food folate analysis: An updated reviewExperimental Biology and Medicine.  230:444-454. 2005
2004 Folate content in commercial white and whole wheat sandwich breadsJournal of Agricultural and Food Chemistry.  52:6338-6340. 2004
2004 Effect of long-term, high-copper intake on the concentrations of plasma homocysteine and B vitamins in young menNutrition.  20:757-759. 2004
2004 Relationship between pre-pregnancy BMI and plasma zinc concentrations in early pregnancy 2004
2004 Effect of cow milk on food folate bioavailability in young womenAmerican Journal of Clinical Nutrition.  80:1565-1569. 2004
2003 Mass spectrometric method for detecting carbon 13 enrichment introduced by folate coenzymes in uric acidAnalytical Biochemistry.  321:188-191. 2003
2003 Oral copper loading test in humansJournal of Trace Elements in Experimental Medicine.  16:61-66. 2003
2003 Effect of zinc supplementation of pregnant women on the mental and psychomotor development of their children at 5 y of ageAmerican Journal of Clinical Nutrition.  77:1512-1516. 2003
2002 Folate concentrations of fast foods measured by trienzyme extraction methodFood Research International.  35:565-569. 2002
2002 Mid-pregnancy serum homocysteine and B-vitamin concentrations and fetal growthProgress in food & nutrition science.  22:1133-1141. 2002
2002 Changes in frequencies of heterozygous thermolabile 5, 10-methylenetetrahydrofolate reductase gene in fetuses with neural tube defects [8]Journal of Medical Genetics.  39:366-367. 2002
2002 Cord serum ferritin concentrations and mental and psychomotor development of children at five years of ageJournal of Pediatrics.  140:165-170. 2002
2002 Elevated amniotic fluid ferritin levels are associated with inflammation-related pregnancy loss following mid-trimester amniocentesis 2002
2002 Folate content of dairy products measured by microbiological assay with trienzyme treatmentJournal of Food Science.  67:817-820. 2002
2002 The Preterm Prediction Study: Elevated cervical ferritin levels at 22 to 24 weeks of gestation are associated with spontaneous preterm delivery in asymptomatic womenAmerican Journal of Obstetrics and Gynecology.  186:458-463. 2002
2001 Effect of smoking on serum concentrations of total homocysteine and B vitamins in mid-pregnancyClinica Chimica Acta.  306:103-109. 2001
2001 Low seminal plasma folate concentrations are associated with low sperm density and count in male smokers and nonsmokersFertility and Sterility.  75:252-259. 2001
2001 Effect of feeding on circulating micronutrient concentrations in the Burmese python (Python molurus) 2001
2001 Metabolism of 10-formyldihydrofolate in humansBiomedicine and Pharmacotherapy.  55:454-457. 2001
2001 Plasma extracellular superoxide dismutase activity in healthy pregnant women is not influenced by zinc supplementationBiological Trace Element Research.  80:107-113. 2001
2001 Re-evaluation of the metabolism of oral doses of racemic carbon-6 isomers of formyltetrahydrofolate in human subjects 2001
2000 Comorbidity of 5,10-methylenetetrahydrofolate reductase and methionine synthase gene polymorphisms and risk for neural tube defects [3]Journal of Medical Genetics.  37:949-951. 2000
2000 Fronto-Ocular syndrome: Newly recognized trigonocephaly syndromeAmerican Journal of Medical Genetics Part A.  93:89-93. 2000
2000 Homocysteine, folate, vitamin B-12 and vitamin B-6 in patients receiving antiepileptic drug monotherapyJournal of epilepsy.  40:7-15. 2000
2000 Effects of dietary zinc deficiency on homocysteine and folate metabolism in ratsJournal of Nutritional Biochemistry.  11:165-169. 2000
2000 Maternal serum ferritin and fetal growthObstetrics and Gynecology.  95:447-452. 2000
2000 Amniotic fluid homocysteine levels, 5,10-methylenetetrahydrafolate reductase genotypes, and neural tube closure sitesAmerican Journal of Medical Genetics Part A.  90:6-11. 2000
2000 Role of amniotic fluid homocysteine level and of fetal 5,10- methylenetetrahydrafolate reductase genotype in the etiology of neural tube defectsAmerican Journal of Medical Genetics Part A.  90:12-16. 2000
2000 Maternal plasma zinc concentrations and pregnancy outcomeAmerican Journal of Clinical Nutrition.  71:109-113. 2000
2000 Quantitative approach to identifying abnormal variation in the human face exemplified by a study of 278 individuals with five craniofacial syndromesAmerican Journal of Medical Genetics Part A.  91:8-17. 2000
2000 Second-trimester plasma homocysteine levels and pregnancy-induced hypertension, preeclampsia, and intrauterine growth restrictionAmerican Journal of Obstetrics and Gynecology.  183:805-809. 2000
1999 Bioactivity of orally administered unnatural isomers, [6R]-5- formyltetrahydrofolate and [6S]-5,10-methenyltetrahydrofolate, in humans 1999
1999 Gender difference in cord serum ferritin concentrations 1999
1999 Folate and homocysteine metabolism in copper-deficient rats 1999
1998 Measurable human milk folate is increased by treatment with α-amylase and protease in addition to folate conjugaseJournal of Micronutrient Analysis.  63:401-407. 1998
1998 Prenatal plasma matrix metalloproteinase-9 levels to predict spontaneous preterm birthObstetrics and Gynecology.  92:446-449. 1998
1998 Determination of food folateJournal of Nutritional Biochemistry.  9:285-293. 1998
1998 Serum leptin concentrations during pregnancy and their relationship to fetal growthObstetrics and Gynecology.  91:389-395. 1998
1998 Corrigendum: The form of folate affects the mechanisms of methotrexate resistance in Enterococcus faecium (Microbiology (1997) 143 (2639-2646))Microbiology.  144:593. 1998
1998 Homocysteine, b vitamins, and vascular-access thrombosis in patients treated with hemodialysisAmerican Journal of Kidney Diseases.  32:475-481. 1998
1998 Hyperhomocysteinemia as a cause of vascular occlusion in end-stage-renal diseaseInternational Journal of Artificial Organs.  21:72-74. 1998
1998 Trienzyme treatment for food folate analysis: Optimal pH and incubation time for α-amylase and protease treatmentsJournal of Nutritional Science and Vitaminology.  44:361-370. 1998
1997 Homocysteine (HCY), folate (FA) and vitamin B-12 (B12) in patients receiving an anticonvulsant 1997
1997 Serum concentrations of zinc, folate, vitamins A and E, and proteins, and their relationships to pregnancy outcomeActa obstetricia et gynecologica Scandinavica. Supplement.  76:63-70. 1997
1997 Bioavailability of folic acid in fortified food.American Journal of Clinical Nutrition.  66:1299-1300. 1997
1997 Food Folate Assay with Protease, α-Amylase, and Folate Conjugase TreatmentsJournal of Agricultural and Food Chemistry.  45:135-139. 1997
1997 In vitro copper stimulation of plasma peptidylglycine α-amidating monooxygenase in menkes disease variant with occipital hornsPediatric Research.  42:862-865. 1997
1997 Plasma alkaline phosphatase and pregnancy outcomeJournal of Maternal-Fetal Medicine.  6:140-145. 1997
1997 Plasma and erythrocyte zinc concentrations and their relationship to dietary zinc intake and zinc supplementation during pregnancy in low-income African-American womenJournal of the Academy of Nutrition and Dietetics.  97:1269-1274. 1997
1997 The form of folate affects the mechanisms of methotrexate resistance in Enterococcus faeciumMicrobiology.  143:2639-2646. 1997
1996 Food folate assay after treatments with protease. a-amylase and folate conjugase 1996
1996 Homocysteine and folate levels in blood from patients treated with hemodialysis 1996
1996 Homocysteine and folate concentrations in blood from patients treated with hemodialysisJournal of the American Society of Nephrology.  7:2414-2418. 1996
1996 Effect of angiotensin-converting enzyme gene polymorphism on pregnancy outcome, enzyme activity, and zinc concentrationObstetrics and Gynecology.  88:497-502. 1996
1996 Effects of erythorbic acid on vitamin C metabolism in young womenAmerican Journal of Clinical Nutrition.  64:336-346. 1996
1996 Elevated amniotic fluid interleukin-6 levels at genetic amniocentesis predict subsequent pregnancy lossAmerican Journal of Obstetrics and Gynecology.  175:830-833. 1996
1996 Factors influencing plasma zinc levels in low-income pregnant womenBiological Trace Element Research.  55:127-135. 1996
1996 In vitro zinc stimulation of angiotensin-converting enzyme activities in human plasmaJournal of Nutritional Biochemistry.  7:55-59. 1996
1996 Plasma ferritin and pregnancy outcomeAmerican Journal of Obstetrics and Gynecology.  175:1356-1359. 1996
1996 Serum ferritin: A predictor of early spontaneous preterm deliveryObstetrics and Gynecology.  87:360-365. 1996
1996 Zinc nutriture and pregnancy outcomeProgress in food & nutrition science.  16:139-181. 1996
1995 Zinc Supplementation During PregnancyJournal of the American Medical Association.  274:1910. 1995
1995 Effect of smoking on plasma ferritin concentrations in pregnant women 1995
1995 Ethnic differences in angiotensin converting enzyme gene polymorphismJournal of Hypertension.  13:710-711. 1995
1994 Refrigeration of blood samples prior to separation is essential for the accurate determination of plasma or serum zinc concentrationsBiological Trace Element Research.  41:165-173. 1994
1994 In vitro zinc stimulation of angiotensin-converting enzyme activities in various tissues of zinc-deficient ratsProgress in food & nutrition science.  14:919-928. 1994
1994 Mid-trimester maternal serum alpha2-macroglobulin and pregnancy outcome in a non-indigent populationJournal of Maternal-Fetal Medicine.  3:56-59. 1994
1994 Plasma folate conjugase activities and folate concentrations in patients receiving hemodialysisJournal of Nutritional Biochemistry.  5:504-508. 1994
1994 Relationship between amniotic fluid and maternal blood nutrient levels 1994
1993 Albumin levels in pregnancy: a hypothesis-decreased levels of albumin are related to increased levels of alpha-fetoproteinEarly Human Development.  34:209-215. 1993
1993 Changes in Zinc and Copper Concentrations in Breast Milk and Blood of Japanese Women during LactationJournal of Nutritional Science and Vitaminology.  39:189-200. 1993
1993 Dietary folate requirement determined for channel catfish, ictalurus punctatus 1993
1993 Indicators of maternal nutritional status and birth weight in term deliveriesObstetrics and Gynecology.  81:165-169. 1993
1993 Neonatal cord serum alpha 2-macroglobulin and fetal size at birthEarly Human Development.  33:201-206. 1993
1992 Evaluation of three nutritional assessment methods in a group of womenEpidemiology.  3:496-502. 1992
1992 Maternal alpha-2-macroglobulin levels and fetal growth in GuatemalaInternational Journal of Gynecology and Obstetrics.  38:25-29. 1992
1992 Maternal serum folate and zinc concentrations and their relationships to pregnancy outcomeAmerican Journal of Clinical Nutrition.  56:365-370. 1992
1992 Nutrient levels in amniotic fluid from women with normal and neural tube defect pregnancies 1992
1992 Oral folic acid supplementation for cervical dysplasia: A clinical intervention trialAmerican Journal of Obstetrics and Gynecology.  166:803-809. 1992
1992 Serum folate and fetal growth retardation: A matter of compliance?Obstetrics and Gynecology.  79:719-722. 1992
1991 Maternal serum α2-macroglobulin levels linked with fetal growth retardation? 1991
1991 Influence of dietary intakes of erythorbic acid on plasma vitamin C analysesAmerican Journal of Clinical Nutrition.  54. 1991
1991 Maternal serum alpha2-macroglobulin and fetal growth retardationObstetrics and Gynecology.  78:594-599. 1991
1991 Pteroylglutamates in human milk [2]American Journal of Clinical Nutrition.  54:760-762. 1991
1991 Pteroylpolyglutamates in human milkAmerican Journal of Clinical Nutrition.  53:930-934. 1991
1991 The absorption of pteroylpolyglutamate and intestinal pteroylpolygammaglutamyl hydrolase activity in zinc-deficient rats 1991
1990 Evaluation of the deoxyuridine suppression test by using whole blood samples from folic acid-supplemented subjectsAmerican Journal of Clinical Nutrition.  51:80-86. 1990
1990 Impaired milk folate secretion is not corrected by supplemental folate during iron deficiency in rats 1990
1990 Inhibition by EDTA of growth of Lactobacillus casei in the folate microbiological assay and its reversal by added manganese or iron 1990
1990 Pteroylpolyglutamate concentration and glutamyl chain length in rat tissues 1990
1990 Rapid improvement in dermatitis after zinc supplementation in a patient with Crohn's diseaseAmerican Journal of Medicine.  88:71-73. 1990
1989 Zinc and copper balance in children on continuous ambulatory peritoneal dialysisPediatric Nephrology.  3:309-313. 1989
1989 Bioavailability of folate in humansVitamins -Kyoto-.  63:59-65. 1989
1989 Blood Vitamin and Trace Metal Levels in Epidermolysis BullosaJAMA Dermatology.  125:374-379. 1989
1989 Folic acid safety and toxicity: A brief reviewAmerican Journal of Clinical Nutrition.  50:353-358. 1989
1988 Zinc concentration in plasma and erythrocytes of subjects receiving folic acid supplementationAmerican Journal of Clinical Nutrition.  47:484-486. 1988
1987 Increased methionine synthetase activity in zinc-deficient rat liverMolecular cell biology research communications : MCBRC.  256:311-316. 1987
1986 Congenital cytomegalovirus infection with unusual ocular anomaliesActa paediatrica Japonica; Overseas edition.  28:431-433. 1986
1986 Effect of long-term administration of anticonvulsants on copper, zinc, and ceruloplasmin levelsDrug-nutrient interactions.  4:269-274. 1986
1985 Changes in hepatic superoxide dismutase activity in alcoholic monkeysAmerican Journal of Clinical Nutrition.  41:929-932. 1985
1985 Nitrogen utilization, enzyme activity, glucose intolerance and leukocyte chemotaxis in human experimental zinc depletionAmerican Journal of Clinical Nutrition.  41:1220-1235. 1985
1985 Vitamins and trace minerals in amniotic fluid: Correlation with alpha-fetoprotein levels 1985
1985 Zinc in peritoneal dialysis.American Journal of Clinical Nutrition.  42:749-750. 1985
1983 Effect of Chronic Ethanol Feeding on Hepatic Collagen in the MonkeyHepatology.  3:41-44. 1983
1983 Effect of Chronic Ethanol Feeding on Hepatic Mitochondria in the MonkeyHepatology.  3:34-40. 1983
1983 Folate turnover in chronically alcoholic monkeys 1983
1983 Iron, Zinc, Copper, and Manganese in Infant FormulasJAMA Pediatrics.  137:433-437. 1983
1983 Synthesis and Analysis of the Pteroylpolyglutamates 1983
1982 Folate Levels in Inflammatory Bowel DiseaseNew England Journal of Medicine.  306:1488. 1982
1982 Effect of chronic ethanol feeding on the activity of superoxide dismutase in monkeysAmerican Journal of Clinical Nutrition.  35:836. 1982
1981 Sulfasalazine Inhibits the Absorption of Folates in Ulcerative ColitisNew England Journal of Medicine.  305:1513-1517. 1981
1981 Hepatic folate metabolism in the chronic alcoholic monkey 1981
1981 Availability of vitamin B6 and pantothenate in an average American diet in manAmerican Journal of Clinical Nutrition.  34:1328-1337. 1981
1981 Effect of chronic ethanol feeding on hepatic collagen in the monkeyHepatology.  1. 1981
1981 Intestinal absorption of [3H]folic acid in the chronic alcoholic monkeyGastroenterology.  80:99-102. 1981
1980 Folate assay: A comparison of radioassay and microbiological methodsClinica Chimica Acta.  100:13-19. 1980
1980 Human milk folate and folate status in lactating mothers and their infantsAmerican Journal of Clinical Nutrition.  33:193-197. 1980
1979 Availability of vitamin B6 and pantothenic acid in a typical American diet in man 1979
1979 Folate metabolism in the alcoholic monkeyGastroenterology.  76:1149. 1979
1979 Folic acid absorption in the alcoholic monkeyClinical research.  27. 1979
1978 Absorption of mono- and polyglutamyl folates in zinc-depleted manAmerican Journal of Clinical Nutrition.  31:1984-1987. 1978
1978 Acne in Zinc DeficiencyJAMA Dermatology.  114:1093. 1978
1978 Availability of monoglutamyl and polyglutamyl folates in normal subjects and in patients with coeliac sprueGut.  19:886-891. 1978
1978 Effect of alcoholism on hepatic folate metabolismClinical research.  26. 1978
1977 Increased folate excretion in acute hepatitisAmerican Journal of Clinical Nutrition.  30:1378-1379. 1977
1976 Serum zinc and copper levels in healthy japanese children 1976
1976 The Availability of Folates in Man: Effect of Orange Juice Supplement on Intestinal ConjugaseBritish Journal of Haematology.  32:123-134. 1976
1976 Zinc deficiency in two infants during total parenteral alimentation for diarrheaAmerican Journal of Clinical Nutrition.  29:197-204. 1976
1976 Zinc deficiency in two infants during total parenteral nutrition for intractable diarrhea 1976
1974 Folate coenzymes of Lactobacillus casei and Streptococcus faecalisJournal of Biological Chemistry.  249:1081-1089. 1974
1973 The Availability of Food Folate in ManBritish Journal of Haematology.  25:513-532. 1973
1972 Enzymatic Hydrolysis of Pteroylpolyglutamates in CabbageExperimental Biology and Medicine.  141:1022-1025. 1972
1972 Lactobacillus casei response to pteroylpolyglutamatesAnalytical Biochemistry.  49:517-521. 1972
1970 Longitudinal Study on Maturation Patterns of EEG Basic Waves of Infants Fed on Milk from Mothers with Low Serum Folate Levels 1970
1969 Increased Urinary Excretion of 3H-Folic Acid Injected to Rats with Riboflavin Deficiency or Excessive Dietary Methionine 1969
1968 Familial Occurrence of Formiminotransferase Deficiency Syndrome 1968
1968 Formiminotransferase Deficiency Syndrome Associated with Megaloblastic Anemia Responsive to Pyridoxine or Folic Acid 1968
1968 Methionine and Glycine Levels in the Liver of Riboflavin Deficient Rats 1968
1968 Tetrahydrofolate-dependent Enzyme Activities of the Rat Liver in Riboflavin Deficiency 1968
1968 Urinary Excretion of Formiminoglutamic Acid in Children with Riboflavin Deficiency 1968
1967 Formiminotransferase Activity of Liver from Mice with Pyridoxine Deficiency 1967
1967 Megaloblastic Anemia and Mental Retardation Associated with Hyperfolic-Acidemia: Probably Due to N5 Methyltetrahydrofolate Transferase Deficiency 1967


Year Title Altmetric
2012 Folate and fetal growth.  2619-2628. 2012
2009 Folate in pregnancy and lactation.  111-131. 2009

Education And Training

  • Doctor of Medicine in Pediatrics Residency Program, 1973
  • Full Name

  • Tsunenobu Tamura