Positions

Overview

  • Dr. Thompson received her graduate training in Marvin Wickens’ laboratory on translational control during early development. As a post-doctoral fellow in Peter Sarnow's laboratory, she developed her expertise in internal ribosome entry site (IRES) mediated mechanisms of translation initiation. She is interested in understanding how IRESs recruit ribosomes and initiate translation. She discovered that a ribosomal protein S25 (eS25/RPS25) on the small ribosomal subunit was essential for IRES-mediated translation, but its knockdown or deletion had no effect on cap-dependent translation initiation. Importantly, her group was the first to show that a cellular protein was essential for diverse mechanisms of non-canonical initiation when they demonstrated that eS25 is also required for ribosomal shunting. Dr. Thompson's group is also interested in understanding the role of host factors in viral amplification. They identified 66 and 79 novel host factors for poliovirus and dengue virus using our thio-uridine cross-linking-mass spectrometry method (TUX-MS). This method has a remarkably low false discovery rate of <12%. Mechanistic studies of these host factors have revealed that they are indeed important for viral amplification. More recently, Dr. Thompson has initiated studies on understanding how polyomaviruses regulated the cell cycle for viral replication. Her group demonstrated that BK polyomavirus activates the DNA damage response to prolong S phase, which both allows for viral replication and prevents host DNA damage from premature mitosis.
  • Research Overview

  • Dr. Thompson's research interests focus on viral-host pathogen interactions. She studies both RNA and DNA viruses, such as picornaviruses, flaviviruses, and polyomaviruses. She has studied how RNA viruses usurp the translational machinery to synthesize viral proteins. Another interest is understanding how viruses regulate the cell cycle for viral production. All of these studies reveal mechanisms that can be targeted for antiviral therapeutics.
  • Teaching Activities

  • GBS768 - Comm Sci: Read Wrtng & Presen (Summer Term 2021) 2021
  • GBSC720 - Journal Club 2 (Spring Term 2021) 2021
  • GBSC742 - Student Theme Meeting Course (Spring Term 2021) 2021
  • GBSC720 - Journal Club 2 (Fall Term 2020) 2020
  • GBSC742 - Student Theme Meeting Course (Fall Term 2020) 2020
  • GBS768 - Comm Sci: Read Wrtng & Presen (Spring Term 2020) 2020
  • GBSC720 - Journal Club 2 (Spring Term 2020) 2020
  • GBSC742 - Student Theme Meeting Course (Spring Term 2020) 2020
  • GBSC720 - Journal Club 2 (Fall Term 2019) 2019
  • GBSC742 - Student Theme Meeting Course (Fall Term 2019) 2019
  • GBS768 - Comm Sci: Read Wrtng & Presen (Summer Term 2019) 2019
  • GBSC700 - Journal Clubs (Spring Term 2019) 2019
  • GBSC742 - Student Theme Meeting Course (Spring Term 2019) 2019
  • GBSC700 - Journal Clubs (Fall Term 2018) 2018
  • GBSC742 - Student Theme Meeting Course (Fall Term 2018) 2018
  • GBS768 - Comm Sci: Read Wrtng & Presen (Summer Term 2018) 2018
  • GBSC700 - Journal Clubs (Spring Term 2018) 2018
  • GBSC700 - Journal Clubs (Fall Term 2017) 2017
  • GBS768 - Comm Sci: Read Wrtng & Presen (Summer Term 2017) 2017
  • GBSC700 - Journal Clubs (Spring Term 2017) 2017
  • GBSC700 - Journal Clubs (Fall Term 2016) 2016
  • GBS768 - Comm Sci: Read Wrtng & Presen (Spring Term 2016) 2016
  • MIC785 - Post-Trx Reg Mech Journal Club (Spring Term 2016) 2016
  • MIC785 - Post-Trx Reg Mech Journal Club (Fall Term 2015) 2015
  • GBS768 - Comm Sci: Read Wrtng & Presen (Spring Term 2015) 2015
  • MIC785 - Post-Trx Reg Mech Journal Club (Spring Term 2015) 2015
  • MIC785 - Post-Trx Reg Mech Journal Club (Fall Term 2014) 2014
  • MIC785 - Post-Trx Reg Mech Journal Club (Spring Term 2014) 2014
  • MIC724 - Virology Journal Club (Fall Term 2013) 2013
  • MIC785 - Post-Trx Reg Mech Journal Club (Fall Term 2013) 2013
  • MIC724 - Virology Journal Club (Spring Term 2013) 2013
  • MIC785 - Post-Trx Reg Mech Journal Club (Spring Term 2013) 2013
  • GBS768 - Comm Sci: Read Wrtng & Presen (Fall Term 2012) 2012
  • MIC724 - Virology Journal Club (Fall Term 2012) 2012
  • MIC785 - Post-Trx Reg Mech Journal Club (Fall Term 2012) 2012
  • MIC724 - Virology Journal Club (Spring Term 2012) 2012
  • MIC785 - Post-Trx Reg Mech Journal Club (Spring Term 2012) 2012
  • GBS768 - Comm Sci: Read Wrtng % Presen (Fall Term 2011) 2011
  • MIC724 - Virology Journal Club (Fall Term 2011) 2011
  • MIC785 - Post-Trx Reg Mech Journal Club (Fall Term 2011) 2011
  • GBS761 - Eukaryotic Molecular Biology (Spring Term 2011) 2011
  • MIC724 - Virology Journal Club (Spring Term 2011) 2011
  • MIC785 - Post-Trx Reg Mech Journal Club (Spring Term 2011) 2011
  • MIC724 - Virology Journal Club (Fall Term 2010) 2010
  • MIC785 - Post-Trx Reg Mech Journal Club (Fall Term 2010) 2010
  • MIC724 - Virology Journal Club (Spring Term 2010) 2010
  • MIC785 - Post-Transcription Reg Mech (Spring Term 2010) 2010
  • MIC791 - Advanced Topics in Virology (Spring Term 2010) 2010
  • CMB720 - CMB II Genes (Fall Term 2009) 2009
  • MIC724 - Virology Journal Club (Spring Term 2009) 2009
  • MIC785 - Post-Transcription Reg Mech (Spring Term 2009) 2009
  • Education And Training

  • Doctor of Philosophy in Biochemistry, University of Wisconsin System : Madison 1998
  • Bachelor of Science or Mathematics in Biochemistry, Oklahoma State University 1991
  • Full Name

  • Sunnie Thompson