Positions

Overview

  • Shah S. Hussain received his MS degree from Jamia Millia Islamia University in 2009, with a specialization in Bioscience, and his MPhil degree from the University of Delhi in 2011. He completed his Ph.D. (Doctor of Philosophy) at the University of Delhi in 2017 while studying the protein chemistry of active (in vitro and in vivo) recombinant glycoengineered hormones and he was trained in molecular biology at the Indian Institute of Sciences, Bangalore (IISc), India.

    In 2017 during his first postdoctoral training at the Department of Immunology, Florida International University, Miami, involved studying the role of Long Noncoding RNA in Allergic Asthma Associated Hyperreactive Response of Airway Epithelial Cells. Dr. Hussain pursued his interest in the field of Respiratory Biology and joined as the Postdoc fellow in Dr. Rowe’s lab, in the Department of Medicine and CFRC center at the University of Alabama at Birmingham, USA. From his postdoctoral work, he has published his work in multiple prestigious journals, including, Nature, JCI, ERJ, and mucosal immunology.

    In 2022, Dr. Hussain was appointed as an Instructor in the UAB Department of Medicine (Pulmonary, Allergy, and Critical Care Medicine). Dr. Hussain is passionate about small airway disease and the role of abnormal mucus in lung diseases including chronic obstructive pulmonary disease, Alpha-1-antitrypsin deficiency, idiopathic pulmonary fibrosis, and Cystic fibrosis. Dr. Hussain’s research interests are grounded in the study of respiratory infectious diseases like SARS-COV-2, and HIV, cutting-edge discovery in airway disease biology and ciliary dynamics, and translational research in IPF, CF, Alpha-1-Antitrypsin COPD, and other airway diseases.

    In Dr. Hussain’s professional engagement at UAB thus far, he has developed a novel technique that enables micro-CT imaging of the microstructure of the smallest airways (less than 2mm) in ferret lungs, paving the path for a new understanding of progressive airway diseases with small airways involvement including COPD, CF, and IPF. Using this novel method, he has been focusing on understanding the complex pathological changes in small airway disease progression, including novel aspects of disease mechanism that heretofore have been repeatedly documented in human specimens, but for which mechanistic understanding has been lacking.
  • Selected Publications

    Chapter

    Year Title Altmetric
    2020 Attaining Epigenetic Rejuvenation: Challenges Ahead.  159-179. 2020
    2015 Gonadotropins: Past, Present and Future 2015

    Research Overview

  • Dr. Hussain has expertise in imaging modalities such as micro-Optical Coherence Tomography to assess the functional micro-anatomy of airway epithelium, SPECT/CT to measure whole lung mucociliary clearance in vivo, and micro-CT to assess disease progression over time. His work is on mucociliary physiology in the context of airway remodeling in a novel ferret model and in COPD patients. In addition to the COPD and IPF ferret, Dr. Hussain has been instrumental in developing the Alpha-1 antitrypsin Knock Out ferret model of COPD and COVID ferret models.

    Area of interest is : Airway remodeling and mucociliary clearance in COPD, Alpha-1 Antitrypsin Deficiency, Emphysema, Idiopathic Pulmonary Fibrosis and cystic fibrosis.
  • Education And Training

  • Doctor of Philosophy in Biochemistry, Biophysics and Molecular Biology, University of Delhi 2016
  • Full Name

  • Shah Hussain