• Shah S. Hussain received his MS degree from Jamia Millia Islamia University in 2009, with a specialization in Bioscience, and his MPhil degree from the University of Delhi in 2011. He completed his Ph.D. (Doctor of Philosophy) at the University of Delhi in 2017 while studying the protein chemistry of active (in vitro and in vivo) recombinant glycoengineered hormones and he was trained in molecular biology at the Indian Institute of Sciences, Bangalore (IISc), India.

    In 2017 during his first postdoctoral training at the Department of Immunology, Florida International University, Miami, involved studying the role of Long Noncoding RNA in Allergic Asthma Associated Hyperreactive Response of Airway Epithelial Cells. Dr. Hussain pursued his interest in the field of Respiratory Biology and joined as the Postdoc fellow in Dr. Rowe’s lab, in the Department of Medicine and CFRC center at the University of Alabama at Birmingham, USA. From his postdoctoral work, he has published his work in multiple prestigious journals, including, Nature, JCI, ERJ, and MucosalImmunology

    In 2022, Dr. Hussain was appointed as an Instructor in the UAB Department of Medicine (Pulmonary, Allergy, and Critical Care Medicine). Dr. Hussain is passionate about small airway disease and the role of abnormal mucus in lung diseases including chronic obstructive pulmonary disease, Alpha-1-antitrypsin deficiency, idiopathic pulmonary fibrosis, and Cystic fibrosis. Dr. Hussain’s research interests are grounded in the study of respiratory infectious diseases like SARS-COV-2, and HIV, cutting-edge discovery in airway disease biology and ciliary dynamics, and translational research in IPF, CF, Alpha-1-Antitrypsin COPD, and other airway diseases.

    In Dr. Hussain’s professional engagement at UAB thus far, he has developed a novel technique that enables micro-CT imaging of the microstructure of the smallest airways (less than 2mm) in ferret lungs, paving the path for a new understanding of progressive airway diseases with small airways involvement including COPD, CF, and IPF. Using this novel method, he has been focusing on understanding the complex pathological changes in small airway disease progression, including novel aspects of disease mechanism that heretofore have been repeatedly documented in human specimens, but for which mechanistic understanding has been lacking.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2023 Mucociliary Clearance Augmenting Drugs Block SARS-Cov-2 Replication in Human Bronchial Epithelial Cells. 2023
    2023 Mucociliary transport deficiency and disease progression in Syrian hamsters with SARS-CoV-2 infectionJCI Insight.  8. 2023
    2022 Comparative transcriptomics in human COPD reveals dysregulated genes uniquely expressed in ferretsRespiratory Research.  23. 2022
    2022 Evaluation of a novel CFTR potentiator in COPD ferrets with acquired CFTR dysfunctionEuropean Respiratory Journal.  60. 2022
    2022 Human distal airways contain a multipotent secretory cell that can regenerate alveoliNature.  604:120-126. 2022
    2022 Mucociliary Transport Deficiency and Disease Progression in Syrian Hamsters with SARS-CoV-2 Infection. 2022
    2022 Ferret Systemic Coronavirus in Alpha-1 Antitrypsin Knockout Ferrets 2022
    2021 Inhaled high molecular weight hyaluronan ameliorates respiratory failure in acute COPD exacerbation: a pilot studyRespiratory Research.  22. 2021
    2021 A long noncoding RNA antisense to ICAM-1 is involved in allergic asthma associated hyperreactive response of airway epithelial cellsMucosal Immunology.  14:630-639. 2021
    2019 Regulation of Ascorbic acid by gonadotropins in rat Ovary 2019
    2019 Emerging roles of autophagy and inflammasome in ehrlichiosisFrontiers in Immunology.  10. 2019
    2018 Cigarette smoke and HIV synergistically affect lung pathology in cynomolgus macaquesJournal of Clinical Investigation.  128:5428-5433. 2018
    2018 A Small Molecule BH3-mimetic Suppresses Cigarette Smoke-Induced Mucous Expression in Airway Epithelial CellsScientific Reports.  8. 2018
    2015 Mammalian Endocrinology and Male Reproductive Biology 2015
    2013 Inhibition of L-Gulonate dehydrogenase from buffalo kidney by naturally occurring Metabolites Authors 2013
    2013 Buffalo Kidney L-Gulonate Dehydrogenase: Isolation and Kinetic Characterization 2013
    2012 Mechanistic Investigations of the Dual Activity of Gonadotropins Using Target Tissue cAMP Level as a Response Parameter 2012


    Year Title Altmetric
    2020 Attaining Epigenetic Rejuvenation: Challenges Ahead.  159-179. 2020
    2015 Gonadotropins: Past, Present and Future 2015

    Research Overview

  • Dr. Hussain has expertise in imaging modalities such as micro-Optical Coherence Tomography to assess the functional micro-anatomy of airway epithelium, SPECT/CT to measure whole lung mucociliary clearance in vivo, and micro-CT to assess disease progression over time. His work is on mucociliary physiology in the context of airway remodeling in a novel ferret model and in COPD patients. In addition to the COPD and IPF ferret, Dr. Hussain has been instrumental in developing the Alpha-1 antitrypsin Knock Out ferret model of COPD and COVID ferret models.

    Area of interest is : Airway remodeling and mucociliary clearance in COPD, Alpha-1 Antitrypsin Deficiency, Emphysema, Idiopathic Pulmonary Fibrosis and cystic fibrosis.
  • Education And Training

  • Doctor of Philosophy in Biochemistry, Biophysics and Molecular Biology, University of Delhi 2016
  • Full Name

  • Shah Hussain