Positions

Selected Publications

Academic Article

Year Title Altmetric
2021 Site 2 of the Yersinia pestis substrate-binding protein YfeA is a dynamic surface metal-binding siteActa Crystallographica Section F: Structural Biology Communications.  77:286-293. 2021
2021 A nonolfactory shark adenosine receptor activates CFTR with unique pharmacology and structural features 2021
2020 Structural and functional diversity calls for a new classification of ABC transportersFEBS Letters.  594:3767-3775. 2020
2020 Structural Consequences of the 1,2,3-Triazole as an Amide Bioisostere in Analogues of the Cystic Fibrosis Drugs VX-809 and VX-770 2020
2020 Structural Consequences of the 1,2,3‐Triazole as an Amide Bioisostere in Analogues of the Cystic Fibrosis Drugs VX‐809 and VX‐770 2020
2020 Structural definition of polyspecific compensatory ligand recognition by P-glycoprotein 2020
2019 Structures of the substrate-binding protein YfeA in apo and zinc-reconstituted holo formsActa Crystallographica. Section d, Structural Biology.  75:831-840. 2019
2019 Evaluation of 1,2,3-Triazoles as Amide Bioisosteres In Cystic Fibrosis Transmembrane Conductance Regulator Modulators VX-770 and VX-809 2019
2018 Essential metal uptake in gram-negative bacteria: X-ray fluorescence, radioisotopes, and cell fractionationJournal of Visualized Experiments.  2018. 2018
2017 The crystal structure of the Yersinia pestis iron chaperone YiuA reveals a basic triad binding motif for the chelated metalActa Crystallographica. Section d, Structural Biology.  73:921-939. 2017
2017 Crystal structure of Yersinia pestis virulence factor YfeA reveals two polyspecific metal-binding sitesActa Crystallographica. Section d, Structural Biology.  73:557-572. 2017
2016 Channel gating regulation by the cystic fibrosis transmembrane conductance regulator (CFTR) first cytosolic loopJournal of Biological Chemistry.  291:1854-1865. 2016
2015 Tools and procedures for visualization of proteins and other biomoleculesCurrent protocols in molecular biology / edited by Frederick M. Ausubel ... [et al.].  2015:19.12.1-19.12.47. 2015
2009 Combining electron crystallography and X-ray crystallography to study the MlotiK1 cyclic nucleotide-regulated potassium channel 2009
2007 A structural perspective on copper uptake in eukaryotes 2007
2006 Mercury toxicity in the shark (Squalus acanthias) rectal gland: Apical CFTR chloride channels are inhibited by mercuric chlorideJournal of Experimental Zoology Part A: Comparative Experimental Biology.  305:259-267. 2006
2006 Mercury and zinc differentially inhibit shark and human CFTR orthologues: Involvement of shark cysteine 102 2006
2004 Eukaryotic CTR copper uptake transporters require two faces of the third transmembrane domain for helix packing, oligomerization, and functionJournal of Biological Chemistry.  279:53435-53441. 2004
2002 Cyclooxygenase cloning in dogfish shark, Squalus acanthias, and its role in rectal gland Cl secretion 2002
1999 Cloning, characterization, and functional expression of a CNP receptor regulating CFTR in the shark rectal gland.American Journal of Physiology.  276:C442-C449. 1999
1999 Cloning, characterization, and functional expression of a CNP receptor regulating CFTR in the shark rectal gland 1999
1998 Vasoactive intestinal peptide, forskolin, and genistein increase apical CFTR trafficking in the rectal gland of the spiny dogfish, Squalus acanthias: Acute regulation of CFTR trafficking in an intact epitheliumJournal of Clinical Investigation.  101:737-745. 1998
1997 Cadmium disrupts the signal transduction pathway of both inhibitory and stimulatory receptors regulating chloride secretion in the shark rectal glandJournal of Experimental Zoology.  279:530-536. 1997
A non-olfactory shark adenosine receptor activates CFTR with unique pharmacology and structural features

Education And Training

  • The Scripps Research Institute, Postdoctoral Fellowship
  • Doctor of Philosophy in Molecular Biophysics, Yale University 2006
  • Full Name

  • Stephen Aller