• I am an Instructor at UAB, Department of Neurology, working on genetic mouse models of isolated dystonia
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2022 Striatal Synaptic Dysfunction in Dystonia and Levodopa-Induced DyskinesiaNeurobiology of Disease.  166. 2022
    2020 STRAP regulates alternative splicing fidelity during lineage commitment of mouse embryonic stem cellsNature Communications.  11. 2020
    2019 Diverse mechanisms lead to common dysfunction of striatal cholinergic interneurons in distinct genetic mouse models of Dystonia 2019
    2017 Strength of cholinergic tone dictates the polarity of dopamine D2 receptor modulation of striatal cholinergic interneuron excitability in DYT1 dystoniaExperimental Neurology.  295:162-175. 2017
    2015 Erratum: Nitric oxide regulates synaptic transmission between spiny projection neurons (Proc Natl Acad Sci USA (2014) 111 49 (17636-17641) DOI: 10.1073/pnas.1420162111) 2015
    2014 Nitric oxide regulates synaptic transmission between spiny projection neurons. 2014
    2013 Modulatory role of androgenic and estrogenic neurosteroids in determining the direction of synaptic plasticity in the CA1 hippocampal region of male ratsPhysiological Reports.  1. 2013
    2013 Synaptic long-term potentiation and depression in the rat medial vestibular nuclei depend on neural activation of estrogenic and androgenic signalsPLoS ONE.  8. 2013
    2013 Opposite long-term synaptic effects of 17β-estradiol and 5α-dihydrotestosterone and localization of their receptors in the medial vestibular nucleus of ratsBrain Research Bulletin.  97:1-7. 2013
    2012 The repetition timing of high frequency afferent stimulation drives the bidirectional plasticity at central synapses in the rat medial vestibular nucleiNeuroscience.  223:1-11. 2012
    2012 Influence of sex and estrous cycle on synaptic responses of the medial vestibular nuclei in rats: Role of circulating 17β-estradiolBrain Research Bulletin.  87:319-327. 2012
    2011 Neural 17β-estradiol facilitates long-term potentiation in the hippocampal CA1 regionNeuroscience.  192:67-73. 2011
    2011 Long-term potentiation of synaptic response and intrinsic excitability in neurons of the rat medial vestibular nucleiNeuroscience.  187:1-14. 2011
    2010 Effects of 17β-estradiol on glutamate synaptic transmission and neuronal excitability in the rat medial vestibular nucleiNeuroscience.  165:1100-1114. 2010
    2009 Effects of 17β-estradiol on synaptic plasticity in the rat medial vestibular nucleiActa Oto-laryngologica.  129:390-394. 2009
    2009 Long-term potentiation in the rat medial vestibular nuclei depends on locally synthesized 17β-estradiol 2009

    Research Overview

  • I am an electrophysiologist interested in the circuitry of movement disorders. In particular, I'm working on understanding how imbalanced dopaminergic and cholinergic signaling lead to the expression of motor deficits.
  • Education And Training

  • University of Perugia Department of Internal Medicine, Faculty of Human Physiology, Postdoctoral Research
  • Doctor of Philosophy in Neurobiology and Anatomy, University of Perugia 2011
  • Bachelor's Degree in Biology, University of Perugia 2006
  • Full Name

  • Mariangela Scarduzio