Positions

Overview

  • Dr. Barnes was trained in Chemistry and Biochemistry in the UK. He joined UAB in 1977 and pursued research on bile acids and latterly polyphenols, particularly soy isoflavones. He was promoted to Associate Professor (with tenure) in 1985 and Full Professor in 1994. He has received NIH support from several areas to pursue the conjugation of bile acids, the chemistry, biochemistry and physiology of polyphenols, the underlying chemistry of lens cataracts and the use of omics approaches in biomedical research. He was the Associate Director of the Purdue UAB Botanicals Center for Age Related Disease (2000-2010) and the UAB Center for Nutrient Gene Interaction (2002-2011). He was an elected member of the National Advisory Council for the Center for Complementary and Alternate Medicine (2007-2010) and the NIH Council of Councils (2010-2012). He was the Director of the NIH funded Workshop in Metabolomics (2012-2018). He received the 2012 Distinguished Faculty Award and in 2018 became a Distinguished Professor of Pharmacology and Toxicology.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2023 Glutamine-dependent effects of nitric oxide on cancer cells subjected to hypoxia-reoxygenationNitric Oxide: Biology and Chemistry.  130:22-35. 2023
    2022 Haemophilus ducreyi Infection Induces Oxidative Stress, Central Metabolic Changes, and a Mixed Pro- and Anti-inflammatory Environment in the Human HostmBio.  13. 2022
    2022 Rationale and study protocol for a randomized controlled feeding study to determine the structural- and functional-level effects of diet-specific interventions on the gut microbiota of non-Hispanic black and white adultsContemporary Clinical Trials.  123. 2022
    2022 Gamma-ray Irradiation of Rodent Diets Alters the Urinary Metabolome in Rats with Chemically Induced Mammary CancerMetabolites.  12. 2022
    2022 A modified standard American diet induces physiological parameters associated with metabolic syndrome in C57BL/6J miceFrontiers in Nutrition.  9. 2022
    2022 Soluble Fc Receptor for IgM in Sera From Subsets of Patients With Chronic Lymphocytic Leukemia as Determined by a New Mouse Monoclonal AntibodyFrontiers in Immunology.  13. 2022
    2022 Gut Microbiome Composition and Serum Metabolome Profile Among Individuals With Spinal Cord Injury and Normal Glucose Tolerance or Prediabetes/Type 2 DiabetesArchives of Physical Medicine and Rehabilitation.  103:702-710. 2022
    2022 Human meibum and tear film derived cholesteryl and wax esters in meibomian gland dysfunction and tear film structure: Cholesteryl and wax esters in meibomian gland dysfunction 2022
    2022 Neither soyfoods nor isoflavones warrant classification as endocrine disruptors: a technical review of the observational and clinical dataCritical Reviews in Food Science and Nutrition.  62:5824-5885. 2022
    2022 Prostaglandin E<sub>2</sub> and F<sub>2α</sub> alter expression of select cholesteryl esters and triacylglycerols produced by human meibomian gland epithelial cellsCornea.  41:95-105. 2022
    2022 αA and αB peptides from human cataractous lenses show antichaperone activity and enhance aggregation of lens proteinsMolecular Vision.  28:147-164. 2022
    2021 Nicotinamide Adenine Dinucleotide Biosynthetic Impairment and Urinary Metabolomic Alterations Observed in Hospitalized Adults With COVID-19–Related Acute Kidney InjuryKidney International Reports.  6:3002-3013. 2021
    2021 R-Ras subfamily proteins elicit distinct physiologic effects and phosphoproteome alterations in neurofibromin-null MPNST cellsCell Communication and Signaling.  19. 2021
    2021 Dietary table grape protects against ultraviolet photodamage in humans: 2. molecular biomarker studiesJournal of the American Academy of Dermatology.  85:1032-1034. 2021
    2021 Fasting drives the metabolic, molecular and geroprotective effects of a calorie-restricted diet in miceNature Metabolism.  3:1327-1341. 2021
    2021 Kudzu isoflavone C-glycosides: Analysis, biological activities, and metabolismFood Frontiers.  2:383-389. 2021
    2021 Human meibum and tear film derived (O-Acyl)-omega-hydroxy fatty acids as biomarkers of tear film dynamics in meibomian gland dysfunction and dry eye disease 2021
    2021 Human meibum and tear film derived (O-acyl)-omega-hydroxy fatty acids in meibomian gland dysfunction 2021
    2021 Triacylglycerol lipidome from human meibomian gland epithelial cells: Description, response to culture conditions, and perspective on functionExperimental Eye Research.  207. 2021
    2021 High Fructose Corn Syrup-Moderate Fat Diet Potentiates Anxio-Depressive Behavior and Alters Ventral Striatal Neuronal SignalingFrontiers in Neuroscience.  15. 2021
    2021 UAB-UCSD o'brien center for acute kidney injury research 2021
    2021 Saturation of cholesteryl esters produced by human meibomian gland epithelial cells after treatment with rosiglitazone 2021
    2021 Associations between Dietary Fiber, the Fecal Microbiota and Estrogen Metabolism in Postmenopausal Women with Breast Cancer 2021
    2020 Cranberry polyphenols-gut microbiota interactions and potential health benefits: An updated reviewFood Frontiers.  1:459-464. 2020
    2020 Transcriptomic and metabolomic profiling of long-lived growth hormone releasing hormone knock-out mice: Evidence for altered mitochondrial function and amino acid metabolismAging.  12:3473-3485. 2020
    2020 Cranberry anti-cancer compounds and their uptake and metabolism: An updated reviewJournal of Berry Research.  10:1-10. 2020
    2019 Evolutionary Analysis of Bile Acid-Conjugating Enzymes Reveals a Complex Duplication and Reciprocal Loss HistoryGenome Biology and Evolution.  11:3256-3268. 2019
    2019 Increased flux through the mevalonate pathway mediates fibrotic repair without injuryJournal of Clinical Investigation.  129:4962-4978. 2019
    2019 Relative stabilities of wild-type and mutant glial fibrillary acidic protein in patients with Alexander diseaseJournal of Biological Chemistry.  294:15604-15612. 2019
    2019 Vaporized e-cigarette liquids induce ion transport dysfunction in airway epitheliaAmerican Journal of Respiratory Cell and Molecular Biology.  61:162-173. 2019
    2019 Absorbent materials to collect urine can affect proteomics and metabolomic biomarker concentrationsClinical Chemistry and Laboratory Medicine.  57:E134-E137. 2019
    2019 Determination of an interaction network between an extracellular bacterial pathogen and the human hostmBio.  10. 2019
    2019 Truncating PKHD1 and PKD2 mutations alter energy metabolism 2019
    2019 Cranberry phytochemicals and their cancer preventive properties. Journal of Berry ResearchJournal of Berry Research2019
    2019 Quantitative proteomics uncovers the interaction between a virulence factor and mutanobactin synthetases in Streptococcus mutansClinical and Vaccine Immunology.  4. 2019
    2018 Early airway microbial metagenomic and metabolomic signatures are associated with development of severe bronchopulmonary dysplasia 2018
    2018 Glucagon receptor signaling regulates energy metabolism via hepatic farnesoid X receptor and fibroblast growth factor 21Diabetes.  67:1773-1782. 2018
    2018 Genetic deletion of 12/15 lipoxygenase promotes effective resolution of inflammation following myocardial infarctionJournal of Molecular and Cellular Cardiology.  118:70-80. 2018
    2018 Glutaminolysis promotes collagen translation and stability via a-ketoglutarate-mediated mTOR activation and proline hydroxylationAmerican Journal of Respiratory Cell and Molecular Biology.  58:378-390. 2018
    2017 Erratum to: Mass spectrometric evidence for the modification of small molecules in a cobalt-60-irradiated rodent diet: Irradiation modifies the content of animal diet (Journal of Mass Spectrometry, (2017), 52, 8, (507-516), 10.1002/jms.3950)Journal of Mass Spectrometry.  52:707. 2017
    2017 Detailed Investigation and Comparison of the XCMS and MZmine 2 Chromatogram Construction and Chromatographic Peak Detection Methods for Preprocessing Mass Spectrometry Metabolomics DataAnalytical Chemistry.  89:8689-8695. 2017
    2017 One Step Forward for Reducing False Positive and False Negative Compound Identifications from Mass Spectrometry Metabolomics Data: New Algorithms for Constructing Extracted Ion Chromatograms and Detecting Chromatographic PeaksAnalytical Chemistry.  89:8696-8703. 2017
    2017 Mass spectrometric evidence for the modification of small molecules in a cobalt-60-irradiated rodent dietJournal of Mass Spectrometry.  52:507-516. 2017
    2017 Lower Levels of Cervicovaginal Tryptophan Are Associated with Natural Clearance of Chlamydia in WomenJournal of Infectious Diseases.  215:1888-1892. 2017
    2017 Origin of platinum deposits in layered intrusions by in situ crystallization: Evidence from undercutting Merensky Reef of the Bushveld ComplexJournal of Petrology.  58:715-762. 2017
    2017 Small molecules, both dietary and endogenous, influence the onset of lens cataractsExperimental Eye Research.  156:87-94. 2017
    2017 Lipoxin A4, a 5-lipoxygenase pathway metabolite, modulates immune response during acute respiratory tularemiaJournal of Leukocyte Biology.  101:531-542. 2017
    2017 The cystic fibrosis transmembrane conductance regulator potentiator ivacaftor augments mucociliary clearance abrogating cystic fibrosis transmembrane conductance regulator inhibition by cigarette smokeAmerican Journal of Respiratory Cell and Molecular Biology.  56:99-108. 2017
    2016 Fecal metabolomics in pediatric spondyloarthritis implicate decreased metabolic diversity and altered tryptophan metabolism as pathogenic factorsGenes and Immunity.  17:400-405. 2016
    2016 An Elevated Perspective: Dyke-Related Fracture Networks Analysed with Uav Photogrammetry 2016
    2016 Metabolism and growth inhibitory activity of cranberry derived flavonoids in bladder cancer cellsFood and Function.  7:4012-4019. 2016
    2016 Review of lithogeochemical exploration tools for komatiite-hosted Ni-Cu-(PGE) depositsJournal of Geochemical Exploration.  168:1-19. 2016
    2016 Training in metabolomics research. II. Processing and statistical analysis of metabolomics data, metabolite identification, pathway analysis, applications of metabolomics and its futureJournal of Mass Spectrometry.  51:535-548. 2016
    2016 Training in metabolomics research. II. Processing and statistical analysis of metabolomics data, metabolite identification, pathway analysis, applications of metabolomics and its futureJournal of Mass Spectrometry.  51:535-548. 2016
    2016 3D textural evidence for the formation of ultra-high tenor precious metal bearing sulphide microdroplets in offset reefs: An extreme example from the Platinova Reef, Skaergaard Intrusion, GreenlandLithos.  256-257:55-74. 2016
    2016 Carboxy-terminal mutations of bile acid CoA: N-acyltransferase alter activity and substrate specificityJournal of Lipid Research.  57:1133-1143. 2016
    2016 Composition of Rosenthal Fibers, the Protein Aggregate Hallmark of Alexander DiseaseJournal of Proteome Research.  15:2265-2282. 2016
    2016 Training in metabolomics research. I. Designing the experiment, collecting and extracting samples and generating metabolomics dataJournal of Mass Spectrometry.  461-475. 2016
    2016 Training in metabolomics research. I. Designing the experiment, collecting and extracting samples and generating metabolomics dataJournal of Mass Spectrometry.  51:ii-iii. 2016
    2016 Early lipid changes in acute kidney injury using SWATH lipidomics coupled with MALDI tissue imaging 2016
    2016 Effect of n-3 and n-6 polyunsaturated fatty acids on microsomal P450 steroidogenic enzyme activities and in vitro cortisol production in adrenal tissue from yorkshire boars 2016
    2016 Modification of platelet proteins by 4-hydroxynonenal: Potential Mechanisms for inhibition of aggregation and metabolismFree Radical Biology and Medicine.  91:143-153. 2016
    2016 Trafficking and function of the cystic fibrosis transmembrane conductance regulator: A complex network of posttranslational modifications 2016
    2015 Cholesterol-independent suppression of lymphocyte activation, autoimmunity, and glomerulonephritis by apolipoprotein A-I in normocholesterolemic lupus-prone miceJournal of Immunology.  195:4685-4698. 2015
    2015 Influences of diet and the gut microbiome on epigenetic modulation in cancer and other diseasesClinical Epigenetics.  7. 2015
    2015 Impact of equol-producing capacity and soy-isoflavone profiles of supplements on bone calcium retention in postmenopausal women: A randomized crossover trial1,2American Journal of Clinical Nutrition.  102:695-703. 2015
    2015 Platinum group elements in mantle melts and mantle samplesLithos.  232:395-417. 2015
    2015 Classic Ras Proteins Promote Proliferation and Survival via Distinct Phosphoproteome Alterations in Neurofibromin-Null Malignant Peripheral Nerve Sheath Tumor CellsJournal of Neuropathology and Experimental Neurology.  74:568-586. 2015
    2015 Hemoglobin-associated oxidative stress in the pericardial compartment of postoperative cardiac surgery patientsLaboratory Investigation.  95:132-141. 2015
    2015 A method to prevent protein delocalization in imaging mass spectrometry of non-adherent tissues: Application to small vertebrate lens imagingAnalytical and Bioanalytical Chemistry.  407:2311-2320. 2015
    2015 Peroxiredoxin-2 recycling is inhibited during erythrocyte storageAntioxidants and Redox Signaling.  22:294-307. 2015
    2015 Obesity superimposed on aging magnifies inflammation and delays the resolving response after myocardial infarction 2015
    2014 Improved high sensitivity analysis of polyphenols and their metabolites by nano-liquid chromatography-mass spectrometryMolecular cell biology research communications : MCBRC.  559:3-11. 2014
    2014 Dietary acrylamide and human cancer: A systematic review of literature 2014
    2014 Pharmacokinetics of equol, a soy isoflavone metabolite, changes with the form of equol (Dietary versus Intestinal Production) in ovariectomized ratsJournal of Agricultural and Food Chemistry.  62:1294-1300. 2014
    2014 Endothelial integrin α3β1 stabilizes carbohydrate-mediated tumor/endothelial cell adhesion and induces macromolecular signaling complex formation at the endothelial cell membraneOncotarget.  5:1382-1389. 2014
    2014 Is midtrimester vitamin D status associated with spontaneous preterm birth and preeclampsia?American Journal of Perinatology.  31:541-546. 2014
    2013 Dysfunctional mitochondrial bioenergetics and oxidative stress in Akita+/Ins2-derived β-cells 2013
    2013 Mitochondria-targeted heme oxygenase-1 decreases oxidative stress in renal epithelial cells 2013
    2013 Erratum: Elevated levels of NO are localized to distal airways in asthma (Free Radical Biology and Medicine (2011) 50 (1679-1688))Free Radical Biology and Medicine.  58:45. 2013
    2013 MRMPath and MRMutation, facilitating discovery of mass transitions for proteotypic peptides in biological pathways using a bioinformatics approachAdvances in Bioinformatics.  2013. 2013
    2013 Isoflavone metabolism in domestic cats (Felis catus): Comparison of plasma metabolites detected after ingestion of two different dietary forms of genistein and daidzeinJournal of Animal Science.  91:1295-1306. 2013
    2013 Temporal patterns of tyrosine nitration in embryo heart developmentFree Radical Biology and Medicine.  55:101-108. 2013
    2013 Simultaneous quantification of F2-isoprostanes and prostaglandins in human urine by liquid chromatography tandem-mass spectrometry 2013
    2013 Effect of soy isoflavone supplementation on menopausal quality of life 2013
    2013 In nutrition, can we 'see' what is good for us?Advances in Nutrition.  4. 2013
    2013 Ovariectomy lowers urine levels of unconjugated (+)-catechin, (-)-epicatechin, and their methylated metabolites in rats fed grape seed extractHormone Molecular Biology and Clinical Investigation.  16:129-138. 2013
    2012 Microbicidal activity of vascular peroxidase 1 in human plasma via generation of hypochlorous acidInfection and Immunity.  80:2528-2537. 2012
    2012 Effect of soy isoflavone supplementation on nitric oxide metabolism and blood pressure in menopausal womenAmerican Journal of Clinical Nutrition.  95:1487-1494. 2012
    2012 The electrophile responsive proteome: Integrating proteomics and lipidomics with cellular functionAntioxidants and Redox Signaling.  17:1580-1589. 2012
    2011 Dietary isoflavone absorption, excretion, and metabolism in captive cheetahs (Acinonyx jubatus)Journal of Zoo and Wildlife Medicine.  42:658-670. 2011
    2011 Enhanced levels of both the membrane-bound and soluble forms of IgM Fc receptor (FcμR) in patients with chronic lymphocytic leukemiaBlood.  118:4902-4909. 2011
    2011 Genistein, a phytoestrogen, improves total cholesterol, and Synergy, a prebiotic, improves calcium utilization, but there were no synergistic effects 2011
    2011 Identification and analysis of signaling networks potentially involved in breast carcinoma metastasis to the brainPLoS One.  6. 2011
    2011 The role of soy isoflavones in menopausal health: Report of the North American Menopause Society/Wulf H. Utian Translational Science Symposium in Chicago, IL (October 2010) 2011
    2011 Determination of cranberry phenolic metabolites in rats by liquid chromatography-tandem mass spectrometryJournal of Agricultural and Food Chemistry.  59:6682-6688. 2011
    2011 Effect of soy isoflavones on breast cancer recurrence and death for patients receiving adjuvant endocrine therapy: Kang X, Zhang Q, Wang S, et al (Cancer Hosp of Harbin Med Univ, China) CMAJ 182:1857-1862, 2010Breast Diseases.  22:184-185. 2011
    2011 Elevated levels of NO are localized to distal airways in asthmaFree Radical Biology and Medicine.  50:1679-1688. 2011
    2011 Serine protease PrtA from Streptococcus pneumoniae plays a role in the killing of S. pneumoniae by apolactoferrinInfection and Immunity.  79:2440-2450. 2011
    2011 Hemodynamic characteristics of midazolam, propofol, and dexmedetomidine in healthy volunteersJournal of Clinical Anesthesia.  23:218-223. 2011
    2011 The metabolism and analysis of isoflavones and other dietary polyphenols in foods and biological systemsFood and Function.  2:235-244. 2011
    2011 Clinical outcomes of a 2-y soy isoflavone supplementation in menopausal womenAmerican Journal of Clinical Nutrition.  93:356-367. 2011
    2011 Genistein and genistein-containing dietary supplements accelerate the early stages of cataractogenesis in the male ICR/f ratExperimental Eye Research.  92:120-127. 2011
    2010 Activation of the cystic fibrosis transmembrane conductance regulator by the flavonoid quercetin: Potential use as a biomarker of ΔF508 cystic fibrosis transmembrane conductance regulator rescueAmerican Journal of Respiratory Cell and Molecular Biology.  43:607-616. 2010
    2010 Tissue localization and solubilities of αA-crystallin and its numerous C-terminal truncation products in pre- and postcataractous ICR/F Rat lenses 2010
    2010 Role of phytoestrogens in cancer therapy 2010
    2010 Glycosylation patterns of HIV-1 gp120 depend on the type of expressing cells and affect antibody recognitionJournal of Biological Chemistry.  285:20860-20869. 2010
    2010 Cautions and research needs identified at the equol, soy, and menopause research leadership conference 2010
    2010 The effect of mannan oligosaccharide supplementation on body weight gain and fat accrual in C57Bl/6J miceObesity.  18:995-999. 2010
    2010 Simultaneous determination of 11 phytoestrogens in human serum using a 2 min liquid chromatography/tandem mass spectrometry method 2010
    2010 The biochemistry, chemistry and physiology of the isoflavones in soybeans and their food productsLymphatic Research and Biology.  8:89-98. 2010
    2010 A large-scale chemical screen for regulators of the arginase 1 promoter identifies the soy isoflavone daidzein as a clinically approved small molecule that can promote neuronal protection or regeneration via a cAMP-independent pathway 2010
    2010 A novel nanoparticle drug delivery system: The anti-inflammatory activity of curcumin is enhanced when encapsulated in exosomesMolecular Therapy.  18:1606-1614. 2010
    2009 Cardiac hypertrophy in mice with long-chain acyl-CoA dehydrogenase or very long-chain acyl-CoA dehydrogenase deficiencyLaboratory Investigation.  89:1348-1354. 2009
    2009 Soy isoflavone supplementation and bone mineral density in menopausal women: A 2-y multicenter clinical trialAmerican Journal of Clinical Nutrition.  90:1433-1439. 2009
    2009 Supplemental dietary racemic equol has modest benefits to bone but has mild uterotropic activity in ovariectomized rats 2009
    2009 Chronic dietary kudzu isoflavones improve components of metabolic syndrome in stroke-prone spontaneously hypertensive ratsJournal of Agricultural and Food Chemistry.  57:7268-7273. 2009
    2009 Liquid chromatography tandem mass spectrometry identification of proanthocyanidins in rat plasma after oral administration of grape seed extractPhytomedicine.  16:233-243. 2009
    2009 Antiresorptive effects of phytoestrogen supplements compared with estradiol or risedronate in postmenopausal women using 41Ca methodologyJournal of Clinical Endocrinology and Metabolism.  94:3798-3805. 2009
    2009 Tissue distribution of puerarin and its conjugated metabolites in rats assessed by liquid chromatography-tandem mass spectrometryPhytomedicine.  16:65-71. 2009
    2008 A liquid chromatography mass spectrometry assay for determination of PD168393, a specific and irreversible inhibitor of erbB membrane tyrosine kinases, in rat serum 2008
    2008 2D difference gel electrophoresis of prepubertal and pubertal rat mammary gland proteomesJournal of Proteome Research.  7:4638-4650. 2008
    2008 Nutritional Genomics, Polyphenols, Diets, and Their Impact on DieteticsJournal of the Academy of Nutrition and Dietetics.  108:1888-1895. 2008
    2008 Proteomic analysis of mouse hypothalamus under simulated microgravityNeurochemical Research.  33:2335-2341. 2008
    2008 High-resolution mass spectrometry analysis of protein oxidations and resultant loss of functionBiochemical Society Transactions.  36:1037-1044. 2008
    2008 Effect of cranberry juice concentrate on chemically-induced urinary bladder cancers 2008
    2008 Evaluating statistical methods using plasmode data sets in the age of massive public databases: An illustration using false discovery ratesPLoS Genetics.  4. 2008
    2008 Inactivation of human liver bile acid CoA:amino acid N-acyltransferase by the electrophilic lipid, 4-hydroxynonenalJournal of Lipid Research.  49:282-294. 2008
    2008 UV-A-induced structural and functional changes in human lens deamidated αB-crystallinMolecular Vision.  14:234-248. 2008
    2008 Clostridium scindens baiCD and baiH genes encode stereo-specific 7α/7β-hydroxy-3-oxo-Δ4-cholenoic acid oxidoreductases 2008
    2007 Effect of a daily supplement of soy protein on body composition and insulin secretion in postmenopausal womenFertility and Sterility.  88:1609-1617. 2007
    2007 Metabolism and bioavailability of flavonoids in chemoprevention: Current analytical strategies and future prospectusMolecular Pharmaceutics.  4:846-864. 2007
    2007 Active site modifications of the brain isoform of creatine kinase by 4-hydroxy-2-nonenal correlate with reduced enzyme activity: Mapping of modified sites by fourier transform-ion cyclotron resonance mass spectrometryChemical Research in Toxicology.  20:1260-1268. 2007
    2007 Curcumin reverses breast tumor exosomes mediated immune suppression of NK cell tumor cytotoxicity 2007
    2007 Quantification and regulation of the subcellular distribution of bile acid coenzyme A:amino acid N-acyltransferase activity in rat liverJournal of Lipid Research.  48:1305-1315. 2007
    2007 2D gel proteomics: An approach to study age-related differences in protein abundance or isoform complexity in biological samplesMethods in Molecular Biology.  371:349-391. 2007
    2007 Pharmacokinetic study of puerarin in rat serum by liquid chromatography tandem mass spectrometryBiomedical Chromatography.  21:410-414. 2007
    2007 Prevention of peroxynitrite-induced apoptosis of motor neurons and PC12 Cells by tyrosine-containing peptidesJournal of Biological Chemistry.  282:6324-6337. 2007
    2007 Anti-inflammatory effects of isoflavones are dependent on flow and human endothelial cell PPARγ 2007
    2007 Assessment of dietary isoflavone intake among middle-aged Chinese men 2007
    2007 Identification of isoflavone glycosides in pueraria lobata cultures by tandem mass spectrometryPhytochemical Analysis.  18:50-59. 2007
    2007 Soy isoflavones do not affect bone resorption in postmenopausal women: A dose-response study using a novel approach with41CaJournal of Clinical Endocrinology and Metabolism.  92:577-582. 2007
    2006 Applications of LC-MS in the study of the uptake, distribution, metabolism and excretion of bioactive polyphenols from dietary supplementsLife Sciences.  78:2054-2059. 2006
    2006 Proteomics analysis of the actions of grape seed extract in rat brain: Technological and biological implications for the study of the actions of psychoactive compoundsLife Sciences.  78:2060-2065. 2006
    2006 In vivo protein sampling using capillary ultrafiltration semi-permeable hollow fiber and protein identification via mass spectrometry-based proteomicsJournal of Chromatography A.  1109:144-151. 2006
    2006 Proteomic analysis of mice hippocampus in simulated microgravity environmentJournal of Proteome Research.  5:548-553. 2006
    2006 Surfactant sodium lauryl sulfate enhances skin vaccination: Molecular characterization via a novel technique using ultrafiltration capillaries and mass spectrometric proteomicsMolecular and Cellular Proteomics.  5:523-532. 2006
    2006 A sensitive method for the quantitative measurement of protein thiol modification in response to oxidative stressFree Radical Biology and Medicine.  40:459-468. 2006
    2006 Murine mammary carcinoma exosomes promote tumor growth by suppression of NK cell functionJournal of Immunology.  176:1375-1385. 2006
    2006 Reliability and validity of an assessment of usual phytoestrogen consumption (United States)Cancer Causes and Control.  17:85-93. 2006
    2006 A proposed metric for assessing the measurement quality of individual microarraysBMC Bioinformatics.  7. 2006
    2006 Differential biliary excretion of genistein metabolites following intraduodenal and intravenous infusion of genistin in female rats 2006
    2006 In the postgenomic era, can high-dimensional analyses deliver the answers we're looking for? 2006
    2006 Production of a novel class of polyreactive pathogenic autoantibodies in BXD2 mice causes glomerulonephritis and arthritisArthritis and Rheumatism.  54:343-355. 2006
    2005 Contrasting effects of puerarin and daidzin on glucose homeostasis in miceJournal of Agricultural and Food Chemistry.  53:8760-8767. 2005
    2005 Prospective highlights of functional skin proteomicsMass Spectrometry Reviews.  24:647-660. 2005
    2005 Sources of variation in Affymetrix microarray experimentsBMC Bioinformatics.  6. 2005
    2005 Revealing anti-inflammatory mechanisms of soy isoflavones by flow: Modulation of leukocyte-endothelial cell interactions 2005
    2005 Electrospray tandem mass spectrometric analysis of zeaxanthin and its oxidation productsJournal of Mass Spectrometry.  40:916-923. 2005
    2005 Induction of cell proliferation, micronuclei and hyperdiploidy/polyploidy in the mammary cells of DDT- and DMBA-treated pubertal ratsEnvironmental and Molecular Mutagenesis.  46:43-52. 2005
    2005 Comparative effect of soy protein, soy isoflavones, and 17β-estradiol on bone metabolism in adult ovariectomized ratsJournal of Bone and Mineral Research.  20:828-839. 2005
    2005 Bile acid coenzyme A: Amino acid N-acyltransferase in the amino acid conjugation of bile acidsMethods in Enzymology.  400:374-394. 2005
    2005 Bile acid coenzyme A: amino acid N-acyltransferase in the amino acid conjugation of bile acids.Methods in Enzymology.  400:374-394. 2005
    2005 Cleavage of p53-vimentin complex enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis of rheumatoid arthritis synovial fibroblastsAmerican Journal of Pathology.  167:705-719. 2005
    2005 Current progress in the use of traditional medicines and nutraceuticalsCurrent Opinion in Plant Biology.  8:324-328. 2005
    2005 Exactly which synephrine alkaloids does Citrus aurantium (bitter orange) contain?International Journal of Obesity.  29:443-446. 2005
    2005 Long-term dietary habits affect soy isoflavone metabolism and accumulation in prostatic fluid in Caucasian men 2005
    2005 Metabolism of phytoestrogen conjugatesMethods in Enzymology.  400:316-342. 2005
    2005 Synthesis of bile acid coenzyme A thioesters in the amino acid conjugation of bile acidsMethods in Enzymology.  400:360-373. 2005
    2005 The case for strategic international alliances to harness nutritional genomics for public and personal health 2005
    2004 Proteomics analysis of rat brain protein modulations by grape seed extractJournal of Agricultural and Food Chemistry.  52:7872-7883. 2004
    2004 Excitement and realities in microarray analysis of the biological effects of polyphenolsArchives of Physiology and Biochemistry.  42:94-101. 2004
    2004 Mass spectrometric methods for the determination of flavonoids in biological samplesFree Radical Biology and Medicine.  37:1324-1350. 2004
    2004 Modification of cytochrome c by 4-hydroxy-2-nonenal: Evidence for histidine, lysine, and arginine-aldehyde adductsJournal of the American Society for Mass Spectrometry.  15:1136-1147. 2004
    2004 Identification of puerarin and its metabolites in rats by liquid chromatography-tandem mass spectrometryJournal of Agricultural and Food Chemistry.  52:3708-3712. 2004
    2004 Inulin Effects on Bioavailability of Soy Isoflavones and Their Calcium Absorption Enhancing AbilityJournal of Agricultural and Food Chemistry.  52:2827-2831. 2004
    2004 Nutriproteomics: Identifying the molecular targets of nutritive and non-nutritive components of the dietBMB Reports.  37:59-74. 2004
    2004 Dietary Phytoestrogens Increase Metabolic Resistance (Cold Tolerance) in Long-Chain Acyl-CoA Dehydrogenase-Deficient Mice 2004
    2004 Foreword from the editorsNutrition.  20:1. 2004
    2004 Individual differences in the response to ingested nutrients.Nutrition.  20:1. 2004
    2004 Proteomics and mass spectrometry in nutrition researchNutrition.  20:155-165. 2004
    2004 Soy Isoflavones-Phytoestrogens and What Else? 2004
    2003 Erratum: Identification of Novel Interactions in HIV-1 Capsid Protein Assembly by High-resolution Mass Spectrometry (Journal of Molecular Biology (2003) 325 (759-772))Journal of Molecular Biology.  334:1133. 2003
    2003 Neutrophil myeloperoxidase chlorinates and nitrates soy isoflavones and enhances their antioxidant propertiesFree Radical Biology and Medicine.  35:1417-1430. 2003
    2003 Rat liver bile acid CoA:amino acid N-acyltransferase: Expression, characterization, and peroxisomal localizationJournal of Lipid Research.  44:2242-2249. 2003
    2003 Sulfenic acid formation in human serum albumin by hydrogen peroxide and peroxynitriteBiochemistry.  42:9906-9914. 2003
    2003 Profiling and quantification of isoflavonoids in kudzu dietary supplements by high-performance liquid chromatography and electrospray ionization tandem mass spectrometryJournal of Agricultural and Food Chemistry.  51:4213-4218. 2003
    2003 DING, a genistein target in human breast cancer: a protein without a gene. 2003
    2003 Mass spectrometric methods for the analysis of chlorinated and nitrated isoflavonoids: A novel class of biological metabolitesJournal of Mass Spectrometry.  38:764-771. 2003
    2003 Nitric oxide-dependent generation of reactive species in sickle cell disease: Actin tyrosine nitration induces defective cytoskeletal polymerizationJournal of Biological Chemistry.  278:4194-4204. 2003
    2003 Identification of novel interactions in HIV-1 capsid protein assembly by high-resolution mass spectrometryJournal of Molecular Biology.  325:759-772. 2003
    2003 A design and statistical perspective on microarray gene expression studies in nutrition: The need for playful creativity and scientific hard-mindednessNutrition.  19:997-1000. 2003
    2002 Conserved residues in the putative catalytic triad of human bile acid coenzyme A:Amino acid N-acyltransferaseJournal of Biological Chemistry.  277:47270-47275. 2002
    2002 Molecular cloning and expression of rat liver bile acid CoA ligaseJournal of Lipid Research.  43:2062-2071. 2002
    2002 Bromination, Chlorination, and Nitration of IsoflavonoidsACS Symposium Series.  807:251-261. 2002
    2002 Effect of soy protein on endogenous hormones in postmenopausal womenAmerican Journal of Clinical Nutrition.  75:145-153. 2002
    2002 Review of the methods used in the determination of phytoestrogens 2002
    2001 Antioxidant mechanisms of isoflavones in lipid systems: Paradoxical effects of peroxyl radical scavengingFree Radical Biology and Medicine.  31:1570-1581. 2001
    2001 Novel fatty acid esters of p-coumaryl alcohol in epicuticular wax of apple fruitJournal of Agricultural and Food Chemistry.  49:3787-3792. 2001
    2001 Soy isoflavonoids and cancer - Metabolism at the target siteMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis.  480-481:121-127. 2001
    2001 L-Arginine Chlorination Products Inhibit Endothelial Nitric Oxide ProductionJournal of Biological Chemistry.  276:27159-27165. 2001
    2001 Actions of the soy phytoestrogen genistein in models of human chronic disease: potential involvement of transforming growth factor beta.Biochemical Society Transactions.  29:216-222. 2001
    2001 Hydrogen-deuterium exchange as a probe of folding and assembly in viral capsidsJournal of Molecular Biology.  306:389-396. 2001
    2001 Enhanced antioxidant activity after chlorination of quercetin by hypochlorous acidAlcoholism: Clinical and Experimental Research.  25:434-443. 2001
    2001 Formation of novel bioactive metabolites from the reactions of pro-inflammatory oxidants with polyphenolicsBioFactors.  15:79-81. 2001
    2001 Oestrogens and their promiscuous receptors: Confronting realityBiochemical Society Transactions.  29:231-236. 2001
    2001 Role of phytochemicals in prevention and treatment of prostate cancerEpidemiologic Reviews.  23:102-105. 2001
    2001 The effect of isolated soy protein on plasma biomarkers in elderly men with elevated serum prostate specific antigenInvestigative urology.  165:294-300. 2001
    2000 Heterogeneity of O-glycosylation in the hinge region of human IgA1Molecular Immunology.  37:1047-1056. 2000
    2000 Retention and changes of soy isoflavones and carotenoids in immature soybean seeds (edamame) during processingJournal of Agricultural and Food Chemistry.  48:6061-6069. 2000
    2000 Biochemical structural analysis of the lantibiotic mutacin IIJournal of Biological Chemistry.  275:15845-15850. 2000
    2000 Nitric oxide reaction with lipid peroxyl radicals spares α-tocopherol during lipid peroxidation. Greater oxidant protection from the pair nitric oxide/α-tocopherol than α-tocopherol/ascorbateJournal of Biological Chemistry.  275:10812-10818. 2000
    2000 The enzymatic formation of novel bile acid primary amidesMolecular cell biology research communications : MCBRC.  374:107-117. 2000
    2000 Assessing phytoestrogen exposure in epidemiologic studies: Development of a database (United States)Cancer Causes and Control.  11:289-298. 2000
    2000 Beyond ERα and ERβ: Estrogen receptor binding is only part of the isoflavone story 2000
    2000 Isoflavonoids and chronic disease: Mechanisms of actionBioFactors.  12:209-215. 2000
    2000 The role of isoflavones in menopausal health: Consensus opinion of the North American Menopause Society 2000
    1999 Chlorination and nitration of soy isoflavonesMolecular cell biology research communications : MCBRC.  368:265-275. 1999
    1999 Antioxidant properties of phytoestrogensJournal of Medicinal Food.  2:163-166. 1999
    1999 Nitration of unsaturated fatty acids by nitric oxide-derived reactive nitrogen species peroxynitrite, nitrous acid, nitrogen dioxide, and nitronium ionChemical Research in Toxicology.  12:83-92. 1999
    1999 Nitration of unsaturated fatty acids by nitric oxide-derived reactive speciesMethods in Enzymology.  301:454-470. 1999
    1998 Mechanisms of action of the soy isoflavone genistein: emerging role for its effects via transforming growth factor beta signaling pathways.American Journal of Clinical Nutrition.  68:1418S-1425S. 1998
    1998 Tyrosine kinase inhibitor effects on avian osteoclastic acid transport.American Journal of Clinical Nutrition.  68:1369S-1374S. 1998
    1998 Nitrosation of uric acid by peroxynitrite: Formation of a vasoactive nitric oxide donorJournal of Biological Chemistry.  273:24491-24497. 1998
    1998 Evolution of the health benefits of soy isoflavonesExperimental Biology and Medicine.  217:386-392. 1998
    1998 Genistein alters the ontogeny of mammary gland development and protects against chemically-induced mammary cancer in ratsExperimental Biology and Medicine.  217:358-364. 1998
    1998 HPLC-mass spectrometry analysis of isoflavonesExperimental Biology and Medicine.  217:254-262. 1998
    1998 Phytoestrogens and breast cancer 1998
    1998 Structure-activity study of the lantibiotic mutacin II from Streptococcus mutans T8 by a gene replacement strategyApplied and Environmental Microbiology.  64:2335-2340. 1998
    1997 Characterization of purified bile acid coenzyme A synthetase (BAS) from rat liver microsomes 1997
    1997 Formation of the NO donors glyceryl mononitrate and glyceryl mononitrite from the reaction of peroxynitrite with glycerolBiochemical Journal.  328:517-524. 1997
    1997 Purification and characterization of a rat liver bile acid coenzyme A ligase from rat liver microsomesMolecular cell biology research communications : MCBRC.  348:15-24. 1997
    1997 The chemopreventive properties of soy isoflavonoids in animal models of breast cancerBreast Cancer Research and Treatment.  46:169-179. 1997
    1997 Cloning, expression, and chromosomal localization of mouse liver bile acid CoA:amino acid N-acyltransferaseJournal of Lipid Research.  38:1139-1148. 1997
    1997 Urinary phytoestrogen levels in young women from a multiethnic populationCancer Epidemiology, Biomarkers and Prevention.  6:339-345. 1997
    1997 Intestinal uptake and biliary excretion of the isoflavone genistein in rats 1997
    1997 Phyto-oestrogens and breast cancer 1997
    1997 Superoxide dismutase catalyzes nitration of tyrosines by peroxynitrite in the rod and head domains of neurofilament-LJournal of Neurochemistry.  69:1945-1953. 1997
    1996 Genistein inhibits both estrogen and growth factor-stimulated proliferation of human breast cancer cellsMolecular Cancer Research.  7:1345-1351. 1996
    1996 Stimulatory influence of soy protein isolate on breast secretion in pre- and postmenopausal womenCancer Epidemiology, Biomarkers and Prevention.  5:785-794. 1996
    1996 Prepubertal genistein exposure suppresses mammary cancer and enhances gland differentiation in ratsCarcinogenesis.  17:1451-1457. 1996
    1996 Variable effects of tyrosine kinase inhibitors on avian osteoclastic activity and reduction of bone loss in ovariectomized ratsJournal of Cellular Biochemistry.  61:629-637. 1996
    1996 Variable effects of tyrosine kinase inhibitors on avian osteoclastic activity and reduction of bone loss in ovariectomized rats.Journal of Cellular Biochemistry.  61:629-637. 1996
    1996 Detection of modified amino acids in lantibiotic peptide mutacin II by chemical derivatization and electrospray ionization-mass spectroscopic analysisAnalytical Biochemistry.  236:358-360. 1996
    1996 Analysis of plasma isoflavones by reversed-phase HPLC-multiple reaction ion monitoring-mass spectrometryClinica Chimica Acta.  247:121-142. 1996
    1996 Peroxynitrite-dependent tryptophan nitrationChemical Research in Toxicology.  9:390-396. 1996
    1996 Selective detection and site-analysis of O-GlcNAc-modified glycopeptides by β-elimination and tandem electrospray mass spectrometryAnalytical Biochemistry.  234:38-49. 1996
    1996 The role of metabolism in mammary epithelial cell growth inhibition by the isoflavones genistein and biochanin ACarcinogenesis.  17:1861-1869. 1996
    1995 Nitric oxide inhibition of lipoxygenase-dependent liposome and low-density lipoprotein oxidation: Termination of radical chain propagation reactions and formation of nitrogen-containing oxidized lipid derivativesMolecular cell biology research communications : MCBRC.  324:15-25. 1995
    1995 Genistein suppresses mammary cancer in ratsCarcinogenesis.  16:2833-2840. 1995
    1995 Antioxidant and Antipromotional Effects of the Soybean Isoflavone GenisteinExperimental Biology and Medicine.  208:124-130. 1995
    1995 Biochemical Targets of the Isoflavone Genistein in Tumor Cell LinesExperimental Biology and Medicine.  208:103-108. 1995
    1995 Imaging biliary lipid secretion in the rat: Ultrastructural evidence for vesiculation of the hepatocyte canalicular membraneJournal of Lipid Research.  36:2147-2163. 1995
    1995 Neonatal Genistein Chemoprevents Mammary CancerExperimental Biology and Medicine.  208:120-123. 1995
    1995 Rationale for the use of genistein‐containing soy matrices in chemoprevention trials for breast and prostate cancerJournal of cellular biochemistry. Supplement.  59:181-187. 1995
    1994 Isoflavones and Their Conjugates in Soy Foods: Extraction Conditions and Analysis by HPLC-Mass SpectrometryJournal of Agricultural and Food Chemistry.  42:2466-2474. 1994
    1994 Glycine and taurine conjugation of bile acids by a single enzyme. Molecular cloning and expression of human liver bile acid CoA:amino acid N- acyltransferaseJournal of Biological Chemistry.  269:19375-19379. 1994
    1994 Nitric oxide regulation of superoxide and peroxynitrite-dependent lipid peroxidation. Formation of novel nitrogen-containing oxidized lipid derivativesJournal of Biological Chemistry.  269:26066-26075. 1994
    1994 Potential role of dietary isoflavones in the prevention of cancerAdvances in Experimental Medicine and Biology.  354:135-147. 1994
    1994 Role of bile salt hydrophobicity in hepatic microtubule-dependent bile salt secretionJournal of Lipid Research.  35:1738-1748. 1994
    1994 Soy intake and cancer risk: A review of the in vitro and in vivo data 1994
    1994 Ultrastructural localization of a fluorinated bile salt in hepatocytesLaboratory Investigation.  71:42-51. 1994
    1993 Genistein, daidzein, and their beta-glycoside conjugates - Antitumor isoflavones in soybean foods from American and Asian dietsJournal of Agricultural and Food Chemistry.  41:1961-1967. 1993
    1993 Heterogenic properties of clonal cell lines derived from canine mammary carcinomas and sensitivity to tamoxifen and doxorubicin. 1993
    1993 Identification of bile acid coenzyme A synthetase in rat kidneyJournal of Lipid Research.  34:95-99. 1993
    1993 Inhibition of tumor promoter-Induced hydrogen peroxide formation in vitro and in vivo by genistein 1993
    1993 Purification and Properties of a Human Platelet Inositol 1,4,5-Trisphosphate 3-KinaseMolecular cell biology research communications : MCBRC.  303:412-420. 1993
    1992 Bioactivation of 7‐hydroxymethyl‐12‐ methyibenz[a]anthracene by rat liver bile acid sulfotransferase IJournal of Biochemical and Molecular Toxicology.  7:241-248. 1992
    1992 Differential intestinal deconjugation of taurine and glycine bile acid N- acyl amidates in ratsAmerican Journal of Physiology.  262. 1992
    1992 Distribution of sulphides and pge within the porphyritic websterite zone of the Munni Munni Complex, Western AustraliaAustralian Journal of Earth Sciences.  39:289-302. 1992
    1992 Pharmacokinetics and tissue distribution of 2-fluoro-β-alanine in rats. Potential relevance to toxicity pattern of 5-fluorouracilDrug Metabolism and Disposition.  20:113-119. 1992
    1991 Genistein inhibition of the growth of human breast cancer cells: Independence from estrogen receptors and the multi-drug resistance geneBiochemical and Biophysical Research Communications.  179:661-667. 1991
    1991 Purification and characterization of bile acid-CoA:amino acid N-acyltransferase from human liverJournal of Biological Chemistry.  266:10227-10233. 1991
    1991 The role of soy products in reducing risk of cancer 1991
    1991 Disposition and metabolism of 2-fluoro-β-alanine conjugates of bile acids following secretion into bile 1991
    1991 A comparative study of bile acid CoA:Amino acid:N-acyltransferase (BAT) from four mammalian speciesComparative Biochemistry and Physiology - B: Comparative Biochemistry.  100:131-136. 1991
    1991 Bile Acid Conjugation Pattern in the Isolated Perfused Rat Liver During Infusion of an Amino Acid FormulationJournal of Parenteral and Enteral Nutrition.  15:303-306. 1991
    1991 Identification of bile acid-CoA:amino acid N-acyltransferase in rat kidneyBiochemical Journal.  280:821-824. 1991
    1990 2-Fluoro-β-alanine, a previously unrecognized substrate for bile acid coenzyme A:Amino acid:N-acyltransferase from human liverBiochemical Pharmacology.  40:1241-1246. 1990
    1990 Phosphorylation by protein kinase C inactivates an inositol 1,4,5-trisphosphate 3-kinase purified from human plateletsBiochemical and Biophysical Research Communications.  170:1371-1376. 1990
    1990 Biological properties of the 2-fluoro-β-alanine conjugates of cholic acid and chenodeoxycholic acid in the isolated perfused rat liver 1990
    1989 Radioassay of bile acid coenzyme A:glycine/taurine: N-acyltransferase using an n-butanol solvent extraction procedureAnalytical Biochemistry.  182:360-365. 1989
    1989 Bile acid sulfotransferase I from rat liver sulfates bile acids and 3-hydroxy steroids: Purification, N-terminal amino acid sequence, and kinetic propertiesJournal of Lipid Research.  30:529-540. 1989
    1988 Formation of Conjugates of 2-Fluoro-β-alanine and Bile Acids during the Metabolism of 5-Fluorouracil and 5-Fluoro-2-deoxyuridine in the Isolated Perfused Rat LiverCancer Research.  48:2010-2014. 1988
    1987 Enantiomeric composition analysis of amphetamine and methamphetamine by chiral phase high-performance liquid chromatography-mass spectrometryJournal of Chromatography A.  398:239-246. 1987
    1987 Structure of the Dysprosium-Glycocholate Complex in Submicellar Aqueous Solution: Paramagnetic Mapping by Proton Nuclear Magnetic Resonance Spectroscopy. An Approximation for the Intrinsic “Bound” Relaxation Rates in the Case of Nondilute Paramagnetic SystemsBiochemistry.  26:6785-6792. 1987
    1986 Evidence for an ordered reaction mechanism for bile salt:3'phosphoadenosine-5'-phosphosulfate: Sulfotransferase from rhesus monkey liver that catalyzes the sulfation of the hepatotoxin glycolithocholateJournal of Lipid Research.  27:1111-1123. 1986
    1986 Biologic properties of cell lines derived from canine mammary carcinomas 1986
    1986 NMR Studies of the Binding of Sodium and Calcium Ions to the Bile Salts Glycocholate and Taurocholate in Dilute Solution, as Probed by the Paramagnetic Lanthanide DysprosiumJournal of the American Chemical Society.  108:7082-7089. 1986
    1985 Nuclear magnetic resonance spectroscopy of bile acids. Development of two-dimensional NMR methods for the elucidation of proton resonance assignments for five common hydroxylated bile acids, and their parent bile acid, 5β-cholanoic acidJournal of Lipid Research.  26:1068-1078. 1985
    1984 Aggregation patterns of bile salts: Crystal structure of calcium cholate chloride heptahydrateJournal of Lipid Research.  25:791-798. 1984
    1984 Autonomous cholesterol biosynthesis in murine hepatoma. A receptor defect with normal coated pitsCancer.  54:1562-1568. 1984
    1984 Bile Salt Micelles: Nuclear Magnetic Resonance Spectroscopy and Crystallographic StudiesHepatology.  4:98S-102S. 1984
    1983 Alkaline butanol extraction of bile salt and steroid sulfate esters: Application to the assay of sulfotransferasesAnalytical Biochemistry.  133:470-475. 1983
    1982 Flash heater derivatization of unconjugated bile acids using trimethylanilinium hydroxide. Rapid analysis by capillary gas-liquid chromatography 1982
    1982 Evidence for heterogeneity of hepatic bile salt sulfotransferases in female hamsters and rats 1982
    1982 High resolution nuclear magnetic resonance spectroscopy of bile salts: individual proton assignments for sodium cholate in aqueous solution at 400 MHzJournal of Lipid Research.  23:161-170. 1982
    1982 Streptozotocin-induced diabetes stimulates bile salt sulfation in male ratsGastroenterology.  82:1013. 1982
    1981 Syndromatic hepatic ductular hypoplasia (arteriohepatic dysplasia) - A clinical and hepatic histologic study of three patientsDigestive Diseases and Sciences.  26:485-497. 1981
    1981 EFFECTS OF SPIRONOLACTONE ON SERUM BILE ACIDSClinical and Experimental Pharmacology and Physiology.  8:87-88. 1981
    1981 Postnatal physiologic hypercholemia in both premature and full-term infantsJournal of Clinical Investigation.  68:775-782. 1981
    1980 Improved enzymatic assays for bile acids using resazurin and nadh oxidoreductase from Clostridium kluyveriClinica Chimica Acta.  102:241-245. 1980
    1980 Determination of the pool size and synthesis rate of bile acids by measurements in blood of patients with liver diseaseClinical Science.  58:485-492. 1980
    1980 Preparation and characterisation of permethylated derivatives of bile acids, and their application to gas chromatographic analysis 1980
    1980 Stoichiometry of the nadh-oxidoreductase reaction for dehydrogenase determinationsClinica Chimica Acta.  107:149-154. 1980
    1979 Enzymatic sulfation of glycochenodeoxycholic acid by tissue fractions from adult hamstersJournal of Lipid Research.  20:952-959. 1979
    1979 Modification of d-galactosamine-induced liver injury in the rat by spironolactonePharmacology.  18:235-240. 1979
    1979 Radiolabeled bile acid clearance in control subjects and patients with liver diseaseClinical Science.  57:499-508. 1979
    1979 The effect of bile duct ligation on hepatic bile acid sulfotransferase activity in the hamsterMolecular Genetics and Metabolism.  22:165-174. 1979
    1978 Bile acids in portal bloodGastroenterology.  74:964-965. 1978
    1978 Serum disappearance of cholylglycine (CG)Gastroenterology.  74:1006. 1978
    1977 A simplified procedure for the isolation of bile acids from serum based on a batch extraction with the non ionic resin Amberlite XAD 7Annals of Clinical Biochemistry.  14:235-239. 1977
    1977 Assessment of the plasma disappearance of cholyl-l-14C-glycine as a test of hepatocellular diseaseGut.  18:697-702. 1977
    1977 Bile acids in liver disease associated with inflammatory bowel disease 1977
    1977 Evidence for renal control of urinary excretion of bile acids and bile acid sulphates in the cholestatic syndromeClinical Science.  52:51-65. 1977
    1977 The role of tubular reabsorption in the renal excretion of bile acidsBiochemical Journal.  166:65-73. 1977
    1976 Effect of Fasting and lleal Resection on the Concentration of Deoxycholic Acid in Rat Portal BloodExperimental Biology and Medicine.  152:292-297. 1976
    1975 Bile acid metabolism in chronic bowel disease: determinations in gallbladder bile, portal blood, and peripheral bloodGut.  16:393-394. 1975
    1975 Diagnostic value of serum bile acid estimations in liver disease 1975
    1973 Proceedings: The diagnostic value of postprandial bile salt estimations in patients with liver disease.Gut.  14:819. 1973
    1973 Total and unconjugated bile acids in rat portal blood following intestinal resection.Clinical Science.  45. 1973

    Chapter

    Year Title Altmetric
    2020 Overview of Experimental Methods and Study Design in Metabolomics, and Statistical and Pathway Considerations.  1-10. 2020
    2018 Analyzing ingredients in dietary supplements and their metabolites.  337-346. 2018
    2013 Uptake and Metabolism of Dietary Proanthocyanidins.  553-560. 2013
    2009 Recent advances in traditional medicines and dietary supplements.  533-546. 2009
    2006 Genistein and Polyphenols in the Study of Cancer Prevention: Chemistry, Biology, Statistics, and Experimental Design.  305-329. 2006
    2006 Soy Isoflavones.  559-571. 2006
    2005 Nutriproteomics approach to understanding dementia-relevant brain protein changes in response to grape seed extract, a dietary antioxidant.  457-480. 2005
    2004 Proteomics: Examining the effects of processing on food proteins.  483-516. 2004
    2003 The importance of in vivo metabolism of polyphenols and their biological actions.  51-59. 2003

    Research Overview

  • I have had a longstanding interest in metabolism and enzymology and the enterohepatic circulation of endogenous and exogenous metabolites. Because of early training in hepatobiliary diseases, this led to studies on bile acid metabolism and purification of the enzymes catalyzing their formation. A second strong area of research has been the roles of polyphenols in health and disease, with a particular emphasis on soy isoflavones. Over the past decade, I have been pursuing the basis of lens cataract formation in the lens. An overarching theme for these research areas has been the pathways of metabolism and the utilization of mass spectrometry for their study. This had led to a strong interest in metabolomics and training in this re-emerging discipline.
  • Principal Investigator On

  • 5500 Q-Trap Mass Spectrometer  awarded by National Center for Research Resources/NIH/DHHS
  • A State of the Art Triple Quadruple Mass Spectrometer for pmol and fmol Analysis  awarded by UNIVERSITY OF ALABAMA HEALTH SERVICES FOUNDATION
  • Botanicals Center for Age-Related Diseases  awarded by Purdue University
  • Botanicals Center for Age-Related Diseases - Core D: In Vivo Analysis  awarded by Purdue University
  • Botanicals Center for Age-Related Diseases - Project 3: Polyphenols, Singlet Oxygen and Protein Damage in the Eye  awarded by Purdue University
  • Botantical Center for Age-Related Diseases - Pilot Projects  awarded by Purdue University
  • Cohort Study of Cancer-Inhibitory Dietary Factors in Men  awarded by VANDERBILT UNIVERSITY
  • Comparative Energetics and Aging - Research Development Core B  awarded by National Institute on Aging/NIH/DHHS
  • Comprehensive Cancer Center Core Support Grant - Mass Spectroscopy  awarded by National Cancer Institute/NIH/DHHS
  • Cross-Platform and Graphical Software Tool for Adaptive LC/MS and GC/MS Metabolomics Data Preprocessing  awarded by University of North Carolina at Charlotte
  • Determination of the Interactome between Haemophilus Ducreyi and the Human Host  awarded by Indiana University
  • Lens Crystallins: Spatial Location and Properties in the ICR/f Rat Cataract Model  awarded by National Eye Institute/NIH/DHHS
  • MicroLC for State of the Art Lipidomics and Metabolomics at UAB  awarded by UNIVERSITY OF ALABAMA HEALTH SERVICES FOUNDATION
  • Neutrophil Exosomes: New Pathogenic Entities in COPD  awarded by VETERANS ADMINISTRATION
  • Nutrient Cycling for Biomass: Interactive Proteomic/Transcriptomic Networks for Global Management Processes within Poplar-Mycorrhizal Interactions  awarded by UNIVERSITY OF ALABAMA (HUNTSVILLE)
  • Obesity Health Disparities Research Center (OHDRC) - Investigator Development Core  awarded by NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES/NIH/DHHS
  • Parameter-free Peak Detection Algorithm for Reducing False Positive/Negative Compound Identification from Raw Mass Spectrometry Metabolomics Data  awarded by University of North Carolina at Charlotte
  • Private Grant  awarded by NESTEC LTD.
  • Private Grant  awarded by VIVOCORE, INC.
  • Private Grant  awarded by NESTEC LTD.
  • UAB -UCSD O'Brien Core Center for Acute Kidney Injury Research - Core C  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • UAB Clinical Nutrition Research Unit - P/F New Investigator  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • UAB Metabolomics Workshop: From Design to Decision  awarded by National Institute of General Medical Sciences/NIH/DHHS
  • UAB Nutrition Obesity Research Center (NORC) - P&F Program  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • UAB Nutrition Obesity Research Center - NORC Pilot and Feasibility Program  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • UAB Nutrition Obesity Research Center - P&F Program  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • UAB Nutrition Obesity Research Center - P&F Program  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • UAB Skin Disease Research Center - Skin Proteomics Core -Core D  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS
  • UAB-UCSD O'Brien Center for Acute Kidney Injury Research - Core C  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • UAB/UCSD O'Brien Core Center for Acute Kidney Injury Research - Core C  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • Urinary Peptide Excretion and Onset of Puberty  awarded by National Center for Complementary and Alternative Medicine/NIH/DHHS
  • Investigator On

  • A Metabolomics Approach to Define a Novel Chemopreventive Pathway  awarded by University of South Alabama
  • Alexander Disease: Cellular and Molecular Mechanisms  awarded by University of Wisconsin-Madison
  • Bacterial Second Messenger Mediated Virulence Regulation in Streptococcus Mutans  awarded by National Institute of Dental and Craniofacial Research/NIH/DHHS
  • Biological Chemistry of Reactive Nitrogen Species Signaling in Cancer Etiology  awarded by National Cancer Institute/NIH/DHHS
  • Blocking CMV Transmission through the Human Milk Metabolome and Microbiome  awarded by National Institute of Child Health and Human Development/NIH/DHHS
  • COPD Cachexia: Deciphering the Impact of Antioxidants, Iron and Mitochondrial Function Using 'Omics Approaches  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • COPD Cachexia: Deciphering the Impact of Antioxidants, Iron and Mitochondrial Function Using 'Omics Approaches  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • CbfB Mediates Articular Cartilage Regeneration and Repair in Aging  awarded by National Institute on Aging/NIH/DHHS
  • Chromatin Remodeling Mechanisms of Gene Transcription in Memory  awarded by National Institute of Mental Health/NIH/DHHS
  • Combinational Environmental Chemicals Altering Susceptibility for Mammary Cancer  awarded by National Institute of Environmental Health Sciences/NIH/DHHS
  • Combinatorial Epigenetic-Based Prevention of Breast Cancer  awarded by National Cancer Institute/NIH/DHHS
  • Comparative Energetics and Aging  awarded by National Institute on Aging/NIH/DHHS
  • Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS
  • Constructing Gene-Regulatory Networks to Reveal the Metabolic Basis of Lifespan in Yeast  awarded by National Institute on Aging/NIH/DHHS
  • DHA Mechanisms in Obesity-Mediated Cardiac Remodeling Post-Myocardial Infarction  awarded by NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH/NIH/DHHS
  • Determining the Structural- and Functional-Level Effects of Diet-Specific Interventions on the Gut Microbiota of a Racially Diverse Sample of Southern United States Adults  awarded by National Cancer Institute/NIH/DHHS
  • Dietary Intervention of Non-Classical Wnt Signaling  awarded by National Cancer Institute/NIH/DHHS
  • Dysbiosis of the Sinus Microbiota in Chronic Rhinosinusitis  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS
  • Early Life Prevention of Breast Cancer with Combined Epigenetic Botanicals  awarded by National Cancer Institute/NIH/DHHS
  • Epigenetic Mechanisms of Maternal Diets in Human Health and Disease Prevention  awarded by NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH/NIH/DHHS
  • Ethnic Differences in Responses to Painful Stimuli  awarded by University of Florida^
  • Ethnic Differences in Responses to Painful Stimuli  awarded by University of Florida^
  • Ethnic Differences in Responses to Painful Stimuli  awarded by University of Florida^
  • Evaluating Bioactive Food Components in Obesity and Cancer Prevention  awarded by National Cancer Institute/NIH/DHHS
  • Evaluation of a Ketogenic Diet for Improvement of Neurological Recovery in Individuals with Acute Spinal Cord Injury  awarded by National Institute of Nursing Research/NIH/DHHS
  • Glycosylation & Function of an Oral Streptococcal Adhesin  awarded by National Institute of Dental and Craniofacial Research/NIH/DHHS
  • Glycosylation and Biogenesis of Streptococcal Adhesins  awarded by National Institute of Dental and Craniofacial Research/NIH/DHHS
  • Glycosylation and Function of an Oral Streptococcal Adhesion  awarded by National Institute of Dental and Craniofacial Research/NIH/DHHS
  • Hydrogen Peroxide and Capsule Production in Streptococcus Pneumoniae  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS
  • Investigation of Nephrotic Syndrome  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • Ivacaftor for Acquired CFTR Dysfunction in Chronic Rhinosinusitis  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Kidney Undergraduate Research Experience (KURE)  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • Longevity Assurance Interventions, Metabolic Health and Aß Toxicity  awarded by National Institute on Aging/NIH/DHHS
  • Mechanosignaling Regulates Macrophage Immunometabolism  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Metabolic Reprogramming in Myofibroblasts as a Mechanism of Pulmonary Fibrosis  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Mitochondrial-Based Determinants of Sex Differences in Acute Kidney Injury  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • Mixed-omics Evaluation of the Impact of Gut Microbiome on Insulin Resistance in Spinal Cord Injury  awarded by Neilsen (Craig H.) Foundation
  • Obesity Health Disparities Research Center (OHDRC)  awarded by NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES/NIH/DHHS
  • Peerless Operator Biologic Aptitude (Peerless)  awarded by FLORIDA INSTITUTE FOR HUMAN & MACHINE COGNITION
  • Peripheral Inflammation and Stress Drive Ventral Striatal Maladaptations  awarded by National Institute of Mental Health/NIH/DHHS
  • Program on Cellular Metabolism and Lung Fibrosis  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Prostaglandins in C. Elegans Fertilization  awarded by National Institute of General Medical Sciences/NIH/DHHS
  • Restore Energy Capacity in the Aging Heart  awarded by National Institute on Aging/NIH/DHHS
  • SULT4A1 in Zebrafish Development  awarded by National Institute of General Medical Sciences/NIH/DHHS
  • Sex-Dependent Synergy Between O3 Exposure, APOE4 E4 Genotype, And Aging in The Onset of Alzheimer's Disease  awarded by National Institute on Aging/NIH/DHHS
  • Significance of Metabolic Activation of Lumisterol in the Skin  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS
  • Small Molecule Inhibitors of Carciogenic Biofilms  awarded by National Institute of Dental and Craniofacial Research/NIH/DHHS
  • Streptococcus Pneumoniae Capsule Inhibitor  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS
  • Targeted Stem Cell Therapy Coupling Angiogenesis and Osteogenesis for Bone Defect  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS
  • Targeting Skeletal Muscle to Improve Metabolic Health in Individuals with Spinal Cord Injury  awarded by National Institute of Child Health and Human Development/NIH/DHHS
  • The Metabolomic Consequences of Small Size and Long Life  awarded by National Institute on Aging/NIH/DHHS
  • The Role of PPARdelta Signaling in Diabetic Cardiomyopathy  awarded by American Diabetes Association, Inc.
  • The Role of Wheat-Gluten in Polycystic Kidney Disease  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • Therapeutic Targeting of the Myofibroblast in Fibrotic Lung Disease  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Therapeutic Targeting of the Myofibroblast in Fibrotic Lung Disease - Clinical Core  awarded by TULANE UNIVERSITY
  • Therapeutic Targeting of the Myofibroblast in Fibrotic Lung Disease - Core C: Clinical Core  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Therapeutic Targeting of the Myofibroblast in Fibrotic Lung Disease - Project Two: Redox Regulation of Metabolic Reprogramming in Activated Myofibroblasts  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Training Program in Cardiovascular Pathophysiology  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • UAB Diabetes Research Center  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • UAB Nutrition Obesity Research Center  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • UAB Nutrition Obesity Research Center  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • UAB Nutrition Obesity Research Center (NORC)  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • UAB Nutrition Obesity Research Center (NORC)  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • UAB Nutrition Obesity Research Center (NORC)  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • UAB Skin Disease Research Center  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS
  • UAB-UCSD O'Brien Center for Acute Kidney Injury Research  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • UAB-UCSD O'Brien Core Center for Acute Kidney Injury Research  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • UAB-UCSD O'Brien Core Center for Acute Kidney Injury Research - Administrative Core  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • UAB/UCSD O'Brien Core Center for Acute Kidney Injury Research  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • Teaching Activities

  • 10-432 - WHAT PRACTITIONERS NEED TO KNOW ABOUT HERBAL MEDICINE (Fall Term 2009)
  • 10-432 - WHAT PRACTITIONERS NEED TO KNOW ABOUT HERBAL MEDICINE (Spring Term 2007)
  • BMG744 - Protein Mass Spectrometry (Spring Term 2008)
  • BMG744 - Protein Mass Spectrometry (Spring Term 2009)
  • BMG744 - Protein Mass Spectrometry (Spring Term 2010)
  • BMG744 - Protein Mass Spectrometry (Spring Term 2011)
  • BMG744 - Protein Mass Spectrometry (Spring Term 2012)
  • BMG744 - Protein Mass Spectrometry (Spring Term 2013)
  • BMG744 - Protein Mass Spectrometry (Spring Term 2014)
  • ENH699 - Masters Level Project Res (Fall Term 2010)
  • ENH699 - Masters Level Project Res (Fall Term 2011)
  • ENH699 - Masters Level Project Res (Spring Term 2010)
  • ENH699 - Masters Level Project Res (Spring Term 2011)
  • ENH699 - Masters Level Project Res (Spring Term 2012)
  • ENH699 - Masters Level Project Res (Summer Term 2010)
  • ENH699 - Masters Level Project Res (Summer Term 2011)
  • ENH699 - Masters Level Project Res (Summer Term 2012)
  • GBS748 - Special Topics (Spring Term 2015)
  • GBSC724 - Metabolomics (Spring Term 2016)
  • GBSC724 - Metabolomics (Spring Term 2017)
  • GBSC724 - Metabolomics (Spring Term 2018)
  • GBSC724 - Metabolomics (Spring Term 2019)
  • GBSC724 - Metabolomics (Spring Term 2020)
  • GBSC724 - Metabolomics (Spring Term 2021)
  • GBSC724 - Metabolomics (Spring Term 2022)
  • GBSC724 - Metabolomics (Spring Term 2023)
  • OBHS121 - Fundamentals of Dent and Opt 2 (Fall Term 2011)
  • PHR744 - Protein Mass Spectrometry (Spring Term 2008)
  • PHR744 - Protein Mass Spectrometry (Spring Term 2009)
  • PHR744 - Protein Mass Spectrometry (Spring Term 2010)
  • PHR744 - Protein Mass Spectrometry (Spring Term 2011)
  • Education And Training

  • Doctor of Philosophy Level Degree in Biochemistry, Imperial College London 1972
  • Bachelor's Level Degree in Chemistry, University of Surrey 1967
  • Full Name

  • Stephen Barnes
  • Fax

  • 205-934-6944