Texas A&M University, College Station, TX Zoology, B.S. 1983
    Texas A&M University, College Station, TX Wildlife Fisheries, M.S 1987
    Emory University School of Medicine, Atlanta, GA Biochemistry, Ph.D. 1993

    1993-1994 Environmental Pathology Postdoctoral Fellow, Vermont Cancer Center, University of Vermont, Burlington, VT

    1994-1996 Alexander Hollaender Distinguished Postdoctoral Fellow, Vermont Cancer Center, Burlington, VT

    2015- present Professor, Nathan Shock Center for Aging, University of Alabama at
    Birmingham, Birmingham, AL.
    2014- present Senior Scientist, Center for Exercise Medicine, University of Alabama
    at Birmingham, Birmingham, AL
    2014- present Senior Scientist, Nutrition and Obesity Research Center, University of
    at Birmingham, Birmingham, AL
    2011- present Professor, Center for Healthy Aging, University of Alabama at
    Birmingham, Birmingham, AL
    2011-present Professor, Comprehensive Cardiovascular Center, University of
    Alabama at Birmingham, Birmingham, AL
    2011-present Professor, Comprehensive Cancer Center, University of
    Alabama at Birmingham, Birmingham, AL
    2011-present Professor, tenured, Department of Pathology,
    University of Alabama at Birmingham, Birmingham, AL
    2011-present Professor, Department of Environmental Health Sciences, University of Alabama at Birmingham, Birmingham, AL
    2011-present Professor, Center for Free Radical Biology, University of
    Alabama at Birmingham, Birmingham, AL
    2010-2011 Associate Professor, Center for Cardiovascular Biology, University of
    Alabama at Birmingham, Birmingham, AL
    2009-2011 Associate Professor, Comprehensive Cancer Center, University of
    Alabama at Birmingham, Birmingham, AL
    2005-2011 Associate Professor, tenured, Department of Pathology,
    University of Alabama at Birmingham, Birmingham, AL
    2002-2005 Associate Professor, tenure earning, Department of Pathology,
    University of Alabama at Birmingham, Birmingham, AL
    2002-2011 Associate Professor, Department of Environmental Health Sciences, University of Alabama at Birmingham, Birmingham, AL
    2002-2011 Associate Professor, Center for Free Radical Biology, University of
    Alabama at Birmingham, Birmingham, AL
    2000-2002 Assistant Professor, Department of Pharmacology, University of Texas
    Medical Branch, Galveston, TX
    2000-2002 Assistant Professor, Department of Preventative Medicine and
    Community Health, University of Texas Medical Branch, Galveston, TX
    1998-2002 Assistant Professor, Sealy Center for Molecular Cardiology, University
    of Texas Medical Branch, Galveston, TX
    1996-1998 Assistant Scientist, Sealy Center for Molecular Cardiology, University
    of Texas Medical Branch, Galveston, TX

    Alexander Hollaender Distinguished Fellowship: U.S. Department of Energy
    Environmental Pathology Fellowship: University of Vermont-NIH
    Young Investigator Award: American Lung Association: New Hampshire-Vermont
    Burroughs-Wellcome Nominee: University of Vermont
    Outstanding Faculty Award, Molecular and Cellular Pathology Graduate Students
    College of Science Academy of Distinguished Former Students Award, Texas A&M University

    Environmental Mutagen Society
    American Heart Association
    American Association for the Advancement of Science
    The Society for Free Radical Biology & Medicine
    The Nitric Oxide Society
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2022 Mesenchymal stem cell bioenergetics and apoptosis are associated with risk for bronchopulmonary dysplasia in extremely low birth weight infantsScientific Reports.  12. 2022
    2022 Scientific opportunities in resilience research for cardiovascular health and wellness. Report from a National Heart, Lung, and Blood Institute workshop 2022
    2022 Mitochondrial haplogroup association with fasting glucose response in African Americans treated with a thiazide diureticF1000Research.  11:758. 2022
    2022 Activation of Autophagic Flux Maintains Mitochondrial Homeostasis during Cardiac Ischemia/Reperfusion InjuryCells.  11. 2022
    2022 Racial Differences in XO (Xanthine Oxidase) and Mitochondrial DNA Damage-Associated Molecular Patterns in Resistant HypertensionHypertension.  79:775-784. 2022
    2022 Targeting whole body metabolism and mitochondrial bioenergetics in the drug development for Alzheimer's diseaseActa Pharmaceutica Sinica B.  12:511-531. 2022
    2022 Mitochondrial haplogroup association with fasting glucose response in African Americans treated with a thiazide diureticF1000Research.  11:758. 2022
    2021 Hedgehog signaling regulates metabolism and polarization of mammary tumor-associated macrophagesCancer Research.  81:5425-5437. 2021
    2021 Mito: Mendelian interactions alter in vivo glucose metabolism and insulin sensitivity in healthy mice 2021
    2021 University of Alabama at Birmingham Nathan Shock Center: comparative energetics of agingGeroscience.  43:2149-2160. 2021
    2020 An evolutionary, or “Mitocentric” perspective on cellular function and diseaseRedox Biology.  36. 2020
    2020 Mitochondrial genetics cooperate with nuclear genetics to selectively alter immune cell development/trafficking 2020
    2020 Role of the tumor microenvironment in regulating the anti-metastatic effect of KISS1Clinical and Experimental Metastasis.  37:209-223. 2020
    2019 Early Life Supraphysiological Levels of Oxygen Exposure Permanently Impairs Hippocampal Mitochondrial FunctionScientific Reports.  9. 2019
    2019 The Histone Demethylase KDM3A, Increased in Human Pancreatic Tumors, Regulates Expression of DCLK1 and Promotes Tumorigenesis in MiceGastroenterology.  157:1646-1659.e11. 2019
    2019 Unlocking the Secrets of Mitochondria in the Cardiovascular System: Path to a Cure in Heart Failure—A Report from the 2018 National Heart, Lung, and Blood Institute WorkshopCirculation.  140:1205-1216. 2019
    2019 KISS1 in breast cancer progression and autophagyCancer and Metastasis Reviews.  38:493-506. 2019
    2019 Mitochondrial genetics regulate nuclear gene expression through metabolites 2019
    2019 Defining the Hallmarks of MetastasisCancer Research.  79:3011-3027. 2019
    2019 HDAC inhibition induces autophagy and mitochondrial biogenesis to maintain mitochondrial homeostasis during cardiac ischemia/reperfusion injuryJournal of Molecular and Cellular Cardiology.  130:36-48. 2019
    2019 The isolated C-terminal nuclear localization sequence of the breast cancer metastasis suppressor 1 is disorderedMolecular cell biology research communications : MCBRC.  664:95-101. 2019
    2019 Bioenergetics and translational metabolism: Implications for genetics, physiology and precision medicine 2019
    2019 Mitochondrial DNA variation modulates alveolar development in newborn mice exposed to hyperoxia 2019
    2018 Mitochondrial polymorphisms contribute to aging phenotypes in MNX mouse modelsCancer and Metastasis Reviews.  37:633-642. 2018
    2018 Roles of the mitochondrial genetics in cancer metastasis: not to be ignored any longerCancer and Metastasis Reviews.  37:615-632. 2018
    2018 Mitochondrial – nuclear genetic interaction modulates whole body metabolism, adiposity and gene expression in vivoEBioMedicine.  36:316-328. 2018
    2018 Reply to shah et al.American Journal of Respiratory and Critical Care Medicine.  197:1363-1364. 2018
    2018 Automated quantitative image analysis for ex vivo metastasis assays reveals differing lung composition requirements for metastasis suppression by KISS1Clinical and Experimental Metastasis.  35:77-86. 2018
    2017 Mitochondrial haplotype alters mammary cancer tumorigenicity and metastasis in an oncogenic driver–dependent mannerCancer Research.  77:6941-6949. 2017
    2017 Mitochondrial genomic backgrounds affect nuclear DNA methylation and gene expressionCancer Research.  77:6202-6214. 2017
    2017 Astrocytes promote progression of breast cancer metastases to the brain via a KISS1-mediated autophagyAutophagy.  13:1905-1923. 2017
    2017 Mitochondrial toxicity of tobacco smoke and air pollutionToxicology.  391:18-33. 2017
    2017 Vascular endothelial mitochondrial function predicts death or pulmonary outcomes in preterm infantsAmerican Journal of Respiratory and Critical Care Medicine.  196:1040-1049. 2017
    2017 The KISS1 metastasis suppressor appears to reverse the Warburg effect by shifting from glycolysis to mitochondrial beta-oxidationJournal of Molecular Medicine.  95:951-963. 2017
    2017 Gd2O3-doped silica @ Au nanoparticles for in vitro imaging cancer biomarkers using surface-enhanced Raman scatteringSpectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy.  181:218-225. 2017
    2017 Mitochondrial DNA mutations and cardiovascular diseaseCurrent Opinion in Cardiology.  32:267-274. 2017
    2017 Genome-wide in vivo RNAi screen identifies ITIH5 as a metastasis suppressor in pancreatic cancerClinical and Experimental Metastasis.  34:229-239. 2017
    2017 Mitophagy and mitochondrial biogenesis in atrial tissue of patients undergoing heart surgery with cardiopulmonary bypassJCI Insight.  2. 2017
    2017 Chloroquine-Inducible Par-4 Secretion Is Essential for Tumor Cell Apoptosis and Inhibition of MetastasisCell Reports.  18:508-519. 2017
    2016 Generation of Mitochondrial-nuclear eXchange Mice via Pronuclear Transfer.Bio-protocol.  6. 2016
    2016 Suppression of pancreatic cancer growth and metastasis by HMP19 identified through genome-wide shRNA screenInternational Journal of Cancer.  139:628-638. 2016
    2016 Targeting the untargetable? Nodal expression in TNBCCell Cycle.  15:1400. 2016
    2016 Tumor cell invasion-not all barriers are created equalCancer Research.  76:1675-1676. 2016
    2016 Mitochondrial DNA damage and vascular function in patients with diabetes mellitus and atherosclerotic cardiovascular diseaseCardiovascular Diabetology.  15. 2016
    2016 Endothelial Cell Bioenergetics and Mitochondrial DNA Damage Differ in Humans Having African or West Eurasian Maternal AncestryCirculation: Cardiovascular Genetics.  9:26-36. 2016
    2016 Cyclin-dependent kinase-mediated phosphorylation of breast cancer metastasis suppressor 1 (BRMS1) affects cell migrationCell Cycle.  15:137-151. 2016
    2016 Tumor heterogeneity - A 'contemporary concept' founded on historical insights and predictionsCancer Research.  76:4-6. 2016
    2015 In vitro biophysical, microspectroscopic and cytotoxic evaluation of metastatic and non-metastatic cancer cells in responses to anti-cancer drug 2015
    2015 Essential components of cancer educationCancer Research.  75:5202-5205. 2015
    2015 Mitochondrial genetics regulate breast cancer Tumorigenicity and Metastatic potentialCancer Research.  75:4429-4436. 2015
    2015 Mitochondrial-nuclear DNA mismatch mattersScience.  349:1449-1450. 2015
    2015 Bioenergetic programming of macrophages by the apolipoprotein A-I mimetic peptide 4FBiochemical Journal.  467:517-527. 2015
    2015 MTBP inhibits migration and metastasis of hepatocellular carcinomaClinical and Experimental Metastasis.  32:301-311. 2015
    2015 Crocetinic acid inhibits hedgehog signaling to inhibit pancreatic cancer stem cellsOncotarget.  6:27661-27673. 2015
    2014 An ex-vivo model for evaluating bioenergetics in aortic ringsRedox Biology.  2:1003-1007. 2014
    2014 Expression of metastasis suppressor BRMS1 in breast cancer cells results in a marked delay in cellular adhesion to matrixMolecular Carcinogenesis.  53:1011-1026. 2014
    2014 Microenvironmental Influences on Metastasis Suppressor Expression and Function during a Metastatic Cell’s JourneyCancer Microenvironment.  7:117-131. 2014
    2014 Imaging of epidermal growth factor receptor on single breast cancer cells using surface-enhanced Raman spectroscopyAnalytica Chimica Acta.  843:73-82. 2014
    2014 Aging and energetics' 'Top 40' future research opportunities 2010-2013F1000Research.  3. 2014
    2014 Toward a drug development path that targets metastatic progression in osteosarcomaClinical Cancer Research.  20:4200-4209. 2014
    2014 Mitochondrial-nuclear genome interactions in non-alcoholic fatty liver disease in miceBiochemical Journal.  461:223-232. 2014
    2014 Metastasis suppressor KISS1Seemsto reverse the warburg effect by enhancing mitochondrial biogenesisCancer Research.  74:954-963. 2014
    2014 Furin is the major proprotein convertase required for KISS1-to-Kisspeptin processingPLoS One.  9. 2014
    2014 A method for assessing mitochondrial bioenergetics in whole white adipose tissuesRedox Biology.  2:656-660. 2014
    2014 Breast cancer metastasis suppressor-1 promoter methylation in cell-free DNA provides prognostic information in non-small cell lung cancer.British Journal of Cancer.  110:2054-2062. 2014
    2014 Metastasis suppressors in breast cancers: Mechanistic insights and clinical potentialJournal of Molecular Medicine.  92:13-30. 2014
    2014 Nuclear localization of Kaiso promotes the poorly differentiated phenotype and EMT in infiltrating ductal carcinomasClinical and Experimental Metastasis.  31:497-510. 2014
    2014 The Bioenergetic Health Index: a new concept in mitochondrial translational research.Clinical Science.  127:367-373. 2014
    2013 Erratum: Mitochondrial genetic background modulates bioenergetics and susceptibility to acute cardiac volume overload (Biochemical Journal (2013) 455 (157-167))Biochemical Journal.  456:147. 2013
    2013 Xanthine oxidase inhibition preserves left ventricular systolic but not diastolic function in cardiac volume overload 2013
    2013 MCF-7 cells expressing nuclear associated lysyl oxidase-like 2 (LOXL2) exhibit an epithelial-to-Mesenchymal transition (EMT) phenotype and are highly invasive in VitroJournal of Biological Chemistry.  288:30000-30008. 2013
    2013 Mitochondrial genetic background modulates bioenergetics and susceptibility to acute cardiac volume overloadBiochemical Journal.  455:157-167. 2013
    2013 BRSM1 promoter methylation provides prognostic information in primary breast tumorsMolecular Cancer Research.  11:1248-1257. 2013
    2013 Mitochondrial Bioenergetics of Metastatic Breast Cancer Cells in Response to Dynamic Changes in Oxygen Tension: Effects of HIF-1αPLoS One.  8. 2013
    2013 Developmental Exposure to Second-Hand Smoke Increases Adult Atherogenesis and Alters Mitochondrial DNA Copy Number and Deletions in apoE-/- MicePLoS One.  8. 2013
    2013 Methods for defining distinct bioenergetic profiles in platelets, lymphocytes, monocytes, and neutrophils, and the oxidative burst from human bloodLaboratory Investigation.  93:690-700. 2013
    2013 Unraveling the 'TGF-β paradox' one metastamir at a timeBreast Cancer Research.  15. 2013
    2013 The C-Terminal Putative Nuclear Localization Sequence of BReast cancer Metastasis Suppressor 1, BRMS1, Is Necessary for Metastasis SuppressionPLoS One.  8. 2013
    2013 Beyond retrograde and anterograde signalling: Mitochondrial-nuclear interactions as a means for evolutionary adaptation and contemporary disease susceptibilityBiochemical Society Transactions.  41:111-117. 2013
    2013 Convergent mechanisms for dysregulation of mitochondrial quality control in metabolic disease: Implications for mitochondrial therapeuticsBiochemical Society Transactions.  41:127-133. 2013
    2013 MTBP suppresses cell migration and filopodia formation by inhibiting ACTN4Oncogene.  32:462-470. 2013
    2013 Mitochondrial genetics and obesity: Evolutionary adaptation and contemporary disease susceptibilityFree Radical Biology and Medicine.  65:1229-1237. 2013
    2012 Integration of cellular bioenergetics with mitochondrial quality control and autophagy 2012
    2012 PrefaceCancer and Metastasis Reviews.  31:417-418. 2012
    2012 Allelic variation and differential expression of the mSIN3A histone deacetylase complex gene Arid4b promote mammary tumor growth and metastasisPLoS Genetics.  8. 2012
    2012 Clinical significance of KISS1 protein expression for brain invasion and metastasisCancer.  118:2096-2105. 2012
    2012 Ubiquitous Brms1 expression is critical for mammary carcinoma metastasis suppression via promotion of apoptosisClinical and Experimental Metastasis.  29:315-325. 2012
    2012 Clinical and biological significance of KISS1 expression in prostate cancerAmerican Journal of Pathology.  180:1170-1178. 2012
    2012 Cytoplasmic BRMS1 expression in malignant melanoma is associated with increased disease-free survivalBMC Cancer.  12. 2012
    2012 Subsets of ATP-sensitive potassium channel (K ATP) inhibitors increase gap junctional intercellular communication in metastatic cancer cell lines independent of sur expressionFEBS Letters.  586:27-31. 2012
    2011 Novel insights into interactions between mitochondria and xanthine oxidase in acute cardiac volume overloadFree Radical Biology and Medicine.  51:1975-1984. 2011
    2011 Protein signatures in human MDA-MB-231 breast cancer cells indicating a more invasive phenotype following knockdown of human endometase/matrilysin-2 by siRNAJournal of Cancer.  2:165-176. 2011
    2011 3,5-bis(2,4-difluorobenzylidene)-4-piperidone, a novel compound that affects pancreatic cancer growth and angiogenesisMolecular Cancer Therapeutics.  10:2146-2156. 2011
    2011 Unraveling the enigmatic complexities of BRMS1-mediated metastasis suppressionFEBS Letters.  585:3185-3190. 2011
    2011 The mitochondrial paradigm for cardiovascular disease susceptibility and cellular function: A complementary concept to Mendelian geneticsLaboratory Investigation.  91:1122-1135. 2011
    2011 Gli1 enhances migration and invasion via up-regulation of MMP-11 and promotes metastasis in ERα negative breast cancer cell linesClinical and Experimental Metastasis.  28:437-449. 2011
    2011 Mitochondrial oxidative stress significantly influences atherogenic risk and cytokine induced oxidant productionEnvironmental Health Perspectives.  119:676-681. 2011
    2011 Metastasis suppressors and the tumor microenvironmentSeminars in Cancer Biology.  21:113-122. 2011
    2011 Role of reactive oxygen species in injury-induced insulin resistance 2011
    2011 Prognostic significance of BRMS1 expression in human melanoma and its role in tumor angiogenesisOncogene.  30:896-906. 2011
    2011 Loss of interstitial collagen causes structural and functional alterations of cardiomyocyte subsarcolemmal mitochondria in acute volume overloadJournal of Molecular and Cellular Cardiology.  50:147-156. 2011
    2011 Metastasis suppressor genes. At the interface between the environment and tumor cell growthInternational review of cell and molecular biology.  286:107-180. 2011
    2011 Pre-osteoblastic MC3T3-E1 cells promote breast cancer growth in bone in a murine xenograft modelChinese journal of cancer.  30:189-196. 2011
    2010 Homotypic gap junctional communication associated with metastasis suppression increases with PKA activity and is unaffected by PI3K inhibitionCancer Research.  70:10002-10011. 2010
    2010 KISS1 over-expression suppresses metastasis of pancreatic adenocarcinoma in a xenograft mouse modelClinical and Experimental Metastasis.  27:591-600. 2010
    2010 Perinatal tobacco smoke exposure increases vascular oxidative stress and mitochondrial damage in non-human primatesCardiovascular Toxicology.  10:216-226. 2010
    2010 Modulation of mammary cancer cell migration by 15-deoxy-Δ 12,14-prostaglandin J2: Implications for anti-metastatic therapyBiochemical Journal.  430:69-78. 2010
    2010 The KISS1 metastasis suppressor: A good night kiss for disseminated cancer cellsEuropean Journal of Cancer.  46:1283-1289. 2010
    2010 Linking metastasis suppression with metastamir regulation 2010
    2009 Free fatty acids enhance breast cancer cell migration through plasminogen activator inhibitor-1 and SMAD4Laboratory Investigation.  89:1221-1228. 2009
    2009 Breast cancer metastasis suppressor 1 coordinately regulates metastasis-associated microRNA expressionInternational Journal of Cancer.  125:1778-1785. 2009
    2009 Metastamir: The field of metastasis-regulatory microRNA is spreadingCancer Research.  69:7495-7498. 2009
    2009 Linking metastasis suppression with metastamiR regulationCell Cycle.  8:2673-2675. 2009
    2009 Expression of the Breast Cancer Metastasis Suppressor 1 (BRMS1) maintains in vitro chemosensitivity of breast cancer cellsCancer Letters.  281:100-107. 2009
    2009 Nuclear magnetic resonance and circular dichroism study of metastin (Kisspeptin-54) structure in solutionClinical and Experimental Metastasis.  26:527-533. 2009
    2009 Pulmonary ozone exposure induces vascular dysfunction, mitochondrial damage, and atherogenesis 2009
    2009 Preclinical drug development must consider the impact on metastasisClinical Cancer Research.  15:4529-4530. 2009
    2009 Inhibition of CXCR4 by CTCE-9908 inhibits breast cancer metastasis to lung and bone 2009
    2009 Over-expression of the BRMS1 family member SUDS3 does not suppress metastasis of human cancer cellsCancer Letters.  276:32-37. 2009
    2009 Ethanol and tobacco smoke increase hepatic steatosis and hypoxia in the hypercholesterolemic apoE-/- mouse: Implications for a "multihit" hypothesis of fatty liver diseaseFree Radical Biology and Medicine.  46:928-938. 2009
    2009 BRMS1 contributes to the negative regulation of uPA gene expression through recruitment of HDAC1 to the NF-κB binding site of the uPA promoterClinical and Experimental Metastasis.  26:229-237. 2009
    2009 Breast cancer metastasis suppressor 1 up-regulates miR-146, Which suppresses breast cancer metastasisCancer Research.  69:1279-1283. 2009
    2009 Multiple forms of BRMS1 are differentially expressed in the MCF10 isogenic breast cancer progression modelClinical and Experimental Metastasis.  26:89-96. 2009
    2009 A shift from nuclear to cytoplasmic breast cancer metastasis suppressor 1 expression is associated with highly proliferative estrogen receptor-negative breast cancers 2009
    2009 Metastasis of hormone receptor positive breast cancerCancer Treatment and Research.  147:73-94. 2009
    2008 Expressing connexin 43 in breast cancer cells reduces their metastasis to lungsClinical and Experimental Metastasis.  25:893-901. 2008
    2008 Metastasis suppressors and the tumor microenvironmentCancer Microenvironment.  1:1-11. 2008
    2008 Epigenetic silencing contributes to the loss of BRMS1 expression in breast cancerClinical and Experimental Metastasis.  25:753-763. 2008
    2008 New insights into the role of CXCR4 in prostate cancer metastasisCancer Biology and Therapy.  7:1849-1851. 2008
    2008 New insights into the role of CXCR4 in prostate cancer metastasisCancer Biology and Therapy.  7:1850-1852. 2008
    2008 Breast cancer metastasis suppressor-1 differentially modulates growth factor signalingJournal of Biological Chemistry.  283:28354-28360. 2008
    2008 Downregulation of osteopontin contributes to metastasis suppression by breast cancer metastasis suppressor 1International Journal of Cancer.  123:526-534. 2008
    2008 Alterations of BRMS1-ARID4A interaction modify gene expression but still suppress metastasis in human breast cancer cellsJournal of Biological Chemistry.  283:7438-7444. 2008
    2008 Metastasis suppressors genes in cancer 2008
    2008 BRMS1 suppresses breast cancer experimental metastasis to multiple organs by inhibiting several steps of the metastatic processAmerican Journal of Pathology.  172:809-817. 2008
    2008 Osteoprotegrin and the bone homing and colonization potential of breast cancer cellsJournal of Cellular Biochemistry.  103:30-41. 2008
    2007 A MSC-ing link in metastasis?Nature Medicine.  13:1289-1291. 2007
    2007 Effect of alcohol and tobacco smoke on mtDNA damage and atherogenesisFree Radical Biology and Medicine.  43:1279-1288. 2007
    2007 Microarray analysis reveals potential mechanisms of BRMS1-mediated metastasis suppressionClinical and Experimental Metastasis.  24:551-565. 2007
    2007 C16 laminin peptide increases angiotropic extravascular migration of human melanoma cells in a shell-less chick chorioallantoic membrane assayBritish Journal of Dermatology.  157:780-782. 2007
    2007 Breast cancer progression: Controversies and consensus in the molecular mechanisms of metastasis and EMTJournal of Mammary Gland Biology and Neoplasia.  12:99-102. 2007
    2007 Metastasis suppressors and their roles in breast carcinomaJournal of Mammary Gland Biology and Neoplasia.  12:175-190. 2007
    2007 The role of tobacco smoke induced mitochondrial damage in vascular dysfunction and atherosclerosisMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis.  621:61-74. 2007
    2007 Metastasis: recent discoveries and novel treatment strategies 2007
    2007 Requirement of KISS1 secretion for multiple organ metastasis suppression and maintenance of tumor dormancy 2007
    2007 Breast cancer metastasis suppressor 1 (BRMS1) inhibits osteopontin transcription by abrogating NF-κB activationMolecular Cancer.  6. 2007
    2007 Human breast fibroblasts inhibit growth of the MCF10AT xenograft model of proliferative breast diseaseAmerican Journal of Pathology.  170:1064-1076. 2007
    2006 Loss of breast cancer metastasis suppressor 1 protein expression predicts reduced disease-free survival in subsets of breast cancer patientsClinical Cancer Research.  12:6702-6708. 2006
    2006 S-adenosylmethionine prevents chronic alcohol-induced mitochondrial dysfunction in the rat liver 2006
    2006 Breast cancer metastasis suppressor 1 (BRMS1) is stabilized by the Hsp90 chaperoneBiochemical and Biophysical Research Communications.  348:1429-1435. 2006
    2006 Free radicals, mitochondria, and oxidized lipids: The emerging role in signal transduction in vascular cellsCirculation Research.  99:924-932. 2006
    2006 Metastasis suppressor proteins: Discovery, molecular mechanisms, and clinical applicationClinical Cancer Research.  12:3882-3889. 2006
    2006 Angiotropism of human melanoma: Studies involving in transit and other cutaneous metastases and the chicken chorioallantoic membrane - Implications for extravascular melanoma invasion and metastasisAmerican Journal of Dermatopathology.  28:187-193. 2006
    2006 Suppression of murine mammary carcinoma metastasis by the murine ortholog of breast cancer metastasis suppressor 1 (Brms1)Cancer Letters.  235:260-265. 2006
    2006 Osteopontin knockdown suppresses tumorigenicity of human metastatic breast carcinoma, MDA-MB-435Clinical and Experimental Metastasis.  23:123-133. 2006
    2006 Kinetics of metastatic breast cancer cell trafficking in boneClinical Cancer Research.  12:1431-1440. 2006
    2006 The metabolic syndrome resulting from a knockout of the NEIL1 DNA glycosylase 2006
    2006 Do we need to redefine a cancer metastasis and staging definitions?Breast Disease.  26:3-12. 2006
    2006 Hedgehog signaling and response to cyclopamine differ in epithelial and stromal cells in benign breast and breast cancerCancer Biology and Therapy.  5:674-683. 2006
    2006 Pathogenesis of osteopenia/osteoporosis induced by highly active anti-retroviral therapy for AIDSAnnals of the New York Academy of Sciences.  1068:297-308. 2006
    2006 The KISS1 metastasis suppressor: Mechanistic insights and clinical utilityFrontiers in Bioscience-Landmark.  11:647-659. 2006
    2005 Environmental contributions to cardiovascular disease: Particulates and ozoneDrug Discovery Today: Disease Mechanisms.  2:71-75. 2005
    2005 Endogenous osteonectin/SPARC/BM-40 expression inhibits MDA-MB-231 breast cancer cell metastasisCancer Research.  65:7370-7377. 2005
    2005 Metastasis of hormone-independent breast cancer to lung and bone is decreased by α-difluoromethylornithine treatmentBreast Cancer Research.  7. 2005
    2005 Mitochondrial dysfunction in cardiovascular diseaseFree Radical Biology and Medicine.  38:1278-1295. 2005
    2005 Breast cancer metastasis suppressor 1 inhibits gene expression by targeting nuclear factor-κB activityCancer Research.  65:3586-3595. 2005
    2005 Reactive species-mediated regulation of cell signaling and the cell cycle: The role of MAPKAntioxidants and Redox Signaling.  7:726-740. 2005
    2005 Differential effects of exercise on aortic mitochondria 2005
    2005 Metastasis suppression by breast cancer metastasis suppressor 1 involves reduction of phosphoinositide signaling in MDA-MB-435 breast carcinoma cellsCancer Research.  65:713-717. 2005
    2005 Breast fibroblasts modulate epithelial cell proliferation in three-dimensional in vitro co-culture.Breast Cancer Research.  7. 2005
    2004 Prenatal environmental tobacco smoke exposure promotes adult atherogenesis and mitochondrial damage in apolipoprotein E-/- mice fed a chow dietCirculation.  110:3715-3720. 2004
    2004 Breast cancer cells induce osteoblast apoptosis: A possible contributor to bone degradationJournal of Cellular Biochemistry.  91:265-276. 2004
    2004 Breast cancer metastatic potential: Correlation with increased heterotypic gap junctional intercellular communication between breast cancer cells and osteoblastic cellsInternational Journal of Cancer.  111:693-697. 2004
    2004 A small molecule antagonist of the αυβ 3 integrin suppresses MDA-MB-435 skeletal metastasisClinical and Experimental Metastasis.  21:119-128. 2004
    2004 Identification of metastasis-associated proteins through protein analysis of metastatic MDA-MB-435 and metastasis-suppressed BRMS1 transfected-MDA-MB-435 cellsClinical and Experimental Metastasis.  21:149-157. 2004
    2004 Modification of the mitochondrial proteome in response to the stress of ethanol-dependent hepatotoxicityJournal of Biological Chemistry.  279:22092-22101. 2004
    2004 Capsaicin-mediated Denervation of Sensory Neurons Promotes Mammary Tumor Metastasis to Lung and Heart 2004
    2004 Microarrays bring new insights into understanding of breast cancer metastasis to boneBreast Cancer Research.  6:61-64. 2004
    2004 Breast Cancer Metastasis Suppressor 1 (BRMS1) Forms Complexes with Retinoblastoma-binding Protein 1 (RBP1) and the mSin3 Histone Deacetylase Complex and Represses TranscriptionJournal of Biological Chemistry.  279:1562-1569. 2004
    2004 Pericyte-Like Location of GFP-Tagged Melanoma Cells: Ex Vivo and in Vivo Studies of Extravascular Migratory MetastasisAmerican Journal of Pathology.  164:1191-1198. 2004
    2003 Reduction of infarct size by short-term pretreatment with atorvastatinCardiovascular Drugs and Therapy.  17:25-30. 2003
    2003 Metastasis suppressor pathways - An evolving paradigmCancer Letters.  198:1-20. 2003
    2003 Effects of α-difluoromethylornithine on local recurrence and pulmonary metastasis from MDA-MB-435 breast cancer xenografts in nude miceClinical and Experimental Metastasis.  20:321-325. 2003
    2003 MDA-MB-435 human breast carcinoma metastasis to boneClinical and Experimental Metastasis.  20:327-334. 2003
    2003 Erratum: Mucosally-derived HPV-40 can infect both human genital foreskin and cutaneous hand skin tissues grafted into athymic mice (Virus Research (2003) 93 (109-114))Virus Research.  94:65. 2003
    2003 A new member of the growing family of metastasis suppressors identified in prostate cancer 2003
    2003 A potential role for gap junctions in breast cancer metastasis to bone 2003
    2003 The skeleton as a unique environment for breast cancer cellsClinical and Experimental Metastasis.  20:275-284. 2003
    2003 Genetic background is an important determinant of metastatic potential [2]Nature Genetics.  34:23-25. 2003
    2003 Mucosally-derived HPV-40 can infect both human genital foreskin and cutaneous hand skin tissues grafted into athymic miceVirus Research.  93:109-114. 2003
    2003 Breast cancer metastasis suppressor 1: UpdateClinical and Experimental Metastasis.  20:45-50. 2003
    2003 KISS1 metastasis suppression and emergent pathwaysClinical and Experimental Metastasis.  20:11-18. 2003
    2003 Breast cancer metastasis to bone: Evolving models and research challenges 2003
    2003 Melanoma metastasis suppression by chromosome 6: Evidence for a pathway regulated by CRSP3 and TXNIPCancer Research.  63:432-440. 2003
    2003 Clinical & Experimental Metastasis: IntroductionClinical and Experimental Metastasis.  20:187. 2003
    2003 Clinical and Experimental Metastasis: IntroductionClinical and Experimental Metastasis.  20:1-2. 2003
    2002 Maintaining GFP tissue fluorescence through bone decalcification and long-term storage 2002
    2002 DNA sequence analysis of interlocus recombination between the human T-cell receptor gamma variable (GV) and beta diversity-joining (BD/BJ) sequences on chromosome 7 (inversion 7)Environmental and Molecular Mutagenesis.  40:85-92. 2002
    2002 B16F10 melanoma cell colonization of mouse lung is enhanced by partial pneumonectomyClinical and Experimental Metastasis.  19:369-376. 2002
    2002 Mitochondrial integrity and function in atherogenesisCirculation.  106:544-549. 2002
    2002 Comparative sequence analysis in eight inbred strains of the metastasis modifier QTL candidate gene Brms1Mammalian Genome.  13:289-292. 2002
    2002 Influence of polyamines on in vitro and in vivo features of aggressive and metastatic behavior by human breast cancer cellsClinical and Experimental Metastasis.  19:95-105. 2002
    2002 Cigarette smoke exposure and hypercholesterolemia increase mitochondrial damage in cardiovascular tissuesCirculation.  105:849-854. 2002
    2002 Cu/Zn superoxide dismutase plays a role in angiogenesisInternational Journal of Cancer.  97:34-41. 2002
    2002 Suppression of human melanoma metastasis by the metastasis suppressor gene, BRMS1Experimental Cell Research.  273:229-239. 2002
    2001 Predisposition to efficient mammary tumor metastatic progression is linked to the breast cancer metastasis suppressor gene Brms1Cancer Research.  61:8866-8872. 2001
    2001 Breast cancer progression and metastasis: Experimental studies and clinical translationJournal of Mammary Gland Biology and Neoplasia.  6:373-374. 2001
    2001 Genetic basis of human breast cancer metastasisJournal of Mammary Gland Biology and Neoplasia.  6:441-451. 2001
    2001 Breast cancer metastatic potential correlates with a breakdown in homospecific and heterospecific gap junctional intercellular communicationCancer Research.  61:1765-1767. 2001
    2001 Aging, oxidative responses, and proliferative capacity in cultured mouse aortic smooth muscle cells 2001
    2001 Analysis of mechanisms underlying BRMS1 suppression of metastasisClinical and Experimental Metastasis.  18:683-693. 2001
    2001 Suppression of C8161 melanoma metastatic ability by chromosome 6 induces differentiation-associated tyrosinase and decreases proliferation on adhesion-restrictive substrates mediated by overexpression of p21WAF1 and down-regulation of bcl-2 and cyclin D3Biochemical and Biophysical Research Communications.  281:159-165. 2001
    2000 Dipeptidyl peptidase IV (DPPIV) inhibits cellular invasion of melanoma cellsClinical and Experimental Metastasis.  18:391-400. 2000
    2000 Molecular biology of breast cancer metastasis. Genetic regulation of human breast carcinoma metastasisBreast Cancer Research.  2:408-416. 2000
    2000 The relationship of BRMS1 and RhoGDI2 gene expression to metastatic potential in lineage related human bladder cancer cell linesClinical and Experimental Metastasis.  18:519-525. 2000
    2000 Metastasis-suppressor genes: A review and perspective on an emerging field 2000
    2000 Defining the biologic role of genes that regulate prostate cancer metastasisCurrent Opinion in Urology.  10:397-401. 2000
    2000 Functional evidence for a novel human breast carcinoma metastasis suppressor, BRMS1, encoded at chromosome 11q13Cancer Research.  60:2764-2769. 2000
    2000 A human melanoma metastasis-suppressor locus maps to 6q16.3-q23International Journal of Cancer.  86:524-528. 2000
    2000 Hydrogen peroxide- and peroxynitrite-induced mitochondrial DNA damage and dysfunction in vascular endothelial and smooth muscle cellsCirculation Research.  86:960-966. 2000
    2000 Transfection of constitutively active mitogen-activated protein/extracellular signal-regulated kinase kinase confers tumorigenic and metastatic potentials to NIH3T3 cellsCancer Research.  60:1552-1556. 2000
    1999 Metastasis-suppressed C8161 melanoma cells arrest in lung but fail to proliferateClinical and Experimental Metastasis.  17:601-607. 1999
    1999 Increased protein kinase Cδ in mammary tumor cells: Relationship to transformation and metastatic progressionOncogene.  18:6748-6757. 1999
    1999 What defines a useful marker of metastasis in human cancer? 1999
    1999 Protein kinase C δ involvement in mammary tumor cell metastasisCancer Research.  59:3230-3238. 1999
    1999 Antioxidant vitamins: Sorting out the good and the not so goodJournal of the American College of Cardiology.  34:1216-1218. 1999
    1999 Hydrogen peroxide causes significant mitochondrial DNA damage in human RPE cellsExperimental Eye Research.  68:765-772. 1999
    1999 Hydrogen peroxide induces oxidative DNA damage in rat type II pulmonary epithelial cellsEnvironmental and Molecular Mutagenesis.  33:273-278. 1999
    1998 Chromosome localization and genomic structure of the KiSS-1 metastasis suppressor gene (KISS1)Genomics.  54:145-148. 1998
    1998 Genetic and epigenetic regulation of human breast cancer progression and metastasisEndocrine-Related Cancer.  5:155-197. 1998
    1998 In vitro loss of heterozygosity targets the PTEN/MMAC1 gene in melanoma 1998
    1998 Human melanoma metastasis is inhibited following ex vivo treatment with an antisense oligonucleotide to protein kinase C-αCancer Letters.  128:65-70. 1998
    1998 Correlation between reduction of metastasis in the MDA-MB-435 model system and increased expression of the kai-1 proteinMolecular Carcinogenesis.  21:111-120. 1998
    1997 KAII, a putative marker for metastatic potential in human breast cancerCancer Letters.  119:149-155. 1997
    1997 Identification of highly expressed genes in metastasis-suppressed chromosome 6/human malignant melanoma hybrid cells using subtractive hybridization and differential displayInternational Journal of Cancer.  71:1035-1044. 1997
    1997 Suppression of human melanoma metastasis following introduction of chromosome 6 is independent of NME1 (Nm23)Clinical and Experimental Metastasis.  15:259-265. 1997
    1997 Technical considerations for studying cancer metastasis in vivoClinical and Experimental Metastasis.  15:272-306. 1997
    1997 Suppression of metastasis in human breast carcinoma MDA-MB-435 cells after transfection with the metastasis suppressor gene, KiSS-1Cancer Research.  57:2384-2387. 1997
    1997 Elevated expression of the neutrophil calcium-binding protein, MRP-14, in metastasis-enhancing neutrophils 1997
    1996 Mitochondrial genome damage associated with cigarette smokingCancer Research.  56:5692-5697. 1996
    1996 Metastasis suppressed, but tumorigenicity and local invasiveness unaffected, in the human melanoma cell line MelJuSo after introduction of human chromosomes 1 or 6Molecular Carcinogenesis.  15:284-299. 1996
    1996 Suppression of MDA-MB-435 breast carcinoma cell metastasis following the introduction of human chromosome 11Cancer Research.  56:1222-1227. 1996
    1996 p53-independent increase in p21WAF1 and reciprocal down-regulation of cyclin A and proliferating cell nuclear antigen in bromodeoxyuridine-mediated growth arrest of human melanoma cellsMolecular Cancer Research.  7:197-202. 1996
    1996 KiSS-1, a novel human malignant melanoma metastasis-suppressor gene 1996
    1996 Molecular mechanisms controlling human melanoma progression and metastasis 1996
    1995 SOD2 (MnSOD) does not suppress tumorigenicity or metastasis of human melanoma C8161 cells 1995
    1995 The melanoma differentiation-associated gene mda-6, which encodes the cyclin-dependent kinase inhibitor p21, is differentially expressed during growth, differentiation and progression in human melanoma cellsOncogene.  10:1855-1864. 1995
    1995 Mitochondrial DNA mutations in human degenerative diseases and aging 1995
    1995 Suppression of human melanoma metastasis by introduction of chromosome 6 may be partially due to inhibition of motility, but not to inhibition of invasionBiochemical and Biophysical Research Communications.  208:476-484. 1995
    1995 Highly metastatic 13762NF rat mammary adenocarcinoma cell clones stimulate bone marrow by secretion of granulocyte-macrophage colony-stimulating factor/interleukin-3 activityAmerican Journal of Pathology.  147:1668-1681. 1995
    1995 Maternally transmitted diabetes and deafnessEndocrinologist.  5:104-112. 1995
    1994 Evidence for paracrine regulation of experimental metastasis in 13762NF rat mammary adenocarcinoma cell clones 1994
    1994 Enhanced metastatic ability of TNF-α-treated malignant melanoma cells is reduced by intercellular adhesion molecule-1 (ICAM-1, CD54) antisense oligonucleotidesExperimental Cell Research.  214:231-241. 1994
    1994 Is Tumor Cell Radiation Resistance Correlated with Metastatic Ability?Cancer Research.  54:1736-1741. 1994
    1994 Microcell-mediated transfer of chromosome 6 into metastatic human C8161 melanoma cells suppresses metastasis but does not inhibit tumorigenicityOncogene.  9:255-262. 1994
    1994 Microcell-mediated transfer of chromosome 6 into metastatic human C8161 melanoma cells suppresses metastasis but does not inhibit tumorigenicityOncogene.  9. 1994
    1994 Mitochondrial DNA Mutations in Epilepsy and Neurological DiseaseEpilepsia.  35:S43-S50. 1994
    1994 Mitochondrial Myopathies: Genetic Aspects 1994
    1994 Mitochondrial diabetes revisitedNature Genetics.  7:458-459. 1994
    1994 Mitochondrial myopathy with anemia, cardiomyopathy, and lactic acidosis: A distinct late onset mitochondrial disorderAmerican Journal of Medical Genetics Part A.  51:114-120. 1994
    1993 U-77,863: a novel cinnanamide isolated from Streptomyces griseoluteus that inhibits cancer invasion and metastasisClinical and Experimental Metastasis.  11:201-212. 1993
    1993 The use of monozygotic and dizygotic twins to estimate the effects of inheritance on the levels of immunoglobulin isotypes and antibodies to phosphocholineClinical Immunology.  66:176-180. 1993
    1992 Coexpression of vimentin and keratins by human melanoma tumor cells: Correlation with invasive and metastatic potential 1992
    1992 Allozyme and mitochondrial DNA analysis of a hybrid zone between white-tailed deer and mule deer (Odocoileus) in west texasBiochemical Genetics.  30:1-11. 1992
    1992 Erratum: Southeast Asian mitochondrial DNA analysis reveals genetic continuity of ancient Mongoloid migrations (Genetics (1992) 130 (139-152)) 1992
    1992 Maternally transmitted diabetes and deafness associated with a 10.4 kb mitochondrial DNA deletionNature Genetics.  1:11-15. 1992
    1992 Maternally transmitted diabetes and deafness associated with a 10.4 kb mitochondrial DNA deletion 1992
    1992 Southeast Asian mitochondrial DNA analysis reveals genetic continuity of ancient mongoloid migrations 1992
    1992 Subacute necrotizing encephalopathy: Oxidative phosphorylation defects and the ATPase 6 point mutationNeurology.  42:2168-2174. 1992
    1991 The structure of human mitochondrial DNA variationJournal of Molecular Evolution.  33:543-555. 1991
    1991 Rupture of the ascending aorta after surgical resection for lung cancer--a case report.The Japanese journal of surgery.  21:476-479. 1991
    1991 Characterization of a highly invasive and spontaneously metastatic human malignant melanoma cell lineInternational Journal of Cancer.  47:227-237. 1991
    1991 Human melanoma cell invasion is inhibited in vitro by swainsonine and deoxymannojirimycin with a concomitant decrease in collagenase IV expression 1991
    1991 Inhibition of Tumor Cell Invasion by VerapamilPigment Cell and Melanoma Research.  4:225-233. 1991
    1990 Tumor progression- and metastasis-associated proteins identified using a model of locally recurrent rat mammary adenocarcinomasClinical and Experimental Metastasis.  8:533-551. 1990
    1990 Myoclonic epilepsy and ragged-red fiber disease (MERRF) is associated with a mitochondrial DNA tRNALys mutationCell.  61:931-937. 1990
    1990 Amerindian mitochondrial DNAs have rare Asian mutations at high frequencies, suggesting they derived from four primary maternal lineagesAmerican Journal of Human Genetics.  46:613-623. 1990
    1990 Quantitation of human melanoma, carcinoma and sarcoma tumor cell adhesion to lymphatic endotheliumLymphology.  23:4-14. 1990
    1990 Transforming growth factor β stimulates mammary adenocarcinoma cell invasion and metastatic potential 1990
    1990 Transforming growth factor β stimulates mammary adenocarcinoma cell invasion and metastatic potential 1990
    1989 Neutrophil-mediated transfer of polar substances from liposomes to mammary tumor cells in vitroInternational Journal of Pharmaceutics.  53:167-173. 1989
    1989 Comparison of tumor cell invasion assays: human amnion versus reconstituted basement membrane barriersInvasion & metastasis.  9:278-297. 1989
    1989 Experimental model for locally recurring mammary tumors. Development, morphology, karyotype, growth kinetics, and experimental metastatic potentialCancer.  63:1353-1362. 1989
    1989 Tumor-elicited polymorphonuclear cells, in contrast to 'normal' circulating polymorphonuclear cells, stimulate invasive and metastatic potentials of rat mammary adenocarcinoma cells 1989
    1989 Use of the membrane invasion culture system (mics) as a screen for anti‐invasive agentsInternational Journal of Cancer.  43:449-457. 1989
    1988 Development and Characterization of a Rat Model for Locally Recurring Mammary Tumors: Sensitivities to 5-Fluoro-2’-deoxyuridine, Adriamycin, and X-IrradiationCancer Research.  48:4549-4554. 1988
    1988 Growth of Rat Mammary Adenocarcinoma Cells in Semisolid Clonogenic Medium Not Correlated with Spontaneous Metastatic Behavior: Heterogeneity in the Metastatic, Antigenic, Enzymatic, and Drug Sensitivity Properties of Cells from Different Sized ColoniesCancer Research.  48:399-404. 1988
    1988 Sensitivity of locally recurrent rat mammary tumour cell lines to syngeneic polymorphonuclear cell, macrophage and natural killer cell cytolysisBritish Journal of Cancer.  58:746-752. 1988
    1988 The role of polymorphonuclear leukocytes (PMN) on the growth and metastatic potential of 13762nf mammary adenocarcinoma cellsInternational Journal of Cancer.  42:748-759. 1988
    1987 Biologic considerations for drug targeting in cancer patientsCancer Treatment Reviews.  14:351-358. 1987
    1987 Degradation of Basement Membrane Type IV Collagen and Lung Subendothelial Matrix by Rat Mammary Adenocarcinoma Cell Clones of Differing Metastatic PotentialsCancer Research.  47:4869-4876. 1987
    1987 Short communication: Rat mammary adenocarcinoma heat-stress proteins in vivoInternational Journal of Hyperthermia.  3:467-473. 1987
    1986 Basement membrane degradative enzymes as possible markers of tumor metastasis.Progress in clinical and biological research.  212:113-122. 1986
    1986 Heat stress proteins and experimental cancer metastasisInternational Journal of Hyperthermia.  2:253-266. 1986
    1986 Mitochondrial DNA analysis of hybridization between sympatric white-tailed deer and mule and deer in west Texas 1986
    1985 Preferential organ attachment and invasion in vitro by B16 melanoma cells selected for differing metastatic colonization and invasive propertiesInvasion & metastasis.  5:144-158. 1985
    1985 Implications of tumor progression on clinical oncologyClinical and Experimental Metastasis.  3:151-188. 1985
    1985 Preferential organ adhesion and invasion by B16 melanoma cells selected for differing metastatic colonization properties 1985
    1984 Chromosome and DNA analyses of rat 13762NF mammary adenocarcinoma cell lines and clones of different metastatic potentialsClinical and Experimental Metastasis.  2:271-286. 1984
    1984 Multiple phenotypic divergence of mammary adenocarcinoma cell clones - I. In vitro and in vivo propertiesClinical and Experimental Metastasis.  2:333-355. 1984
    1984 Multiple phenotypic divergence of mammary adenocarcinoma cell clones. - II. Sensitivity to radiation, hyperthermia and FUdRClinical and Experimental Metastasis.  2:357-371. 1984
    1983 Comparison of 'spontaneous' and 'experimental' metastasis using rat 13762 mammary adenocarcinoma metastatic cell clonesInvasion & metastasis.  3:65-80. 1983
    1983 Phenotypic drift and heterogeneity in response of metastatic mammary adenocarcinoma cell clones to Adriamycin, 5-fluoro-2′-deoxyuridine and methotrexate treatment in vitroClinical and Experimental Metastasis.  1:317-325. 1983
    1983 Heterogeneous response and clonal drift of sensitivities of metastatic 13762nf mammary adenocarcinoma clones to ϒ-radiation in vitroCancer Research.  43:6-10. 1983
    1982 Development and biologic properties of malignant cell sublines and clones of a spontaneously metastasizing rat mammary adenocarcinoma 1982


    Year Title Altmetric
    2016 Preface.  Ed. 132.  2016


    Year Title Altmetric
    2021 Electrons and protons.  545-550. 2021
    2019 The second genome: Effects of the mitochondrial genome on cancer progression.  63-105. 2019
    2016 Beyond the primary tumor: Progression, invasion, and metastasis.  203-216. 2016
    2016 Breast Cancer Metastasis Suppressor 1 (BRMS1): Robust Biological and Pathological Data, But Still Enigmatic Mechanism of Action.  111-137. 2016
    2015 Invasion and Metastasis 2015
    2013 Reactive Oxygen and Nitrogen Species: Interactions with Mitochondria and Pathophysiology.  17-22. 2013
    2008 Invasion and metastasis.  253-264. 2008

    Research Overview

  • Dr. Ballinger’s group hypothesizes that mitochondrial – nuclear genetic interaction processes significantly influence common disease development. Because the genetic selection processes for mitochondrial – nuclear interaction are influenced by survival and reproductive success, the changing environmental challenges from original prehistoric conditions to contemporary (along with increased lifespan) have significantly affected cell function. In this regard, his work explores the influence of “mito-Mendelian” genetics upon bioenergetics, inflammation, metabolism, and nuclear gene expression. For these studies, he invented and has developed the Mitochondrial – Nuclear eXchange (MNX) model that enables unambiguous testing of mitochondrial and nuclear genetic backgrounds upon cell function and disease development. From this research, it is becoming clear that “mito-Mendelian” genetics influences cell function and response to acute and chronic stimuli. Consequently, the genetic basis for disease is not based solely upon Mendelian nor Mitochondrial genetics, but is the consequence of “mito-Mendelian” genetics. This concept is paradigm challenging. Current laboratory projects investigate the role for mito-Mendelian genetics upon various metabolic diseases (cancer, cardiovascular, ulcerative colitis and obesity).
  • Investigator On

  • Alcoholic Liver Dysfunction Potentiation by Hyperlipidemia and Cigarette Smoke  awarded by National Institute on Alcohol Abuse and Alcoholism/NIH/DHHS
  • Apical Trans-Membrane Electron Transport Drives ELF Reducing Capacity  awarded by National Institute of Environmental Health Sciences/NIH/DHHS
  • Comparative Bioenergetics of Aging  awarded by National Institute on Aging/NIH/DHHS
  • Comparative Bioenergetics of Aging - Core D - Comparative Mitochondrial Health Assessment Core  awarded by National Institute on Aging/NIH/DHHS
  • Comparative Energetics and Aging  awarded by National Institute on Aging/NIH/DHHS
  • Comparative Energetics and Aging - Comparative Molecular Energetics Analysis Core D  awarded by National Institute on Aging/NIH/DHHS
  • Comparative Energetics and Aging - Comparative Molecular Energetics Analysis Core D  awarded by National Institute on Aging/NIH/DHHS
  • Glycosylation-dependent Mechanisms Regulating Ovarian Tumor cell Phenotype  awarded by National Cancer Institute/NIH/DHHS
  • Lumina III System for UAB Optical Imaging  awarded by NIH - OFFICE OF THE DIRECTOR
  • Mitochondrial Haplotype Influences LV Dysfunction in Heart Failure  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Race - Adiposity Interactions Regulate Mechanisms Determining Insulin Sensitivity  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • Restore Energy Capacity in the Aging Heart  awarded by National Institute on Aging/NIH/DHHS
  • The Role of PPARdelta Signaling in Diabetic Cardiomyopathy  awarded by American Diabetes Association, Inc.
  • The Role of the Mitochondrial Protein Thiol Modification in Endothelial Dysfunction  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Training Program in Cardiovascular Pathophysiology  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • UAB Diabetes Research Center  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • UAB Diabetes Research Center  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • UAB Diabetes Research and Training Center  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • UAB Diabetes Research and Training Center - Administrative Core  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • Teaching Overview

  • Curriculum Development – Coursemaster:
    3/2022-present Co-director and curriculum development, UAB Heersink School of Medicine Promotion & Tenure Workshops
    8/2011-present Coursemaster and curriculum development, GBS 707
    (Graduate Biochemistry – Core curriculum)
    6/2012-2021 Coursemaster and curriculum development, GBS 758 (New Perspectives in Cardiovascular Biology)

    GBS 707
    GBS 749
    GBS 758
    GBS 772
    GGSC 320
    MSTP 793
  • Teaching Activities

  • GBS707 - Basic Biochem/Metabolism (Fall Term 2010)
  • GBS707 - Basic Biochem/Metabolism (Fall Term 2011)
  • GBS707 - Basic Biochem/Metabolism (Fall Term 2012)
  • GBS707 - Basic Biochem/Metabolism (Fall Term 2013)
  • GBS707 - Basic Biochem/Metabolism (Fall Term 2014)
  • GBS707 - Basic Biochem/Metabolism (Fall Term 2015)
  • GBS707 - Basic Biochem/Metabolism (Fall Term 2016)
  • GBS707 - Basic Biochem/Metabolism (Fall Term 2017)
  • GBS707 - Basic Biochem/Metabolism (Fall Term 2018)
  • GBS707 - Basic Biochem/Metabolism (Fall Term 2019)
  • GBS707 - Basic Biochem/Metabolism (Fall Term 2020)
  • GBS707 - Basic Biochem/Metabolism (Fall Term 2021)
  • GBS707 - Basic Biochem/Metabolism (Fall Term 2022)
  • GBS758 - Cardiovasculaar Biology (Summer Term 2014)
  • GBS758 - Cardiovasculaar Biology (Summer Term 2016)
  • GBS758 - Cardiovasculaar Biology (Summer Term 2018)
  • GBS758 - Cardiovascular Biology (Summer Term 2020)
  • IBS709 - New Perspective in Cardio Bio (Summer Term 2010)
  • PAT703 - Intro to Pathology Research (Fall Term 2007)
  • PAT730 - Lab Rotation (Fall Term 2007)
  • PAT730 - Lab Rotation (Spring Term 2008)
  • PAT752 - Lab Rotation Pathology (Spring Term 2008)
  • PAT752 - Lab Rotation Pathology (Summer Term 2008)
  • PAT777 - Autospy Experience (Spring Term 2010)
  • PAT777 - Autospy Experience (Spring Term 2011)
  • PAT778 - Cardiovascular Biology (Summer Term 2008)
  • PAT790 - Spec Topics (Doctoral Level) (Fall Term 2007)
  • PAT790 - Spec Topics (Doctoral Level) (Spring Term 2008)
  • PAT798 - Doc Level Non-Dissertation Res (Fall Term 2007)
  • PAT798 - Doc Level Non-Dissertation Res (Spring Term 2008)
  • PAT798 - Doc Level Non-Dissertation Res (Summer Term 2008)
  • PAT798 - Doc Level Non-Dissertation Res (Summer Term 2009)
  • PAT799 - Doc Lev Dissertation Research (Fall Term 2007)
  • PAT799 - Doc Lev Dissertation Research (Spring Term 2008)
  • Education And Training

  • US Department of Energy, Postdoctoral Fellowship
  • University of Vermont, Postdoctoral Fellowship
  • Doctor of Philosophy in Biochemistry, Emory University 1993
  • Master of Science in Fishing and Fisheries Sciences and Management, Texas A&M University System : College Station 1987
  • Bachelor of Science or Mathematics in Zoology / Animal Biology, Texas A&M University System : College Station 1983
  • Full Name

  • Scott Ballinger