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Syed Shaida Andrabi
Professor
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E-mail
sandrabi@uab.edu
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Map of Science
Co-investigator Network
Syed Shaida Andrabi
Professor
Positions
Associate Professor (S)
,
Neurology
,
School of Medicine
Scientist (C)
,
Center for Free Radical Biology (CFRB)
,
General Clinical Research Center
Scientist (C)
,
Comprehensive Neuroscience Center
,
General Clinical Research Center
Scientist (C)
,
Neurodegeneration and Experimental Therapeutics (CNET)
,
Neurology
Scientist (C)
,
Civitan International Research Center
,
Academic Joint Departments
Professor (P)
,
Pharmacology and Toxicology
,
Academic Joint Departments
Publications
Research
Teaching
Background
Contact
Publications
Selected Publications
Academic Article
Filter
Year
Title
Altmetric
2023
Cdk5 mediates rotational force-induced brain injury
.
Scientific Reports
. 13:3394.
2023
2022
Correction: PHGDH expression is required for mitochondrial redox homeostasis, breast cancer stem cell maintenance, and lung metastasis (Cancer Research (2016) 76 (4430-4442) DOI: 10.1158/0008-5472.CAN-16-0530)
.
Cancer Research
. 82:1153.
2022
2021
Author Correction: Patched1 haploinsufficiency severely impacts intermediary metabolism in the skin of Ptch1
+/−
/ODC transgenic mice (Scientific Reports, (2019), 9, 1, (13072), 10.1038/s41598-019-49470-w)
.
Scientific Reports
. 11.
2021
2021
PARP-1 activation leads to cytosolic accumulation of TDP-43 in neurons
2021
2021
PARIS farnesylation prevents neurodegeneration in models of Parkinson's disease
.
Science Translational Medicine
. 13.
2021
2021
Puma, noxa, p53, and p63 differentially mediate stress pathway induced apoptosis
.
Cell Death and Disease
. 12.
2021
2021
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
1
.
Autophagy
. 17:1-382.
2021
2021
Restoration of CTSD (cathepsin D) and lysosomal function in stroke is neuroprotective
.
Autophagy
. 17:1330-1348.
2021
2020
Neuronal and Cerebrovascular Complications in Coronavirus Disease 2019
.
Frontiers in Pharmacology
. 11.
2020
2020
AMPA Receptor Surface Expression Is Regulated by S-Nitrosylation of Thorase and Transnitrosylation of NSF
.
Cell Reports
. 33.
2020
2020
Defects in Mitochondrial Biogenesis Drive Mitochondrial Alterations in PARKIN-Deficient Human Dopamine Neurons
.
Stem Cell Reports
. 15:629-645.
2020
2020
Quantitative mass spectrometric analysis of the mouse cerebral cortex after ischemic stroke
.
PLoS One
. 15.
2020
2019
Patched1 haploinsufficiency severely impacts intermediary metabolism in the skin of Ptch1
+/−
/ODC transgenic mice
.
Scientific Reports
. 9.
2019
2019
Mitochondrial calcium uniporter regulates PGC-1α expression to mediate metabolic reprogramming in pulmonary fibrosis
.
Redox Biology
. 26.
2019
2019
The AAA + ATPase Thorase is neuroprotective against ischemic injury
.
Cerebrovascular and brain metabolism reviews
. 39:1836-1848.
2019
2019
LSO:Ce Inorganic Scintillators are Biocompatible with Neuronal and Circuit Function
2019
2019
SULT4A1 protects against oxidative-stress induced mitochondrial dysfunction in neuronal cells
.
Drug Metabolism and Disposition
. 47:949-953.
2019
2018
DISC1 regulates lactate metabolism in astrocytes: Implications for psychiatric disorders
.
Translational Psychiatry
. 8.
2018
2018
Poly(ADP-ribose) drives pathologic a-synuclein neurodegeneration in Parkinson’s disease
.
Science
. 362.
2018
2018
Sirt3 regulation under cellular stress: Making sense of the ups and downs
.
Frontiers in Neuroscience
. 12.
2018
2018
Short communication generation and characterization of SULT4A1 mutant mouse models
.
Drug Metabolism and Disposition
. 46:41-45.
2018
2017
Thorase variants are associated with defects in glutamatergic neurotransmission that can be rescued by Perampanel
.
Science Translational Medicine
. 9.
2017
2017
Augmentation of poly(ADP-ribose) polymerase-dependent neuronal cell death by acidosis
.
Cerebrovascular and brain metabolism reviews
. 37:1982-1993.
2017
2016
A nuclease that mediates cell death induced by DNA damage and poly(ADP-ribose) polymerase-1
.
Science
. 354.
2016
2016
A nuclease that mediates cell death induced by DNA damage and poly(ADP-ribose) polymerase-1
.
Science
. 354.
2016
2016
LRRK2 G2019S transgenic mice display increased susceptibility to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-mediated neurotoxicity
.
Journal of Chemical Neuroanatomy
. 76:90-97.
2016
2016
Pathological α-synuclein transmission initiated by binding lymphocyte-activation gene 3
.
Science
. 353.
2016
2016
Pathological α-synuclein transmission initiated by binding lymphocyte-activation gene 3
.
Science
. 353.
2016
2016
Pathological α-synuclein transmission initiated by binding lymphocyte-activation gene 3
.
Science
. 353.
2016
2016
High-content genome-wide rnai screen reveals ccr3 as a key mediator of neuronal cell death
.
eNeuro
. 3.
2016
2016
PHGDH expression is required for mitochondrial redox homeostasis, breast cancer stem cell maintenance, and lung metastasis
.
Cancer Research
. 76:4430-4442.
2016
2016
Adult conditional knockout of PGC-1α leads to loss of dopamine neurons
.
eNeuro
. 3.
2016
2015
Parkin loss leads to Paris-dependent declines in mitochondrial mass and respiration
2015
2014
Parkin-independent mitophagy requires Drp1 and maintains the integrity of mammalian heart and brain
2014
2014
Msp1/ATAD1 maintains mitochondrial function by facilitating the degradation of mislocalized tail-anchored proteins
2014
2014
Poly(ADP-ribose) polymerase-dependent energy depletion occurs through inhibition of glycolysis
2014
2014
Ribosomal protein s15 phosphorylation mediates LRRK2 neurodegeneration in parkinson's disease
.
Cell
. 157:472-485.
2014
2013
Urocortin 1 administered into the hypothalamic supraoptic nucleus inhibits food intake in freely fed and food-deprived rats
.
Amino Acids
. 44:879-885.
2013
2012
Pharmacological rescue of mitochondrial deficits in iPSC-derived neural cells from patients with familial Parkinson's disease
.
Science Translational Medicine
. 4.
2012
2011
Iduna is a poly(ADP-ribose) (PAR)-dependent E3 ubiquitin ligase that regulates DNA damage
2011
2011
Iduna protects the brain from glutamate excitotoxicity and stroke by interfering with poly(ADP-ribose) polymer-induced cell death
.
Nature Medicine
. 17:692-699.
2011
2011
Poly(ADP-ribose) (PAR) binding to apoptosis-inducing factor is critical for PAR polymerase-1-dependent cell death (parthanatos)
.
Science Signaling
. 4.
2011
2011
Resistance to MPTP-Neurotoxicity in α-synuclein knockout mice is complemented by human α-synuclein and associated with increased β-synuclein and Akt activation
.
PLoS One
. 6.
2011
2010
Contributions of poly(ADP-ribose) polymerase-1 and -2 to nuclear translocation of apoptosis-inducing factor and injury from focal cerebral ischemia
.
Journal of Neurochemistry
. 113:1012-1022.
2010
2009
Parthanatos, A messenger of death
.
Frontiers in Bioscience-Landmark
. 14:1116-1128.
2009
2007
Spatial and functional relationship between poly(ADP-ribose) polymerase-1 and poly(ADP-ribose) glycohydrolase in the brain
.
Neuroscience
. 148:198-211.
2007
2007
Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity
.
Human Molecular Genetics
. 16:223-232.
2007
2007
Influence of duration of focal cerebral ischemia and neuronal nitric oxide synthase on translocation of apoptosis-inducing factor to the nucleus
.
Neuroscience
. 144:56-65.
2007
2006
Apoptosis-inducing factor mediates poly(ADP-ribose) (PAR) polymer-induced cell death
2006
2006
Poly(ADP-ribose) (PAR) polymer is a signal
2006
2006
Localization of LRRK2 to membranous and vesicular structures in mammalian brain
.
Annals of Neurology
. 60:557-569.
2006
2006
Inclusion body formation and neurodegeneration are parkin independent in a mouse model of α-synucleinopathy
2006
2006
Blood-brain barrier permeability to the neuroprotectant oxyresveratrol
.
Neuroscience Letters
. 393:113-118.
2006
2005
Nitric oxide applications prior and simultaneous to potentially excitotoxic NMDA-evoked calcium transients: Cell death or survival
.
Brain Research
. 1060:1-15.
2005
2004
Oxyresveratrol (trans-2,3′,4,5′-tetrahydroxystilbene) is neuroprotective and inhibits the apoptotic cell death in transient cerebral ischemia
.
Brain Research
. 1017:98-107.
2004
2004
Direct inhibition of the mitochondrial permeability transition pore: a possible mechanism responsible for anti-apoptotic effects of melatonin.
2004
Research
Principal Investigator On
Poly (ADP-ribose) Mediates Cell Death in Stroke by Inhibiting Glucose Metabolism
awarded by
National Institute of Neurological Disorders and Stroke/NIH/DHHS
SULT4a1, A Novel Neuroprotective Protein in Stroke
awarded by
National Institute of Neurological Disorders and Stroke/NIH/DHHS
Investigator On
Analysis of SULT4A1 in Protein Interactions
awarded by
National Institute of Neurological Disorders and Stroke/NIH/DHHS
Teaching
Teaching Overview
Professor (p), Academic Joint Departments - Pharmacology and Toxicology, The University of Alabama at Birmingham, Oct 2022 - present
Teaching Activities
MBS612 - Systems Pharmacology I (Spring Term 2020)
MBS612 - Systems Pharmacology I (Spring Term 2022)
PHR612 - Systems Pharmacology I (Spring Term 2021)
PHR612 - Systems Physiology Pharm I (Spring Term 2023)
Background
Education And Training
Doctor of Philosophy Level Degree in Neurobiology and Neurosciences,
Otto-von-Guericke University Magdeburg
2005
Contact
Full Name
Syed Shaida
Andrabi