• Samuel T. Windham, III, M.D., joined the faculty of the UAB Department of Surgery's Division of Acute Care Surgery in 2001. He currently serves as the Medical Director for the SICU (Surgical Intensive Care Unit).
    He is involved with teaching in the School of Medicine as well as being an ATLS Instructor. He was given the Argus Award for Teaching Excellence in 1998. His clinical and research interests include: Trauma systems development and integration, pre-hospital notification and injury prediction, blunt or penetrating trauma, vacuum assisted wound closure and tracheostomy.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2021 Associations of muscle lipid content with physical function and resistance training outcomes in older adults: altered responses with metforminGeroscience.  43:629-644. 2021
    2021 Muscle transcriptional networks linked to resistance exercise training hypertrophic response heterogeneityPhysiological Genomics.  53:206-221. 2021
    2020 Metformin alters skeletal muscle transcriptome adaptations to resistance training in older adultsAging.  12:19852-19866. 2020
    2020 Rehabilitative Impact of Exercise Training on Human Skeletal Muscle Transcriptional Programs in Parkinson’s DiseaseFrontiers in Physiology.  11. 2020
    2020 Exercise Effects on Mitochondrial Function and Lipid Metabolism during Energy BalanceMedicine and Science in Sports and Exercise.  52:827-834. 2020
    2020 Skeletal muscle transcriptional networks linked to type I myofiber grouping in Parkinson's diseaseJournal of Applied Physiology.  128:229-240. 2020
    2019 Metformin blunts muscle hypertrophy in response to progressive resistance exercise training in older adults: A randomized, double-blind, placebo-controlled, multicenter trial: The MASTERS trialAging Cell.  18. 2019
    2019 Video telehealth pulmonary rehabilitation intervention in chronic obstructive pulmonary disease reduces 30-day readmissionsAmerican Journal of Respiratory and Critical Care Medicine.  200:511-513. 2019
    2019 Relationship between VO2 peak, cycle economy, and mitochondrial respiration in untrained/trainedJournal of Applied Physiology.  127:1562-1568. 2019
    2018 A high-protein diet or combination exercise training to improve metabolic health in individuals with long-standing spinal cord injury: a pilot randomized studyPhysiological Reports.  6. 2018
    2018 Paralytic and nonparalytic muscle adaptations to exercise training versus high-protein diet in individuals with long-standing spinal cord injuryJournal of Applied Physiology.  125:64-72. 2018
    2018 Human neuromuscular aging: Sex differences revealed at the myocellular levelExperimental Gerontology.  106:116-124. 2018
    2018 Effects of aging and Parkinson's disease on motor unit remodeling: Influence of resistance exercise trainingJournal of Applied Physiology.  124:888-898. 2018
    2018 Quantification and characterization of grouped type I myofibers in human agingMuscle and Nerve.  57:E52-E59. 2018
    2017 Effects of acute hyperinsulinemia on skeletal muscle mitochondrial function, reactive oxygen species production, and metabolism in premenopausal women 2017
    2017 Randomized, four-arm, dose-response clinical trial to optimize resistance exercise training for older adults with age-related muscle atrophyExperimental Gerontology.  99:98-109. 2017
    2017 Associations of human skeletal muscle fiber type and insulin sensitivity, blood lipids, and vascular hemodynamics in a cohort of premenopausal womenEuropean Journal of Applied Physiology.  117:1413-1422. 2017
    2017 Associations of Mitochondrial Fatty Acid Oxidation with Body Fat in Premenopausal WomenJournal of Nutrition and Metabolism.  2017. 2017
    2017 Evaluation of vasopressin for septic shock in patients on chronic renin-angiotensin-aldosterone system inhibitorsCritical Care Medicine.  45:e1226-e1232. 2017
    2016 Heightened TWEAK-NF-κB signaling and inflammation-associated fibrosis in paralyzed muscles of men with chronic spinal cord injury 2016
    2016 Ribosome biogenesis may augment resistance training-induced myofiber hypertrophy and is required for myotube growth in vitro 2016
    2015 Serum from human burn victims impairs myogenesis and protein synthesis in primary myoblastsFrontiers in Physiology.  6. 2015
    2014 Mechanosensitivity may be enhanced in skeletal muscles of spinal cord-injured versus able-bodied menMuscle and Nerve.  50:599-601. 2014
    2014 Novel, high-intensity exercise prescription improves muscle mass, mitochondrial function, and physical capacity in individuals with Parkinson's diseaseJournal of Applied Physiology.  116:582-592. 2014
    2013 Heightened muscle inflammation susceptibility may impair regenerative capacity in aging humansJournal of Applied Physiology.  115:937-948. 2013
    2013 Increased expression of atrogenes and TWEAK family members after severe burn injury in nonburned human skeletal muscleJournal of Burn Care and Research.  34. 2013
    2013 Skeletal muscle signaling associated with impaired glucose tolerance in spinal cord-injured men and the effects of contractile activityJournal of Applied Physiology.  115:756-764. 2013
    2013 Cluster analysis reveals differential transcript profiles associated with resistance training-induced human skeletal muscle hypertrophyPhysiological Genomics.  45:499-507. 2013
    2004 Adrenal Gland Hematomas in Trauma PatientsRadiology.  230:669-675. 2004
    2004 The Evolution of Chest Computed Tomography for the Definitive Diagnosis of Blunt Aortic Injury: A Single-Center ExperienceJournal of Trauma and Acute Care Surgery.  56:243-250. 2004
    2003 Age-related gender differential in outcome after blunt or penetrating trauma.Shock.  19:28-32. 2003
    2003 Vacuum-assisted complex wound closure with elastic vessel loop augmentation: a novel technique.Journal of Wound Care.  12:212-213. 2003
    2002 Identifying injuries and motor vehicle collision characteristics that together are suggestive of diaphragmatic ruptureJournal of Trauma and Acute Care Surgery.  53:1139-1145. 2002
    2002 Injury rates among restrained drivers in motor vehicle collisions; the role of body habitusJournal of Trauma and Acute Care Surgery.  52:1116-1120. 2002
    An Unusual Presentation of Neuroleptic Malignant Syndrome without CK Elevation


    Year Title Altmetric
    2018 Atypical neuroleptic malignant syndrome: Diagnosis and proposal for an expanded treatment algorithm: A case report 2018
    2015 Cricothyroidotomy.  11-14. 2015
    2015 Open Tracheostomy.  5-10. 2015
    2015 Tracheostomy : Endoscopic.  15-20. 2015

    Research Overview

  • exercise physiology, surgical critical care, organ donor management
  • Principal Investigator On

    Investigator On

  • ACES - ACE Inhibitors Combined with Exercise for Hypertensive Seniors  awarded by National Institute on Aging/NIH/DHHS
  • Exercise Intensity, Metabolic Rate & Insulin Sensitivity  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • Network Medicine Approaches to Cachexia in COPD  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Novel Actions of Metformin to Augment Resistance Training Adaptations in Older Adults  awarded by UNIVERSITY OF KENTUCKY (RESEARCH FOUNDATION)
  • Overcoming TWEAK Signaling to Restore Muscle and Mobility after Joint Replacement  awarded by National Institute of Child Health and Human Development/NIH/DHHS
  • Pragmatic, Randomized Optimal Platelet and Plasma Ratios (PROPPR)  awarded by UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER (HOUSTON)
  • Private Grant  awarded by ATOX BIO LTD.
  • Reduced Carbohydrate Diet Intervention for PCOS  awarded by National Institute of Child Health and Human Development/NIH/DHHS
  • Resveratrol and Exercise to Treat Functional Limitations in Late Life  awarded by National Institute on Aging/NIH/DHHS
  • The Exercise and Physical Activity Collaborative Team (ExPACT): a Proposed MoTrPAC Clinical Center  awarded by BALL STATE UNIVERSITY
  • The Exercise and Physical Activity Collaborative Team (ExPact): A Proposed MoTrPAC Clinical Center  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS
  • The Role of Spienic Autonomic Dysfunction in Critical Illness and End-Organ Injury  awarded by East Tennessee State University
  • Education And Training

  • UAB Hospital, Internship
  • UAB Hospital, Residency
  • Doctor of Medicine, University of Alabama at Birmingham 1995
  • Full Name

  • Samuel Windham