Positions

Selected Publications

Academic Article

Year Title Altmetric
2021 Chlorine inhalation induces acute chest syndrome in humanized sickle cell mouse model and ameliorated by postexposure hemopexinRedox Biology.  44. 2021
2021 Nitration of protein kinase G-Iα modulates cyclic nucleotide crosstalk via phosphodiesterase 3A: Implications for acute lung injuryJournal of Biological Chemistry.  297. 2021
2021 LPS decreases CFTR open probability and mucociliary transport through generation of reactive oxygen speciesRedox Biology.  43. 2021
2021 AICAR decreases acute lung injury by phosphorylating AMPK and upregulating heme oxygenase-1.European Respiratory Journal2021
2021 Instillation of hyaluronan reverses acid instillation injury to the mammalian blood gas barrier 2021
2021 RAC1 nitration at Y32 IS involved in the endothelial barrier disruption associated with lipopolysaccharide-mediated acute lung injuryRedox Biology.  38. 2021
2020 Heme attenuates beta-endorphin levels in leukocytes of HIV positive individuals with chronic widespread painRedox Biology.  36. 2020
2020 Hyaluronan and halogen-induced airway hyperresponsiveness and lung injuryAnnals of the New York Academy of Sciences.  1479:29-43. 2020
2020 Reactive species generated by heme impair alveolar epithelial sodium channel function in acute respiratory distress syndromeRedox Biology.  36. 2020
2020 Vascular permeability disruption explored in the proteomes of mouse lungs and human microvascular cells following acute bromine exposure 2020
2020 Vascular Endothelial Growth Factor-121 Administration Mitigates Halogen Inhalation-Induced Pulmonary Injury and Fetal Growth Restriction in Pregnant Mice 2020
2020 Chronic Pain in HIVMolecular Pain.  16. 2020
2019 Phosgene inhalation causes hemolysis and acute lung injuryToxicology Letters.  312:204-213. 2019
2018 Heme scavenging reduces pulmonary endoplasmic reticulum stress, fibrosis, and emphysemaJCI insight.  3. 2018
2018 Can a Vitamin A day keep tuberculosis away?American Journal of Respiratory Cell and Molecular Biology.  59:523-524. 2018
2018 LPS-induced acute lung injury involves NF-kB–mediated downregulation of SOX18American Journal of Respiratory Cell and Molecular Biology.  58:614-624. 2018
2018 Exposure of neonatal mice to bromine impairs their alveolar development and lung function 2018
2017 Mechanisms and Treatment of Halogen Inhalation-Induced Pulmonary and Systemic Injuries in Pregnant MiceHypertension.  70:390-400. 2017
2017 Hyper-activation of pp60Src limits nitric oxide signaling by increasing asymmetric dimethylarginine levels during acute lung injuryFree Radical Biology and Medicine.  102:217-228. 2017
2017 Role of apoptosis and autophagy in tuberculosis 2017
2016 Differential regulation of autophagy and mitophagy in pulmonary diseases 2016
2016 Redox regulation of epidermal growth factor receptor signaling during the development of pulmonary hypertension.Free Radical Biology and Medicine.  95:96-111. 2016
2016 Heme Attenuation Ameliorates Irritant Gas Inhalation-Induced Acute Lung InjuryAntioxidants and Redox Signaling.  24:99-112. 2016
2016 Chlorine-induced cardiopulmonary injuryAnnals of the New York Academy of Sciences.  1374:159-167. 2016
2016 Role of heme in bromine-induced lung injuryAnnals of the New York Academy of Sciences.  1374:105-110. 2016
2015 Influenza virus M2 targets cystic fibrosis transmembrane conductance regulator for lysosomal degradation during viral infectionThe FASEB Journal.  29:2712-2725. 2015
2015 Upregulation of autophagy decreases chlorine-induced mitochondrial injury and lung inflammationFree Radical Biology and Medicine.  85:83-94. 2015
2015 Endothelial nitric oxide synthase deficient mice are protected from lipopolysaccharide induced acute lung injury.PLoS ONE.  10:e0119918. 2015
2015 Hyaluronan mediates airway hyperresponsiveness in oxidative lung injury 2015
2014 Heme Scavenging Attenuates Bromine Induced Lung InjuryFree Radical Biology and Medicine.  76:S77-S77. 2014
2014 Sox18 preserves the pulmonary endothelial barrier under conditions of increased shear stress.Journal of Cellular Physiology.  229:1802-1816. 2014
2014 Endothelin-1 Induces a Glycolytic Switch in Pulmonary Arterial Endothelial Cells via the Mitochondrial Translocation of Endothelial Nitric Oxide SynthaseAmerican Journal of Respiratory Cell and Molecular Biology.  50:1084-1095. 2014
2014 Nitration of tyrosine 247 inhibits protein kinase G-1α activity by attenuating cyclic guanosine monophosphate binding.Journal of Biological Chemistry.  289:7948-7961. 2014
2014 Dimethylarginine dimethylaminohydrolase II overexpression attenuates LPS-mediated lung leak in acute lung injury.American Journal of Respiratory Cell and Molecular Biology.  50:614-625. 2014
2014 Endothelin-1 stimulates catalase activity through the PKCδ-mediated phosphorylation of serine 167.Free Radical Biology and Medicine.  67:255-264. 2014
2014 Lipopolysaccharide-induced Lung Injury Involves the Nitration-mediated Activation of RhoAJournal of Biological Chemistry.  289:4710-4722. 2014
2014 PKC-dependent phosphorylation of eNOS at T495 regulates eNOS coupling and endothelial barrier function in response to G+ -toxins.PLoS ONE.  9:e99823. 2014
2014 Protein engineering to develop a redox insensitive endothelial nitric oxide synthase.Redox Biology.  2:156-164. 2014
2013 pp60Src Limits Nitric Oxide Signaling through Increases in Asymmetric DimethylarginineFree Radical Biology and Medicine.  65:S100-S100. 2013
2013 Reactive oxygen species in pulmonary vascular remodeling.Comprehensive Physiology.  3:1011-1034. 2013
2013 Disruption of endothelial cell mitochondrial bioenergetics in lambs with increased pulmonary blood flow.Antioxidants and Redox Signaling.  18:1739-1752. 2013
2013 Chronic inhibition of PPAR-γ signaling induces endothelial dysfunction in the juvenile lamb.Pulmonary Pharmacology and Therapeutics.  26:271-280. 2013
2013 Asymmetric dimethylarginine induces endothelial nitric-oxide synthase mitochondrial redistribution through the nitration-mediated activation of Akt1.Journal of Biological Chemistry.  288:6212-6226. 2013
2013 Bosentan inhibits oxidative and nitrosative stress and rescues occlusive pulmonaryhypertensionFree Radical Biology and Medicine.  56:28-43. 2013
2013 Tezosentan increases nitric oxide signaling via enhanced hydrogen peroxide generation in lambs with surgically induced acute increases in pulmonary blood flow.Journal of Cellular Biochemistry.  114:435-447. 2013
2013 Rosiglitazone preserves pulmonary vascular function in lambs with increased pulmonary blood flowPediatric Research.  73:54-61. 2013
2012 Role of Carnitine Acetyl Transferase in Regulation of Nitric Oxide Signaling in Pulmonary Arterial Endothelial CellsInternational Journal of Molecular Sciences.  14:255-272. 2012
2012 Increased NADPH oxidase-derived superoxide is involved in the neuronal cell death induced by hypoxia-ischemia in neonatal hippocampal slice cultures.Free Radical Biology and Medicine.  53:1139-1151. 2012
2012 Glutathione supplementation attenuates lipopolysaccharide-induced mitochondrial dysfunction and apoptosis in a mouse model of acute lung injury.Frontiers in Physiology.  3:161. 2012
2011 Attenuated vasodilatation in lambs with endogenous and exogenous activation of cGMP signaling: role of protein kinase G nitration.Journal of Cellular Physiology.  226:3104-3113. 2011
2011 Purification and functional analysis of protein kinase G-1α using a bacterial expression system.Protein Expression and Purification.  79:271-276. 2011
2011 LPS‐Induced Hyper‐permeability in Human Lung Microvascular Endothelial Cells (HLMVEC) Involves the Nitration‐Mediated Activation of RhoAThe FASEB Journal.  25. 2011
2010 Oxidative stress and the development of endothelial dysfunction in congenital heart disease with increased pulmonary blood flow: lessons from the neonatal lamb.Trends in Cardiovascular Medicine.  20:238-246. 2010
2010 Mechanisms of nitric oxide synthase uncoupling in endotoxin-induced acute lung injury: role of asymmetric dimethylarginine.Vascular Pharmacology.  52:182-190. 2010
2010 The lectin-like domain of TNF protects from listeriolysin-induced hyperpermeability in human pulmonary microvascular endothelial cells - a crucial role for protein kinase C-alpha inhibition.Vascular Pharmacology.  52:207-213. 2010
2010 Nitration-mediated Activation of RhoA: Its Role in LPS-induced Endothelial Barrier DysfunctionFree Radical Biology and Medicine.  49:S49-S49. 2010
2009 Effect of PPARgamma inhibition on pulmonary endothelial cell gene expression: gene profiling in pulmonary hypertension.Physiological Genomics.  40:48-60. 2009
2009 GTP cyclohydrolase I expression is regulated by nitric oxide: role of cyclic AMP. 2009

Chapter

Year Title Altmetric
2016 Role of Heme in Bromine Induced Lung Injury 2016
2015 Pulmonary Hemodynamics 2015
2014 Oxidative Stress and Pulmonary Vascular Disorders 2014
2014 Endothelial Dysfunction in Acute Lung Injury 2014
2014 Endothelial dysfunction in acute lung injury.  27-49. 2014
2008 Prognosis of Asperger’s Disorder 2008

Education And Training

  • Doctor of Philosophy in Vascular Surgery, Medical College of Georgia 2011
  • Doctor of Medicine, Odessa National Medical University 2002
  • Full Name

  • Saurabh Aggarwal