Positions

Overview

  • Dr. Russell received his initial medical training (MD) at the University of Texas Medical Branch with his internal medicine internship and residency completed at Vanderbilt University. Dr. Russell began a clinical and research fellowship in pulmonary and critical care medicine at UAB in 2014. Following his fellowship, he joined the UAB faculty in July 2017. His research and clinical interests relate to the role of neutrophils and extracellular vesicles in pulmonary diseases characterized by neutrophilic inflammation and parenchymal damage such as COPD and ARDS, as well as pragmatic clinical trials on the management of critically ill patients. Dr. Russell has published and presented work on endotracheal intubation, management of respiratory failure, pragmatic clinical trials in the MICU, neutrophils in COPD, matrikines in COPD, exhaled breath biomarkers in ARDS and extracellular vesicles in neutrophilic inflammation. His ongoing work explores the role of neutrophil-derived exosomes in matrix destruction and lung disease.

    • Selected Publications

    Academic Article

    Year Title Altmetric
    2023 Effect of Laryngoscope Blade Size on First Pass Success of Tracheal Intubation in Critically Ill Adults.  Critical Care Explorations.  5:E0855. 2023
    2023 Early Restrictive or Liberal Fluid Management for Sepsis-Induced Hypotension..  New England Journal of Medicine.  388:499-510. 2023
    2023 Assessment of Symptom, Disability, and Financial Trajectories in Patients Hospitalized for COVID-19 at 6 Months..  JAMA Network Open.  6:e2255795. 2023
    2023 DirEct versus VIdeo LaryngosCopE (DEVICE): protocol and statistical analysis plan for a randomised clinical trial in critically ill adults undergoing emergency tracheal intubation.  BMJ Open.  13:e068978. 2023
    2022 Fluid Bolus Administration and Cardiovascular Collapse in Critically Ill Patients Undergoing Tracheal Intubation - Reply.  Journal of the American Medical Association.  328:2071-2072. 2022
    2022 Effect of Fluid Bolus Administration on Cardiovascular Collapse among Critically Ill Patients Undergoing Tracheal Intubation: A Randomized Clinical Trial.  Journal of the American Medical Association.  328:270-279. 2022
    2022 Bag-Mask Ventilation Versus Apneic Oxygenation During Tracheal Intubation in Critically Ill Adults: A Secondary Analysis of 2 Randomized Trials.  Journal of Intensive Care Medicine.  37:899-907. 2022
    2022 I-SPY COVID adaptive platform trial for COVID-19 acute respiratory failure: rationale, design and operations.  BMJ Open.  12. 2022
    2022 Use of inhaled epoprostenol with high flow nasal oxygen in non-intubated patients with severe COVID-19.  Journal of Critical Care.  69. 2022
    2022 Prolonged Prone Positioning for COVID-19-induced Acute Respiratory Distress Syndrome: A Randomized Pilot Clinical Trial.  Annals of the American Thoracic Society.  19:685-687. 2022
    2022 An in vivo model for extracellular vesicle–induced emphysema.  JCI Insight.  7. 2022
    2022 Clinical trial design during and beyond the pandemic: the I-SPY COVID trial.  Nature Medicine.  28:9-11. 2022
    2022 Extracellular Vesicles as Central Mediators of COPD Pathophysiology.  Annual Review of Physiology.  84:631-654. 2022
    2021 Effect of Use of a Bougie vs Endotracheal Tube with Stylet on Successful Intubation on the First Attempt among Critically Ill Patients Undergoing Tracheal Intubation: A Randomized Clinical Trial.  Journal of the American Medical Association.  326:2488-2497. 2021
    2021 Extracellular vesicles: Progress and challenges in the study of human immunodeficiency virus and cocaine-associated pulmonary arterial hypertension.  American Journal of Respiratory Cell and Molecular Biology.  65:341-342. 2021
    2021 Therapeutic anticoagulation with heparin in critically ill patients with covid-19.  New England Journal of Medicine.  385:777-789. 2021
    2021 Therapeutic anticoagulation with heparin in noncritically ill patients with covid-19.  New England Journal of Medicine.  385:790-802. 2021
    2021 The long and the short of it: Is "long covid" more than slow resolution of the acute disease?.  Annals of the American Thoracic Society.  18:948-950. 2021
    2021 BOugie or stylet in patients UnderGoing Intubation Emergently (BOUGIE): Protocol and statistical analysis plan for a randomised clinical trial.  BMJ Open.  11. 2021
    2021 Atrial arrhythmia related outcomes in critically ill COVID-19 patients.  Pacing and Clinical Electrophysiology.  44:814-823. 2021
    2020 The validity of surface EMG of extra-diaphragmatic muscles in assessing respiratory responses during mechanical ventilation: A systematic review.  Pulmonology.  26:378-385. 2020
    2020 Protocol and statistical analysis plan for the PREventing cardiovascular collaPse with Administration of fluid REsuscitation during Induction and Intubation (PREPARE II) randomised clinical trial.  BMJ Open.  10:e036671. 2020
    2020 Atrial Arrhythmias in COVID-19 Patients.  JACC: Clinical Electrophysiology.  6:1189-1190. 2020
    2020 Risk Factors for Cardiovascular Collapse during Tracheal Intubation of Critically III Adults.  Annals of the American Thoracic Society.  17:1021-1024. 2020
    2020 A fatal case of pneumocephalus during computed tomography-guided lung biopsy.  American Journal of Respiratory and Critical Care Medicine.  201:E83-E84. 2020
    2020 Comment on: Pathological consequences of Anti-Citrullinated Protein Antibodies in Tear Fluid and therapeutic potential of Pooled Human Immune Globulin-Eye Drops in Dry Eye Disease: Too much of a good thing, how chronic neutrophilic inflammation can drive human disease 2020
    2019 Effect of a fluid bolus on cardiovascular collapse among critically ill adults undergoing tracheal intubation (PrePARE): a randomised controlled trial 2019
    2019 Benzyloxycarbonyl-proline-prolinal (ZPP): Dual complementary roles for neutrophil inhibition.  Biochemical and Biophysical Research Communications.  517:691-696. 2019
    2019 Emulating a novel clinical trial using existing observational data predicting results of the PREVENT study.  Annals of the American Thoracic Society.  16:998-1007. 2019
    2019 Bag-mask ventilation during tracheal intubation of critically ill adults.  New England Journal of Medicine.  380:811-821. 2019
    2019 Activated PMN Exosomes: Pathogenic Entities Causing Matrix Destruction and Disease in the Lung.  Cell.  176:113-126.e15. 2019
    2018 ADAM9: A damaging player in chronic obstructive pulmonary disease.  American Journal of Respiratory and Critical Care Medicine.  198:1465-1466. 2018
    2018 Letter by Russell and Janz Regarding Article, "Association Between Early Hyperoxia Exposure After Resuscitation From Cardiac Arrest and Neurological Disability: A Prospective Multicenter Protocol-Directed Cohort Study".  Circulation.  138:2858-2859. 2018
    2018 Risk factors for and prediction of hypoxemia during tracheal intubation of Critically Ill Adults.  Annals of the American Thoracic Society.  15:1320-1327. 2018
    2018 Searching for the source of the leak: PIE and the macklin effect.  Annals of the American Thoracic Society.  15:1354-1356. 2018
    2018 COPD ground zero: small airways rather than alveoli as the initial site of injury 2018
    2018 Manual ventilation to prevent hypoxaemia during endotracheal intubation of critically ill adults: Protocol and statistical analysis plan for a multicentre randomised trial.  BMJ Open.  8. 2018
    2018 Fibroblast growth factor 23 and Klotho contribute to airway inflammation.  European Respiratory Journal.  52. 2018
    2018 Novel method for noninvasive sampling of the distal airspace in acute respiratory distress syndrome.  American Journal of Respiratory and Critical Care Medicine.  197:1027-1035. 2018
    2018 Exosomal microRNA predicts and protects against severe bronchopulmonary dysplasia in extremely premature infants.  JCI Insight.  3. 2018
    2018 Response.  Chest.  153:568-569. 2018
    2017 Response.  Chest.  152:1351. 2017
    2017 Response.  Chest.  152:1092-1093. 2017
    2017 A Multicenter, Randomized Trial of Ramped Position vs Sniffing Position During Endotracheal Intubation of Critically Ill Adults.  Chest.  152:712-722. 2017
    2017 Early exposure to hyperoxia and mortality in critically ill patients with severe traumatic injuries.  BMC Pulmonary Medicine.  17. 2017
    2016 Neutrophil fates in bronchiectasis and alpha-1 antitrypsin deficiency.  Annals of the American Thoracic Society.  13:S123-S129. 2016
    2016 Disease phenotyping in chronic obstructive pulmonary disease: The neutrophilic endotype.  Current Opinion in Pulmonary Medicine.  22:91-99. 2016
    2015 The soot of all evil.  eLife.  4. 2015

    Research Overview

  • Dr. Russell's research interests include Biomarkers in inflammatory lung diseases such as COPD and ARDS, Extracellular vesicles, Exosomes, Innate immune cells such as neutrophils and their interaction with extracellular matrix, Pragmatic Clinical Trials in the critically ill, Translational Medicine, and Respiratory Failure

    • Principal Investigator On

    Investigator On

    Education And Training

  • Vanderbilt University, Residency
  • Vanderbilt University Medical Center Department of Medicine, Residency
  • University of Alabama at Birmingham, Postdoctoral Fellowship
  • University of Alabama at Birmingham Division of Pulmonary, Allergy, and Critical Care Medicine; Department of Medicine, Postdoctoral Fellowship
  • University of Alabama at Birmingham Division of Pulmonary, Allergy, and Critical Care Medicine; Department of Medicine, Postdoctoral Fellowship
  • Doctor of Medicine, University of Texas System : Medical Branch 2011

    • Full Name

  • Derek Russell