Ranu Surolia

Ranu Surolia
Assistant Professor

Associate Scientist (C), Center for Clinical and Translational Science (CCTS) , General Clinical Research Center
Assistant Professor (P), Medicine - Pulmonary, Allergy, & Critical Care Medicine , Department of Medicine

Overview

Dr. Surolia received her PhD in Biochemistry from the University of Delhi South Campus in 2011. In 2011, she joined UAB’s Division of Pulmonary, Allergy, and Critical Care Medicine as postdoctoral fellow and subsequently assistant professor. Dr. Surolia is interested in understanding the molecular pathology of lung injury and repair related to environmental exposures and agents.

Selected Publications

Academic Article

Year	Title	Altmetric
2023	Cutaneous Exposure to Arsenicals is Associated with Development of Constrictive Bronchiolitis in Mice.. American Journal of Respiratory Cell and Molecular Biology. 2023
2022	Pathophysiological Role of Vimentin Intermediate Filaments in Lung Diseases. Frontiers in Cell and Developmental Biology. 10. 2022
2022	Fibrinogen mediates cadmium-induced macrophage activation and serves as a predictor of cadmium exposure in chronic obstructive pulmonary disease 2022
2022	Targeting Cpt1a-Bcl-2 interaction modulates apoptosis resistance and fibrotic remodeling. Cell Death and Differentiation. 29:118-132. 2022
2021	NETosis in the pathogenesis of acute lung injury following cutaneous chemical burns. JCI Insight. 6. 2021
2021	Citrullinated vimentin mediates development and progression of lung fibrosis. Science Translational Medicine. 13. 2021
2020	Cutaneous lewisite exposure causes acute lung injury. Annals of the New York Academy of Sciences. 1479:210-222. 2020
2019	Increased flux through the mevalonate pathway mediates fibrotic repair without injury. Journal of Clinical Investigation. 129:4962-4978. 2019
2019	Vimentin intermediate filament assembly regulates fibroblast invasion in fibrogenic lung injury. JCI Insight. 4. 2019
2017	Autoimmunity to vimentin is associated with outcomes of patients with idiopathic pulmonary fibrosis. Journal of Immunology. 199:1596-1605. 2017
2017	Erratum: 3D pulmospheres serve as a personalized and predictive multicellular model for assessment of antifibrotic drugs (JCI Insight. (2017) 2:2 (e91377) DOI: 10.1172/jci.insight.91377). JCI Insight. 2. 2017
2017	3D pulmospheres serve as a personalized and predictive multicellular model for assessment of antifibrotic drugs.. JCI Insight. 2:e91377. 2017
2017	Low-dose cadmium exposure induces peribronchiolar fibrosis through site-specific phosphorylation of vimentin 2017
2016	Attenuated heme oxygenase-1 responses predispose the elderly to pulmonary nontuberculous mycobacterial infections 2016
2015	Heme oxygenase-1-mediated autophagy protects against pulmonary endothelial cell death and development of emphysema in cadmium-treated mice 2015
2015	Heme oxygenase-1 protects Corexit 9500ainduced respiratory epithelial injury across species. PLoS One. 10. 2015
2014	Wilms' tumor 1 (Wt1) regulates pleural mesothelial cell plasticity and transition into myofibroblasts in idiopathic pulmonary fibrosis 2014
2013	Pleural mesothelial cell differentiation and invasion in fibrogenic lung injury. American Journal of Pathology. 182:1239-1247. 2013
2012	Heme oxygenase-1 promotes granuloma development and protects against dissemination of mycobacteria. Laboratory Investigation. 92:1541-1552. 2012
2012	Preparation and characterization of monensin loaded PLGA nanoparticles: In vitro anti-malarial activity against Plasmodium falciparum. Journal of Biomedical Nanotechnology. 8:172-181. 2012
2011	Inhibition of the growth of plasmodium falciparum in culture by stearylamine-phosphatidylcholine liposomes. Journal of Parasitology Research. 2011. 2011

Chapter

Year	Title	Altmetric
2022	3D modeling of the lung in health and disease. 627-646. 2022

Research Overview

Dr. Surolia's ongoing research projects involve toxic environmental exposure leading to COPD and pulmonary fibrosis. Currently, she has also successfully developed and characterized ex-vivo 3D model of lung tissue from patients with IPF. These ex-vivo 3D models are very important in basic research and translational medicine studies such as understanding various biological phenomenon of disease and repair mechanisms. They are an important tool to develop personalized therapies and to develop new drug targets.