Positions

Overview

  • Robin Lorenz received her M.D., Ph.D. in Immunology from Washington University in St. Louis in 1990. She then completed her residency in Clinical Pathology at Barnes-Jewish Hospital, while also doing postdoctoral research in Gastrointestinal Biology at Washington University in St. Louis. Dr. Lorenz was hired at Washington University as an Assistant Professor of Pathology and Medicine in 1994. In addition, she served as the Medical Director of the Joint Clinical Immunology Laboratory for Barnes-Jewish and St. Louis Childrens Hospitals and as the Associate Director of the Laboratory Medicine Residency Training Program. Dr. Lorenz joined the UAB faculty in 2002 as an Associate Professor in the Department of Pathology. The National Institutes of Health, the Strategic Program for Asthma Research, and the Juvenile Diabetes Research Foundation have funded her laboratory research investigating the mucosal immune system. Dr. Lorenz is also Director of the UAB Medical Scientist Training Program and the Physician Scientist Development Office. She is married and has two children.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2021 Early life stress in mice alters gut microbiota independent of maternal microbiota inheritance 2021
    2020 Erratum: The Xenobiotic Transporter Mdr1 Enforces T Cell Homeostasis in the Presence of Intestinal Bile Acids (Immunity (2017) 47(6) (1182–1196.e10), (S1074761317304892), (10.1016/j.immuni.2017.11.012))Immunity.  52:571. 2020
    2019 Clinical factors and biomarkers predict outcome in patients with immune-mediated thrombotic thrombocytopenic purpura 2019
    2017 The Xenobiotic Transporter Mdr1 Enforces T Cell Homeostasis in the Presence of Intestinal Bile AcidsImmunity.  47:1182-1196.e10. 2017
    2016 Human neutrophil peptides and complement factor Bb in pathogenesis of acquired thrombotic thrombocytopenic purpura 2016
    2016 Anti–Blood Group Antibodies in Intravenous Immunoglobulin May Complicate Interpretation of Antibody Titers in ABO-Incompatible TransplantationAmerican Journal of Transplantation.  16:2483-2486. 2016
    2016 Hybrid inhibitor of peripheral cannabinoid-1 receptors and inducible nitric oxide synthase mitigates liver fibrosisJCI insight.  1. 2016
    2015 Response to Comment on Sofi et al. pH of drinking water influences the composition of gut microbiome and type 1 diabetes incidence. Diabetes 2014;63:632-644Diabetes.  64:e20-e21. 2015
    2015 Insights into environmental factors impacting celiac disease microbiota modulation of disease pathogenesisAmerican Journal of Pathology.  185:2864-2866. 2015
    2015 Pathogenesis of necrotizing enterocolitis: Modeling the innate immune responseAmerican Journal of Pathology.  185:4-16. 2015
    2012 Gut Microbiota and ObesityCurrent Obesity Reports.  1:1-8. 2012
    2009 Differential susceptibility of P-glycoprotein deficient mice to colitis induction by environmental insultsInflammatory Bowel Diseases.  15:684-696. 2009
    2008 Celiac disease refractory to a gluten-free diet? Commentary 2008
    2008 Helicobacter pylori Gastritis in Children Is Associated With a Regulatory T-Cell ResponseGastroenterology.  134:491-499. 2008
    2006 Safety of celecoxib in patients with ulcerative colitis in remission: A randomized, placebo-controlled, pilot studyClinical Gastroenterology and Hepatology.  4:203-211. 2006
    2005 The Helicobacter felis model of adoptive transfer gastritisImmunologic Research.  33:183-194. 2005
    2005 Experimental models of inflammatory bowel disease reveal innate, adaptive, and regulatory mechanisms of host dialogue with the microbiotaImmunological Reviews.  206:260-276. 2005
    2005 Organizing a mucosal defenseImmunological Reviews.  206:6-21. 2005
    2005 Increased prevalence of celiac disease and need for routine screening among patients with osteoporosisArchives of Internal Medicine.  165:393-399. 2005
    2005 Experimental models of inflammatory bowel disease reveal innate, adaptive, and regulatory mechanisms of host dialogue with the microbiotaImmunological Reviews.  206:260-76. 2005
    2004 New developments in experimental models of inflammatory bowel diseaseCurrent Opinion in Gastroenterology.  20:360-367. 2004
    2004 Isolated lymphoid follicles can function as sites for induction of mucosal immune responsesAnnals of the New York Academy of Sciences.  1029:44-57. 2004
    2004 New developments in experimental inflammatory bowel diseaseCurrent Opinion in Gastroenterology.  20:360-7. 2004
    2004 TNFR1 mediates the radioprotective effects of lipopolysaccharide in the mouse intestine 2004
    2004 TNFR1 mediates the radioprotective effects of lipopolysaccharide in the mouse intestine. 2004
    2003 CD14- and toll-like receptor-dependent activation of bladder epithelial cells by lipopolysaccharide and type 1 piliated Escherichia coliInfection and Immunity.  71:1470-1480. 2003
    2002 Effect of trimethoprim-sulfamethoxazole on recurrent bacteriuria and bacterial persistence in mice infected with uropathogenic Escherichia coliInfection and Immunity.  70:7042-7049. 2002
    2002 A gnotobiotic transgenic mouse model for studying interactions between small intestinal enterocytes and intraepithelial lymphocytesJournal of Biological Chemistry.  277:37811-37819. 2002
    2002 Recent advances in the molecular basis of pathogen recognition and host responses in the urinary tractInternational Reviews of Immunology.  21:291-304. 2002
    2001 The gastrointestinal ecosystem: A precarious alliance among epithelium, immunity and microbiotaCellular Microbiology.  3:1-11. 2001
    2000 The requirement for lymphotoxin and Peyer's patches in the development of intestinal lamina propria lymphocytesGastroenterology.  118:A361-A361. 2000
    1997 Expression of thin aggregative fimbriae promotes interaction of Salmonella typhimurium SR-11 with mouse small intestinal epithelialInfection and Immunity.  65:5320-5325. 1997
    1995 Moluccella laevis lectin, a marker for cellular differentiation programs in mouse gut epithelium 1995
    1989 Binding of self-antigens to Ia molecules 1989
    1988 Processing and Presentation of Self ProteinsImmunological Reviews.  106:115-127. 1988
    1983 Elucidation of the antigenic determinant in lipotropin for two monoclonal antibodiesBiochemical and Biophysical Research Communications.  116:527-533. 1983
    1983 Identification of gastrin releasing peptide-related substances in guinea pig and rat brainBiochemical and Biophysical Research Communications.  112:528-536. 1983
    1982 Variants of alpha-melanocyte stimulating hormone in rat brain and pituitary: Evidence that acetylated α-MSH exists only in the intermediate lobe of pituitaryBiochemical and Biophysical Research Communications.  106:910-919. 1982

    Chapter

    Year Title Altmetric
    2017 Data interpretation in laboratory medicine.  489-510. 2017
    2008 Microbial Sensing in the Intestine by Pattern Recognition Receptors.  33-43. 2008

    Research Overview

  • Mucosal Immunology - The focus of research in our laboratory is the study of the cellular components of the mucosal immune system and their interactions with the gastrointestinal epithelium, the GI microbiome, and the systemic immune response.
  • Principal Investigator On

  • Altered Handling and Sensing of Xenobiotics in Inflammatory Bowel Disease  awarded by Crohn's & Colitis Foundation of America
  • Antimicrobial Molecule Expression in the FVB.mdr1a Model of Colitis  awarded by Crohn's & Colitis Foundation of America
  • Impact of Bacterial Stimulation of Antimicrobial Peptide Expression in P-glycoprotein Models of Colitis  awarded by Crohn's & Colitis Foundation of America
  • Innate and Adaptive Immunity in IBD - Project 2  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • Medical Scientist Training Program  awarded by National Institute of General Medical Sciences/NIH/DHHS
  • Medical Scientist Training Program  awarded by National Institute of General Medical Sciences/NIH/DHHS
  • Molecular Mechanisms of Early Life Stress and Risk of Inflammatory Bowel Disease  awarded by Crohn's & Colitis Foundation of America
  • PRedOctoral Phd and MD Research Training In TEams (PROmoTE)  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • Preparation for Graduate and Medical Education (PARAdiGM) Program  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Preparation for Graduate and Medical Education (PreGAME) Program  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Short Term Training in Health Professional Schools  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Short Term Training in Health Professional Schools  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Short Term Training in Health Professional Schools  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Southeastern Medical Scientist Symposium  awarded by National Institute of General Medical Sciences/NIH/DHHS
  • Southeastern Medical Scientist Symposium  awarded by National Institute of General Medical Sciences/NIH/DHHS
  • The Gastrointestinal Ecosystem and Risk of Diabetes Development  awarded by Juvenile Diabetes Research Foundation International
  • Teaching Activities

  • STP2043 - SURVIVAL SKILLS FOR PHYSICIAN SCIENTISTS (Fall Term 2019) 2019
  • STP2043 - SURVIVAL SKILLS FOR PHYSICIAN SCIENTISTS (Fall Term 2019) 2019
  • STP2043 - SURVIVAL SKILLS FOR PHYSICIAN SCIENTISTS (Fall Term 2018) 2018
  • MSTP798 - MSTP Non-Dissertation Hours (Summer Term 2018) 2018
  • MSTP799 - MSTP Dissertation Hours (Summer Term 2018) 2018
  • 48-606 - PHYSICIAN SCIENTIST RESEARCH ELECTIVE (Fall Term 2018) 2018
  • 48-606 - PHYSICIAN SCIENTIST RESEARCH ELECTIVE (Spring Term 2018) 2018
  • MSTP798 - MSTP Non-Dissertation Hours (Spring Term 2018) 2018
  • MSTP799 - MSTP Dissertation Hours (Spring Term 2018) 2018
  • MSTP799 - MSTP Dissertation Hours (Spring Term 2018) 2018
  • GBS744 - MUCOSAL IMMUNOLOGY (Spring Term 2018) 2018
  • MSTP798 - MSTP Non-Dissertation Hours (Fall Term 2017) 2017
  • MSTP799 - MSTP Dissertation Hours (Fall Term 2017) 2017
  • TMS702 - Phenotyping Human Disease (Fall Term 2017) 2017
  • 48-606 - PHYSICIAN SCIENTIST RESEARCH ELECTIVE (Fall Term 2017) 2017
  • 48-606 - PHYSICIAN SCIENTIST RESEARCH ELECTIVE (Fall Term 2017) 2017
  • STP2043 - SURVIVAL SKILLS FOR PHYSICIAN SCIENTISTS (Fall Term 2017) 2017
  • MSTP798 - MSTP Non-Dissertation Hours (Summer Term 2017) 2017
  • MSTP799 - MSTP Dissertation Hours (Summer Term 2017) 2017
  • 48-606 - PHYSICIAN SCIENTIST RESEARCH ELECTIVE (Spring Term 2017) 2017
  • GBS744 - Mucosal Immunology (Spring Term 2017) 2017
  • MSTP798 - MSTP Non-Dissertation Hours (Spring Term 2017) 2017
  • MSTP799 - MSTP Dissertation Hours (Spring Term 2017) 2017
  • GBS744 - MUCOSAL IMMUNOLOGY (Spring Term 2017) 2017
  • GBS747 - CARCINOGENESIS (Spring Term 2017) 2017
  • MSTP798 - MSTP Non-Dissertation Hours (Fall Term 2016) 2016
  • MSTP799 - MSTP Dissertation Hours (Fall Term 2016) 2016
  • 48-606 - PHYSICIAN SCIENTIST RESEARCH ELECTIVE (Fall Term 2016) 2016
  • STP2043 - SURVIVAL SKILLS FOR PHYSICIAN SCIENTISTS (Fall Term 2016) 2016
  • MSTP798 - MSTP Non-Dissertation Hours (Summer Term 2016) 2016
  • MSTP799 - MSTP Dissertation Hours (Summer Term 2016) 2016
  • MSTP798 - MSTP Non-Dissertation Hours (Spring Term 2016) 2016
  • MSTP799 - MSTP Dissertation Hours (Spring Term 2016) 2016
  • GBS729 - TRANS APPROACH NEURODEGEN (Spring Term 2016) 2016
  • MSTP794 - Translational Research Seminar (Fall Term 2015) 2015
  • MSTP798 - MSTP Non-Dissertation Hours (Fall Term 2015) 2015
  • MSTP799 - MSTP Dissertation Hours (Fall Term 2015) 2015
  • TMS702 - Phenotyping Human Disease (Fall Term 2015) 2015
  • STP2043 - SURVIVAL SKILLS FOR PHYSICIAN SCIENTISTS (Fall Term 2015) 2015
  • MSTP798 - MSTP Non-Dissertation Hours (Summer Term 2015) 2015
  • MSTP799 - MSTP Dissertation Hours (Summer Term 2015) 2015
  • GBS744 - MUCOSAL IMMUNOLOGY (Spring Term 2015) 2015
  • GBS744 - Mucosal Immunology (Spring Term 2015) 2015
  • MSTP798 - MSTP Non-Dissertation Hours (Spring Term 2015) 2015
  • MSTP799 - MSTP Dissertation Hours (Spring Term 2015) 2015
  • MSTP794 - Translational Research Seminar (Fall Term 2014) 2014
  • MSTP798 - MSTP Non-Dissertation Hours (Fall Term 2014) 2014
  • MSTP799 - MSTP Dissertation Hours (Fall Term 2014) 2014
  • STP2043 - SURVIVAL SKILLS FOR PHYSICIAN SCIENTISTS (Fall Term 2014) 2014
  • MSTP794 - Translational Research Seminar (Summer Term 2014) 2014
  • MSTP798 - MSTP Non-Dissertation Hours (Summer Term 2014) 2014
  • MSTP799 - MSTP Dissertation Hours (Summer Term 2014) 2014
  • GBS744 - Mucosal Immunology (Spring Term 2014) 2014
  • MSTP794 - Translational Research Seminar (Spring Term 2014) 2014
  • MSTP798 - MSTP Non-Dissertation Hours (Spring Term 2014) 2014
  • MSTP799 - MSTP Dissertation Hours (Spring Term 2014) 2014
  • GBS744 - MUCOSAL IMMUNOLOGY (Spring Term 2014) 2014
  • HMG702 - Phenotyping Human Disease (Fall Term 2013) 2013
  • MSTP794 - Translational Research Seminar (Fall Term 2013) 2013
  • MSTP798 - MSTP Non-Dissertation Hours (Fall Term 2013) 2013
  • MSTP799 - MSTP Dissertation Hours (Fall Term 2013) 2013
  • STP2043 - SURVIVAL SKILLS FOR PHYSICIAN SCIENTISTS (Fall Term 2013) 2013
  • STP2043 - SURVIVAL SKILLS FOR PHYSICIAN SCIENTISTS (Fall Term 2013) 2013
  • STP2043 - SURVIVAL SKILLS FOR PHYSICIAN SCIENTISTS (Fall Term 2013) 2013
  • MSTP794 - Translational Research Seminar (Summer Term 2013) 2013
  • MSTP798 - MSTP Non-Dissertation Hours (Summer Term 2013) 2013
  • MSTP799 - MSTP Dissertation Hours (Summer Term 2013) 2013
  • GBS744 - Mucosal Immunology (Spring Term 2013) 2013
  • MSTP794 - Translational Research Seminar (Spring Term 2013) 2013
  • MSTP795 - Continuing Clinical Education (Spring Term 2013) 2013
  • MSTP798 - MSTP Non-Dissertation Hours (Spring Term 2013) 2013
  • MSTP799 - MSTP Dissertation Hours (Spring Term 2013) 2013
  • HMG702 - Phenotyping Human Disease (Fall Term 2012) 2012
  • MSTP794 - Translational Research Seminar (Fall Term 2012) 2012
  • MSTP795 - Continuing Clinical Education (Fall Term 2012) 2012
  • MSTP798 - MSTP Non-Dissertation Hours (Fall Term 2012) 2012
  • MSTP799 - MSTP Dissertation Hours (Fall Term 2012) 2012
  • STP2043 - SURVIVAL SKILLS FOR PHYSICIAN SCIENTISTS (Fall Term 2012) 2012
  • MSTP794 - Translational Research Seminar (Summer Term 2012) 2012
  • MSTP798 - MSTP Non-Dissertation Hours (Summer Term 2012) 2012
  • MSTP799 - MSTP Dissertation Hours (Summer Term 2012) 2012
  • MSTP794 - Translational Research Seminar (Spring Term 2012) 2012
  • MSTP795 - Continuing Clinical Education (Spring Term 2012) 2012
  • MSTP798 - MSTP Non-Dissertation Hours (Spring Term 2012) 2012
  • PAT794 - Comparative Medicine Seminar (Spring Term 2012) 2012
  • GBS744 - MUCOSAL IMMUNOLOGY (Spring Term 2012) 2012
  • HMG702 - Phenotyping Human Disease (Fall Term 2011) 2011
  • PAT794 - Comparative Medicine Seminar (Fall Term 2011) 2011
  • OBHS111 - Fundamentals of Dent and Opt I (Fall Term 2011) 2011
  • STP2043 - SURVIVAL SKILLS FOR PHYSICIAN SCIENTISTS (Fall Term 2011) 2011
  • STP2043 - SURVIVAL SKILLS FOR PHYSICIAN SCIENTISTS (Fall Term 2011) 2011
  • PAT794 - Comparative Medicine Seminar (Summer Term 2011) 2011
  • GBS744 - Mucosal Immunology (Spring Term 2011) 2011
  • PAT794 - Comparative Medicine Seminar (Spring Term 2011) 2011
  • GBS744 - MUCOSAL IMMUNOLOGY (Spring Term 2011) 2011
  • HMG702 - Phenotyping Human Disease (Fall Term 2010) 2010
  • PAT794 - Comparative Medicine Seminar (Fall Term 2010) 2010
  • OBHS111 - Fundamentals of Dent and Opt I (Fall Term 2010) 2010
  • STP2043 - SURVIVAL SKILLS FOR PHYSICIAN SCIENTISTS (Fall Term 2010) 2010
  • PAT794 - Comparative Medicine Seminar (Summer Term 2010) 2010
  • PAT794 - Comparative Medicine Seminar (Spring Term 2010) 2010
  • HMG702 - Phenotyping Human Disease (Fall Term 2009) 2009
  • PAT794 - Comparative Medicine Seminar (Fall Term 2009) 2009
  • OBHS111 - Fundamentals of Dent and Opt I (Fall Term 2009) 2009
  • STP2043 - SURVIVAL SKILLS FOR PHYSICIAN SCIENTIST (Fall Term 2009) 2009
  • PAT794 - Comparative Medicine Seminar (Summer Term 2009) 2009
  • PAT794 - Comparative Medicine Seminar (Spring Term 2009) 2009
  • HMG702 - Phenotyping Human Disease (Fall Term 2008) 2008
  • PAT794 - Comparative Medicine Seminar (Fall Term 2008) 2008
  • STP2043 - SURVIVAL SKILLS FOR PHYSICIAN SCIENTIST (Fall Term 2008) 2008
  • PAT794 - Comparative Medicine Seminar (Summer Term 2008) 2008
  • PAT794 - Comparative Medicine Seminar (Spring Term 2008) 2008
  • PAT702 - Phenotyping Human Disease (Fall Term 2007) 2007
  • PAT794 - Comparative Medicine Seminar (Fall Term 2007) 2007
  • Education And Training

  • Barnes Hospital, Residency
  • Doctor of Medicine in Immunology, Washington University/St. Louis 1990
  • Bachelor's Degree in Biology / Biological Sciences, Stanford University 1984
  • Full Name

  • Robin Lorenz