Positions

Overview

  • Dr Reynolds is an Assistant Professor of Medicine in the Division of Clinical Immunology and Rheumatology. His current research interests include genetic epidemiology of gout and associated comorbidities and the genetic and epigenetic causes of gout flares. Dr. Reynolds earned his Ph.D. from the University of Maryland College Park's Department of Biology in 2008. He completed a post doctoral fellowship in UAB's Department of Biostatistics, section on Statistical Genetics in 2010 and thereafter joined the faculty at UAB.

    • Selected Publications

    Academic Article

    Year Title Altmetric
    2022 SMOC2 gene interacts with APOL1 in the development of end-stage kidney disease: A genome-wide association study.  Frontiers in Medicine.  9. 2022
    2022 Local genetic covariance between serum urate and kidney function estimated with Bayesian multitrait models 2022
    2022 Genetic association studies of the progression from hyperuricaemia to gout.  Rheumatology.  61:E139-E140. 2022
    2022 APOL1 Risk Variants Associated with Serum Albumin in a Population-Based Cohort Study.  American Journal of Nephrology.  53:182-190. 2022
    2021 The comparative effect of exposure to various risk factors on the risk of hyperuricaemia: diet has a weak causal effect.  Arthritis Research and Therapy.  23. 2021
    2021 Higher Serum Urate Levels Are Associated With an Increased Risk for Sudden Cardiac Death.  Journal of Rheumatology.  48:1745-1753. 2021
    2021 Genetic correlations between traits associated with hyperuricemia, gout, and comorbidities.  European Journal of Human Genetics.  29:1438-1445. 2021
    2021 Decreased Levels of STAT1 and Interferon-γ–Induced STAT1 Phosphorylation in Rheumatoid Arthritis CD4 and CD8 T Cells.  ACR Open Rheumatology.  3:277-283. 2021
    2021 Correspondence on 'Variants in urate transporters, ADH1B, GCKR and MEPE genes associated with transition from asymptomatic hyperuricaemia to gout: Results of the first gout versus asymptomatic hyperuricaemia GWAS in Caucasians using data from the UK Biobank'.  Annals of the Rheumatic Diseases.  2021
    2020 The Shared Genetic Basis of Hyperuricemia, Gout, and Kidney Function.  Seminars in Nephrology.  40:586-599. 2020
    2020 Variable and sexually conflicting selection on Silene stellata floral traits by a putative moth pollinator selective agent.  Evolution.  74:1321-1334. 2020
    2020 Gout is associated with an increased risk for incident heart failure among older adults: The REasons for Geographic and Racial Differences in Stroke (REGARDS) cohort study.  Arthritis Research and Therapy.  22. 2020
    2020 Comorbidities in gout and hyperuricemia: Causality or epiphenomena?.  Current Opinion in Rheumatology.  32:126-133. 2020
    2020 Severity of Hypertension Mediates the Association of Hyperuricemia With Stroke in the REGARDS Case Cohort Study.  Hypertension.  75:246-256. 2020
    2019 Genetic influences on susceptibility to rheumatoid arthritis in African-Americans.  Human Molecular Genetics.  28:858-874. 2019
    2019 HLA-DRB1 amino acid positions and residues associated with antibody-positive rheumatoid arthritis in black south africans.  Journal of Rheumatology.  46:138-144. 2019
    2018 Untangling the complex relationships between incident gout risk, serum urate, and its comorbidities.  Arthritis Research and Therapy.  20. 2018
    2017 Coronary Artery Calcification and Rheumatoid Arthritis: Lack of Relationship to Risk Alleles for Coronary Artery Disease in the General Population.  Arthritis and Rheumatology.  69:529-541. 2017
    2017 Dense genotyping of immune-related regions identifies loci for rheumatoid arthritis risk and damage in African Americans.  Molecular Medicine.  23:177-187. 2017
    2016 Killer cell immunoglobulin-like receptors are associated with common variable immune deficiency pathogenesis.  Journal of Allergy and Clinical Immunology.  138:1495-1498. 2016
    2016 Association of anti-peptidyl arginine deiminase antibodies with radiographic severity of rheumatoid arthritis in African Americans.  Arthritis Research and Therapy.  18. 2016
    2016 Serum urate gene associations with incident gout, measured in the Framingham Heart Study, are modified by renal disease and not by body mass index 2016
    2016 Modelling heterogeneity among fitness functions using random regression.  Methods in Ecology and Evolution.  7:70-79. 2016
    2015 The role of genetic variants in CRP in radiographic severity in African Americans with early and established rheumatoid arthritis.  Genes and Immunity.  16:446-451. 2015
    2015 Brief report: Expression of interferon-γ receptor genes in peripheral blood mononuclear cells is associated with rheumatoid arthritis and its radiographic severity in african americans.  Arthritis and Rheumatology.  67:1165-1170. 2015
    2015 Quantifying hummingbird preference for floral trait combinations: The role of selection on trait interactions in the evolution of pollination syndromes.  Evolution.  69:1113-1127. 2015
    2015 Simulation, fabrication and impact testing of a novel football helmet padding system that decreases rotational acceleration.  Sports Engineering.  18:11-20. 2015
    2015 Simple regression for correcting δCt bias in RT-qPCR low-density array data normalization.  BMC Genomics.  16. 2015
    2014 Evaluation of the Quasi-Analytical Algorithm for estimating the inherent optical properties of seawater from ocean color: Comparison of Arctic and lower-latitude waters 2014
    2014 HLA-DRB1-associated rheumatoid arthritis risk at multiple levels in African Americans: Hierarchical classification systems, amino acid positions, and residues.  Arthritis and Rheumatology.  66:3274-3282. 2014
    2014 Genetic variants associated with methotrexate efficacy and toxicity in early rheumatoid arthritis: Results from the treatment of early aggressive rheumatoid arthritis trial 2014
    2014 Gene-body mass index interactions are associated with methotrexate toxicity in rheumatoid arthritis.  Annals of the Rheumatic Diseases.  73:785-786. 2014
    2014 Immunochip identifies novel, and replicates known, genetic risk loci for rheumatoid arthritis in black South Africans.  Molecular Medicine.  20:341-349. 2014
    2014 Periodontitis and porphyromonas gingivalis in patients with rheumatoid arthritis.  Arthritis and Rheumatology.  66:1090-1100. 2014
    2014 Phytoplankton blooms beneath the sea ice in the Chukchi sea 2014
    2014 Within-day variability of particulate organic carbon and remote-sensing reflectance during a bloom of Phaeocystis antarctica in the Ross Sea, Antarctica.  International Journal of Remote Sensing.  35:454-477. 2014
    2013 Editorial: Ethnic-specific genetic analyses in rheumatoid arthritis: Incremental gains but valuable contributions to the big picture.  Arthritis and Rheumatism.  65:3014-3016. 2013
    2013 Comparison of the disease activity score using erythrocyte sedimentation rate and C-reactive protein in African Americans with rheumatoid arthritis.  Journal of Rheumatology.  40:1812-1822. 2013
    2013 Clinical response within 12 weeks as a predictor of future low disease activity in patients with early RA: Results from the TEAR trial.  Journal of Rheumatology.  40:572-578. 2013
    2013 Gene expression patterns in peripheral blood cells associated with radiographic severity in African Americans with early rheumatoid arthritis 2013
    2012 Association of single-nucleotide polymorphisms in CCR6, TAGAP, and TNFAIP3 with rheumatoid arthritis in African Americans.  Arthritis and Rheumatism.  64:1355-1358. 2012
    2012 Use of a multiethnic approach to identify rheumatoid- arthritis- susceptibility loci, 1p36 and 17q12.  American Journal of Human Genetics.  90:524-532. 2012
    2012 Impact of interactions of cigarette smoking with NAT2 polymorphisms on rheumatoid arthritis risk in African Americans.  Arthritis and Rheumatism.  64:655-664. 2012
    2012 Variable nursery pollinator importance and its effect on plant reproductive success.  Oecologia.  168:439-448. 2012
    2010 Associations of cigarette smoking with rheumatoid arthritis in African Americans.  Arthritis and Rheumatism.  62:3560-3568. 2010
    2010 Most common single-nucleotide polymorphisms associated with rheumatoid arthritis in persons of European ancestry confer risk of rheumatoid arthritis in African Americans.  Arthritis and Rheumatism.  62:3547-3553. 2010
    2010 Variations in the optical properties of a particle suspension associated with viral infection of marine bacteria.  Limnology and Oceanography.  55:2317-2330. 2010
    2010 The distribution and hypothesis testing of eigenvalues from the canonical analysis of the gamma matrix of quadratic and correlational selection gradients.  Evolution.  64:1076-1085. 2010
    2010 Mapping interacting QTL for count phenotypes using hierarchical Poisson and binomial models: An application to reproductive traits in mice 2010
    2010 Multiyear study of multivariate linear and nonlinear phenotypic selection on floral traits of hummingbird-pollinated silene virginica.  Evolution.  64:358-369. 2010
    2010 Genetic association of htSNPs across the major histocompatibility complex with rheumatoid arthritis in an African-American population.  Genes and Immunity.  11:94-97. 2010
    2010 Measurements and characterization of particle size distributions in coastal waters.  Journal of Geophysical Research.  115. 2010
    2010 Optical variability of seawater in relation to particle concentration, composition, and size distribution in the nearshore marine environment at Imperial Beach, California.  Journal of Geophysical Research.  115. 2010
    2009 Pollinator specialization and pollination syndromes of three related North American Silene.  Ecology.  90:2077-2087. 2009
    2008 Point and interval estimation of pollinator importance: A study using pollination data of Silene caroliniana.  Oecologia.  156:325-332. 2008
    2006 Nectar reward and advertisement in hummingbird-pollinated Silene virginica (Caryophyllaceae).  American Journal of Botany.  93:1800-1807. 2006
    2006 Pollination and seed predation by moths on Silene and allied Caryophyllaceae: Evaluating a model system to study the evolution of mutualisms.  New Phytologist.  169:667-680. 2006

    Research Overview

  • Genetic epidemiology of rheumatoid arthritis, gout and its comorbidities. Mechanisms of inflammation in gout.

    • Principal Investigator On

    Investigator On

  • Centers of Research Translation (CoRT)  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS
  • Dissection of the ACPA Response in African-Americans with Rheumatoid Arthritis  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS
  • INvestigations In Gout, Hyperuricemia, and ComorbidiTies (INSIGHT) Center of Research Translation (CORT)  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS
  • INvestigations In Gout, Hyperuricemia, and ComorbidiTies (INSIGHT) Center of Research Translation (CORT) - Project 3: Translational Genomics of Hyperuricemia  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS
  • Molecular Mechanisms of Multiple Sclerosis Disease Severity in African Americans  awarded by NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES/NIH/DHHS
  • Molecular, Functional and Structural Analyses of Anti-PAD Antibodies in Rheumatoid Arthritis  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS
  • The Role of the Interferon-Gamma-Jak/STAT Pathway in Rheumatoid Arthritis  awarded by DOD - ARMY MEDICAL RESEARCH ACQUISITION ACTIVITY
  • Timing of Sodium Intake and Nocturnal Sodium Excretion and Blood Pressure in Obese African Americans  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • UAB Multidisciplinary Clinical Research Center (P60)  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS

    • Teaching Overview

  • Dr. Reynolds is the current course director for GRD 770, Introduction to Biostatistics, taught in the fall term.

    • Teaching Activities

    Education And Training

  • Doctor of Philosophy in Biology, University of Maryland System : College Park 2008

    • Full Name

  • Richard Reynolds