| Year |
Title |
Altmetric |
| 2021
|
Erratum: Comparing and Validating Machine Learning Models forMycobacterium tuberculosisDrug Discovery(Mol. Pharmaceutics (2018) 15: 10 (4346−4360) DOI: 10.1021/acs.molpharmaceut.8b00083).
Molecular Pharmaceutics.
18:2833.
2021
|
|
| 2020
|
Molecule Property Analyses of Active Compounds for Mycobacterium tuberculosis.
Journal of Medicinal Chemistry.
63:8917-8955.
2020
|
|
| 2020
|
Identification of DOT1L inhibitors by structure-based virtual screening adapted from a nucleoside-focused library
2020
|
|
| 2019
|
Parallel Solution Phase Synthesis and Preliminary Biological Activity of a 5′-Substituted Cytidine Analog Library.
ACS Combinatorial Science.
21:628-634.
2019
|
|
| 2019
|
Synthesis of Aza-acyclic Nucleoside Libraries of Purine, Pyrimidine, and 1,2,4-Triazole.
ACS Combinatorial Science.
21:183-191.
2019
|
|
| 2018
|
Comparing and Validating Machine Learning Models for Mycobacterium tuberculosis Drug Discovery.
Molecular Pharmaceutics.
15:4346-4360.
2018
|
|
| 2018
|
A small diversity library of α-methyl amide analogs of sulindac for probing anticancer structure-activity relationships.
Bioorganic and Medicinal Chemistry Letters.
28:2136-2142.
2018
|
|
| 2018
|
Oxazole and thiazole analogs of sulindac for cancer prevention.
Future Medicinal Chemistry.
10:743-753.
2018
|
|
| 2018
|
Amine containing analogs of sulindac for cancer prevention.
Open Medicinal Chemistry Journal.
12:1-12.
2018
|
|
| 2017
|
Synthesis and preliminary assessment of the anticancer and Wnt/β-catenin inhibitory activity of small amide libraries of fenamates and profens.
Medicinal Chemistry Research.
26:3038-3045.
2017
|
|
| 2017
|
Diverse amide analogs of sulindac for cancer treatment and prevention.
Bioorganic and Medicinal Chemistry Letters.
27:4614-4621.
2017
|
|
| 2016
|
Screening and development of new inhibitors of FtsZ from M. tuberculosis.
PLoS ONE.
11.
2016
|
|
| 2016
|
Machine Learning Model Analysis and Data Visualization with Small Molecules Tested in a Mouse Model of Mycobacterium tuberculosis Infection (2014-2015)
2016
|
|
| 2015
|
Autocrine fibroblast growth factor 18 signaling mediates Wnt-dependent stimulation of CD44-positive human colorectal adenoma cells.
Molecular Carcinogenesis.
54:789-799.
2015
|
|
| 2015
|
Open Source Bayesian Models. 1. Application to ADME/Tox and Drug Discovery Datasets
2015
|
|
| 2014
|
Biochemical and structural characterization of mycobacterial aspartyl-tRNA synthetase AspS, a promising TB drug target.
PLoS ONE.
9.
2014
|
|
| 2014
|
Synthesis and General Biological Activity of a Small Adenosine-5′-(Carboxamide and Sulfanilamide) Library
2014
|
|
| 2014
|
Solution-phase parallel synthesis of acyclic nucleoside libraries of purine, pyrimidine, and triazole acetamides.
ACS Combinatorial Science.
16:485-493.
2014
|
|
| 2014
|
Are bigger data sets better for machine learning? Fusing single-point and dual-event dose response data for mycobacterium tuberculosis
2014
|
|
| 2014
|
Parallel solution-phase synthesis and general biological activity of a uridine antibiotic analog library.
ACS Combinatorial Science.
16:232-237.
2014
|
|
| 2014
|
Looking back to the future: Predicting in vivo efficacy of small molecules versus Mycobacterium tuberculosis
2014
|
|
| 2014
|
Identification of shikimate kinase inhibitors among anti-Mycobacterium tuberculosis compounds by LC-MS.
Tuberculosis.
94:152-158.
2014
|
|
| 2014
|
Combining computational methods for hit to lead optimization in mycobacterium tuberculosis drug discovery.
Pharmaceutical Research.
31:414-435.
2014
|
|
| 2014
|
Synthesis of novel Peptidyl adenosine antibiotic analogs
2014
|
|
| 2014
|
Global human-kinase screening identifies therapeutic host targets against influenza.
Journal of Biomolecular Screening.
19:936-946.
2014
|
|
| 2013
|
Fusing dual-event data sets for mycobacterium tuberculosis machine learning models and their evaluation
2013
|
|
| 2013
|
A novel quinoline derivative that inhibits mycobacterial FtsZ.
Tuberculosis.
93:398-400.
2013
|
|
| 2013
|
A chemical proteomics approach to profiling the ATP-binding proteome of Mycobacterium tuberculosis.
Molecular and Cellular Proteomics.
12:1644-1660.
2013
|
|
| 2013
|
Enhancing Hit Identification in Mycobacterium tuberculosis Drug Discovery Using Validated Dual-Event Bayesian Models.
PLoS ONE.
8.
2013
|
|
| 2013
|
6-Oxo and 6-thio purine analogs as antimycobacterial agents.
Bioorganic and Medicinal Chemistry.
21:1685-1695.
2013
|
|
| 2013
|
Bayesian models leveraging bioactivity and cytotoxicity information for drug discovery
2013
|
|
| 2013
|
Parallel solution-phase synthesis of an adenosine antibiotic analog library.
ACS Combinatorial Science.
15:147-152.
2013
|
|
| 2012
|
Design, synthesis and activity of thio-linked arabinofuranosyl disaccharides against mycobacterial tuberculosis (MTB) and Mycobacterium avium complex (MAC)
2012
|
|
| 2012
|
Silibinin inhibits Wnt/β-catenin signaling by suppressing Wnt co-receptor LRP6 expression in human prostate and breast cancer cells.
Cellular Signalling.
24:2291-2296.
2012
|
|
| 2012
|
Synthesis and SAR of geminal substitutions at the C5′ carbosugar position of pyrimidine-derived HCV inhibitors.
Bioorganic and Medicinal Chemistry Letters.
22:6967-6973.
2012
|
|
| 2012
|
Synthesis and SAR of pyridothiazole substituted pyrimidine derived HCV replication inhibitors.
Bioorganic and Medicinal Chemistry Letters.
22:5652-5657.
2012
|
|
| 2012
|
Pyridofuran substituted pyrimidine derivatives as HCV replication (replicase) inhibitors.
Bioorganic and Medicinal Chemistry Letters.
22:5144-5149.
2012
|
|
| 2012
|
5-Benzothiazole substituted pyrimidine derivatives as HCV replication (replicase) inhibitors.
Bioorganic and Medicinal Chemistry Letters.
22:3229-3234.
2012
|
|
| 2012
|
Identification of novel Mt-Guab2 inhibitor series active against M. tuberculosis.
PLoS ONE.
7.
2012
|
|
| 2012
|
Novel substituted pyrimidines as HCV replication (replicase) inhibitors.
Bioorganic and Medicinal Chemistry Letters.
22:1160-1164.
2012
|
|
| 2012
|
High throughput screening of a library based on kinase inhibitor scaffolds against Mycobacterium tuberculosis H37Rv.
Tuberculosis.
92:72-83.
2012
|
|
| 2011
|
Novel pyridopyrazine and pyrimidothiazine derivatives as FtsZ inhibitors.
Bioorganic and Medicinal Chemistry.
19:7120-7128.
2011
|
|
| 2011
|
Identification of novel diphenyl urea inhibitors of Mt-GuaB2 active against Mycobacterium tuberculosis.
Microbiology.
157:290-299.
2011
|
|
| 2010
|
A novel sulindac derivative lacking cyclooxygenase-inhibitory activities suppresses carcinogenesis in the transgenic adenocarcinoma of mouse prostate model.
Cancer Prevention Research.
3:885-895.
2010
|
|
| 2010
|
NSAIDs: Old drugs reveal new anticancer targets.
Pharmaceuticals.
3:1652-1667.
2010
|
|
| 2009
|
Sulindac sulfide selectively inhibits growth and induces apoptosis of human breast tumor cells by phosphodiesterase 5 inhibition, elevation of cyclic GMP, and activation of protein kinase G.
Molecular Cancer Therapeutics.
8:3331-3340.
2009
|
|
| 2009
|
Antituberculosis activity of the molecular libraries screening center network library.
Tuberculosis.
89:354-363.
2009
|
|
| 2009
|
High-throughput screening for inhibitors of Mycobacterium tuberculosis H37Rv.
Tuberculosis.
89:334-353.
2009
|
|
| 2009
|
A novel sulindac derivative that does not inhibit cyclooxygenases but potently inhibits colon tumor cell growth and induces apoptosis with antitumor activity.
Cancer Prevention Research.
2:572-580.
2009
|
|
| 2009
|
Mycolic acid methyltransferase, MmaA4, is necessary for thiacetazone susceptibility in Mycobacterium tuberculosis
2009
|
|
| 2009
|
Synthesis of deoxygenated α(1 → 5)-linked arabinofuranose disaccharides as substrates and inhibitors of arabinosyltransferases of Mycobacterium tuberculosis.
Bioorganic and Medicinal Chemistry.
17:872-881.
2009
|
|
| 2008
|
Synthesis of 4-deoxy-4-thioarabinofuranosyl disaccharides, analogs of Mycobacterial arabinogalactan.
Indian Journal of Chemistry : Section B.
47:1748-1752.
2008
|
|
| 2008
|
Expression, purification and characterisation of soluble GlfT and the identification of a novel galactofuranosyltransferase Rv3782 involved in priming GlfT-mediated galactan polymerisation in Mycobacterium tuberculosis.
Protein Expression and Purification.
58:332-341.
2008
|
|
| 2008
|
EmbR2, a structural homologue of EmbR, inhibits the Mycobacterium tuberculosis kinase/substrate pair PknH/EmbR.
Biochemical Journal.
410:309-317.
2008
|
|
| 2008
|
Binding mode analysis of 2, 4-diamino-5-methyl-5-deaza-6-substituted pteridines with mycobacterium tuberculosis and human dihydrofolate reductases.
Journal of Biomolecular Structure and Dynamics.
25:377-385.
2008
|
|
| 2007
|
Thiacetazone, an antitubercular drug that inhibits cyclopropanation of cell wall mycolic acids in mycobacteria.
PLoS ONE.
2.
2007
|
|
| 2007
|
Disaccharide analogs as probes for glycosyltransferases in Mycobacterium tuberculosis.
Bioorganic and Medicinal Chemistry.
15:5629-5650.
2007
|
|
| 2007
|
Synthesis of symmetrical C- and pseudo-symmetrical O-linked disaccharide analogs for arabinosyltransferase inhibitory activity in Mycobacterium tuberculosis.
Bioorganic and Medicinal Chemistry Letters.
17:4527-4530.
2007
|
|
| 2007
|
Novel boron-containing, nonclassical antifolates: Synthesis and preliminary biological and structural evaluation.
Journal of Medicinal Chemistry.
50:3283-3289.
2007
|
|
| 2007
|
Programs to facilitate tuberculosis drug discovery: The tuberculosis antimicrobial acquisition and coordinating facility
2007
|
|
| 2007
|
EthA, a common activator of thiocarbamide-containing drugs acting on different mycobacterial targets.
Antimicrobial Agents and Chemotherapy.
51:1055-1063.
2007
|
|
| 2006
|
Symmetrical and unsymmetrical analogues of isoxyl; active agents against Mycobacterium tuberculosis.
Bioorganic and Medicinal Chemistry Letters.
16:4743-4747.
2006
|
|
| 2006
|
New antifolate inhibitors for Mycobacterium avium.
Medicinal Chemistry.
2:505-510.
2006
|
|
| 2006
|
Novel conjugate of moxifloxacin and carboxymethylated glucan with enhanced activity against Mycobacterium tuberculosis.
Antimicrobial Agents and Chemotherapy.
50:1982-1988.
2006
|
|
| 2006
|
Mycobacterium tuberculosis cells growing in macrophages are filamentous and deficient in FtsZ rings.
Journal of Bacteriology.
188:1856-1865.
2006
|
|
| 2005
|
New Mycobactenum avium antifolate shows synergistic effect when used in combination with dihydropteroate synthase inhibitors.
Antimicrobial Agents and Chemotherapy.
49:4801-4803.
2005
|
|
| 2005
|
Erratum: Degradation of Quillaja saponaria Molina saponins: Loss of the protective effects of a herpes simplex virus 1 subunit vaccine (International Immunopharmacology (2002) 2:12 (1703-1711) DOI: 10.1016/S1567-5769(02)00192-3).
International Immunopharmacology.
5:1658.
2005
|
|
| 2005
|
Synthesis of novel 5-aryl-2-thio-1,3,4-oxadiazoles and the study of their structure-anti-mycobacterial activities.
Bioorganic and Medicinal Chemistry.
13:4842-4850.
2005
|
|
| 2005
|
Preclinical testing of the nitroimidazopyran PA-824 for activity against Mycobacterium tuberculosis in a series of in vitro and in vivo models.
Antimicrobial Agents and Chemotherapy.
49:2294-2301.
2005
|
|
| 2004
|
Synthesis and preliminary in vitro evaluation of antimycobacterial activity of new pyrrolo[1,2-a] quinoxaline-carboxylic acid hydrazide derivatives.
Journal of Enzyme Inhibition and Medicinal Chemistry.
19:489-495.
2004
|
|
| 2004
|
Structure of Mycobacterium tuberculosis FtsZ reveals unexpected, G protein-like conformational switches.
Journal of Molecular Biology.
342:953-970.
2004
|
|
| 2004
|
SRI-286, a thiosemicarbazole, in combination with mefloquine and moxifloxacin for treatment of murine Mycobacterium avium complex disease.
Antimicrobial Agents and Chemotherapy.
48:3556-3558.
2004
|
|
| 2004
|
The use of microarray analysis to determine the gene expression profiles of Mycobacterium tuberculosis in response to anti-bacterial compounds.
Tuberculosis.
84:263-274.
2004
|
|
| 2004
|
A new 2-carbamoyl pteridine that inhibits mycobacterial FtsZ.
Bioorganic and Medicinal Chemistry Letters.
14:3161-3164.
2004
|
|
| 2004
|
Synthesis of mannopyranose disaccharides as photoaffinity probes for mannosyltransferases in Mycobacterium tuberculosis.
Carbohydrate Research.
339:683-691.
2004
|
|
| 2004
|
Antimycobacterial Agents. 1. Thio Analogues of Purine.
Journal of Medicinal Chemistry.
47:273-276.
2004
|
|
| 2003
|
Arabinofuranose disaccharide analogs as inhibitors of Mycobacterium tuberculosis
2003
|
|
| 2003
|
Thiosemicarbazole (thiacetazone-like) compound with activity against Mycobacterium avium in mice.
Antimicrobial Agents and Chemotherapy.
47:2685-2687.
2003
|
|
| 2003
|
Fractionation, structural studies, and immunological characterization of the semi-synthetic Quillaja saponins derivative GPI-0100.
Vaccine.
21:3961-3971.
2003
|
|
| 2002
|
Synthesis and antimycobacterial activity of pyrazine and quinoxaline derivatives.
Journal of Medicinal Chemistry.
45:5604-5606.
2002
|
|
| 2002
|
Synthesis of an arabinofuranosyl disaccharide photoaffinity probe for arabinosyltransferase activity in Mycobacterium tuberculosis.
Bioorganic and Medicinal Chemistry Letters.
12:2749-2752.
2002
|
|
| 2002
|
Studies on n-octyl-5-(α-D-arabinofuranosyl)-β-D-galactofuranosides for mycobacterial glycosyltransferase activity.
Bioorganic and Medicinal Chemistry.
10:923-928.
2002
|
|
| 2002
|
2-Alkoxycarbonylaminopyridines: Inhibitors of Mycobacterium tuberculosis FtsZ.
Journal of Antimicrobial Chemotherapy.
50:111-114.
2002
|
|
| 2002
|
Degradation of Quillaja saponaria Molina saponins: Loss of the protective effects of a herpes simplex virus 1 subunit vaccine.
International Immunopharmacology.
2:1703-1711.
2002
|
|
| 2002
|
Synthesis and biological evaluation of trehalose analogs as potential inhibitors of mycobacterial cell wall biosynthesis.
Carbohydrate Research.
337:105-120.
2002
|
|
| 2001
|
A facile method for deprotection of trityl ethers using column chromatography
2001
|
|
| 2001
|
Synthesis and antifolate evaluation of the aminopterin analogue with a bicyclo[2.2.2]octane ring in place of the benzene ring
2001
|
|
| 2001
|
Altered immunomodulating and toxicological properties of degraded Quillaja saponaria Molina saponins.
International Immunopharmacology.
1:813-818.
2001
|
|
| 2001
|
Synthesis of a fluorescent arabinofuranosyl disaccharide: A probe for arabinosyltransferase activity in Mycobacterium tuberculosis
2001
|
|
| 2001
|
Studies on (β,1→5) and (β,1→6) linked octyl Galf disaccharides as substrates for mycobacterial galactosyltransferase activity.
Bioorganic and Medicinal Chemistry.
9:3129-3143.
2001
|
|
| 2001
|
Studies on α(1→5) linked octyl arabinofuranosyl disaccharides for mycobacterial arabinosyl transferase activity.
Bioorganic and Medicinal Chemistry.
9:3145-3151.
2001
|
|
| 2000
|
Synthesis of disaccharides related to the mycobacterial arabinogalactan.
Carbohydrate Letters.
4:117-122.
2000
|
|
| 2000
|
Synthesis and evaluation of several new (2-chloroethyl)nitrosocarbamates as potential anticancer agents.
Journal of Medicinal Chemistry.
43:1484-1488.
2000
|
|
| 2000
|
Development of semisynthetic triterpenoid saponin derivatives with immune stimulating activity.
Vaccine.
18:3141-3151.
2000
|
|
| 2000
|
Slow polymerization of Mycobacterium tuberculosis FtsZ.
Journal of Bacteriology.
182:4028-4034.
2000
|
|
| 2000
|
Antimycobacterial activities of 2,4-diamino-5-deazapteridine derivatives and effects on mycobacterial dihydrofolate reductase.
Antimicrobial Agents and Chemotherapy.
44:2784-2793.
2000
|
|
| 2000
|
Structure/function relationships of immunostimulating saponins.
Studies in Natural Products Chemistry.
24:131-174.
2000
|
|
| 1999
|
Studies on β-D-Gal(f)-(1→4)-α-L-Rha(p) octyl analogues as substrates for mycobacterial galactosyl transferase activity.
Bioorganic and Medicinal Chemistry.
7:2407-2413.
1999
|
|
| 1999
|
Ethambutol-sugar hybrids as potential inhibitors of mycobacterial cell-wall biosynthesis.
Carbohydrate Research.
317:164-179.
1999
|
|
| 1998
|
Susceptibilities of Mycobacterium tuberculosis and Mycobacterium avium complex to lipophilic deazapteridine derivatives, inhibitors of dihydrofolate reductase.
Journal of Antimicrobial Chemotherapy.
42:811-815.
1998
|
|
| 1998
|
Tin(IV) chloride mediated glycosylation in arabinofuranose, galactofuranose and rhamnopyranose
1998
|
|
| 1998
|
Homologated aza analogs of arabinose as antimycobacterial agents.
Bioorganic and Medicinal Chemistry Letters.
8:237-242.
1998
|
|
| 1998
|
In vitro activities of several diaminomethylpyridopyrimidines against Mycobacterium avium complex.
Antimicrobial Agents and Chemotherapy.
42:3315-3316.
1998
|
|
| 1996
|
Development of drug targeting based on recombinant expression of the chicken avidin gene.
Journal of Drug Targeting.
4:41-49.
1996
|
|
| 1996
|
Glycosyltransferases as targets for inhibition of cell wall synthesis in M. tuberculosis and M. avium.
Research in Microbiology.
147:106-121.
1996
|
|
| 1996
|
Structure-activity relationships of quinolone agents against Mycobacteria: Effect of structural modifications at the 8 position.
Antimicrobial Agents and Chemotherapy.
40:2363-2368.
1996
|
|
| 1994
|
The ABC's of chromatography: A colorful demonstration.
Journal of Chemical Education.
71:1075-1077.
1994
|
|
| 1993
|
Conformational studies of thymidine dimers containing sulfonate and sulfonamide linkages by NMR spectroscopy
1993
|
|
| 1992
|
5,5-Disubstituted Hydantoins: Syntheses and Anti-HIV Activity.
Journal of Medicinal Chemistry.
35:3567-3572.
1992
|
|
| 1992
|
Nucleoside Sultones: Synthons for the Preparation of Novel Nucleotide Analogsues. 1. Synthesis and Ring-Opening Reactions.
Journal of Organic Chemistry.
57:2830-2835.
1992
|
|
| 1992
|
Synthesis of Thymidine Dimers Containing Internucleoside Sulfonate and Sulfonamide Linkages.
Journal of Organic Chemistry.
57:2983-2985.
1992
|
|
| 1992
|
A thin-layer and column chromatography experiment adapted for use in secondary schools: A quick, safe, colorful, convenient introduction to two basic techniques.
Journal of Chemical Education.
69:989-991.
1992
|
|
| 1991
|
2,4-Dichloro-5-(1-o-carboranylmethyl)-6-methylpyrimidine: A Potential Synthon for 5-(1-o-Carboranylmethyl)pyrimidines.
Journal of Organic Chemistry.
56:2391-2395.
1991
|
|
| 1991
|
Progress toward the synthesis of nonionic oligonucleotide analogues with sulfonate and sulfonamide internucleotide linkages..
Nucleic Acids Symposium Series.
5-8.
1991
|
|
