Selected Publications

Academic Article

Year Title Altmetric
2023 Maturation of GABAergic Synaptic Transmission From Neocortical Parvalbumin Interneurons Involves N-methyl-D-aspartate Receptor Recruitment of Cav2.1 ChannelsNeuroscience.  513:38-53. 2023
2023 Maturation of GABAergic Synaptic Transmission From Neocortical Parvalbumin Interneurons Involves N-methyl-D-aspartate Receptor Recruitment of Cav2.1 ChannelsNeuroscience.  513:38-53. 2023
2022 Estrogen-related receptor gamma regulates mitochondrial and synaptic genes and modulates vulnerability to synucleinopathynpj Parkinson's Disease.  8. 2022
2022 Identification of Cytoprotective Small-Molecule Inducers of Heme-Oxygenase-1Antioxidants.  11. 2022
2022 Corrigendum to “Estrogen-related Receptor Alpha (ERRα) is Required for PGC-1α-dependent Gene Expression in the Mouse Brain” [Neuroscience 479 (2021) 70–90, (Neuroscience (2021) 479(70-90) (S0306452221005078), (10.1016/j.neuroscience.2021.10.007))Neuroscience.  493:119. 2022
2022 PV-specific loss of the transcriptional coactivator PGC-1a slows down the evolution of epileptic activity in an acute ictogenic modelJournal of Neurophysiology.  127:86-98. 2022
2022 The nrf2-dependent transcriptional regulation of antioxidant defense pathways: Relevance for cell type-specific vulnerability to neurodegeneration and therapeutic interventionAntioxidants.  11. 2022
2021 Estrogen-related Receptor Alpha (ERRα) is Required for PGC-1α-dependent Gene Expression in the Mouse BrainNeuroscience.  479:70-90. 2021
2021 Dysregulated clock gene expression and abnormal diurnal regulation of hippocampal inhibitory transmission and spatial memory in amyloid precursor protein transgenic miceNeurobiology of Disease.  158. 2021
2021 PARP-1 activation leads to cytosolic accumulation of TDP-43 in neurons 2021
2021 Molecular Mechanisms Underlying Synaptic and Axon Degeneration in Parkinson’s DiseaseFrontiers in Cellular Neuroscience.  15. 2021
2021 Dysregulation of PGC-1α-dependent transcriptional programs in neurological and developmental disorders: Therapeutic challenges and opportunitiesCells.  10:1-31. 2021
2021 Structure-activity relationship (SAR) studies of N-(3-methylpyridin-2-yl)-4-(pyridin-2-yl)thiazol-2-amine (SRI-22819) as NF-ҡB activators for the treatment of ALSEuropean Journal of Medicinal Chemistry.  210. 2021
2021 Neuronal VPS35 deletion induces spinal cord motor neuron degeneration and early post-natal lethalityBrain Communications.  3. 2021
2020 High-Fat and High-Sucrose Diets Impair Time-of-Day Differences in Spatial Working Memory of Male MiceObesity.  28:2347-2356. 2020
2020 Interactions between knockout of schizophrenia risk factor Dysbindin-1 and copper metabolism in miceBrain Research Bulletin.  164:339-349. 2020
2020 A Role for PGC-1α in Transcription and Excitability of Neocortical and Hippocampal Excitatory NeuronsNeuroscience.  435:73-94. 2020
2019 PINK1 phosphorylates ubiquitin predominantly in astrocytes.npj Parkinson's Disease.  5:29. 2019
2019 PINK1 phosphorylates ubiquitin predominantly in astrocytesnpj Parkinson's Disease.  5. 2019
2018 Cell-specific deletion of PGC-1α from medium spiny neurons causes transcriptional alterations and age-related motor impairment 2018
2017 The impact of the Standard American Diet in rats: Effects on behavior, physiology and recovery from inflammatory injuryScandinavian Journal of Pain.  17:316-324. 2017
2017 Glycogen synthase kinase 3 regulates photic signaling in the suprachiasmatic nucleusEuropean Journal of Neuroscience.  45:1102-1110. 2017
2016 Transcriptional dysregulation causes altered modulation of inhibition by haloperidolNeuropharmacology.  111:304-313. 2016
2016 Regulation of persistent sodium currents by glycogen synthase kinase 3 encodes daily rhythms of neuronal excitabilityNature Communications.  7. 2016
2016 Cortical PGC-1?-dependent transcripts are reduced in postmortem tissue from patients with schizophreniaSchizophrenia Bulletin.  42:1009-1017. 2016
2015 Interneuron transcriptional dysregulation causes frequency-dependent alterations in the balance of inhibition and excitation in hippocampus 2015
2015 Cerebellar transcriptional alterations with Purkinje cell dysfunction and loss in mice lacking PGC-1αFrontiers in Cellular Neuroscience.  8. 2015
2014 PGC-1α provides a transcriptional framework for synchronous neurotransmitter release from parvalbumin-positive interneurons 2014
2014 Differential LRRK2 expression in the cortex, striatum, and substantia nigra in transgenic and nontransgenic rodentsJournal of Comparative Neurology.  522:2465-2480. 2014
2014 Mice lacking the transcriptional coactivator PGC-1α exhibit alterations in inhibitory synaptic transmission in the motor cortexNeuroscience.  271:137-148. 2014
2014 Hyperactivity and cortical disinhibition in mice with restricted expression of mutant huntingtin to parvalbumin-positive cellsNeurobiology of Disease.  62:160-171. 2014
2013 LRRK2 secretion in exosomes is regulated by 14-3-3Human Molecular Genetics.  22:4988-5000. 2013
2013 Convergence of genetic and environmental factors on parvalbumin-positive interneurons in schizophreniaFrontiers in Behavioral Neuroscience2013
2013 Comprehensive characterization and optimization of anti-LRRK2 (leucine-rich repeat kinase 2) monoclonal antibodiesBiochemical Journal.  453:101-113. 2013
2013 Social isolation exacerbates schizophrenia-like phenotypes via oxidative stress in cortical interneuronsBiological Psychiatry.  73:1024-1034. 2013
2013 Purkinje cell dysfunction and loss in a knock-in mouse model of Huntington DiseaseExperimental Neurology.  240:96-102. 2013
2012 Developmental alterations in motor coordination and medium spiny neuron markers in mice lacking PGC-1αPLoS One.  7. 2012
2012 Disruption of Purkinje cell function prior to huntingtin accumulation and cell loss in an animal model of Huntington DiseaseExperimental Neurology.  236:171-178. 2012
2012 LRRK2 inhibition attenuates microglial inflammatory responses 2012
2010 Neuronal inactivation of peroxisome proliferator-activated receptor γ coactivator 1α(PGC-1α) protects mice from diet-induced obesity and leads to degenerative lesionsJournal of Biological Chemistry.  285:39087-39095. 2010
2010 Parvalbumin deficiency and GABAergic dysfunction in mice lacking PGC-1α 2010
2009 Identification of novel targets for PGC-1α and histone deacetylase inhibitors in neuroblastoma cellsBiochemical and Biophysical Research Communications.  379:578-582. 2009
2008 Regulation of PGC-1α and PGC-1α-responsive genes with forskolin-induced Schwann cell differentiationNeuroscience Letters.  439:269-274. 2008
2007 Localization of the transcriptional coactivator PGC-1α to GABAergic neurons during maturation of the rat brainJournal of Comparative Neurology.  502:1-18. 2007
2006 Microglial expression of chemokine receptor CCR5 during rat forebrain development and after perinatal hypoxia-ischemiaJournal of Neuroimmunology.  173:155-165. 2006
2003 Complement Activation Contributes to Hypoxic-Ischemic Brain Injury in Neonatal Rats 2003
2003 Developmental changes in the expression of chemokine receptor CCR1 in the rat cerebellumJournal of Comparative Neurology.  457:7-23. 2003
2002 Hypoxic-ischemic injury induces macrophage inflammatory protein-1α expression in immature rat brainStroke.  33:795-801. 2002
2000 Dopamine transporter antagonists block phorbol ester-induced dopamine release and dopamine transporter phosphorylation in striatal synaptosomesEuropean Journal of Pharmacology.  389:59-65. 2000
2000 Acute excitotoxic injury induces expression of monocyte chemoattractant protein-1 and its receptor, CCR2, in neonatal rat brainExperimental Neurology.  165:295-305. 2000
1998 Therapeutic effects of complex motor training on motor performance deficits induced by neonatal binge-like alcohol exposure in rats I. Behavioral resultsBrain Research.  800:48-61. 1998


Year Title Altmetric
2013 Peripheral Neuropathy and the Schwann Cell 2013

Research Overview

  • Neurodegeneration; animal models; neuroanatomy; transcriptomics; confocal microscopy; Parkinson Disease; Huntington Disease; Frontotemporal Dementia; Amyotrophic Lateral Sclerosis.
  • Education And Training

  • University of Michigan Medical School Neurology, Postdoctoral Fellowship
  • Doctor of Philosophy in Neuroscience, University of Michigan System : Ann Arbor 2002
  • Full Name

  • Rita Cowell