Selected Publications

Academic Article

Year Title Altmetric
2022 Identification of Cytoprotective Small-Molecule Inducers of Heme-Oxygenase-1Antioxidants.  11. 2022
2022 Corrigendum to “Estrogen-related Receptor Alpha (ERRα) is Required for PGC-1α-dependent Gene Expression in the Mouse Brain” [Neuroscience 479 (2021) 70–90, (Neuroscience (2021) 479(70-90) (S0306452221005078), (10.1016/j.neuroscience.2021.10.007))Neuroscience.  493:119. 2022
2022 PV-specific loss of the transcriptional coactivator PGC-1a slows down the evolution of epileptic activity in an acute ictogenic modelJournal of Neurophysiology.  127:86-98. 2022
2022 The nrf2-dependent transcriptional regulation of antioxidant defense pathways: Relevance for cell type-specific vulnerability to neurodegeneration and therapeutic interventionAntioxidants.  11. 2022
2021 Estrogen-related Receptor Alpha (ERRα) is Required for PGC-1α-dependent Gene Expression in the Mouse BrainNeuroscience.  479:70-90. 2021
2021 Dysregulated clock gene expression and abnormal diurnal regulation of hippocampal inhibitory transmission and spatial memory in amyloid precursor protein transgenic miceNeurobiology of Disease.  158. 2021
2021 PARP-1 activation leads to cytosolic accumulation of TDP-43 in neuronsNeurochemistry International: the journal for the publication of cellular and molecular aspects of neurochemistry.  148. 2021
2021 Molecular Mechanisms Underlying Synaptic and Axon Degeneration in Parkinson’s DiseaseFrontiers in Cellular Neuroscience.  15. 2021
2021 Dysregulation of PGC-1α-dependent transcriptional programs in neurological and developmental disorders: Therapeutic challenges and opportunitiesCells.  10:1-31. 2021
2021 Structure-activity relationship (SAR) studies of N-(3-methylpyridin-2-yl)-4-(pyridin-2-yl)thiazol-2-amine (SRI-22819) as NF-ҡB activators for the treatment of ALSEuropean Journal of Medicinal Chemistry.  210. 2021
2021 Neuronal VPS35 deletion induces spinal cord motor neuron degeneration and early post-natal lethalityBrain Communications.  3. 2021
2020 High-Fat and High-Sucrose Diets Impair Time-of-Day Differences in Spatial Working Memory of Male MiceObesity.  28:2347-2356. 2020
2020 Interactions between knockout of schizophrenia risk factor Dysbindin-1 and copper metabolism in miceBrain Research Bulletin.  164:339-349. 2020
2020 A Role for PGC-1α in Transcription and Excitability of Neocortical and Hippocampal Excitatory NeuronsNeuroscience.  435:73-94. 2020
2019 PINK1 phosphorylates ubiquitin predominantly in astrocytes.npj Parkinson's Disease.  5:29. 2019
2019 PINK1 phosphorylates ubiquitin predominantly in astrocytesnpj Parkinson's Disease.  5. 2019
2018 Cell-specific deletion of PGC-1α from medium spiny neurons causes transcriptional alterations and age-related motor impairmentThe Journal of Neuroscience.  38:3273-3286. 2018
2017 The impact of the Standard American Diet in rats: Effects on behavior, physiology and recovery from inflammatory injuryScandinavian Journal of Pain.  17:316-324. 2017
2017 Glycogen synthase kinase 3 regulates photic signaling in the suprachiasmatic nucleusEuropean Journal of Neuroscience.  45:1102-1110. 2017
2016 Transcriptional dysregulation causes altered modulation of inhibition by haloperidolNeuropharmacology.  111:304-313. 2016
2016 Regulation of persistent sodium currents by glycogen synthase kinase 3 encodes daily rhythms of neuronal excitabilityNature Communications.  7. 2016
2016 Cortical PGC-1?-dependent transcripts are reduced in postmortem tissue from patients with schizophreniaSchizophrenia Bulletin.  42:1009-1017. 2016
2015 Interneuron transcriptional dysregulation causes frequency-dependent alterations in the balance of inhibition and excitation in hippocampusThe Journal of Neuroscience.  35:15276-15290. 2015
2015 Cerebellar transcriptional alterations with Purkinje cell dysfunction and loss in mice lacking PGC-1αFrontiers in Cellular Neuroscience.  8. 2015
2014 PGC-1α provides a transcriptional framework for synchronous neurotransmitter release from parvalbumin-positive interneuronsThe Journal of Neuroscience.  34:14375-14387. 2014
2014 Differential LRRK2 expression in the cortex, striatum, and substantia nigra in transgenic and nontransgenic rodentsJournal of Comparative Neurology.  522:2465-2480. 2014
2014 Mice lacking the transcriptional coactivator PGC-1α exhibit alterations in inhibitory synaptic transmission in the motor cortexNeuroscience.  271:137-148. 2014
2014 Hyperactivity and cortical disinhibition in mice with restricted expression of mutant huntingtin to parvalbumin-positive cellsNeurobiology of Disease.  62:160-171. 2014
2013 LRRK2 secretion in exosomes is regulated by 14-3-3Human Molecular Genetics.  22:4988-5000. 2013
2013 Convergence of genetic and environmental factors on parvalbumin-positive interneurons in schizophreniaFrontiers in Behavioral Neuroscience2013
2013 Comprehensive characterization and optimization of anti-LRRK2 (leucine-rich repeat kinase 2) monoclonal antibodiesBiochemical Journal.  453:101-113. 2013
2013 Social isolation exacerbates schizophrenia-like phenotypes via oxidative stress in cortical interneuronsBiological Psychiatry.  73:1024-1034. 2013
2013 Purkinje cell dysfunction and loss in a knock-in mouse model of Huntington DiseaseExperimental Neurology.  240:96-102. 2013
2012 Developmental alterations in motor coordination and medium spiny neuron markers in mice lacking PGC-1αPLoS One.  7. 2012
2012 Disruption of Purkinje cell function prior to huntingtin accumulation and cell loss in an animal model of Huntington DiseaseExperimental Neurology.  236:171-178. 2012
2012 LRRK2 inhibition attenuates microglial inflammatory responsesThe Journal of Neuroscience.  32:1602-1611. 2012
2010 Neuronal inactivation of peroxisome proliferator-activated receptor γ coactivator 1α(PGC-1α) protects mice from diet-induced obesity and leads to degenerative lesionsJournal of Biological Chemistry.  285:39087-39095. 2010
2010 Parvalbumin deficiency and GABAergic dysfunction in mice lacking PGC-1αThe Journal of Neuroscience.  30:7227-7235. 2010
2009 Identification of novel targets for PGC-1α and histone deacetylase inhibitors in neuroblastoma cellsBiochemical and Biophysical Research Communications.  379:578-582. 2009
2008 Regulation of PGC-1α and PGC-1α-responsive genes with forskolin-induced Schwann cell differentiationNeuroscience Letters.  439:269-274. 2008
2007 Localization of the transcriptional coactivator PGC-1α to GABAergic neurons during maturation of the rat brainJournal of Comparative Neurology.  502:1-18. 2007
2006 Microglial expression of chemokine receptor CCR5 during rat forebrain development and after perinatal hypoxia-ischemiaJournal of Neuroimmunology.  173:155-165. 2006
2003 Complement Activation Contributes to Hypoxic-Ischemic Brain Injury in Neonatal RatsThe Journal of Neuroscience.  23:9459-9468. 2003
2003 Developmental changes in the expression of chemokine receptor CCR1 in the rat cerebellumJournal of Comparative Neurology.  457:7-23. 2003
2002 Hypoxic-ischemic injury induces macrophage inflammatory protein-1α expression in immature rat brainStroke.  33:795-801. 2002
2000 Dopamine transporter antagonists block phorbol ester-induced dopamine release and dopamine transporter phosphorylation in striatal synaptosomes 2000
2000 Acute excitotoxic injury induces expression of monocyte chemoattractant protein-1 and its receptor, CCR2, in neonatal rat brainExperimental Neurology.  165:295-305. 2000
1998 Therapeutic effects of complex motor training on motor performance deficits induced by neonatal binge-like alcohol exposure in rats I. Behavioral resultsBrain Research.  800:48-61. 1998


Year Title Altmetric
2013 Peripheral Neuropathy and the Schwann Cell 2013

Research Overview

  • Neurodegeneration; animal models; neuroanatomy; transcriptomics; confocal microscopy; Parkinson Disease; Huntington Disease; Frontotemporal Dementia; Amyotrophic Lateral Sclerosis.
  • Education And Training

  • University of Michigan Medical School Neurology, Postdoctoral Fellowship
  • Doctor of Philosophy in Neuroscience, University of Michigan System : Ann Arbor 2002
  • Full Name

  • Rita Cowell