Positions

Overview

  • Rakesh Patel PhD is Professor and Vice Chair for Research in the Department of Pathology, and Director of the UAB Center for Free Radical Biology. He is a graduate of the University of Essex, England (BSc with Hons (1993) and PhD in Biochemistry (1996)) and moved to UAB in 1997. He is also director of the UAB Translational and Molecular sciences Certificate and T32 Program (for Predocs), and past Director of the Department of Pathology Graduate Program (7y), UAB Pathobiology and Molecular Medicine Graduate theme (5y) and HHMI-UAB Med to Grad predoctoral program (6y). Since establishing his independent research laboratory in 2000, his lab has focused on understanding the role of oxidative / nitrosative intermediates in modulating acute and chronic inflammatory diseases.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2023 Myeloperoxidase-derived hypochlorous acid targets human airway epithelial plasmalogens liberating protein modifying electrophilic 2-chlorofatty aldehydesRedox Biology.  59. 2023
    2023 Different-sized extracellular vesicles derived from stored red blood cells package diverse cargoes and cause distinct cellular effectsTransfusion2023
    2022 Clustering Patients With Gout Based on Comorbidities and Biomarkers: A Cross-Sectional Study.Journal of Rheumatology2022
    2022 Endothelial alpha globin is a nitrite reductaseNature Communications.  13. 2022
    2022 Red blood cell exosome hemoglobin content increases after cardiopulmonary bypass and mediates acute kidney injury in an animal modelJournal of Thoracic and Cardiovascular Surgery.  164:e289-e308. 2022
    2022 Pathways Linking Oral Bacteria, Nitric Oxide Metabolism, and Health 2022
    2022 Peroxiredoxin-2 recycling is slower in denser and pediatric sickle cell red cells 2022
    2022 Tri-iodide and vanadium chloride based chemiluminescent methods for quantification of nitrogen oxidesNitric Oxide: Biology and Chemistry.  121:11-19. 2022
    2022 Plasma Exosome Hemoglobin Released During Surgery Is Associated With Cardiac Injury in Animal ModelAnnals of Thoracic Surgery2022
    2021 Supplemental nitrite increases choroidal neovascularization in miceNitric Oxide: Biology and Chemistry.  117:7-15. 2021
    2021 Safety and toxicology assessment of sodium nitrite administered by intramuscular injectionToxicology and Applied Pharmacology.  429. 2021
    2021 Human and rodent red blood cells do not demonstrate xanthine oxidase activity or XO-catalyzed nitrite reduction to NOFree Radical Biology and Medicine.  174:84-88. 2021
    2021 Corrigendum to “Potential role for age as a modulator of oral nitrate reductase activity”. [Nitric oxide J, (2021 Mar 1). 108. 1–7] (Nitric Oxide (2021) 108 (1–7), (S1089860320302123), (10.1016/j.niox.2020.12.001))Nitric Oxide: Biology and Chemistry.  113-114:78-79. 2021
    2021 Endogenous generation of nitro-fatty acid hybrids having dual nitrate ester (RONO2) and nitroalkene (RNO2) substituentsRedox Biology.  41. 2021
    2021 Spatial mapping of SARS-CoV-2 and H1N1 lung injury identifies differential transcriptional signaturesCell Reports Medicine.  2. 2021
    2021 A mechanism for matrikine regulation in acute inflammatory lung injuryJCI Insight.  6. 2021
    2021 Potential role for age as a modulator of oral nitrate reductase activityNitric Oxide: Biology and Chemistry.  108:1-7. 2021
    2021 Xanthine Oxidase Drives Hemolysis and Vascular Malfunction in Sickle Cell Disease 2021
    2021 Bronchopulmonary dysplasia is associated with reduced oral nitrate reductase activity in extremely preterm infantsRedox Biology.  38. 2021
    2021 Resveratrol and exercise combined to treat functional limitations in late life: A pilot randomized controlled trialExperimental Gerontology.  143. 2021
    2020 Acute beetroot juice supplementation improves exercise tolerance and cycling efficiency in adults with obesityPhysiological Reports.  8. 2020
    2020 Airway nitrite is increased in extremely preterm infants with bronchopulmonary dysplasiaRespiratory Research.  21. 2020
    2020 Damage to red blood cells during whole blood storageJournal of Trauma and Acute Care Surgery.  89:344-350. 2020
    2020 Hydrogen peroxide regulates endothelial surface N-glycoforms to control inflammatory monocyte rolling and adhesionRedox Biology.  34. 2020
    2020 Selective Recruitment of Monocyte Subsets by Endothelial N-GlycansAmerican Journal of Pathology.  190:947-957. 2020
    2020 Local Peroxynitrite Impairs Endothelial Transient Receptor Potential Vanilloid 4 Channels and Elevates Blood Pressure in ObesityCirculation.  141:1318-1333. 2020
    2020 Neonatal comorbidities and gasotransmittersNitric Oxide: Biology and Chemistry.  97:27-32. 2020
    2020 Over-the-counter mouthwash use, nitric oxide and hypertension risk 2020
    2020 Assessment of ICAM-1 N-glycoforms in mouse and human models of endothelial dysfunctionPLoS One.  15. 2020
    2019 A murine neonatal model of necrotizing enterocolitis caused by anemia and red blood cell transfusionsNature Communications.  10. 2019
    2019 SOD2 acetylation and deacetylation: Another tale of Jekyll and Hyde in cancer 2019
    2019 Response by Lundberg et al to Letter Regarding Article, "hemoglobin β93 Cysteine Is Not Required for Export of Nitric Oxide Bioactivity from the Red Blood Cell"Circulation.  140:E760-E761. 2019
    2019 High-mannose intercellular adhesion molecule-1 enhances CD16+ monocyte adhesion to the endothelium 2019
    2019 Serum mir-204 is an early biomarker of type 1 diabetes-associated pancreatic beta-cell loss 2019
    2019 Phosgene inhalation causes hemolysis and acute lung injuryToxicology Letters.  312:204-213. 2019
    2019 Erythrocyte and plasma oxidative stress appears to be compensated in patients with sickle cell disease during a period of relative health, despite the presence of known oxidative agentsFree Radical Biology and Medicine.  141:408-415. 2019
    2019 Hemoglobin β93 Cysteine Is Not Required for Export of Nitric Oxide Bioactivity from the Red Blood CellCirculation.  139:2654-2663. 2019
    2019 Older Blood Is Associated With Increased Mortality and Adverse Events in Massively Transfused Trauma Patients: Secondary Analysis of the PROPPR TrialAnnals of Emergency Medicine.  73:650-661. 2019
    2019 Plasma xanthine oxidase activity is related to increased sodium and left ventricular hypertrophy in resistant hypertensionFree Radical Biology and Medicine.  134:343-349. 2019
    2019 The role of redox-dependent mechanisms in heme release from hemoglobin and erythrocyte hemolysatesMolecular cell biology research communications : MCBRC.  662:111-120. 2019
    2019 Characterizing red blood cell age exposure in massive transfusion therapy: the scalar age of blood index (SBI)Transfusion.  59:2699-2708. 2019
    2019 Erratum: Correction: Role of heme in lung bacterial infection after trauma hemorrhage and stored red blood cell transfusion: A preclinical experimental study (PLoS Med (2018) 15:3 (e1002522) DOI: 10.1371/journal.pmed.1002522)PLoS Medicine.  16. 2019
    2019 Nitrite and nitrate chemical biology and signallingBritish Journal of Pharmacology.  176:228-245. 2019
    2018 Non-invasive analysis of stored red blood cells using diffuse resonance Raman spectroscopy 2018
    2018 Characterization of storage-induced red blood cell hemolysis using Raman spectroscopyLaboratory Medicine.  49:298-310. 2018
    2018 Role of common γ-Chain cytokines in lung interleukin-22 regulation after acute exposure to aspergillus fumigatusInfection and Immunity.  86. 2018
    2018 Acute kidney injury during parvovirus B19-induced transient aplastic crisis in sickle cell diseaseAmerican Journal of Hematology.  93:E198-E200. 2018
    2018 Potential biomarkers of tissue hypoxia during acute hemodilutional anemia in cardiac surgery: A prospective study to assess tissue hypoxia as a mechanism of organ injury 2018
    2018 Things we “kNOw” and do not “kNOw” about pulmonary hypertensionAmerican Journal of Respiratory and Critical Care Medicine.  198:151-152. 2018
    2018 Role of heme in lung bacterial infection after trauma hemorrhage and stored red blood cell transfusion: A preclinical experimental studyPLoS Medicine.  15. 2018
    2018 Bromofatty aldehyde derived from bromine exposure and myeloperoxidase and eosinophil peroxidase modify GSH and proteinJournal of Lipid Research.  59:696-705. 2018
    2018 Proceedings of the Food and Drug Administration's public workshop on new red blood cell product regulatory science 2016Transfusion.  58:255-266. 2018
    2017 Over-the-counter mouthwash use and risk of pre-diabetes/diabetesNitric Oxide: Biology and Chemistry.  71:14-20. 2017
    2017 The Matrikine Acetylated Proline-Glycine-Proline Couples Vascular Inflammation and Acute Cardiac RejectionScientific Reports.  7. 2017
    2017 Mechanisms and Treatment of Halogen Inhalation-Induced Pulmonary and Systemic Injuries in Pregnant MiceHypertension.  70:390-400. 2017
    2017 Measuring nitrate reductase activity from human and rodent tonguesNitric Oxide: Biology and Chemistry.  66:62-70. 2017
    2017 Assuring hospital supply of fresh red blood cells for critically ill patientsTransfusion.  57:1320-1321. 2017
    2017 Nitrite therapy prevents chlorine gas toxicity in rabbitsToxicology Letters.  271:20-25. 2017
    2017 Validation of two point-of-care tests against standard lab measures of NO in saliva and in serumNitric Oxide: Biology and Chemistry.  64:16-21. 2017
    2016 Corrigendum to “Assessment of endothelial glycocalyx disruption in term parturients receiving a fluid bolus before spinal anesthesia: a prospective observational study” (International Journal of Obstetric Anesthesia (2014) 23 (330–334)(S0959289X14000843)(10.1016/j.ijoa.2014.06.001))International Journal of Obstetric Anesthesia.  28:100. 2016
    2016 Red blood cell transfusion and its effect on microvascular dysfunction in shock states 2016
    2016 464 Characterization of Microparticles and Exosomes from Red Blood Cells During Storage: Implications for Transfusion ToxicityFree Radical Biology and Medicine.  100:s193. 2016
    2016 Absorbance and redox based approaches for measuring free heme and free hemoglobin in biological matricesRedox Biology.  9:167-177. 2016
    2016 Formation of chlorinated lipids post-chlorine gas exposureJournal of Lipid Research.  57:1529-1540. 2016
    2016 The role of red blood cell S-nitrosation in nitrite bioactivation and its modulation by leucine and glucoseRedox Biology.  8:415-421. 2016
    2016 Compartmentalization is key in limiting nitric oxide scavenging by cell-free hemoglobinAmerican Journal of Respiratory and Critical Care Medicine.  193:1072-1074. 2016
    2016 There is blood in the water: Hemolysis, hemoglobin, and heme in acute lung injury 2016
    2016 Yes to "NO" host flora symbiosis 2016
    2015 Predicting storage-dependent damage to red blood cells using nitrite oxidation kinetics, peroxiredoxin-2 oxidation, and hemoglobin and free heme measurementsTransfusion.  55:2967-2978. 2015
    2015 A nitric oxide-releasing self-assembled peptide amphiphile nanomatrix for improving the biocompatibility of microporous hollow fibersASAIO Journal.  61:589-595. 2015
    2015 Inhaled nitric oxide therapy for extrapulmonary inflammationFuture Science OA.  1. 2015
    2015 Red blood cell washing, nitrite therapy, and antiheme therapies prevent stored red blood cell toxicity after trauma-hemorrhageFree Radical Biology and Medicine.  85:207-218. 2015
    2015 The matrikine N-α-PGP couples extracellular matrix fragmentation to endothelial permeabilityScience Advances.  1. 2015
    2015 Peroxiredoxin-2 recycling is inhibited during erythrocyte storageAntioxidants and Redox Signaling.  22:294-307. 2015
    2015 Working with nitric oxide and hydrogen sulfide in biological systems 2015
    2014 Assessment of endothelial glycocalyx disruption in term parturients receiving a fluid bolus before spinal anesthesia: A prospective observational studyInternational Journal of Obstetric Anesthesia.  23:330-334. 2014
    2014 Nitrite therapy improves survival postexposure to chlorine gas 2014
    2014 A novel model of chronic wounds: Importance of redox imbalance and biofilm-forming bacteria for establishment of chronicityPLoS One.  9. 2014
    2014 Chlorine gas exposure disrupts nitric oxide homeostasis in the pulmonary vasculatureToxicology.  321:96-102. 2014
    2014 The transcription factor E26 transformation-specific sequence-1 mediates neointima formation in arteriovenous fistulaJournal of the American Society of Nephrology.  25:475-487. 2014
    2014 Redox therapeutics in hepatic ischemia reperfusion injuryWorld Journal of Hepatology.  6:1-8. 2014
    2014 A randomized clinical trial testing the anti-inflammatory effects of preemptive inhaled nitric oxide in human liver transplantationPLoS One.  9. 2014
    2014 Mechanism of faster NO scavenging by older stored red blood cellsRedox Biology.  2:211-219. 2014
    2014 Increased sensitivity of Apolipoprotein E knockout mice to swainsonine dependent immunomodulationImmunobiology.  219:497-502. 2014
    2014 Membrane attack complex generation increases as a function of time in stored bloodTransfusion Medicine.  24:114-116. 2014
    2013 The level of complement activation fragments is higher in red blood cell units than segmentsTransfusion and Apheresis Science.  49:692-693. 2013
    2013 The deleterious effect of red blood cell storage on microvascular response to transfusionJournal of Trauma and Acute Care Surgery.  75:807-812. 2013
    2013 Effects of erythrocyte aging on nitric oxide and nitrite metabolismAntioxidants and Redox Signaling.  19:1198-1208. 2013
    2013 Targeting endothelial adhesion molecule mrna to control inflammation: Novel insights into potential anti-inflammatory effects of il-19. focus on "interleukin-19 decreases leukocyte-endothelial cell interactions by reduction in endothelial cell adhesion molecule mrna stability" 2013
    2013 Identification of a high-mannose ICAM-1 glycoform: Effects of ICAM-1 hypoglycosylation on monocyte adhesion and outside in signaling 2013
    2013 Endothelial heterogeneity and adhesion molecules N-glycosylation: Implications in leukocyte trafficking in inflammationGlycobiology.  23:622-633. 2013
    2013 Erratum: Elevated levels of NO are localized to distal airways in asthma (Free Radical Biology and Medicine (2011) 50 (1679-1688))Free Radical Biology and Medicine.  58:45. 2013
    2013 Role of the b93cys, ATP and adenosine in red cell dependent hypoxic vasorelaxationInternational Journal of Physiology, Pathophysiology and Pharmacology.  5:21-31. 2013
    2013 Antioxidant functions for the hemoglobin β93 cysteine residue in erythrocytes and in the vascular compartment in vivoFree Radical Biology and Medicine.  55:119-129. 2013
    2013 Heterogenic endothelial responses to inflammation: role for differential N-glycosylation and vascular bed of origin.Journal of the American Heart Association.  2. 2013
    2013 Is methemoglobin an inert bystander, biomarker or a mediator of oxidative stress-the example of anemia?Redox Biology.  1:65-69. 2013
    2012 Overexpression of endothelial nitric oxide synthase prevents diet-induced obesity and regulates adipocyte phenotypeCirculation Research.  111:1176-1189. 2012
    2012 Administration of nitrite after chlorine gas exposure prevents lung injury: Effect of administration modalityFree Radical Biology and Medicine.  53:1431-1439. 2012
    2012 Nitric oxide formation versus scavenging: The red blood cell balancing act 2012
    2012 Erythrocyte storage increases rates of NO and nitrite scavenging: Implications for transfusion-related toxicityBiochemical Journal.  446:499-508. 2012
    2012 ABO Blood Group Is Associated with Response to Inhaled Nitric Oxide in Neonates with Respiratory FailurePLoS One.  7. 2012
    2012 Role of endothelial N-glycan mannose residues in monocyte recruitment during atherogenesis 2012
    2012 Sodium nitrite protects against kidney injury induced by brain death and improves post-transplant functionKidney International.  82:304-313. 2012
    2012 Single-dose pharmacokinetics of different oral sodium nitrite formulations in diabetes patientsDiabetes Technology and Therapeutics.  14:552-560. 2012
    2012 Metabolic and cardiac signaling effects of inhaled hydrogen sulfide and low oxygen in male ratsJournal of Applied Physiology.  112:1659-1669. 2012
    2012 Encapsulation of hemoglobin inside liposomes surface conjugated with poly(ethylene glycol) attenuates their reactions with gaseous ligands and regulates nitric oxide dependent vasodilationBiotechnology Progress.  28:636-645. 2012
    2012 Inhalation of nitric oxide prevents ischemic brain damage in experimental stroke by selective dilatation of collateral arteriolesCirculation Research.  110:727-738. 2012
    2012 Microvascular response to red blood cell transfusion in trauma patientsShock.  37:276-281. 2012
    2011 Endothelial surface N-glycans mediate monocyte adhesion and are targets for anti-inflammatory effects of peroxisome proliferator-activated receptor γ ligandsJournal of Biological Chemistry.  286:38738-38747. 2011
    2011 A Role for Endothelial Mannose Residues in Inflammation Dependent Monocyte Adhesion Under FlowGlycobiology.  21:1504-1504. 2011
    2011 Losing control over adenosine 5′-triphosphate release: Implications for the red blood cell storage lesionCritical Care Medicine.  39:2573-2574. 2011
    2011 Current perspectives and challenges in understanding the role of nitrite as an integral player in nitric oxide biology and therapyFree Radical Biology and Medicine.  51:805-812. 2011
    2011 Chlorine gas exposure causes systemic endothelial dysfunction by inhibiting endothelial nitric oxide synthase-dependent signalingAmerican Journal of Respiratory Cell and Molecular Biology.  45:419-425. 2011
    2011 Effects of T- and R-state stabilization on deoxyhemoglobin-nitrite reactions and stimulation of nitric oxide signalingNitric Oxide: Biology and Chemistry.  25:59-69. 2011
    2011 Elevated levels of NO are localized to distal airways in asthmaFree Radical Biology and Medicine.  50:1679-1688. 2011
    2011 P75. The effects of red blood cell storage time on nitric oxide and nitrite-dependent signalingNitric Oxide: Biology and Chemistry.  24:s42. 2011
    2011 Red blood cell age and potentiation of transfusion-related pathology in trauma patientsTransfusion.  51:867-873. 2011
    2011 Mitigation of chlorine gas lung injury in rats by postexposure administration of sodium nitrite 2011
    2011 Acyloxy nitroso compounds as nitroxyl (HNO) donors: Kinetics, reactions with thiols, and vasodilation propertiesJournal of Medicinal Chemistry.  54:1059-1070. 2011
    2011 The detection of the nitrite reductase and NO-generating properties of haemoglobin by mitochondrial inhibitionCardioscience.  89:566-573. 2011
    2011 The potential role of the red blood cell in nitrite-dependent regulation of blood flowCardioscience.  89:507-515. 2011
    2011 Dipyridamole reverses peripheral ischemia and induces angiogenesis in the Db/Db diabetic mouse hind-limb model by decreasing oxidative stressFree Radical Biology and Medicine.  50:262-269. 2011
    2010 Erythrocyte-dependent regulation of human skeletal muscle blood flow: Role of varied oxyhemoglobin and exercise on nitrite, S-nitrosohemoglobin, and ATP 2010
    2010 Isoflavones and PPAR signaling: A critical target in cardiovascular, metastatic, and metabolic diseasePPAR Research2010
    2010 S-Nitrosothiol biology and therapeutic potential in metabolic disease 2010
    2010 ICAM-1 cytoplasmic tail regulates endothelial glutathione synthesis through a NOX4/PI3-kinase-dependent pathwayFree Radical Biology and Medicine.  49:1119-1128. 2010
    2010 The apolipoprotein A-I mimetic peptide 4F prevents defects in vascular function in endotoxemic ratsJournal of Lipid Research.  51:2695-2705. 2010
    2010 Dietary flavonoid quercetin stimulates vasorelaxation in aortic vesselsFree Radical Biology and Medicine.  49:339-347. 2010
    2010 Potential for chlorine gas-induced injury in the extrapulmonary vasculatureAnnals of the American Thoracic Society.  7:290-293. 2010
    2010 Dipyridamole enhances ischaemia-induced arteriogenesis through an endocrine nitrite/nitric oxide-dependent pathwayCardioscience.  85:661-670. 2010
    2010 Effects of T-state and R-state stabilization on Deoxyhemoglobin-nitrite Reactions and Stimulation of Nitric Oxide (NO) SignalingFree Radical Biology and Medicine.  49:s111. 2010
    2010 Post–Cl2 Exposure Therapeutics Using Nitrite: Different Effects of IM vs. IP AdministrationFree Radical Biology and Medicine.  49:s196. 2010
    2010 Role of Hemoglobin Beta93Cys as an Antioxidant in the Vascular Compartment: Implications for Vascular Homeostasis During EndotoxemiaFree Radical Biology and Medicine.  49:s150. 2010
    2010 The Effects of Red Blood Cell Storage Time on Nitric Oxide and Nitrite-dependent SignalingFree Radical Biology and Medicine.  49:s30. 2010
    2009 Sodium nitrite therapy attenuates the hypertensive effects of HBOC-201 via nitrite reductionBiochemical Journal.  422:423-432. 2009
    2009 A mitochondria-targeted S-nitrosothiol modulates respiration, nitrosates thiols, and protects against ischemia-reperfusion injury 2009
    2009 Regulation of nitrite transport in red blood cells by hemoglobin oxygen fractional saturation 2009
    2009 Low intensity shear stress increases endothelial ELR+ CXC chemokine production via a focal adhesion kinase-p38β MAPK-NF-κB pathwayJournal of Biological Chemistry.  284:5945-5955. 2009
    2009 Antioxidant Role of Hemoglobin Beta93 Cysteine in the Red Blood Cell and the Vascular CompartmentFree Radical Biology and Medicine.  47:S67-S68. 2009
    2009 Developmental changes in circulating IL-8/CXCL8 isoforms in neonatesCytokine.  46:12-16. 2009
    2009 Hypoxic Nitrite Reduction to Nitric Oxide Varies by Cell TypeFree Radical Biology and Medicine.  47:S33-S34. 2009
    2009 Nitrate and nitrite in biology, nutrition and therapeuticsNature Chemical Biology.  5:865-869. 2009
    2009 Reply to 'Nitrite-methemoglobin inadequate for hypoxic vasodilation'Nature Chemical Biology.  5:367. 2009
    2009 Sodium Nitrite Administration Mitigates Lung Injury After Chlorine Gas Exposure in RatsFree Radical Biology and Medicine.  47:S103-S103. 2009
    2008 Modulatory effects of hypercapnia on in vitro and in vivo pulmonary endothelial-neutrophil adhesive responses during inflammationCytokine.  44:108-117. 2008
    2008 Preserving vessel function during ischemic disease: New possibilities of inorganic nitrite therapyExpert Review of Cardiovascular Therapy.  6:1175-1179. 2008
    2008 SNO-hemoglobin and hypoxic vasodilationNature Medicine.  14:1009. 2008
    2008 SNO-hemoglobin and hypoxic vasodilationNature Medicine.  14:1009-1009. 2008
    2008 Dipyridamole promotes ischemia-induced angiogenesis and tissue blood flow in critical limb ischemia througha PKA dependent nitric oxide pathwayEuropean Heart Journal.  29:241-241. 2008
    2008 SNO-hemoglobin is not essential for red blood cell-dependent hypoxic vasodilationNature Medicine.  14:773-777. 2008
    2008 Chronic sodium nitrite therapy augments ischemia-induced angiogenesis and arteriogenesis 2008
    2008 The role of red blood cells and hemoglobin-nitric oxide interactions on blood flowAmerican Journal of Respiratory Cell and Molecular Biology.  38:125-126. 2008
    2008 Activation of Endothelial Nitric Oxide Synthase and Heme Oxygenase 1 Expression in Vasculature by Nitro-Fatty AcidsFree Radical Biology and Medicine.  45:S32-S32. 2008
    2008 Chapter 9 Novel Method for Measuring S-Nitrosothiols Using Hydrogen SulfideMethods in Enzymology.  441:161-172. 2008
    2008 Inhibition of CXCR2 and P38 signaling can block ECMO-related inflammationJournal of Investigative Medicine.  56:423-424. 2008
    2008 Inhibition of CXCR2 and p38 signaling can block ECMO-related inflammationJournal of Investigative Medicine.  56:478-479. 2008
    2007 The hemoglobin‐nitric oxide axis: implications for transfusion therapeuticsTransfusion Alternatives in Transfusion Medicine.  9:273-280. 2007
    2007 Hydrogen sulfide mediates the vasoactivity of garlic 2007
    2007 Hemoglobin oxygen fractional saturation regulates nitrite-dependent vasodilation of aortic ring bioassays 2007
    2007 Inhaled NO accelerates restoration of liver function in adults following orthotopic liver transplantationJournal of Clinical Investigation.  117:2583-2591. 2007
    2007 Sildenafil promotes ischemia-induced angiogenesis through a PKG-dependent pathway 2007
    2007 Mycobacterium tuberculosis DosS is a redox sensor and DosT is a hypoxia sensor 2007
    2007 Effects of venous needle turbulence during ex vivo hemodialysis on endothelial morphology and nitric oxide formationJournal of Biomechanics.  40:2158-2166. 2007
    2007 Modulation of pulmonary endothelial endothelin B receptor expression and signaling: Implications for experimental hepatopulmonary syndrome 2007
    2007 Hydrogen sulfide mediates vasoactivity in an O2-dependent manner 2007
    2007 Pentoxifylline attenuation of experimental hepatopulmonary syndromeJournal of Applied Physiology.  102:949-955. 2007
    2007 Regulation of endothelial glutathione by ICAM-1 governs VEGF-A-mediated eNOS activity and angiogenesisFree Radical Biology and Medicine.  42:720-729. 2007
    2007 Anti-inflammatory effects of isoflavones are dependent on flow and human endothelial cell PPARγ 2007
    2007 Catalytic generation of N2O3 by the concerted nitrite reductase and anhydrase activity of hemoglobinNature Chemical Biology.  3:785-794. 2007
    2007 Deoxyhemoglobin possesses dual functions as NO scavenger and a nitrite dependent NO generator: Insights from oxygen controlled vessel bioassaysFree Radical Biology and Medicine.  43:S167-S167. 2007
    2007 ICAM-1 cross-linking stimulates endothelial glutathione synthesisAntioxidants and Redox Signaling.  9:159-164. 2007
    2007 ICAM-1 cytoplasmic tail regulates endothelial cell redox status through an NADPH oxidase pathwayFree Radical Biology and Medicine.  43:S78-S78. 2007
    2007 Nitrite transport in erythrocytes: Evidence for oxygen-dependent modulation of exportFree Radical Biology and Medicine.  43:S172-S173. 2007
    2006 Nitrated fatty acids: Endogenous anti-inflammatory signaling mediatorsJournal of Biological Chemistry.  281:35686-35698. 2006
    2006 Nitrite as a vascular endocrine nitric oxide reservoir that contributes to hypoxic signaling, cytoprotection, and vasodilation 2006
    2006 Formation ofNitroso compounds in the reaction of nitrite and hemoglobin.Blood.  108:449A-449A. 2006
    2006 Hydrolysis of acyloxy nitroso compounds yields nitroxyl (HNO)Journal of the American Chemical Society.  128:9687-9692. 2006
    2006 Effects of S-nitrosation on hemoglobin-induced microvascular damageAntioxidants and Redox Signaling.  8:1093-1101. 2006
    2006 O27. Effects of inhaled nitric oxide on human orthotopic liver transplantationNitric Oxide: Biology and Chemistry.  14:8-9. 2006
    2006 Mechanisms of cystic fibrosis transmembrane conductance regulator activation by S-nitrosoglutathioneJournal of Biological Chemistry.  281:9190-9199. 2006
    2006 Regulation of endothelial intracellular glutathione by ICAM-1 2006
    2006 ICAM-1 governs angiogenesis via redox regulation of PTEN expression and eNOS activity 2006
    2006 Sildenafil enhances angiogenesis after mice hind limb ischemia independent of nitric oxide 2006
    2006 Sildenafil enhances angiogenesis after mice Hindlimb ischemiaJournal of the American College of Cardiology.  47:291A-291A. 2006
    2006 Hypoxia, red blood cells, and nitrite regulate NO-dependent hypoxic vasodilationBlood.  107:566-574. 2006
    2006 Chlorination modulates anti-inflammatory effects of isoflavones via PPAR gamma: Insights into the structure-activity relationshipsFree Radical Biology and Medicine.  41:S20-S20. 2006
    2006 Chronic administration of nitrite therapy protects blood flow in the murine hind limb ischemia induced angiogenesis modelFree Radical Biology and Medicine.  41:S51-S51. 2006
    2006 Effects of sodium nitrite on ischemia-reperfusion injury in the rat kidney 2006
    2006 Erratum: The emerging biology of the nitrite anion (Nature Chemical Biology (2005) 1, (308-314))Nature Chemical Biology.  2:110. 2006
    2006 Is S-nitrosohemoglobin dependent valsodilatation under allosteric control? Insights from a hemoglobin beta C93A mouse modelFree Radical Biology and Medicine.  41:S50-S50. 2006
    2006 Nitrite uptake by erythrocytes: Insights into mechanism and regulationFree Radical Biology and Medicine.  41:S55-S55. 2006
    2006 Sildenafil enhances ischemia-induced angiogenesis independent of nitric oxideFree Radical Biology and Medicine.  41:S48-S48. 2006
    2006 The cytoplasmic tail of ICAM-1 regulates endothelial glutathione synthesisFree Radical Biology and Medicine.  41:S72-S72. 2006
    2005 ICAM-1 governs angiogenesis via regulation of eNOS activity: Role of glutathione and PTENCirculation.  112:U156-U156. 2005
    2005 The reaction between nitrite and deoxyhemoglobin. Reassessment of reaction kinetics and stoichiometry.Journal of Biological Chemistry.  280:31126-31131. 2005
    2005 Enzymatic function of hemoglobin as a nitrite reductase that produces NO under allosteric controlJournal of Clinical Investigation.  115:2099-2107. 2005
    2005 Revealing anti-inflammatory mechanisms of soy isoflavones by flow: Modulation of leukocyte-endothelial cell interactions 2005
    2005 Polarographic measurement of hydrogen sulfide production and consumption by mammalian tissuesAnalytical Biochemistry.  341:40-51. 2005
    2005 Fatty acid transduction of nitric oxide signaling: Nitrolinoleic acid is a hydrophobically stabilized nitric oxide donorJournal of Biological Chemistry.  280:19289-19297. 2005
    2005 Glutathione inhibits VEGF angiogenesis through an eNOS dependent pathway 2005
    2005 Modulation of endothelial signaling and glycocalyx by isoflavones: Implications for inflammation 2005
    2005 Assessing NO-dependent vasodilatation using vessel bioassays at defined oxygen tensionsMethods in Enzymology.  396:553-568. 2005
    2005 Cytoprotective effects of nitrite during in vivo ischemia-reperfusion of the heart and liverJournal of Clinical Investigation.  115:1232-1240. 2005
    2005 Dietary modulation of vascular N-glycosylation: Mechanistic implications for anti-inflammatory effects of polyphenolsFree Radical Biology and Medicine.  39:S31-S31. 2005
    2005 Hemoglobin mediated nitrite activation of soluble guanylyl cyclase 2005
    2005 Metabolism of phytoestrogen conjugatesMethods in Enzymology.  400:316-342. 2005
    2005 The Emerging Biology of the Nitrite AnionNature Chemical Biology.  1:308-314. 2005
    2005 The reaction between nitrite and hemoglobin: The role of nitrite in hemoglobin-mediated hypoxic vasodilationJournal of Inorganic Biochemistry.  99:237-246. 2005
    2004 The Red Blood Cell and Vascular Function in Health and DiseaseAntioxidants and Redox Signaling.  6:992-999. 2004
    2004 The red blood cell and vascular function in health and diseaseAntioxidants and Redox Signaling.  6:992-999. 2004
    2004 Transduction of NO-bioactivity by the red blood cell in sepsis: Novel mechanisms of vasodilation during acute inflammatory diseaseBlood.  104:1375-1382. 2004
    2004 Weight loss and race modulate nitric oxide metabolism in overweight womenFree Radical Biology and Medicine.  37:695-702. 2004
    2004 What's right about nitrite? 2004
    2004 Nitrosative chemistry in the red blood cell: implications for the pathogenesis of sepsisNitric Oxide: Biology and Chemistry.  11:67-67. 2004
    2004 Regulation of endothelial glutathione by ICAM-1: Implications for inflammation 2004
    2004 Vasoactivity of nitrite and erythrocytes supports a novel mechanism of hypoxic vasodilationNitric Oxide: Biology and Chemistry.  11:49-50. 2004
    2004 Intercellular Adhesion Molecule-1 (ICAM-1) Regulates Endothelial Cell Motility through a Nitric Oxide-dependent PathwayJournal of Biological Chemistry.  279:19230-19238. 2004
    2004 Mechanisms of the interaction of nitroxyl with mitochondriaBiochemical Journal.  379:359-366. 2004
    2004 ICAM-1 regulates endothelial cell motility through an NO dependent pathway 2004
    2004 Glutathione modulates VEGF angiogenic responses in an adhesion molecule dependent manner 2004
    2004 The biochemistry of nitric oxide, nitrite, and hemoglobin: Role in blood flow regulationFree Radical Biology and Medicine.  36:707-717. 2004
    2004 The biochemistry of nitric oxide, nitrite, and hemoglobin: Role in blood flow regulationFree Radical Biology and Medicine.  36:707-717. 2004
    2004 L-Arginine inhibits xanthine oxidase-dependent endothelial dysfunction in hypercholesterolemiaFEBS Letters.  561:94-98. 2004
    2004 Physiologic, pathologic and therapeutic implications for hemoglobin interactions with nitric oxideFree Radical Biology and Medicine.  36:399-401. 2004
    2004 How do red blood cells dilate blood vessels?--Reply.Circulation Research.  95. 2004
    2004 Mechanistic re-examination of the reaction between nitrite and hemoglobinFree Radical Biology and Medicine.  37:S82-S82. 2004
    2004 Nitrite activation of sGC in bloodFree Radical Biology and Medicine.  37:S84-S84. 2004
    2004 Redox signalling: From nitric oxide to oxidized lipidsBiochemical Society Symposia.  71:107-120. 2004
    2004 Regulation of vascular function by haemoglobinBiochemical Society Symposia.  71:135-142. 2004
    2004 Simulation of the diffusion and reaction of nitric oxide produced within erythrocytesBiophysical Journal.  86:249A-249A. 2004
    2003 Neutrophil myeloperoxidase chlorinates and nitrates soy isoflavones and enhances their antioxidant propertiesFree Radical Biology and Medicine.  35:1417-1430. 2003
    2003 Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulationNature Medicine.  9:1498-1505. 2003
    2003 Novel function of human hemoglobin as a nitrite reductase regulates nitric oxide homeostasis and hypoxic vasodilation.Blood.  102:255A-255A. 2003
    2003 Control of mitochondrial respiration by NO., Effects of low oxygen and respiratory stateJournal of Biological Chemistry.  278:31603-31609. 2003
    2003 Blood flow and SNOHb: an allosteric controversyBlood.  102:412-413. 2003
    2003 Mass spectrometric methods for the analysis of chlorinated and nitrated isoflavonoids: A novel class of biological metabolitesJournal of Mass Spectrometry.  38:764-771. 2003
    2003 S-nitrosohemoglobin is distinguished from other nitrosovasodilators by unique oxygen-dependent responses that support an allosteric mechanism of action [4] (multiple letters)Blood.  102:410-413. 2003
    2003 S-nitrosothiols inhibit uterine smooth muscle cell proliferation independent of metabolism to NO and cGMP formation 2003
    2003 S-nitrosothiols inhibit uterine smooth muscle cell proliferation independent of metabolism to NO and cGMP formation. 2003
    2003 Vasoactivity of S-nitrosohemoglobin: Role of oxygen, heme, and NO oxidation statesBlood.  101:4408-4415. 2003
    2003 Cytoprotection against oxidative stress and the regulation of glutathione synthesis 2003
    2003 Oxidant regulation of gene expression and neural tube development: Insights gained from diabetic pregnancy on molecular causes of neural tube defectsDiabetologia.  46:538-545. 2003
    2002 Effects of S-nitrosation and cross-linking of hemoglobin on hypoxic pulmonary vasoconstriction in isolated rat lungsCirculation Research.  91:626-632. 2002
    2002 Nanotransducers in cellular redox signaling: Modification of thiols by reactive oxygen and nitrogen speciesTrends in Biochemical Sciences.  27:489-492. 2002
    2002 Haemoglobin: NO transporter, NO inactivator or NOne of the above?Trends in Pharmacological Sciences.  23:406-411. 2002
    2002 Activation of c-Jun N-terminal kinase and apoptosis in endothelial cells mediated by endogenous generation of hydrogen peroxide 2002
    2002 Induction of glutathione synthesis by oxidized low-density lipoprotein and 1-palmitoyl-2-arachidonyl phosphatidylcholine: Protection against quinone-mediated oxidative stressBiochemical Journal.  362:51-59. 2002
    2002 Associations of weight loss and race with plasma NO3-/NO2-and 3-nitrotyrosineFree Radical Biology and Medicine.  33:S366-S366. 2002
    2002 Bromination, Chlorination, and Nitration of IsoflavonoidsACS Symposium Series.  807:251-261. 2002
    2002 Measurement of mitochondrial respiratory thresholds and the control of respiration by nitric oxideMethods in Enzymology.  359:305-319. 2002
    2002 Obesity, aerobic exercise, and vascular disease: The role of oxidant stressObesity.  10:964-968. 2002
    2001 Oxygen radical inhibition of nitric oxide-dependent vascular function in sickle cell disease 2001
    2001 Antioxidant mechanisms of isoflavones in lipid systems: Paradoxical effects of peroxyl radical scavengingFree Radical Biology and Medicine.  31:1570-1581. 2001
    2001 Endothelial NOS-dependent activation of c-Jun NH(2)- terminal kinase by oxidized low-density lipoprotein. 2001
    2001 Endothelial NOS-dependent activation of c-Jun NH2-terminal kinase by oxidized low-density lipoprotein 2001
    2001 Essential role of ICAM-1 in mediating monocyte adhesion to aortic endothelial cells. 2001
    2001 Endothelial dysfunction is induced by proinflammatory oxidant hypochlorous acid. 2001
    2001 Formation of nanomolar concentrations of S-nitroso-albumin in human plasma by nitric oxideFree Radical Biology and Medicine.  31:688-696. 2001
    2001 Soy isoflavonoids and cancer - Metabolism at the target siteMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis.  480-481:121-127. 2001
    2001 Nitric oxide partitioning into mitochondrial membranes and the control of respiration at cytochrome c oxidase 2001
    2001 Monocyte adhesion to ICAM-1 deficient mouse aortic endothelium: Differential requirements for ICAM-1 in response to oxidized LDL and TNF-[alpha] 2001
    2001 Anti-inflammatory effects of soy-isoflavones: Inhibition of leukocyte-endothelial interactionsFree Radical Biology and Medicine.  31:S35-S35. 2001
    2001 Cytoprotection mediated by oxidized lipids in endothelial cellsFree Radical Biology and Medicine.  31:S88-S88. 2001
    2001 Endothelial NOS-dependent activation of c-Jun NH2-terminal kinase by oxidized low-density lipoprotein 2001
    2001 Enhanced antioxidant activity after chlorination of quercetin by hypochlorous acidAlcoholism: Clinical and Experimental Research.  25:434-443. 2001
    2001 Essential role of ICAM-1 in mediating monocyte adhesion to aortic endothelial cells 2001
    2001 Formation of novel bioactive metabolites from the reactions of pro-inflammatory oxidants with polyphenolicsBioFactors.  15:79-81. 2001
    2001 Glutathione nitroso-sulfoxide: a potential reaction product of glutathione and peroxynitriteFree Radical Biology and Medicine.  31:S76-S76. 2001
    2001 Mechanisms of cell signaling by nitric oxide and peroxynitrite: From mitochondria to MAP kinasesAntioxidants and Redox Signaling.  3:215-229. 2001
    2001 Mitochondrial sensitivity to nitric oxide is dependent on respiratory stateFree Radical Biology and Medicine.  31:S73-S73. 2001
    2001 Non-heme iron enhances the induction of glutamate-cysteine ligase and heme oxygenase-1 by nitric oxide in human endothelial cellsFree Radical Biology and Medicine.  31:S70-S70. 2001
    2001 Protein kinase B/Akt activates c-Jun NH2-terminal kinase by increasing NO production in response to shear stressJournal of Applied Physiology.  91:1574-1581. 2001
    2001 Redox reactions of hemoglobin and myoglobin: Biological and toxicological implicationsAntioxidants and Redox Signaling.  3:313-327. 2001
    2001 Regulation of endothelial cell redox status by ICAM-1: Identification of a novel pathway governing endothelial cell reactivityFree Radical Biology and Medicine.  31:S47-S47. 2001
    2000 Reaction of S-nitrosoglutathione with the heme group of deoxyhemoglobinJournal of Biological Chemistry.  275:36562-36567. 2000
    2000 Mechanisms of the pro- and anti-oxidant actions of nitric oxide in atherosclerosisCardioscience.  47:465-474. 2000
    2000 Cell signaling by reactive nitrogen and oxygen species in atherosclerosisFree Radical Biology and Medicine.  28:1780-1794. 2000
    2000 Biochemical aspects of the reaction of hemoglobin and NO: Implications for Hb-based blood substitutesFree Radical Biology and Medicine.  28:1518-1525. 2000
    2000 Beyond ERα and ERβ: Estrogen receptor binding is only part of the isoflavone story 2000
    2000 Isoflavonoids and chronic disease: Mechanisms of actionBioFactors.  12:209-215. 2000
    1999 A causative role for redox cycling of myoglobin and its inhibition by alkalinization in the pathogenesis and treatment of rhabdomyolysis-induced renal failureJournal of Biological Chemistry.  273:31731-31737. 1999
    1999 Evidence for peroxynitrite as a signaling molecule in flow-dependent activation of c-Jun NH(2)-terminal kinase.American Journal of Physiology.  277:H1647-H1653. 1999
    1999 Evidence for peroxynitrite as a signaling molecule in flow-dependent activation of c-Jun NH2-terminal kinase 1999
    1999 Chlorination and nitration of soy isoflavonesMolecular cell biology research communications : MCBRC.  368:265-275. 1999
    1999 Biochemical characterization of human S-nitrosohemoglobin. Effects on oxygen binding and transnitrosationJournal of Biological Chemistry.  274:15487-15492. 1999
    1999 Biological aspects of reactive nitrogen species 1999
    1999 The induction of GSH synthesis by nanomolar concentrations of NO in endothelial cells: A role for γ-glutamylcysteine synthetase and γ-glutamyl transpeptidaseFEBS Letters.  448:292-296. 1999
    1999 A critical appraisal of hydrogen peroxide and superoxide as signaling molecules using the JNK/SAPK map kinase pathwayFree Radical Biology and Medicine.  27:S64-S64. 1999
    1999 Antioxidant properties of phytoestrogensJournal of Medicinal Food.  2:163-166. 1999
    1999 Evidence for peroxynitrite as a signaling molecule in flow-dependent activation of c-Jun NH2-terminal kinase 1999
    1999 Is endothelium relaxing factor nitric oxide or an S-nitrosothiol? Insights from scavenging by hemoglobinFree Radical Biology and Medicine.  27:S83-S83. 1999
    1999 Molecular mechanisms of the copper dependent oxidation of low-density lipoprotein 1999
    1999 Molecular mechanisms of the copper dependent oxidation of low-density lipoprotein 1999
    1999 Nitric oxide donor generation from reactions of peroxynitriteMethods in Enzymology.  301:288-298. 1999
    1999 Shear stress simulates cJUN N-terminal kinase (JNK) by activation of PI-3-kinase (PI3K), Akt and endothelial NO synthase (eNOS).Free Radical Biology and Medicine.  27:S62-S62. 1999
    1998 Nitric oxide-dependent induction of glutathione synthesis through increased expression of γ-glutamylcysteine synthetaseMolecular cell biology research communications : MCBRC.  358:74-82. 1998
    1998 Nitrosation of uric acid by peroxynitrite: Formation of a vasoactive nitric oxide donorJournal of Biological Chemistry.  273:24491-24497. 1998
    1998 Making and working with peroxynitrite.Methods in Molecular Biology.  100:215-230. 1998
    1998 Pathophysiology of nitric oxide and related species: Free radical reactions and modification of biomoleculesMolecular Aspects of Medicine.  19:221-357. 1998
    1998 S-nitrosation of hemoglobin: Effects on O-2 delivery and antioxidant propertiesFree Radical Biology and Medicine.  25:S17-S17. 1998
    1997 Formation of the NO donors glyceryl mononitrate and glyceryl mononitrite from the reaction of peroxynitrite with glycerolBiochemical Journal.  328:517-524. 1997
    1997 The globin-based free radical of ferryl hemoglobin is detected in normal human bloodJournal of Biological Chemistry.  272:7114-7121. 1997
    1997 Reduction of Cu(II) by lipid hydroperoxides: Implications for the copper-dependent oxidation of low-density lipoproteinBiochemical Journal.  322:425-433. 1997
    1997 Nitric oxide, free radicals and cell signalling in cardiovascular diseaseBiochemical Society Transactions.  25. 1997
    1997 The interplay of nitric oxide and peroxynitrite with signal transduction pathways: Implications for diseaseSeminars in Perinatology.  21:351-366. 1997
    1996 An EPR investigation of human methaemoglobin oxidation by hydrogen peroxide: Methods to quantify all paramagnetic species observed in the reaction 1996
    1996 Formation of oxysterols during oxidation of low density lipoprotein by peroxynitrite, myoglobin, and copperJournal of Lipid Research.  37:2361-2371. 1996
    1996 Redox cycling of human methaemoglobin by H2O2 yields persistent ferryl iron and protein based radicals 1996
    1996 Using peroxynitrite as oxidant with low-density lipoproteinMethods in Enzymology.  269:375-384. 1996
    1995 Novel reactions of nitric oxide in biological systemsChemical Communications.  915-916. 1995
    1995 Pro-oxidant effects of cross-linked haemoglobins explored using liposome and cytochrome c oxidase vesicle model membranesBiochemical Journal.  310:827-833. 1995

    Book

    Year Title Altmetric
    2008 Preface.  Ed. 61.  2008

    Chapter

    Year Title Altmetric
    2017 Chapter 4 S-Nitrosothiols and Nitric Oxide Biology.  45-56. 2017
    2017 S-Nitrosothiols and Nitric Oxide Biology.  45-56. 2017
    2014 Assessment of endothelial glycocalyx disruption in term parturients receiving a fluid bolus before spinal anesthesia 2014
    2011 Biochemistry of Storage of Red Blood Cells.  231-241. 2011
    2009 Nitric Oxide Regulation in Redox Signaling.  271-291. 2009
    2008 The reaction between nitrite and hemoglobin. the role of nitrite in hemoglobin-mediated hypoxic vasodilation.  269-289. 2008
    2008 Oxidative and Nitrosative Lung Injury.  359-369. 2008
    2008 Chapter 11 The Reaction between Nitrite and Hemoglobin: The Role of Nitrite in Hemoglobin-mediated Hypoxic Vasodilation.  269-289. 2008
    2008 Preface.  xvii-xviii. 2008
    2003 The importance of in vivo metabolism of polyphenols and their biological actions.  51-59. 2003
    2000 Cytoprotective mechanisms of nitric oxide: the role of cell signaling.  191-199. 2000
    1998 Making and Working with Peroxynitrite.  215-230. 1998

    Research Overview

  • Redox biology is a broad and multidisciplinary area of science that encompasses physiologic, pathophysiologic and therapeutic arenas. Also referred to by the terms ‘oxidative stress’ or ‘free radical biology’, perturbations in redox homeostasis has been implicated in all major diseases, in multiple cell and organ systems and across prokaryotic and eukaryotic systems. Moreover, redox biology is at the interface of how the environment and lifestyle choices affect health and disease. With this broad background, our laboratories goal is to understand the biochemical and molecular mechanisms underlying perturbations in redox signaling to development of inflammatory disease, and then using these insights to develop and test therapeutics. We employ an interdisciplinary approach encompassing test-tube biochemistry, cell and animal models of disease, therapeutics and translational / clinical studies. Specific and recent areas of focus include i) Determine mechanisms of lung injury in response to Sepsis and inhaled toxicants, ii) Understanding mechanisms by which red blood cells hemolyse in critically ill patients and, in turn, how this may contribute to cardiopulmonary injury in Sepsis, trauma and Cystic Fibrosis. iii) Determine how endothelial N-glycans control chronic inflammation associated with atherosclerosis and diseases that increase risk for CVD (e.g. Diabetes). iv) Assess how the oral microbiome may affect oral, pulmonary and systemic nitric oxide bioavailability to modulate cardiopulmonary disease (e.g. bronchopulmonary dysplasia).
  • Principal Investigator On

  • Howard Huges Med Into Grad Fellowship Program  awarded by Hughes (Howard) Medical Institute
  • Howard Hughes Med Into Grad Fellowship Program  awarded by Hughes (Howard) Medical Institute
  • Nitrite Dependent Protection Against Cl2 Gas Toxicity Role of Chlorinated Lipids  awarded by National Institute of Environmental Health Sciences/NIH/DHHS
  • Online Flipped Classroom to Enhance Student Learning of Pathobiology  awarded by Howard Hughes Medical Institute
  • Oral Microbiome, Nitric Oxide Metabolism, and Oral And Cardiometabolic Health  awarded by UNIVERSITY OF PUERTO RICO MEDICAL SCIENCES CAMPUS
  • Oral Nitrate Metabolism as a Predictor for Bronchopulmonary in Preterm Infants  awarded by National Institute of Child Health and Human Development/NIH/DHHS
  • Private Grant  awarded by INO THERAPEUTICS, INC.
  • Private Grant  awarded by THERAVASC, LLC
  • Private Grant  awarded by RYTHRX THERAPEUTICS
  • Private Grant  awarded by HEMANEXT INC
  • Private Grant  awarded by HEMANEXT INC
  • Private Grant  awarded by MITSUBISHI TANABE PHARMA DEVELOPMENT AMERICA
  • RBC Age and Potentiation of Transfusion Related Pathology in Trauma Patients  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Redox Signaling in the Endoplasmic Reticulum Regulates Endothelial Surface N-glycoforms: implications for vascular inflammation  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Role of Endothelial N-glycosylation in Mediating Monocyte Adhesion  awarded by American Heart Association (Southeast Affiliate)
  • Role of Heme and PGP Matrikines in Lung Inflammation  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Role of Hemoglobin b93cys Residue in Nitric Oxide Bioactivity  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • The Halolipid-Neutrophil Extracellular Trap Axis in Halogen Lung Injury  awarded by Saint Louis University
  • UAB Predoctoral Training Grant in Translational and Molecular Sciences  awarded by National Institute of General Medical Sciences/NIH/DHHS
  • UAB Predoctoral Training Grant in Translational and Molecular Sciences  awarded by National Institute of General Medical Sciences/NIH/DHHS
  • Investigator On

  • Bromine Inhalation Induced Lung Injury: Novel Mechanisms and Treatment Strategies  awarded by National Institute of Environmental Health Sciences/NIH/DHHS
  • CIALIS® Reverses Halogen Induced Injury to Pregnant Animals and Their Offspring  awarded by National Institute of Environmental Health Sciences/NIH/DHHS
  • COPD Cachexia: Deciphering the Impact of Antioxidants, Iron and Mitochondrial Function Using 'Omics Approaches  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • COPD Cachexia: Deciphering the Impact of Antioxidants, Iron and Mitochondrial Function Using 'Omics Approaches  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Glycocalyx Mechanoregulation of Anglopoietln-2 and Post-Traumatic Lung Injury  awarded by DOD - Department of Defense
  • INvestigations In Gout, Hyperuricemia, and ComorbidiTies (INSIGHT) Center of Research Translation (CORT)  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS
  • INvestigations In Gout, Hyperuricemia, and ComorbidiTies (INSIGHT) Center of Research Translation (CORT) - Project 4: Protecting Renal Function with Urate-Lowering Drugs  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS
  • Identification of AMD3100 (Plerixafor) as a Potential Lead Compound for Chlorine Toxicity  awarded by National Institute of Environmental Health Sciences/NIH/DHHS
  • Interdisciplinary Training In Kidney-Related Research  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • Interdisciplinary Training in Kidney-Related Research  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • Kidney Undergraduate Research Experience (KURE)  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • Mechanisms Driving Endothelial Angiopoietin-2 Expression and Vascular Dysfunction during Pediatric Sepsis  awarded by National Institute of General Medical Sciences/NIH/DHHS
  • Mechanisms and Countermeasures of Halogen-Induced Injury to Pregnant Mice  awarded by National Institute of Environmental Health Sciences/NIH/DHHS
  • Mitochondrial Mechanisms of Hydrogen Sulfide-Induced Suspended Animation  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • PRedOctoral Phd and MD Research Training In TEams (PROmoTE)  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • PRedoctoral Interdisciplinary Training in Renal Physiology and MEdIcIne (PRIME)  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • Private Grant  awarded by HEART BIOTECH HOLDINGS, LLC
  • Private Grant  awarded by Pfizer Inc., U.S. Pharmaceuticals Group
  • Prohealing Multifunctional Endothelium Nanomatrix Coated Stent  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Saturated Fatty Acid-Induced Autophagy in Vascular Endothelium  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • The Role of the Mitochondrial Protein Thiol Modification in Endothelial Dysfunction  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Training Program in Cardiovascular Pathophysiology  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • UAB CF Research and Translation Core Center  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • UAB Statistical Genetics Post-Doctoral Training Program  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Vascular Effects of Mineralocorticoid Receptor Antagonism in Kidney Disease.  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • Teaching Activities

  • GBS704 - Intro to Experimental Med (Fall Term 2012)
  • GBSC733 - Art of Reproducible Science (Fall Term 2021)
  • GBSC743 - Glycobiology (Spring Term 2020)
  • GBSC743 - Glycosylation in Health & Dis (Spring Term 2022)
  • HMG705 - Vocabulary in Drug Discovery (Spring Term 2011)
  • HMG705 - Vocabulary in Drug Discovery (Spring Term 2012)
  • HMG705 - Vocabulary in Drug Discovery (Spring Term 2013)
  • HMG705 - Vocabulary in Drug Discovery (Spring Term 2014)
  • HMG707 - Vocab in Clinical Research (Fall Term 2011)
  • HMG707 - Vocab in Clinical Research (Fall Term 2012)
  • HMG707 - Vocab in Clinical Research (Fall Term 2013)
  • HMG707 - Vocab in Clinical Research (Fall Term 2014)
  • IBS700 - Biological Chem/Cell Physiol (Fall Term 2007)
  • NEUR711 - Princ of Cell Neurosci-Mod I (Fall Term 2007)
  • PAT703 - Intro to Pathology Research (Fall Term 2008)
  • PAT730 - Lab Rotation (Fall Term 2008)
  • PAT730 - Lab Rotation (Spring Term 2009)
  • PAT730 - Lab Rotation (Spring Term 2010)
  • PAT752 - Lab Rotation Pathology (Spring Term 2009)
  • PAT776 - Cancer Biology Journal Club (Summer Term 2011)
  • PAT790 - Spec Topics (Doctoral Level) (Fall Term 2008)
  • PAT790 - Spec Topics (Doctoral Level) (Fall Term 2009)
  • PAT790 - Spec Topics (Doctoral Level) (Spring Term 2009)
  • PAT790 - Spec Topics (Doctoral Level) (Spring Term 2010)
  • PAT790 - Spec Topics (Doctoral Level) (Spring Term 2013)
  • PAT798 - Doc Level Non-Dissertation Res (Fall Term 2008)
  • PAT798 - Doc Level Non-Dissertation Res (Fall Term 2009)
  • PAT798 - Doc Level Non-Dissertation Res (Fall Term 2010)
  • PAT798 - Doc Level Non-Dissertation Res (Fall Term 2011)
  • PAT798 - Doc Level Non-Dissertation Res (Fall Term 2012)
  • PAT798 - Doc Level Non-Dissertation Res (Fall Term 2013)
  • PAT798 - Doc Level Non-Dissertation Res (Spring Term 2009)
  • PAT798 - Doc Level Non-Dissertation Res (Spring Term 2010)
  • PAT798 - Doc Level Non-Dissertation Res (Spring Term 2011)
  • PAT798 - Doc Level Non-Dissertation Res (Spring Term 2012)
  • PAT798 - Doc Level Non-Dissertation Res (Spring Term 2013)
  • PAT798 - Doc Level Non-Dissertation Res (Spring Term 2014)
  • PAT798 - Doc Level Non-Dissertation Res (Summer Term 2010)
  • PAT798 - Doc Level Non-Dissertation Res (Summer Term 2011)
  • PAT798 - Doc Level Non-Dissertation Res (Summer Term 2012)
  • PAT798 - Doc Level Non-Dissertation Res (Summer Term 2013)
  • PAT799 - Doc Lev Dissertation Research (Fall Term 2008)
  • PAT799 - Doc Lev Dissertation Research (Fall Term 2009)
  • PAT799 - Doc Lev Dissertation Research (Fall Term 2010)
  • PAT799 - Doc Lev Dissertation Research (Fall Term 2011)
  • PAT799 - Doc Lev Dissertation Research (Fall Term 2012)
  • PAT799 - Doc Lev Dissertation Research (Fall Term 2013)
  • PAT799 - Doc Lev Dissertation Research (Fall Term 2014)
  • PAT799 - Doc Lev Dissertation Research (Fall Term 2015)
  • PAT799 - Doc Lev Dissertation Research (Fall Term 2016)
  • PAT799 - Doc Lev Dissertation Research (Fall Term 2017)
  • PAT799 - Doc Lev Dissertation Research (Spring Term 2009)
  • PAT799 - Doc Lev Dissertation Research (Spring Term 2010)
  • PAT799 - Doc Lev Dissertation Research (Spring Term 2011)
  • PAT799 - Doc Lev Dissertation Research (Spring Term 2012)
  • PAT799 - Doc Lev Dissertation Research (Spring Term 2013)
  • PAT799 - Doc Lev Dissertation Research (Spring Term 2014)
  • PAT799 - Doc Lev Dissertation Research (Spring Term 2015)
  • PAT799 - Doc Lev Dissertation Research (Spring Term 2016)
  • PAT799 - Doc Lev Dissertation Research (Spring Term 2017)
  • PAT799 - Doc Lev Dissertation Research (Summer Term 2009)
  • PAT799 - Doc Lev Dissertation Research (Summer Term 2010)
  • PAT799 - Doc Lev Dissertation Research (Summer Term 2011)
  • PAT799 - Doc Lev Dissertation Research (Summer Term 2012)
  • PAT799 - Doc Lev Dissertation Research (Summer Term 2013)
  • PAT799 - Doc Lev Dissertation Research (Summer Term 2014)
  • PAT799 - Doc Lev Dissertation Research (Summer Term 2015)
  • PAT799 - Doc Lev Dissertation Research (Summer Term 2016)
  • PAT799 - Doc Lev Dissertation Research (Summer Term 2017)
  • TMS704 - Modeling Human Disease (Summer Term 2017)
  • TMS704 - Modeling Human Disease (Summer Term 2018)
  • TMS704 - Modeling Human Disease (Summer Term 2019)
  • TMS707 - Vocab in Clinical Research (Fall Term 2015)
  • TMS707 - Vocab in Clinical Research (Fall Term 2017)
  • TMS707 - Vocab in Clinical Research (Fall Term 2018)
  • TMS707 - Vocab in Clinical Research (Spring Term 2016)
  • TMS707 - Vocab in Clinical Research (Spring Term 2018)
  • TMS707 - Vocab in Clinical Research (Spring Term 2019)
  • TMS714 - Modeling Human Disease II (Summer Term 2018)
  • TMS714 - Modeling Human Disease II (Summer Term 2019)
  • TMS724 - Modeling Human Disease III (Summer Term 2017)
  • TMS724 - Modeling Human Disease III (Summer Term 2018)
  • TMS724 - Modeling Human Disease III (Summer Term 2019)
  • Education And Training

  • Doctor of Philosophy Level Degree in Biochemistry, University of Essex 1996
  • Full Name

  • Rakesh Patel