Positions

Overview

  • Dr. Qiang Ding is an Professor of Department of Anesthesiology & Perioperative Medicine, Division of Molecular and Translational Biomedicine, University of Alabama at Birmingham. Dr. Ding received his PhD degree in molecular and cellular pathology at the University of Alabama at Birmingham. After completing his postdoctoral fellowship training in the UAB Department of Pathology. Dr. Ding is actively involved in education, research, training, and service for the community. He holds a secondary appointment in the Department of Cell, Developmental, and Integrative Biology (CDIB), is a member of the Intellectual and Developmental Disabilities Research Center (IDDRC), and is a faculty member of the Graduate Biomedical Science PhD program at the University of Alabama at Birmingham.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2022 Loss of Spike N370 glycosylation as an important evolutionary event for the enhanced infectivity of SARS-CoV-2Cell Research.  32:315-318. 2022
    2022 Comparison of viral RNA–host protein interactomes across pathogenic RNA viruses informs rapid antiviral drug discovery for SARS-CoV-2Cell Research.  32:9-23. 2022
    2021 Molecular determinants for regulation of G3BP1/2 phase separation by the SARS-CoV-2 nucleocapsid proteinCell Discovery.  7. 2021
    2021 Radium-223 in Asian patients with castration-resistant prostate cancer with symptomatic bone metastases: A single-arm phase 3 study 2021
    2021 A nucleocapsid-based transcomplementation cell culture system of sars-cov-2 to recapitulate the complete viral life cycleBio-protocol.  11. 2021
    2021 Novel quinolone derivatives targeting human dihydroorotate dehydrogenase suppress Ebola virus infection in vitroAntiviral Research.  194. 2021
    2021 Microwave ablation of primary breast cancer inhibits metastatic progression in model mice via activation of natural killer cellsCellular and Molecular Immunology.  18:2153-2164. 2021
    2021 Compartmentalization-aided interaction screening reveals extensive high-order complexes within the SARS-CoV-2 proteomeCell Reports.  36. 2021
    2021 In vivo structural characterization of the SARS-CoV-2 RNA genome identifies host proteins vulnerable to repurposed drugsCell.  184:1865-1883.e20. 2021
    2021 Integrin αvβ3 engagement regulates glucose metabolism and migration through focal adhesion kinase (Fak) and protein arginine methyltransferase 5 (prmt5) in glioblastoma cellsCancers.  13:1-16. 2021
    2021 Isocotoin suppresses hepatitis E virus replication through inhibition of heat shock protein 90Antiviral Research.  185. 2021
    2020 Prostate volume does not provide additional predictive value to prostate health index for prostate cancer or clinically significant prostate cancer: Results from a multicenter study in ChinaAsian Journal of Andrology.  22:539-543. 2020
    2020 Cell division cycle proteinising prognostic biomarker of breast cancer 2020
    2020 HOXA9, PCDH17, POU4F2, and ONECUT2 as a Urinary Biomarker Combination for the Detection of Bladder Cancer in Chinese Patients with HematuriaEuropean urology focus.  6:284-291. 2020
    2020 Enhanced O-linked Glcnacylation in Crohn's disease promotes intestinal inflammationEBioMedicine.  53. 2020
    2020 Targeting Src family kinase member Fyn by Saracatinib attenuated liver fibrosis in vitro and in vivoCell Death and Disease.  11. 2020
    2019 Anticancer effect of icaritin on prostate cancer via regulating miR-381-3p and its target gene UBE2CCancer Medicine.  8:7833-7845. 2019
    2019 Phi-based risk calculators performed better in the prediction of prostate cancer in the Chinese populationAsian Journal of Andrology.  21:592-597. 2019
    2019 SWELL1 promotes cell growth and metastasis of hepatocellular carcinoma in vitro and in vivoEBioMedicine.  48:100-116. 2019
    2019 4-Hydroxy estrogen metabolite, causing genomic instability by attenuating the function of spindle-assembly checkpoint, can serve as a biomarker for breast cancerAmerican Journal of Translational Research.  11:4992-5007. 2019
    2019 CRISPR/Cas9-mediated MSTN gene editing induced mitochondrial alterations in C2C12 myoblast cellsElectronic Journal of Biotechnology.  40:30-39. 2019
    2019 Differences across cyclophilin a orthologs contribute to the host range restriction of hepatitis c viruseLife.  8. 2019
    2019 Overexpression of steroid sulfotransferase genes is associated with worsened prognosis and with immune exclusion in clear cell-renal cell carcinomaAging.  11:9209-9219. 2019
    2019 TCDD-inducible poly-ADP-ribose polymerase (TIPARP), a novel therapeutic target of breast cancerCancer Management and Research.  11:8991-9004. 2019
    2018 Microwave ablation combined with doxorubicin enhances cell death via promoting reactive oxygen species generation in breast cancer cellsDiagnostic and Interventional Imaging.  99:783-791. 2018
    2018 Germline mutations in DNA repair genes are associated with bladder cancer risk and unfavourable prognosisBJU International.  122:808-813. 2018
    2018 NOS3 895G>T and CBR3 730G>A Are Associated with Recurrence Risk in Non-Muscle-Invasive Bladder Cancer with Intravesical Instillations of THP 2018
    2018 Overexpression of low density lipoprotein receptor-related protein 1 (LRP1) is associated with worsened prognosis and decreased cancer immunity in clear-cell renal cell carcinomaBiochemical and Biophysical Research Communications.  503:1537-1543. 2018
    2018 Review of grid dispatching considering thermal power and large-scale wind power integrationDianli Xitong Baohu Yu Kongzhi.  46:162-170. 2018
    2018 Circulating microRNAs from the miR-106a–363 cluster on chromosome X as novel diagnostic biomarkers for breast cancerBreast Cancer Research and Treatment.  170:257-270. 2018
    2018 D Rhamnose β-hederin inhibits migration and invasion of human breast cancer cell line MDA-MB-231Biochemical and Biophysical Research Communications.  495:775-780. 2018
    2017 Focal adhesion kinase signaling determines the fate of lung epithelial cells in response to TGF-β 2017
    2017 Predictive value of deregulated cryptochrome genes in human hepatocellular carcinomaAnalytical and Quantitative Cytopathology and Histopathology.  39:127-133. 2017
    2016 CXCL9: evidence and contradictions for its role in tumor progressionCancer Medicine.  5:3246-3259. 2016
    2016 Great tumour burden in the axilla may influence lymphatic drainage in breast cancer patientsBreast Cancer Research and Treatment.  157:503-510. 2016
    2014 Effects of oxymatrine on the apoptosis and proliferation of gallbladder cancer cells 2014
    2014 Image and pathological changes after microwave ablation of breast cancer: a pilot studyEuropean Journal of Radiology.  83:1771-1777. 2014
    2014 Baicalin induces apoptosis of gallbladder carcinoma cells in vitro via a mitochondrial-mediated pathway and suppresses tumor growth in vivo 2014
    2014 Clinical and prognostic significance of preoperative plasma hyperfibrinogenemia in gallbladder cancer patients following surgical resection: A retrospective and in vitro studyBMC Cancer.  14. 2014
    2014 RNA-binding protein RNPC1: Acting as a tumor suppressor in breast cancerBMC Cancer.  14. 2014
    2014 Evaluation of two inflammation-based prognostic scores in patients with resectable gallbladder carcinomaAnnals of Surgical Oncology.  21:449-457. 2014
    2014 Reproductive factors and breast cancer risk among BRCA1 or BRCA2 mutation carriers: Results from ten studies 2014
    2014 Role of polymorphisms of the IGF2 and IGFBP3 genes and risk of gastric carcinoma in ChinaChinese Medical Journal.  127:412-416. 2014
    2014 Downregulation of miR-106b induced breast cancer cell invasion and motility in association with overexpression of matrix metalloproteinase 2Cancer Science.  105:18-25. 2014
    2014 Ursolic acid induces cell cycle arrest and apoptosis of gallbladder carcinoma cellsCancer Cell International.  14. 2014
    2013 FAK-related nonkinase is a multifunctional negative regulator of pulmonary fibrosisAmerican Journal of Pathology.  182:1572-1584. 2013
    2013 Establishment of a stable urethral stricture model in New Zealand rabbitsActas Urológicas Españolas.  37:162-166. 2013
    2012 A novel mouse model of gastric cancer with human gastric microenvironmentCancer Letters.  325:108-115. 2012
    2012 Urinary BLCA-4 level is useful to detect upper urinary tract urothelial cell carcinomaActas Urológicas Españolas.  36:597-602. 2012
    2012 Bone metastasis in a novel breast cancer mouse model containing human breast and human boneBreast Cancer Research and Treatment.  132:471-486. 2012
    2012 Bloody nipple discharge is a predictor of breast cancer risk: A meta-analysisBreast Cancer Research and Treatment.  132:9-14. 2012
    2012 Postmenopausal hormone therapy is associated with in situ breast cancer riskAsian Pacific Journal of Cancer Prevention.  13:3917-3925. 2012
    2011 Toremifene is an effective and safe alternative to tamoxifen in adjuvant endocrine therapy for breast cancer: Results of four randomized trialsBreast Cancer Research and Treatment.  128:625-631. 2011
    2010 A novel orthotopic and metastatic mouse model of breast cancer in human mammary microenvironmentBreast Cancer Research and Treatment.  120:337-344. 2010
    2002 Resin-capture and release strategy toward combinatorial libraries of 2,6,9-substituted purinesACS Combinatorial Science.  4:183-186. 2002

    Chapter

    Year Title Altmetric
    2019 Mouse models for studying HCV vaccines and therapeutic antibodies.  481-503. 2019

    Research Overview

  • Dr. Ding's research focuses on cellular and extracellular environment interaction in various diseases and how such interactions affect the molecular mechanisms contributing to tissue injury and repair, as well as what drive these normal processes into deadly diseases. Dr. Ding's laboratory investigates the mechanisms by which multiple cell types and moleucalr signaling pathways regulate the development and outcome of lung fibrosis, lung injury, and even cancer progression. One of the projects is about focal adhesion kinase (FAK)-related non-kinase (FRNK). FAK plays an important role in regulation of fibroblast migration, differentiation, and proliferation, and cancer progression. Data from Dr. Ding's Laboratory have shown that FAK regulates cell proliferation through regulation of the expression of extracellular matrix proteins and Cyclin D1. The cytoplasmic protein FRNK acts to limit FAK-dependent cell migration and proliferation, as well as FAK mediated lung fibrosis, lung injury and cancer progression. For example, data from Dr. Ding's laboratory suggest that FRNK acts to limit myofibroblast differentiation induced by transforming growth factor beta-1 (TGF-beta-1), a core signaling process in the development of lung fibrosis. Another project in Dr. Ding's Laboratory is exploring the mechanism regulating the expression of FRNK, its signaling pathways, and how that signaling regulates the pro-fibrotic phenotype and plasticity of the cell types involved. Recently, the lab investigated post-transcriptional regulation and its role in pathogenesis, along with examining the therapeutic potentials of small molecular inhibitors of involved signaling pathways in treating pulmonary fibrosis, acute and chronic lung injury, cancer, cognitive dysfunction, and excessive tissue injury.
  • Education And Training

  • Doctor of Philosophy in Pathology Residency Program, University of Alabama at Birmingham 1999
  • Bachelor's Level Degree in Biochemistry, Biophysics and Molecular Biology, Fudan University 1986
  • Full Name

  • Qiang Ding