Positions

Overview

  • Dr. Qiang Ding is an Professor of Department of Anesthesiology & Perioperative Medicine, Division of Molecular and Translational Biomedicine, University of Alabama at Birmingham. Dr. Ding received his PhD degree in molecular and cellular pathology at the University of Alabama at Birmingham. After completing his postdoctoral fellowship training in the UAB Department of Pathology. Dr. Ding is actively involved in education, research, training, and service for the community. He holds a secondary appointment in the Department of Cell, Developmental, and Integrative Biology (CDIB), is a member of the Intellectual and Developmental Disabilities Research Center (IDDRC), and is a faculty member of the Graduate Biomedical Science PhD program at the University of Alabama at Birmingham.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2021 Novel quinolone derivatives targeting human dihydroorotate dehydrogenase suppress Ebola virus infection in vitroAntiviral Research.  194. 2021
    2021 Microwave ablation of primary breast cancer inhibits metastatic progression in model mice via activation of natural killer cellsCellular and Molecular Immunology.  18:2153-2164. 2021
    2021 Compartmentalization-aided interaction screening reveals extensive high-order complexes within the SARS-CoV-2 proteomeCell Reports.  36. 2021
    2021 Analysis of SARS-CoV-2 variant mutations reveals neutralization escape mechanisms and the ability to use ACE2 receptors from additional speciesImmunity.  54:1611-1621.e5. 2021
    2021 In vivo structural characterization of the SARS-CoV-2 RNA genome identifies host proteins vulnerable to repurposed drugsCell.  184:1865-1883.e20. 2021
    2021 Integrin αvβ3 engagement regulates glucose metabolism and migration through focal adhesion kinase (Fak) and protein arginine methyltransferase 5 (prmt5) in glioblastoma cellsCancers.  13:1-16. 2021
    2021 Isocotoin suppresses hepatitis E virus replication through inhibition of heat shock protein 90Antiviral Research.  185. 2021
    2020 Prostate volume does not provide additional predictive value to prostate health index for prostate cancer or clinically significant prostate cancer: Results from a multicenter study in ChinaAsian Journal of Andrology.  22:539-543. 2020
    2020 Cell division cycle proteinising prognostic biomarker of breast cancer 2020
    2020 HOXA9, PCDH17, POU4F2, and ONECUT2 as a Urinary Biomarker Combination for the Detection of Bladder Cancer in Chinese Patients with HematuriaEuropean urology focus.  6:284-291. 2020
    2020 Enhanced O-linked Glcnacylation in Crohn's disease promotes intestinal inflammationEBioMedicine.  53. 2020
    2020 First-time versus recurrent penoscrotal extramammary Paget's disease: Clinicopathological characteristics and risk factors in 164 Chinese male patientsIndian Journal of Dermatology, Venereology and Leprology.  86:134-140. 2020
    2020 The Rare Variant rs35356162 in UHRF1BP1 Increases Bladder Cancer Risk in Han Chinese PopulationFrontiers in Oncology.  10. 2020
    2020 Targeting Src family kinase member Fyn by Saracatinib attenuated liver fibrosis in vitro and in vivoCell Death and Disease.  11. 2020
    2020 Radium-223 in Asian patients with castration-resistant prostate cancer with symptomatic bone metastases: A single-arm phase 3 study 2020
    2019 Anticancer effect of icaritin on prostate cancer via regulating miR-381-3p and its target gene UBE2CCancer Medicine.  8:7833-7845. 2019
    2019 Phi-based risk calculators performed better in the prediction of prostate cancer in the Chinese populationAsian Journal of Andrology.  21:592-597. 2019
    2019 SWELL1 promotes cell growth and metastasis of hepatocellular carcinoma in vitro and in vivoEBioMedicine.  48:100-116. 2019
    2019 4-Hydroxy estrogen metabolite, causing genomic instability by attenuating the function of spindle-assembly checkpoint, can serve as a biomarker for breast cancerAmerican Journal of Translational Research.  11:4992-5007. 2019
    2019 CRISPR/Cas9-mediated MSTN gene editing induced mitochondrial alterations in C2C12 myoblast cellsElectronic Journal of Biotechnology.  40:30-39. 2019
    2019 Differences across cyclophilin a orthologs contribute to the host range restriction of hepatitis c viruseLife.  8. 2019
    2019 FABP5 regulates the proliferation of clear cell renal cell carcinoma cells via the PI3K/AKT signaling pathwayInternational Journal of Oncology.  54:1221-1232. 2019
    2019 Lymph node dissection could bring survival benefits to patients diagnosed with clinically node-negative upper urinary tract urothelial cancer: a population-based, propensity score-matched studyInternational Journal of Clinical Oncology.  24:296-305. 2019
    2019 Effects of diabetes mellitus and Metformin administration on prostate cancer detection at biopsy among Chinese men: a case-control studyJournal of Balkan Union of Oncology.  24:227-232. 2019
    2019 Effects of diabetes mellitus and metformin administration on prostate cancer detection at biopsy among Chinese men: A case-control studyJournal of Balkan Union of Oncology.  24:214-219. 2019
    2019 Exosomal micro RNAs derived from dermal papilla cells mediate hair follicle stem cell proliferation and differentiationInternational Journal of Biological Sciences.  15:1368-1382. 2019
    2019 Programmable base editing of the sheep genome revealed no genome-wide off-target mutationsFrontiers in Genetics.  10. 2019
    2019 TCDD-inducible poly-ADP-ribose polymerase (TIPARP), a novel therapeutic target of breast cancerCancer Management and Research.  11:8991-9004. 2019
    2018 Microwave ablation combined with doxorubicin enhances cell death via promoting reactive oxygen species generation in breast cancer cellsDiagnostic and Interventional Imaging.  99:783-791. 2018
    2018 Technical analysis of US imaging for precise microwave ablation for benign breast tumoursInternational Journal of Hyperthermia.  34:1179-1185. 2018
    2018 Germline mutations in DNA repair genes are associated with bladder cancer risk and unfavourable prognosisBJU International.  122:808-813. 2018
    2018 NOS3 895G>T and CBR3 730G>A Are Associated with Recurrence Risk in Non-Muscle-Invasive Bladder Cancer with Intravesical Instillations of THP 2018
    2018 Pathologically examining a minimum of three lymph nodes could better determine node negativity in patients with non-metastatic chromophobe renal cell carcinomaJapanese Journal of Clinical Oncology.  48:942-949. 2018
    2018 Overexpression of low density lipoprotein receptor-related protein 1 (LRP1) is associated with worsened prognosis and decreased cancer immunity in clear-cell renal cell carcinomaBiochemical and Biophysical Research Communications.  503:1537-1543. 2018
    2018 Review of grid dispatching considering thermal power and large-scale wind power integrationDianli Xitong Baohu Yu Kongzhi.  46:162-170. 2018
    2018 Circulating microRNAs from the miR-106a–363 cluster on chromosome X as novel diagnostic biomarkers for breast cancerBreast Cancer Research and Treatment.  170:257-270. 2018
    2018 D Rhamnose β-hederin inhibits migration and invasion of human breast cancer cell line MDA-MB-231Biochemical and Biophysical Research Communications.  495:775-780. 2018
    2017 Angiotensin-converting enzyme defines matrikine-regulated inflammation and fibrosisJCI insight.  2. 2017
    2017 Focal adhesion kinase signaling determines the fate of lung epithelial cells in response to TGF-β 2017
    2017 Predictive value of deregulated cryptochrome genes in human hepatocellular carcinomaAnalytical and Quantitative Cytopathology and Histopathology.  39:127-133. 2017
    2016 CXCL9: evidence and contradictions for its role in tumor progressionCancer Medicine.  5:3246-3259. 2016
    2016 Breast cancer metastasis to the contralateral neck 22 years remote from initial diagnosis: A case reportInternational Journal of Clinical and Experimental Medicine.  9:18659-18663. 2016
    2016 Great tumour burden in the axilla may influence lymphatic drainage in breast cancer patientsBreast Cancer Research and Treatment.  157:503-510. 2016
    2015 Integrative genomic analyses of the RNA-binding protein, RNPC1, and its potential role in cancer predictionInternational Journal of Molecular Medicine.  36:473-484. 2015
    2014 Effects of oxymatrine on the apoptosis and proliferation of gallbladder cancer cells 2014
    2014 Image and pathological changes after microwave ablation of breast cancer: a pilot studyEuropean Journal of Radiology.  83:1771-1777. 2014
    2014 Baicalin induces apoptosis of gallbladder carcinoma cells in vitro via a mitochondrial-mediated pathway and suppresses tumor growth in vivo 2014
    2014 Clinical and prognostic significance of preoperative plasma hyperfibrinogenemia in gallbladder cancer patients following surgical resection: A retrospective and in vitro studyBMC Cancer.  14. 2014
    2014 RNA-binding protein RNPC1: Acting as a tumor suppressor in breast cancerBMC Cancer.  14. 2014
    2014 Evaluation of two inflammation-based prognostic scores in patients with resectable gallbladder carcinomaAnnals of Surgical Oncology.  21:449-457. 2014
    2014 Reproductive factors and breast cancer risk among BRCA1 or BRCA2 mutation carriers: Results from ten studies 2014
    2014 Role of polymorphisms of the IGF2 and IGFBP3 genes and risk of gastric carcinoma in ChinaChinese Medical Journal.  127:412-416. 2014
    2014 Downregulation of miR-106b induced breast cancer cell invasion and motility in association with overexpression of matrix metalloproteinase 2Cancer Science.  105:18-25. 2014
    2014 The anticancer effect and mechanism of α-hederin on breast cancer cellsInternational Journal of Oncology.  45:757-763. 2014
    2014 Ursolic acid induces cell cycle arrest and apoptosis of gallbladder carcinoma cellsCancer Cell International.  14. 2014
    2013 The role of prophylactic transpapillary pancreatic stenting in distal pancreatectomy: A meta-analysisFrontiers of Medicine in China.  7:499-505. 2013
    2013 Regulation of cell proliferation and migration in gallbladder cancer by zinc finger X-chromosomal proteinGene.  528:261-266. 2013
    2013 FAK-related nonkinase is a multifunctional negative regulator of pulmonary fibrosisAmerican Journal of Pathology.  182:1572-1584. 2013
    2012 A novel mouse model of gastric cancer with human gastric microenvironmentCancer Letters.  325:108-115. 2012
    2012 Cancer/testis antigen SSX2 enhances invasiveness in MCF-7 cells by repressing ERá signalingInternational Journal of Oncology.  40:1986-1994. 2012
    2012 Bone metastasis in a novel breast cancer mouse model containing human breast and human boneBreast Cancer Research and Treatment.  132:471-486. 2012
    2012 Bloody nipple discharge is a predictor of breast cancer risk: A meta-analysisBreast Cancer Research and Treatment.  132:9-14. 2012
    2012 Ethyl pyruvate administration suppresses growth and invasion of gallbladder cancer cells via downregulation of HMGB1-RAGE axisInternational Journal of Immunopathology and Pharmacology.  25:955-965. 2012
    2012 Postmenopausal hormone therapy is associated with in situ breast cancer riskAsian Pacific Journal of Cancer Prevention.  13:3917-3925. 2012
    2011 Toremifene is an effective and safe alternative to tamoxifen in adjuvant endocrine therapy for breast cancer: Results of four randomized trialsBreast Cancer Research and Treatment.  128:625-631. 2011
    2010 A novel orthotopic and metastatic mouse model of breast cancer in human mammary microenvironmentBreast Cancer Research and Treatment.  120:337-344. 2010

    Chapter

    Year Title Altmetric
    2019 Mouse models for studying HCV vaccines and therapeutic antibodies.  481-503. 2019

    Research Overview

  • Dr. Ding's research focuses on cellular and extracellular environment interaction in various diseases and how such interactions affect the molecular mechanisms contributing to tissue injury and repair, as well as what drive these normal processes into deadly diseases. Dr. Ding's laboratory investigates the mechanisms by which multiple cell types and moleucalr signaling pathways regulate the development and outcome of lung fibrosis, lung injury, and even cancer progression. One of the projects is about focal adhesion kinase (FAK)-related non-kinase (FRNK). FAK plays an important role in regulation of fibroblast migration, differentiation, and proliferation, and cancer progression. Data from Dr. Ding's Laboratory have shown that FAK regulates cell proliferation through regulation of the expression of extracellular matrix proteins and Cyclin D1. The cytoplasmic protein FRNK acts to limit FAK-dependent cell migration and proliferation, as well as FAK mediated lung fibrosis, lung injury and cancer progression. For example, data from Dr. Ding's laboratory suggest that FRNK acts to limit myofibroblast differentiation induced by transforming growth factor beta-1 (TGF-beta-1), a core signaling process in the development of lung fibrosis. Another project in Dr. Ding's Laboratory is exploring the mechanism regulating the expression of FRNK, its signaling pathways, and how that signaling regulates the pro-fibrotic phenotype and plasticity of the cell types involved. Recently, the lab investigated post-transcriptional regulation and its role in pathogenesis, along with examining the therapeutic potentials of small molecular inhibitors of involved signaling pathways in treating pulmonary fibrosis, acute and chronic lung injury, cancer, cognitive dysfunction, and excessive tissue injury.
  • Education And Training

  • Doctor of Philosophy in Pathology Residency Program, University of Alabama at Birmingham 1999
  • Bachelor's Level Degree in Biochemistry, Biophysics and Molecular Biology, Fudan University 1986
  • Full Name

  • Qiang Ding