Menopausal symptoms and cardiovascular disease mortality in the Women's Ischemia Syndrome Evaluation (WISE)

Academic Article


  • Objective: Studies have linked vasomotor symptoms (VMS) to markers of cardiovascular disease (CVD) risk, yet few have considered clinical cardiovascular events. Data suggest that associations may depend upon the age that symptoms occur. We examined associations between VMS and cardiovascular events and endothelial function, considering age of symptom onset. Methods: The Women's Ischemia Syndrome Evaluation enrolled women referred for coronary angiography for suspected myocardial ischemia. A total of 254 women aged more than 50 years, postmenopausal, with both ovaries, not taking hormone therapy underwent a baseline evaluation, were followed annually (median=6.0 y), and the National Death Index was searched to ascertain CVD mortality (median=9.3 y). A subset of participants underwent brachial artery ultrasound for flow-mediated dilation (FMD). Receiver-operating curve analysis was used to determine vasomotor symptom groups (symptoms beginning
  • Authors

    Digital Object Identifier (doi)

    Author List

  • Thurston RC; Johnson BD; Shufelt CL; Braunstein GD; Berga SL; Stanczyk FZ; Pepine CJ; Bittner V; Reis SE; Thompson DV
  • Start Page

  • 126
  • End Page

  • 132
  • Volume

  • 24
  • Issue

  • 2