Transmission of HIV-1 and HLA-B allele-sharing within serodiscordant heterosexual Zambian couples

Academic Article

Abstract

  • Factors that might increase risk of HIV-1 transmission include age, sex, and amount of HIV-1 RNA in plasma, but findings for HLA allele-sharing are not in agreement. We tested the hypothesis that allele sharing at HLA loci is associated with increased risk of transmission of HIV-1 infection in cohabiting heterosexual Zambian couples. We studied 125 initially serodiscordant partners with sequence-confirmed interpartner HIV-1 transmission and 104 couples who were persistently serodiscordant, and we analysed relations with molecularly typed HLA-A, B, and C alleles by survival techniques. After adjustment for other genetic and non-genetic risk factors seen with heterosexual transmission of HIV-1 in this cohort, sharing of HLA-B alleles was independently associated with accelerated intracouple transmission (relative hazard 2·23, 95% CI 1·52-3·26, p<0·0001). Selective pressure by HLA-B alleles on transmitted viruses accords with current understanding of the effect of B locus polymorphism in HIV-1 and perhaps other infections.
  • Digital Object Identifier (doi)

    Author List

  • Dorak MT; Tang J; Penman-Aguilar A; Westfall AO; Zulu I; Lobashevsky ES; Kancheya NG; Schaen MM; Allen SA; Kaslow RA
  • Start Page

  • 2137
  • End Page

  • 2139
  • Volume

  • 363
  • Issue

  • 9427