Three large, functioning cystic parathyroid adenomas

Academic Article


  • Objective: To report a very rare case of 3 large, functioning cystic parathyroid adenomas causing primary hyperparathyroidism.Methods: We present the history, clinical findings, laboratory test results, radiologic findings, endocrine workup results, intraoperative surgical challenges, and surgical pathology report of the study patient. We review the literature and discuss the importance of intraoperative parathyroid hormone (PTH) measurement in such cases.Results: A 79-year-old woman presented with primary hyperparathyroidism and elevated levels of calcium and PTH. Localization studies confirmed the presence of a large right upper parathyroid adenoma. On exploration, a very large cystic parathyroid gland was identified at that location. Because intraoperative PTH levels remained elevated, further exploration was pursued, which revealed 2 more large cystic glands on the left side that were resected. This resulted in an adequate but slow PTH drop. The right lower gland appeared normal. On follow-up 4 days and 6 weeks after surgery, the calcium and PTH levels had normalized.Conclusion: This case highlights the aspects of intraoperative PTH use and underscores the need to exclude multigland disease even in the setting of a very large parathyroid cyst with concordant localization studies. © 2012 AACE.
  • Published In

  • Endocrine Practice  Journal
  • Digital Object Identifier (doi)

    Author List

  • Mazeh H; Sippel RS; Chen H
  • Volume

  • 18
  • Issue

  • 1