Increased cervical cancer risk associated with screening at longer intervals

Academic Article


  • The 2012 national recommendations for cervical cancer screening will produce a lower level of cervical cancer protection than previously afforded by annual cytology or 3-year cotesting. After a single negative cotest result, the risk of cervical cancer is twice as large at 5 years as it is at 3 years. Modeling published since the 2012 guidelines were drafted indicates that extending the cotesting screening interval from 3 to 5 years at ages 30-64 years will result in an additional 1 woman in 369 compliant with screening receiving a cervical cancer diagnosis during her lifetime, and an additional 1 in 1,639 dying of cervical cancer. The authors believe that a significant number of patients and providers would not choose to accept these additional risks if they understood them, despite the recognition of potential harms associated with more intensive screening.
  • Authors

    Published In

    Digital Object Identifier (doi)

    Author List

  • Kinney W; Wright TC; Dinkelspiel HE; Defrancesco M; Thomas Cox J; Huh W
  • Start Page

  • 311
  • End Page

  • 315
  • Volume

  • 125
  • Issue

  • 2