Creation of monoclonal antibodies against tumor necrosis factor-alpha (TNF-alpha) and transforming growth factor alpha (TFG-alpha), their definition and possible use

Academic Article


  • These antibodies were characterised immunoserologically and immunohistochemically. The antibodies proved suitable in the detection of TNF-alpha and TGF-alpha production by different cells and tissues. These anti-TNF-alpha specific monoclonal antibodies were able to inhibit the cytotoxic effect of hrTNF-alpha in vitro. These monoclonal antibodies may potentially be useful in the future for determining TNF-alpha or TGF-alpha level by different immunodiagnostical assays (ELISA, RIA, FIA) in the medical practice.
  • Authors

    Author List

  • Bebök Z; Szekeres G; Horváth G; Duda E; Németh P
  • Start Page

  • 1303
  • End Page

  • 1307
  • Volume

  • 134
  • Issue

  • 24