Paradoxical organ-specific adaptations to streptozotocin diabetes mellitus in adult rats.

Academic Article


  • Adult male Fisher rats injected with streptozotocin (Stz) to produce diabetes mellitus demonstrated a significant loss of total body weight associated with adipose and muscle tissue wasting. Paradoxically, intestinal mass and length were increased in Stz-treated rats despite catabolism of other tissues. Concomitant with increased intestinal mass, food and water intake increased significantly in Stz-diabetic animals. Renal weight was not reduced despite the fall in total body weight. It is proposed that the adult Stz-diabetic rat responds to a loss of available insulin by polyphagia, polydipsia, and catabolism of adipose and muscle tissue and that a large percentage of available synthetic fuel is devoted to the production of additional intestinal tissue.
  • Published In


  • Adaptation, Physiological, Adipose Tissue, Adrenal Glands, Animals, Blood Glucose, Body Weight, Diabetes Mellitus, Experimental, Digestive System, Drinking, Eating, Kidney, Liver, Male, Muscles, Myocardium, Organ Size, Rats, Spleen, Streptozocin, Urinary Bladder
  • Digital Object Identifier (doi)

    Author List

  • Pillion DJ; Jenkins RL; Atchison JA; Stockard CR; Clements RS; Grizzle WE
  • Start Page

  • E749
  • End Page

  • E755
  • Volume

  • 254
  • Issue

  • 6 Pt 1