Alpha-toxin damages the air-blood barrier of the lung in a rat model of Staphylococcus aureus-induced pneumonia

Academic Article

Abstract

  • We have shown that injury to alveolar epithelial type I cells may account, in part, for damage to the air-blood barrier of the lung in a rat model of Staphylococcus aureus pneumonia. We have also shown that alpha-toxin is an important cause of damage to the air-blood barrier; however, our data suggest that the toxin is not acting directly on alveolar type I cells.
  • Published In

    Digital Object Identifier (doi)

    Author List

  • McElroy MC; Harty HR; Hosford GE; Boylan GM; Pittet JF; Foster TJ
  • Start Page

  • 5541
  • End Page

  • 5544
  • Volume

  • 67
  • Issue

  • 10