No compelling evidence that sibutramine prolongs life in rodents despite providing a dose-dependent reduction in body weight

Academic Article


  • Objective: The health and longevity effects of body weight reduction resulting from exercise and caloric restriction in rodents are well known, but less is known about whether similar effects occur with weight reduction from the use of a pharmaceutical agent such as sibutramine, a serotonin-norepinephrine reuptake inhibitor.Results and conclusion: Using data from a 2-year toxicology study of sibutramine in Sprague-Dawley CD rats and CD-1 mice, despite a dose-dependent reduction in food intake and body weight in rats compared with controls, and a body weight reduction in mice at the highest dose, there was no compelling evidence for reductions in mortality rate. © 2011 Macmillan Publishers Limited All rights reserved.
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Smith DL; Robertson HT; Desmond RA; Nagy TR; Allison DB
  • Start Page

  • 652
  • End Page

  • 657
  • Volume

  • 35
  • Issue

  • 5