Adults age 50 and older with HIV represent approximately 20% to 25% of the entire HIV population in the United States. This unique clinical population is expected to grow; therefore, understanding how to facilitate successful aging in this population is needed. Issues that can negatively affect successful aging with HIV have been identified, and include social isolation, suicidal ideation, HIV-related stigma, cognitive decline, sarcopenia, HIV-medication toxicity, osteoporosis, and fatigue. This brief overview provides nurses with specific insights for practice, intervention, and research.