EPSPs in rat neocortical neurons in vitro II. Involvement of N-methyl-D-aspartate receptors in the generation of EPSPs

Academic Article


  • Intracellular recordings were obtained from neurons in layer II/III of rat frontal cortex. Single-electrode current- and voltage-clamp techniques were employed to compare the sensitivity of excitatory postsynaptic potentials (EPSPs) and iontophoretically evoked responses to N-methyl-D-aspartate (NMDA) to the selective NMDA antagonist D-2-amino-5-phosphonovaleric acid (D-2-APV). The voltage dependence of the amplitudes of the EPSPs before and after pharmacologic changes in the neuron's current-voltage relationship was also examined.
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    Author List

  • Sutor B; Hablitz JJ
  • Start Page

  • 621
  • End Page

  • 634
  • Volume

  • 61
  • Issue

  • 3