Altered Serum Cytokine Signature in Common Variable Immunodeficiency

Academic Article


  • Purpose: Common variable immunodeficiency (CVID) is the most frequent form of primary symptomatic hypogammaglobulinemia. CVID patients display a number of abnormalities in lymphocyte subpopulations including chronic T-cell activation and decreased numbers of circulating CD4+ T cells and NK cells. We and others have recently shown that CVID is associated with increased concentration of soluble CD14 (sCD14) and other factors indicating limited microbial translocation.
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Hel Z; Huijbregts RPH; Xu J; Nechvatalova J; Vlkova M; Litzman J
  • Start Page

  • 971
  • End Page

  • 978
  • Volume

  • 34
  • Issue

  • 8