Alpha-tocopherol mediated peroxidation in the copper (II) and met myoglobin induced oxidation of human low density lipoprotein: the influence of lipid hydroperoxides.

Academic Article


  • The principal antioxidant in human LDL, alpha-tocopherol, is converted to the alpha-tocopheroxyl radical after reaction with peroxyl radicals or Cu2+, and, if it does not terminate with peroxyl radicals, could initiate lipid peroxidation; a phenomenon called 'tocopherol mediated peroxidation'. Only in the presence of Cu2+ and low levels of lipid hydroperoxides was an alpha-tocopherol dependent decrease in the resistance of LDL to oxidation detected. This suggests that tocopherol mediated peroxidation will probably not contribute significantly as a pro-oxidant process in those individuals most at risk of developing atherosclerosis through an oxidative mechanism.
  • Published In

  • FEBS Letters  Journal
  • Keywords

  • Azoles, Cations, Divalent, Copper, Humans, In Vitro Techniques, Isoindoles, Lipid Peroxides, Lipoproteins, LDL, Metmyoglobin, Organoselenium Compounds, Oxidation-Reduction, Vitamin E
  • Digital Object Identifier (doi)

    Author List

  • Iwatsuki M; Niki E; Stone D; Darley-Usmar VM
  • Start Page

  • 271
  • End Page

  • 276
  • Volume

  • 360
  • Issue

  • 3