Therapeutic vaccination against chronic viral infection: The importance of cooperation between CD4+ and CD8+ T cells

Academic Article


  • The goal of therapeutic vaccination is to elicit an antiviral immune response within persistently infected individuals and consequently eradicate the infection. CD8+ T cells are potent mediators of viral clearance; however, during chronic infections CD4+ T cell help is required to sustain antiviral CD8+ T cell activity. Therapeutic vaccination should be targeted towards enhancing both CD4+ and CD8+ T cell virus-specific responses.
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Zajac AJ; Murali-Krishna K; Blattman JN; Ahmed R
  • Start Page

  • 444
  • End Page

  • 449
  • Volume

  • 10
  • Issue

  • 4