Interleukin-21: A multifunctional regulator of immunity to infections

Academic Article


  • Interleukin-21 (IL-21) is a cytokine that has broad effects on both innate and adaptive immune responses. The roles of IL-21 in determining immunity to infections are currently being defined, and notably, it has been shown that IL-21 is most critical for sustaining T cell responses during chronic viral infections. This article discusses our current understanding of the immunobiology of IL-21, as well as its known and potential roles in influencing immunity to infections. © 2010 Institut Pasteur.
  • Digital Object Identifier (doi)

    Author List

  • Yi JS; Cox MA; Zajac AJ
  • Start Page

  • 1111
  • End Page

  • 1119
  • Volume

  • 12
  • Issue

  • 14-15