IL-21 optimizes T cell and humoral responses in the central nervous system during viral encephalitis

Academic Article


  • Acute coronavirus encephalomyelitis is controlled by T cells while humoral responses suppress virus persistence. This study defines the contribution of interleukin (IL)-21, a regulator of T and B cell function, to central nervous system (CNS) immunity. IL-21 receptor deficiency did not affect peripheral T cell activation or trafficking, but dampened granzyme B, gamma interferon and IL-10 expression by CNS T cells and reduced serum and intrathecal humoral responses. Viral control was already lost prior to humoral CNS responses, but demyelination remained comparable. These data demonstrate a critical role of IL-21 in regulating CNS immunity, sustaining viral persistence and preventing mortality. © 2013 Elsevier B.V.
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    Digital Object Identifier (doi)

    Author List

  • Phares TW; DiSano KD; Hinton DR; Hwang M; Zajac AJ; Stohlman SA; Bergmann CC
  • Start Page

  • 43
  • End Page

  • 54
  • Volume

  • 263
  • Issue

  • 1-2