Endogenous mutations in human uncoupling protein 3 alter its functional properties

Academic Article


  • Human uncoupling protein 3 (UCP3) is a mitochondrial transmembrane carrier that uncouples oxidative phosphorylation and is a candidate gene for obesity. Expression of native human UCP3 mutations in yeast showed complete loss (R70W), significant reduction (R143X), or no effect (V102I and IVS6+1G>A) on the uncoupling activity of UCP3. It is concluded that certain mutations in UCP3 alter its functional impact on membrane potential (ΔΨ), possibly conferring susceptibility to develop metabolic diseases.
  • Published In

  • FEBS Letters  Journal
  • Digital Object Identifier (doi)

    Author List

  • Brown AM; Dolan JW; Willi SM; Garvey WT; Argyropoulos G
  • Start Page

  • 189
  • End Page

  • 193
  • Volume

  • 464
  • Issue

  • 3