Marginal zone and B1 B cells unite in the early response against T-independent blood-borne particulate antigens

Academic Article


  • The rate of pathogen elimination determines the extent and consequences of an infection. In this context, the spleen with its highly specialized lymphoid compartments plays a central role in clearing blood-borne pathogens. Splenic marginal zone B cells (MZ), by virtue of their preactivated state and topographical location, join B1 B cells to generate a massive wave of IgM producing plasmablasts in the initial 3 days of a primary response to particulate bacterial antigens. Because of the intensity and rapidity of this response, combined with the types of antibodies produced, splenic MZ and B1 B cells endowed with a "natural memory" provide a bridge between the very early innate and the later appearing adaptive immune response.
  • Published In

  • Immunity  Journal
  • Digital Object Identifier (doi)

    Pubmed Id

  • 15738555
  • Author List

  • Martin F; Oliver AM; Kearney JF
  • Start Page

  • 617
  • End Page

  • 629
  • Volume

  • 14
  • Issue

  • 5