Marginal zone B cells in lymphocyte activation and regulation

Academic Article


  • Marginal zone (MZ) B cells, together with other strategically located innate cells, constitute the first line of defense against blood-borne microorganisms, viruses and toxins in the spleen. Their fast and efficient protective antibody responses are well characterized; however, much less is known of their interactions with other cell types during immune responses. Recent work has demonstrated that MZ B cells can directly activate T cells; and MZ B cells also interact with other antigen presenting cells, transporting and concentrating antigen during the course of T-dependent and T-independent immune responses. © 2005 Elsevier Ltd. All rights reserved.
  • Published In

    Digital Object Identifier (doi)

    Pubmed Id

  • 15869445
  • Author List

  • Lopes-Carvalho T; Foote J; Kearney JF
  • Start Page

  • 244
  • End Page

  • 250
  • Volume

  • 17
  • Issue

  • 3