Protein serotyping of Streptococcus pneumoniae based on reactivity to six monoclonal antibodies

Academic Article


  • Six monoclonal antibodies to proteins of Streptococcus pneumoniae were tested in a dot blot assay for reactivity with 499 clinical isolates of pneumococci. Forty-four percent of the isolates reacted with at least one of the antibodies. Nineteen patterns of reactivity were identified and each designated as a provisional protein serotype. Protein serotyping identified pneumococcal strains independently of their capsular type and made it possible to differentiate strains within most capsular types. A protein serotyping system provides a new dimension to the phenotypic identification of S. pneumoniae and may eventually provide a basis for assessing the population structure of these organisms. © 1988.
  • Authors

    Published In

    Digital Object Identifier (doi)

    Pubmed Id

  • 9746736
  • Author List

  • Waltman WD; McDaniel LS; Andersson B; Bland L; Gray BM; Eden CS; Briles DE
  • Start Page

  • 159
  • End Page

  • 167
  • Volume

  • 5
  • Issue

  • 3