Resistance of T-cell receptor δ-chain-deficient mice to experimental Candida albicans vaginitis

Academic Article


  • Conditions consistent with tolerance or immunoregulation have been observed in experimental Candida albicans vaginal infections. The present study investigated the role of γ/δ T cells in experimental vaginal candidiasis. Results showed that T-cell receptor δ-chain-knockout mice had significantly less vaginal fungal burden when compared to wild-type mice, suggesting an immunoregulatory role for γ/δ T cells in Candida vaginitis.
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Wormley J; Steele C; Wozniak K; Fujihashi K; McGhee JR; Fidel J
  • Start Page

  • 7162
  • End Page

  • 7164
  • Volume

  • 69
  • Issue

  • 11