Change in CCK-8 response after diet-induced obesity and MC3/4-receptor blockade

Academic Article


  • Little is known regarding satiety effects of systemically administered cholecystokinin (CCK-8) in propensity or resistance to dietary-induced obesity (DIO), and of its effect under conditions of melanocortin-3/4R blockade. We found that CCK-8 exerted greater satiety effects in DIO-prone but not DIO-resistant rats, and this occurred only when the rats were placed on a high-fat (HF) diet, when DIO-prone rats failed to compensate for the greater energy density of the diet. CCK-8 also suppressed intake stimulated by melanocortin-3/4R antagonist, SHU9119, but only after 24h of increased feeding. This suggests that under both of these conditions, responsiveness to CCK's satiety effect is not so much affected by a HF diet or significant increases in body weight per se, but by a failure to rapidly limit food intake to that needed only for metabolic need. Identification of an early feeding mediator that is most strongly activated by a HF diet or by an acute challenge to energy homeostasis should provide an ideal anti-obesity target adjunct to CCK-8. © 2004 Elsevier Inc. All rights reserved.
  • Published In

  • Peptides  Journal
  • Digital Object Identifier (doi)

    Author List

  • Chandler PC; Wauford PK; Oswald KD; Maldonado CR; Hagan MM
  • Start Page

  • 299
  • End Page

  • 306
  • Volume

  • 25
  • Issue

  • 2