Although bedside placement of inferior vena cava (IVC) filters by means of transabdominal duplex ultrasound is possible in most patients, those with inadequate visualization have traditionally required fluoroscopy. The purpose of this study was to assess the safety and efficacy of bedside IVC filter placement with intravascular ultrasound (IVUS) when transabdominal duplex ultrasound imaging is inadequate. Between January 1, 1999 and December 31, 2002, 256 IVC filter placements were performed (207 with transabdominal duplex ultrasound [81%], 21 with fluoroscopy [8%], and 28 with IVUS [11%]). IVC filter placement with IVUS was performed only if visualization with transabdominal duplex ultrasound was determined to be inadequate. Demographics, technical data, and outcome for patients undergoing IVC filter placement with IVUS were reviewed and form the basis of this report. Bedside IVC filter placement with IVUS was technically successful in 26 of 28 patients (93%). Post-procedure abdominal radiographs confirmed proper placement, based on bony landmarks in 24 of 26 patients (92%). Post-procedure complications included insertion site thrombosis in two patients and possible recurrent pulmonary embolism in one patient 2 months following filter placement. One patient died from causes unrelated to IVC filter placement. From these results we conclude that IVC filter placement with IVUS is technically feasible and safe. This may allow for expanded bedside IVC filter placement capabilities in patients with inadequate IVC visualization on transabdominal duplex ultrasound.